Paul Bleicher

Paul Bleicher

@pbleic.bsky.social

MD/PhD, Academia => Biotech => Pharma/HealthIT => PE/VC. Immunology, medicine,dermatology, clinical trials, EDC, RWE, AI

422 followers341 following295 posts

It seems like I am in a “Red Pill” moment where I now realize that a lot of the chaos and anxiety I have been feeling was artificially created by foreign agent bots on social media designed for exactly that purpose. www.nytimes.com/2026/10/22/u...

nytimes.comCovert Russian Group Targets James Talarico With Baseless Claims in Texas Senate RaceRussian influence operations appear to be stepping up efforts to meddle in the midterms, according to intelligence officials. Most are targeting Democrats.

Yes, and we can use AI to predict which of the immigrants is likely to be a highly successful entrepreneur. I am sure it would be amazingly successful at doing that. 🤦🤦

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Most people are going to want to make more money by leveraging the tools and time they have. If AI has people enjoying 3 day work weeks, others will work 5-7 days using AI. The 3 day people will fall behind. AI will only allow individuals to do more in the time they work, not work less.

The Tennessee Holler @thetnholler.bsky.social

They think we’re all idiots As Jon Stewart says — if the goal is guaranteed income and jobs, why wait? Why is it only “socialism” if we don’t hand them trillions of dollars first?

No, Jeopardy. MItzvah doesn’t mean “good deed.” It means commandment. A Bar Mitzvah is now obligated by the commandments of Jewish law. Sheesh.

Pneumonic plague is a fatal bacterial disease that is highly treatable with antibiotics if started early (80-90% reduction in mortality). Ebola, not so much. A single unusual event sometimes garners much larger press interest than something that affects large numbers over time. Unfortunately.

Krutika Kuppalli, MD FIDSA@krutikakuppalli.bsky.social

One unexplained death in Russia, with possible concerns about #plague, is dominating headlines. Meanwhile, #Ebola continues to worsen in DRC with 8,300 cases. 4,018 deaths since May Yet much of the world and the media seems to have moved on. What’s wrong with this picture?

Scotland recently announced that they had eliminated cervical cancer in women vaccinated at age 12-13. This is about making money as a plaintiff. At the real cost of people’s lives.

Prof Gavin Yamey MD MPH@gavinyamey.bsky.social

I really wish the world’s most dangerous, extreme anti-vaccine activist & conspiracy theorist, RFK Jr, who is a eugenicist & a MAHA dude who repeatedly peddles vile lies, had not been put in charge of the US health system Here he is telling truly horrific, dangerous lies about HPV & COVID vaccines

Why George Mason’s refused to sign the Constitution: #8: An unrestricted pardon power could let a President pardon accomplices in treason, concealing his own involvement. #15: The new government could evolve into either monarchy or a corrupt, tyrannical aristocracy.

Past 24 hours of "I am the Code" and naming everything in sight (including Ford's Theater) stories suggested this to me, and ChatGPT provided. With apologies to Louis-Dieudonné.

This has nothing to do with Israel. It is pure antisemitism, which has alternately simmered and boiled over for millennia. Israel is a convenient excuse to go after anyone who identifies as being an engaged Jew.

StandWithUs@standwithus.bsky.social

Jewish students at Wilfrid Laurier University returned from celebrating Rosh Hashanah to find mezuzahs on their residence doors smashed and torn down. Smashing mezuzahs in a university residence is an act of hate and intimidation. No student should ever have to experience this.

Paul Bleicher reposted

My mom had polio when she was five. She was living on a US military base in Japan (1947). Four kids on the base died. She was the only survivor.

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Paul Bleicher reposted

My grandfather, who is 102 and a medical doctor, has told me about the times before polio was cured. Most years, upon returning to school after summer’s break, there would be some children would didn’t make it back to school because of polio.

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My first vote was during Carter vs. Ford in 1976. The 26th Amendment changed the vote from 21 to 18 in 1971, but I was 2 mos. too young to vote in 72, the McGovern vs. Nixon election. What election was your first vote?

Sky Marchini@sky.skymarchini.net

Got hurt by my church friends tonight They mentioned how politics in America used to be so different, and that they were learning about Obama in history class and they watched a clip of him debating Romney and it was like a completely different world And I was like, what do you mean history class

“And another one down, another one down, another one bites the dust.”

This is a 5 alarm fire. Later in the thread - 35% of working STEM PhDs in the US are foreign born. This will have a huge ripple effects to universities, silicon valley, medical science - in short, sending us further towards a bleak future.

Michael Clemens@mclem.org

The US President's new proposal to tax international students has been approved by the White House for release this week. It's an unprecedented $100,000 tax on int'l grads who stay to work after graduation on Optional Practical Training (most grads do), a crucial bridge to remaining by any channel.

And race and ethnicity, while arguably flawed constructs, are still an indicator of many things related to education, health, etc. Health data research uses the census all the time. Results will be dramatically skewed and non-comparable to the past. That appears to be the desired outcome. (2/2)

Paul Bleicher reposted

The number of cases of cervical cancer reported in Scotland among women given the HPV vaccine at 12-13 years of age is now zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. www.bbc.com/news/article...

bbc.comNo cervical cancer cases in fully HPV-vaccinated women in ScotlandA study published by Public Health Scotland finds that the HPV vaccine is "highly effective".

