Jay Hinton

Jay Hinton

@jayhinton.bsky.social

Salmonella admirer & Prof of Microbiology - Working on Salmonella bloodstream infections (iNTS) in sub- Saharan Africa context. Functional genomics. T1D.

2.2K followers1.3K following1.2K posts

Jay Hinton reposted

Vivek Mutalik
@vivekmutalik.bsky.social

Happy to share that @averynoonan.bsky.social paper “Phylogeny-agnostic strain-level prediction of phage–host interactions from genomes using machine learning” is now published in @natmicrobiol.nature.com 🎉🎊 👉🏽 rdcu.be/nR2NizD7H5va

Avery Noonan@averynoonan.bsky.social

We built GenoPHI: a machine learning workflow that predicts phage-host interactions at strain level. This could help rapidly select phages to treat drug-resistant bacterial infections or for microbiome engineering without exhaustive lab testing. www.biorxiv.org/content/10.1...

biorxiv.orgbiorxiv.org

Jay Hinton reposted

Eliza_coli
@eliza-coli.bsky.social

Happy international microorganism day! Deck the halls with vials of agar... Fa lalalalaa la la la la! #IntMicroDay 🦠🐡🧪🧬🧫

Microbiology Society@microbiologysociety.org

It’s International Microorganism Day! For a third year running, some of our Champions have told us about their favourite microbes and our very talented Champion, Eliza Wolfson, has brought these to life with her illustrations! @eliza-coli.bsky.social @femsmicro.org

Jay Hinton reposted

Pedro Escoll
@pescoll.bsky.social

New preprint in the lab! "Single-cell metabolomics reveals infection-specific metabolic reprogramming of human macrophages". Led by Paula Martínez, with @cbuch.bsky.social , Sandrine Aros and @jytinevez.bsky.social How does Legionella pneumophila reshape host metabolism at the single-cell scale? 🧵👇

bioRxiv Microbiology@biorxiv-microbiol.bsky.social

Single-cell metabolomics reveals infection-specific metabolic reprogramming of human macrophages https://www.biorxiv.org/content/10.64898/2026.09.03.749052v1

Jay Hinton reposted

Ed Cunningham-Oakes
@edcoakes.bsky.social

We are advertising an exciting PhD opportunity based at Newcastle University. You’ll use epidemiological and genomic data to characterise Campylobacter burden… and work with me on some cool datasets! Deadline: 28th July 2026 - NB UK Students only due to funding restrictions. Don’t miss out!

findaphd.comNIHR PhD Studentship: Modernising Campylobacter burden assessment using integrated genomics, symptoms and surveillance data at Newcastle University on FindAPhD.comPhD Project - NIHR PhD Studentship: Modernising Campylobacter burden assessment using integrated genomics, symptoms and surveillance data at Newcastle University, listed on FindAPhD.com

Jay Hinton reposted

Vivek Mutalik
@vivekmutalik.bsky.social

Beyond AMGs: Phage-encoded transcription and sigma factors as understudied virocell reprogramming tools #phage #phagesky Trends in Microbiology www.cell.com/trends/micro...

cell.comBeyond AMGs: Phage-encoded transcription and sigma factors as understudied virocell reprogramming toolsPhages, the most abundant biological entities on Earth, infect bacteria and reprogram them into ‘virocells’ with altered physiology and ecology. While metagenomic studies have largely inferred reprogr...

Jay Hinton reposted

Camila Valenzuela, PhD
@kamovalenz.bsky.social

Hate to see this happening, but it's a common thing now with all Frontiers journals. Time to stop publishing there people!!! Please read the full thread!

Michael Okun@michael-okun.bsky.social

I’ve officially resigned as Associate Editor for Frontiers in Systems Neuroscience. It used to be a reputable journal, but became a case study in how forced automation destroys academic integrity. 👇

Jay Hinton reposted

Ed Cunningham-Oakes
@edcoakes.bsky.social

Our paper is now published in eBioMedicine and I'm genuinely thrilled it's out 🎉 🧵 www.thelancet.com/journals/EBI... Despite the fact that this is a 2026 paper (such is peer review!), I wanted to write something and take you back to 2023, where the story of this work began. (1/7)

thelancet.comImplementing portable, real-time 16S rRNA sequencing in the healthcare sector enhances antimicrobial stewardshipThe integration of ONT 16S sequencing into routine NHS diagnostics has enabled antimicrobial stewardship by offering a faster method with improved taxonomic resolution. Its earlier use in cases where ...
Research@LivUni@livuniresearch.bsky.social

In a UK first study, Liverpool researchers have shown that advanced sequencing technologies can be used in routine NHS microbiology services to support real-world patient care. Discover more👉 www.liverpool.ac.uk/research/fro... @edcoakes.bsky.social @annasmielewska.bsky.social @acdarby.bsky.social

Jay Hinton reposted

Camila Valenzuela, PhD
@kamovalenz.bsky.social

Read the short highlight commentary I wrote with @enningalab.bsky.social for @molecularmicro.bsky.social about the latest story by the Humphreys lab onlinelibrary.wiley.com/doi/full/10.... ISG15 and toxins doing cool things during! #Salmonella

onlinelibrary.wiley.comISG15 At the Crossroads of Innate Immunity and Host Survival in Response to Typhoid ToxinTyphoid toxin, a genotoxin secreted by typhoidal Salmonella serovars, has been implicated in diverse host responses ranging from DNA damage to cellular senescence. In this Research Highlight, we disc...

