Nicky O’Boyle

Nicky O’Boyle

@oboylelab.bsky.social

Assistant Professor in molecular microbiology - host-pathogen interactions, transcription, translation, signalling, and metabolism 🧬🔬🦠(Trinity College Dublin)

591 followers243 following27 posts

Nicky O’Boyle
@oboylelab.bsky.social

Fantastic opportunity for Microbiology/Immunology graduates to do amazing science with a supportive lab!

James Connolly@ruamicro.bsky.social

Want to research the basis of how drug resistant bacteria interact with human immune cells? Fully funded 4-year PhD position available (UK home students). Come and join our amazing interdisciplinary team at the intersection of microbiology, immunity, metabolism and the clinic! Please spread the word

findaphd.comHiding in plain sight: How a multi-drug resistant pathogen evades detection and killing by human neutrophils at Newcastle University on FindAPhD.comPhD Project - Hiding in plain sight: How a multi-drug resistant pathogen evades detection and killing by human neutrophils at Newcastle University, listed on FindAPhD.com

Nicky O’Boyle reposted

Siobhán O'Brien
@siderophile.bsky.social

Just over two weeks left to register for MENI 2026! A !!free!! microbial evolution meeting in Ireland with some fantastic keynote speakers @jpjhall.bsky.social @rachelmwheatley.bsky.social @drrebeccajhall.bsky.social @tweethinking.bsky.social #Evolution #microbes www.eventbrite.com/e/3rd-microb...

eventbrite.com3rd Microbial Evolution Network Ireland meeting2026 Microbial Evolution Network Ireland meeting, at Trinity College Dublin
Nicky O’Boyle
@oboylelab.bsky.social

Delighted to share our latest research on EHEC type 3 secretion regulation through amino acid deamination. Big collaborative effort over several years. Thanks to all our co-authors and funders. 📄 www.pnas.org/doi/10.1073/...

pnas.orgCatabolism of serine enantiomers represses enterohemorrhagic Escherichia coli virulence factors via modulation of the nitrogen stress response | PNASAttaching and effacing pathogens, including enterohemorrhagic Escherichia coli (EHEC), colonize their preferred intestinal niche by sensing diverse...
Nicky O’Boyle
@oboylelab.bsky.social

Delighted to share the hard work of undergraduate student Ella Rellis and first publication from my group since relocating to TCD. Here we identify a new stress response regulator induced by D-serine. 🦠🔬🧫 @microbiologysociety.org #publishforthecommunity www.microbiologyresearch.org/content/jour...

microbiologyresearch.orgThe glucose uptake inhibitor SgrS is induced by D-serine yet does not contribute to growth arrest in enterohaemorrhagic Escherichia coliBacterial pathogens sense and respond to host-derived metabolites to regulate virulence and establish successful infections. d-Serine, an amino acid abundant in some extraintestinal environments but s...
Nicky O’Boyle
@oboylelab.bsky.social

👏🎉 Congrats Aalap et al. #publishforthecommunity @microbiologysociety.org

Kröger Lab@kroegerlab.bsky.social

This work is now out in Microbiology! www.microbiologyresearch.org/content/jour.... Congrats to first author Aalap Mogre! Publish with the Microbiology Society! A membership charity and not-for-profit publisher: @microbiologysociety.org !

microbiologyresearch.orgDevelopment of two compatible plasmids to assess sRNA-mediated post-transcriptional regulation in Acinetobacter baumanniiPost-transcriptional regulation can be mediated by small regulatory RNAs (sRNAs) in bacteria, which can act by base-pairing to a target mRNA. The discovery and mechanistic validation of base-pairing s...