Jews are a joinable people (through conversion) whose members share overlapping religious, historical, cultural and genetic heritage. Most long-established Jewish communities show significant shared ancestry originating in the ancient Levant, alongside varying local admixture.

Astonishing. RFK Jr. adds 8 members to a 6 member FDA advisory panel. 6 of them were sellers of peptides, and the 7th a compounding pharmacist. In an 8-6 vote with all 8 votes coming from these new panel members, the panel approved 4 peptides against the objections of FDA scientists.

nytimes.comFDA Panel Supports Lifting Restrictions on Four Peptides (Gift Article)In an all-day hearing, the agency’s scientists argued against allowing broad access to unproven drugs that the agency had banned three years ago.
View full thread

For those less familiar with the basics, an explanatory infographic on amino acids, proteins, and peptides and the 7 compounds before the committee yesterday and today.

An explanatory infographic on amino acids, proteins, and peptides and the 7 compounds before the committee yesterday and today. Consideration is whether these should be on the "allowed" list for manufacture by compounding pharmacies for individual prescriptions.

Astonishing. RFK Jr. adds 8 members to a 6 member FDA advisory panel. 6 of them were sellers of peptides, and the 7th a compounding pharmacist. In an 8-6 vote with all 8 votes coming from these new panel members, the panel approved 4 peptides against the objections of FDA scientists.

nytimes.comFDA Panel Supports Lifting Restrictions on Four Peptides (Gift Article)In an all-day hearing, the agency’s scientists argued against allowing broad access to unproven drugs that the agency had banned three years ago.
View full thread

Regarding whether this will at least improve safety and controls in manufacturing (as in the chatGPT comment, above), this from the March NY times article above:

Paul Bleicher@pbleic.bsky.social

Astonishing. RFK Jr. adds 8 members to a 6 member FDA advisory panel. 6 of them were sellers of peptides, and the 7th a compounding pharmacist. In an 8-6 vote with all 8 votes coming from these new panel members, the panel approved 4 peptides against the objections of FDA scientists.

Astonishing. RFK Jr. adds 8 members to a 6 member FDA advisory panel. 6 of them were sellers of peptides, and the 7th a compounding pharmacist. In an 8-6 vote with all 8 votes coming from these new panel members, the panel approved 4 peptides against the objections of FDA scientists.

nytimes.comFDA Panel Supports Lifting Restrictions on Four Peptides (Gift Article)In an all-day hearing, the agency’s scientists argued against allowing broad access to unproven drugs that the agency had banned three years ago.
View full thread

Astonishing. RFK Jr. adds 8 members to a 6 member FDA advisory panel. 6 of them were sellers of peptides, and the 7th a compounding pharmacist. In an 8-6 vote with all 8 votes coming from these new panel members, the panel approved 4 peptides against the objections of FDA scientists.

nytimes.comFDA Panel Supports Lifting Restrictions on Four Peptides (Gift Article)In an all-day hearing, the agency’s scientists argued against allowing broad access to unproven drugs that the agency had banned three years ago.
View full thread

A more precise description is: The FDA advisory panel voted to recommend adding BPC-157 to the FDA’s 503A Bulks List, which would allow compounding pharmacies to prepare the peptide from bulk active ingredient for individually prescribed patients, provided the FDA accepts the recommendation.

Astonishing. RFK Jr. adds 8 members to a 6 member FDA advisory panel. 6 of them were sellers of peptides, and the 7th a compounding pharmacist. In an 8-6 vote with all 8 votes coming from these new panel members, the panel approved 4 peptides against the objections of FDA scientists.

nytimes.comFDA Panel Supports Lifting Restrictions on Four Peptides (Gift Article)In an all-day hearing, the agency’s scientists argued against allowing broad access to unproven drugs that the agency had banned three years ago.
View full thread

Note that in the past, the members of the advisory panels were mostly, if not all, distinguished physicians, pharmacists, and scientists who were experts in the field. If you are curious as to whether there is ANY rationale for approving these peptides, this answer from chatGPT is helpful.

Another important note - this is an Advisory Panel, which typically has substantial, if not overwhelming influence in FDA approval decisions. However, the FDA isn’t required to follow their recommendations, and on occasion haven’t.

Astonishing. RFK Jr. adds 8 members to a 6 member FDA advisory panel. 6 of them were sellers of peptides, and the 7th a compounding pharmacist. In an 8-6 vote with all 8 votes coming from these new panel members, the panel approved 4 peptides against the objections of FDA scientists.

nytimes.comFDA Panel Supports Lifting Restrictions on Four Peptides (Gift Article)In an all-day hearing, the agency’s scientists argued against allowing broad access to unproven drugs that the agency had banned three years ago.

These peptides are “research-grade” and supporting data were primarily animal and in vitro results. Typical large scale blinded clinical trials for safety and efficacy have not been done. This is the Wild West.