Nicky O’Boyle reposted

Kate Beckham
@kshbeckham.bsky.social

Want to find ways to combat TB? Check out this PhD position 👇

Alistair Brown@mycobacterium-ncl.bsky.social

PhD opportunity with me and @kshbeckham.bsky.social www.findaphd.com/phds/project...

findaphd.comMRC DiMeN Doctoral Training Partnership: Structural and Functional Analysis of Drug Resistance in Tuberculosis via a Novel MmpL3 Binding Site at Newcastle University on FindAPhD.comPhD Project - MRC DiMeN Doctoral Training Partnership: Structural and Functional Analysis of Drug Resistance in Tuberculosis via a Novel MmpL3 Binding Site at Newcastle University, listed on FindAPhD....

Nicky O’Boyle reposted

Alistair Brown
@mycobacterium-ncl.bsky.social

PhD opportunity with me and @kshbeckham.bsky.social www.findaphd.com/phds/project...

findaphd.comMRC DiMeN Doctoral Training Partnership: Structural and Functional Analysis of Drug Resistance in Tuberculosis via a Novel MmpL3 Binding Site at Newcastle University on FindAPhD.comPhD Project - MRC DiMeN Doctoral Training Partnership: Structural and Functional Analysis of Drug Resistance in Tuberculosis via a Novel MmpL3 Binding Site at Newcastle University, listed on FindAPhD....
Nicky O’Boyle
@oboylelab.bsky.social

Fantastic PhD opportunity 👇

James Connolly@ruamicro.bsky.social

If you are interested in researching how drug resistant bacteria evade killing by our immune system, them this PhD project is for you. Come join the our team at Newcastle, in collaboration with University of Liverpool, and lead research at the interface of microbiology, immunology and metabolomics.

findaphd.comMRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University on FindAPhD.comPhD Project - MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University, listed on Fin...
Nicky O’Boyle
@oboylelab.bsky.social

The Microbiology Society returns to Belfast in April. From microbiomes to natural products, phage to protists, infection models to plant pathogens, together with all the usual fora, and ECM development opportunities. There truly is something for everyone! Get your abstracts in now and join us! 🦠

Microbiology Society@microbiologysociety.org

Submit your abstract for the UK’s largest annual gathering of microbiologists, Annual Conference 2026. Held in Belfast, UK, this year’s conference now features two-day attendance tickets.

Nicky O’Boyle reposted

Microbiology Society
@microbiologysociety.org

Register today for Microbiology Society Annual Meeting in Ireland 2025. Join us for a one-and-a-half day meeting in Athlone, Ireland for an opportunity to explore current Microbiology research and spark collaboration amongst fellow researchers, educators and early careers.

Nicky O’Boyle
@oboylelab.bsky.social

🚨One week left to apply for this exciting postdoctoral opportunity. 4 year project investigating novel therapeutics targeting IBD-associated pathobionts. Come and join us at TCD Microbiology 🦠🧬🔬

Nicky O’Boyle@oboylelab.bsky.social

Looking to appoint a new or experienced Postdoc to join my team. Investigating novel therapeutics targeting Crohn's disease associated bacteria. Background in Microbiology, Immunology, Biochemistry or related field. 🦠🔬 Apply here: my.corehr.com/pls/trrecrui... Closing date: 31st May 2025

Nicky O’Boyle
@oboylelab.bsky.social

🚨One week left to apply for this PhD opportunity. Come and join us at TCD Microbiology. All fees and full €25000 stipend covered for 4 years.

Nicky O’Boyle@oboylelab.bsky.social

Looking to appoint a PhD candidate with background in Microbiology, Biochemistry, Biotechnology or related field to work on discovery of infection combatting therapeutics in marine sponge-associated bacteria. Closing date 31st May 2025. International applications welcomed!🌎

findaphd.comFour year fully funded PhD studentship: Bioprospecting Marine Sponge Streptomyces for Novel Anti-Virulence Therapeutics at Trinity College Dublin on FindAPhD.comPhD Project - Four year fully funded PhD studentship: Bioprospecting Marine Sponge Streptomyces for Novel Anti-Virulence Therapeutics at Trinity College Dublin, listed on FindAPhD.com
Nicky O’Boyle
@oboylelab.bsky.social

Looking to appoint a PhD candidate with background in Microbiology, Biochemistry, Biotechnology or related field to work on discovery of infection combatting therapeutics in marine sponge-associated bacteria. Closing date 31st May 2025. International applications welcomed!🌎

findaphd.comFour year fully funded PhD studentship: Bioprospecting Marine Sponge Streptomyces for Novel Anti-Virulence Therapeutics at Trinity College Dublin on FindAPhD.comPhD Project - Four year fully funded PhD studentship: Bioprospecting Marine Sponge Streptomyces for Novel Anti-Virulence Therapeutics at Trinity College Dublin, listed on FindAPhD.com

Nicky O’Boyle reposted

Justine Rudkin
@scousemicrobe.bsky.social

First PhD student of the Rudkin Lab presenting at her first Microbiology Society event. Super proud of how well she's doing. Hope it's the first of many #MicroBio25

Megan Smith-Cerdán@megssc.bsky.social

Absolutely loved my first @microbiologysociety.org annual conference! 🦠 It was great to attend so many fascinating talks, chat over lots of interesting posters and share my research with such a supportive community!

Nicky O’Boyle reposted

John F. Cryan
@jfcryan.bsky.social

Study finds strongest evidence yet that shingles vaccine helps cut dementia risk Older adults in Wales who had the jab were 20% less likely to be diagnosed with dementia that those not vaccinated www.theguardian.com/society/2025...

theguardian.comStudy finds strongest evidence yet that shingles vaccine helps cut dementia riskOlder adults in Wales who had the jab were 20% less likely to be diagnosed with dementia that those not vaccinated

Nicky O’Boyle reposted

Connor G G Bamford
@connorggbamford.bsky.social

Our final PhD position is now live - come help us see if AI approaches can aid our understanding of cellular signalling systems during infection and cancer. Maybe this could help develop new clinical interventions? www.findaphd.com/phds/project...

findaphd.comNILAB: EVOLVE-AI: Evolutionary-Informed Deep Learning for Deciphering and Modifying Cell-Cell Communication During Infection, Inflammation, and Cancer at Queen’s University Belfast on FindAPhD.comPhD Project - NILAB: EVOLVE-AI: Evolutionary-Informed Deep Learning for Deciphering and Modifying Cell-Cell Communication During Infection, Inflammation, and Cancer at Queen’s University Belfast, list...

Nicky O’Boyle reposted

Conor Feehily
@sligomicrobe.bsky.social

📣Publication alert! Another great output from @metagymomics.bsky.social for his PhD. Looking at strain level genetic variation within members of the vaginal microbiome. #microsky @pauldcotter.bsky.social @calumwalsh.bsky.social www.nature.com/articles/s41...

nature.comStrain-level variation among vaginal Lactobacillus crispatus and Lactobacillus iners as identified by comparative metagenomics - npj Biofilms and Microbiomesnpj Biofilms and Microbiomes - Strain-level variation among vaginal Lactobacillus crispatus and Lactobacillus iners as identified by comparative metagenomics

Nicky O’Boyle reposted

Kröger Lab
@kroegerlab.bsky.social

Our lab contributed to this including @hamrockfergal.bsky.social : CsrA-mediated regulation of a virulence switch in Acinetobacter baumannii. Great work led by Phil Rather's group. journals.asm.org/doi/10.1128/...

journals.asm.orgCsrA-mediated regulation of a virulence switch in Acinetobacter baumannii | mBioThe World Health Organization has ranked Acinetobacter baumannii atop its “priority pathogens” list highlighting the urgent need for new therapeutics against this pathogen. Many A. baumannii strains i...

Nicky O’Boyle reposted

Kröger Lab
@kroegerlab.bsky.social

A work that started 10y ago with a simple experiment with a curious result. Great to see it finally published. Massive effort by @nic-ler.bsky.social and Andrew Cameron! Happy to have contributed to this!

Jay Hinton@jayhinton.bsky.social

Really exciting work: The Salmonella Colicin Col1b cannot only KILL a competing E. coli population, but also AMPLIFY metabolic contributions of susceptible bacteria by liberating β-gal… From @nic-ler.bsky.social. @kroegerlab.bsky.social, Andrew Cameron and others ‼️ academic.oup.com/ismej/advanc...

academic.oup.comLysis of Escherichia coli by colicin Ib contributes to bacterial cross-feeding by releasing active β-galactosidaseAbstract. The diffusible toxin ColIb produced by Salmonella enterica serovar Typhimurium SL1344 is a potent inhibitor of Escherichia coli growth. To identi

Nicky O’Boyle reposted

Teresa Thurston
@thurstonlab.bsky.social

Interested in a PhD in bacterial pathogenesis? Then consider applying to the inaugural David Holden PhD Studentship at Imperial inaugural David Holden PhD Studentship (home funded students only). Deadline Jan 31st! www.findaphd.com/phds/project...

findaphd.comThe David Holden PhD Studentship in Bacterial Pathogenesis at Imperial College London: Molecular Mechanisms in Bacterial Pathogenesis at Imperial College London on FindAPhD.comPhD Project - The David Holden PhD Studentship in Bacterial Pathogenesis at Imperial College London: Molecular Mechanisms in Bacterial Pathogenesis at Imperial College London, listed on FindAPhD.com

Nicky O’Boyle reposted

Kate Beckham
@kshbeckham.bsky.social

First post of the year to mark my return from maternity leave :) Excited to share the first open PhD position in my group. Deadline end of February. Please spread the word. www.findaphd.com/phds/projectdetails.aspx?PJID=181239

findaphd.comPhD studentship: Structural and functional characterisation of mycobacterial outer membrane proteins at Newcastle University on FindAPhD.comPhD Project - PhD studentship: Structural and functional characterisation of mycobacterial outer membrane proteins at Newcastle University, listed on FindAPhD.com

Nicky O’Boyle reposted

Knut Drescher
@knutdrescher.bsky.social

We found that many bacterial species use exogenous peptidoglycan fragments - released by lysis of neighboring cells - as a general danger signal, triggering a danger response that protects bacteria against many dangers: biofilm formation. Details here 👇 www.nature.com/articles/s41...

nature.comBacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation - Nature MicrobiologyPeptidoglycan released by neighbouring kin or non-kin cell lysis induces physiological changes that protect from a range of stresses, including phage predation.

Nicky O’Boyle reposted

Lars Barquist
@lbarquist.bsky.social

New paper from the Faber lab in @plosbiology.org characterizing the C. difficle ncRNA ModT, with effects on sporulation and the transition into stationary phase, evidence for RBP association -- and similar abundance to some ribosomal RNAs! 🧫🦠 journals.plos.org/plosbiology/...

journals.plos.orgThe conserved noncoding RNA ModT coordinates growth and virulence in Clostridioides difficileBacterial non-coding RNAs influence various cellular functions and often have complex tertiary structures. This study characterizes ModT, a conserved ncRNA found in 2,500 bacterial species, found to r...

Nicky O’Boyle reposted

Grainger Lab
@graingerlab.bsky.social

PhD projects available in our lab all listed in the below link. All focus on bacterial gene regulation, in the context of basic understanding, disease, or antibiotic resistance. Deadlines in January... www.findaphd.com/phds/?Keywor...

findaphd.comgrainger birmingham PhD Projects, Programmes & ScholarshipsFindAPhD. Search Funded PhD Projects, Programmes & Scholarships in grainger birmingham. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
Nicky O’Boyle
@oboylelab.bsky.social

Delighted to receive the Emerging Investigator Award from @hrbireland to fund this research aimed at developing new Crohn's disease therapeutics. Huge thanks to UCC collaborators Subrata Ghosh, Marietta Iacucci, Susan Joyce and Jens Walter for their support! 🤩🦠🔬💊

hrb.ieHRB invests €12.5 million in 13 new projects to develop Ireland’s future research leaders | HRB | Health Research BoardThe research projects supported in this round will tackle research questions that include topics such as suicide prevention in children, adolescents and

Nicky O’Boyle reposted

Justine Rudkin
@scousemicrobe.bsky.social

Anyone have a good paper looking at presence/absence rates of outer membrane porins in E. coli clinically? What is the occurrence rates of infections caused by E. coli lacking ompA/C/F? I've lots of papers showing the impact of omp loss on AMR and virulence, but how common is this? #MicroSky

Nicky O’Boyle reposted

Jessica Blair
@jessicamablair.bsky.social

Another PhD opportunity in the team! This time its an exciting collaboration with @halllab.bsky.social and @kimhardie.bsky.social looking at why not all bacteria become resistant! www.findaphd.com/phds/project... Deadline 10th Jan and open to Uk and overseas! Pls repost!

findaphd.comWhy does Acinetobacter lwoffii not become resistant to antibiotics? at University of Birmingham on FindAPhD.comPhD Project - Why does Acinetobacter lwoffii not become resistant to antibiotics? at University of Birmingham, listed on FindAPhD.com
Nicky O’Boyle
@oboylelab.bsky.social

An inspirational superstar of the Microbiology world! 🦑🦠💡

HHMI@hhmi-science.bsky.social

“We’ve shown that bacteria have this profound importance on earth,” HHMI Investigator Bonnie Bassler said. “They communicate with chemical words, they count their numbers, they act in groups, and they carry out tasks as collectives that they could never accomplish as individuals.”

youtu.beScientist Spotlights: HHMI Investigator Bonnie BasslerYouTube video by Howard Hughes Medical Institute (HHMI)

Nicky O’Boyle reposted

James Connolly
@ruamicro.bsky.social

Really happy to share our latest paper on how metabolic regulation and overlaps directly with virulence in enteric pathogens. Congrats to Kabo Wale on this work, it was a pleasure to co supervise this PhD with Prof Andy Roe journals.plos.org/plospathogen...

journals.plos.orgA master regulator of central carbon metabolism directly activates virulence gene expression in attaching and effacing pathogensAuthor summary This study reveals an unexpected role for a metabolic regulatory protein in the attaching and effacing family of pathogenic Gram-negatives. The transcription factor PdhR normally functi...

Nicky O’Boyle reposted

Michael Brockhurst
@brockhurstlab.bsky.social

Replying to @brockhurstlab.bsky.social

Choose to support a society that gives back rather than a big publisher that only cares about making profits or predatory publisher with questionable peer review and practices! I promise you our editors will treat your work more care, value and attention than they will.

Nicky O’Boyle reposted

Michael Brockhurst
@brockhurstlab.bsky.social

Use it or lose it: Unless we publish papers in our society owned and published journals they will cease to be, along with all the conferences and meetings the proceeds support. Microbiology Society publishes many excellent journals, all edited by experts. #microsky www.microbiologyresearch.org

microbiologyresearch.orgMicrobiology SocietyMicrobiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefi...
Nicky O’Boyle
@oboylelab.bsky.social

Fantastic opportunity for a motivated student!

Michael Ormsby@michaeljormsby.bsky.social

🚨 #PhD Opportunity! 🚨 Explore Reservoirs of Bacterial Pathogens in Captive Animal Enclosures 🦠🌿🐅🐧 and uncover evolutionary drivers in a changing climate 🌎🔍 with me, @RS_Quilliam, and @RZSS! @IapetusDTP 🔗 tinyurl.com/f2eem9zk #OneHealth #ClimateChange #Zoonoses

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