Jay Hinton reposted

Zamin Iqbal
@zaminiqbal.bsky.social

This is awful to hear, describing how Sean Eddy (HMMER, infernal, pfam, rfam) has been defunded. The letter said his work "had been determined to be of absolutely no value to the US taxpayer, and therefore it was being specifically terminated," www.npr.org/2026/05/21/n...

npr.orgResearchers say the Trump administration is finding new ways to punish scienceEven with federal grants largely restored, scientists say the Trump administration is still preventing those funds from reaching them. The consequences, they say, are already becoming clear.

Jay Hinton reposted

Carl T. Bergstrom
@carlbergstrom.com

"An email from NIH’s National Institute of General Medical Sciences (NIGMS) to research-center grantees, seen by Science, requires their institutions to promise that U.S. authors of papers NIH has flagged because of foreign co-authors will not collaborate with them in the future."

Carl T. Bergstrom@carlbergstrom.com

“Units of the NIH are privately directing grantees to request permission in advance for any co-authorship with a scholar affiliated with a foreign institution, even if all the work was done in the United States.” Grantees also told to remove papers with foreign authors from progress reports.

science.orgU.S. researchers face new restrictions on publishing with foreign collaboratorsNIH, NASA grantees are confused and concerned amid agencies’ piecemeal communication

Jay Hinton reposted

Kai Kupferschmidt
@kakape.bsky.social

There’s a LOT going on as researchers and public health experts race to respond to the Ebola Bundibugyo outbreak in DRC and Uganda before it grows bigger. Some really important questions still open, but also a few answers coming into view🧪 My overview in @science.org is here (and thread coming):

science.orgScientists play catch-up to startling Ebola outbreakTesting, sequencing, and clinical trial efforts spring to life as Bundibugyo virus spreads

Jay Hinton reposted

Helen Branswell 🇨🇦
@helenbranswell.bsky.social

As @statnews.com reported yesterday, several Americans in DRC had high-risk exposures to #Ebola in the latest outbreak. One has tested positive. These individuals are being flown to Germany for observation and treatment as needed. www.statnews.com/2026/05/18/c...

statnews.comU.S. bans entry from Ebola-affected countries as American patient is identifiedIn response to an Ebola outbreak, the U.S. has banned entry for foreign travelers who have been in the Democratic Republic of the Congo, Uganda, or South Sudan in the past 21 days.

Jay Hinton reposted

Daniel Padfield
@padpadpadpad.bsky.social

BBSRC Early Independence Fellowships had an Outline stage this year to try help with amount of peer review. Turns out they received 586 applications, a 110% increase on 2025, and only typically fund 15 a year. They are cancelling this stage and going straight to full app with an institutional sift.

Jay Hinton reposted

ASM
@asm.org

Pathogen genomics is increasingly being implemented in clinical microbiology. Discover the factors that represent barriers to, and potential enablers of, this implementation, including the availability of funding and genomics-trained staff. #ClinMicroRev: asm.social/2VH

Jay Hinton reposted

Eliza_coli
@eliza-coli.bsky.social

Hello world, what on earth going on with bluesky right now?! In the meantime, please enjoy this picture of me riding an E. coli in LB broth (not to scale). I drew it as my bio pic for Upfest - I'm taking part in Europe's largest graffiti festival this year! #microsky #sciart #science #scicomm

Jay Hinton reposted

Nature
@nature.com

Bacteria have been fighting off viruses using a huge arsenal of molecular weaponry that scientists did not know about — until now. Researchers have identified proteins that could lead to virus-fighting drugs and technologies. go.nature.com/4dqQnXI

go.nature.com‘Treasure trove’ of antiviral proteins could inspire powerful molecular toolsTwo research teams mined genomic data from bacteria to create databases containing thousands of antiviral defence proteins that could inspire powerful biotechnologies.

Jay Hinton reposted

Andreas Bäumler
@abaumler.bsky.social

Genome sequence of a 5,000 year old bacterium (Psychrobacter) from cave ice contains more than 100 genes associated with antimicrobial resistance 😳 www.frontiersin.org/journals/mic...

frontiersin.orgFrontiers | First genome sequence and functional profiling of Psychrobacter SC65A.3 preserved in 5,000-year-old cave ice: insights into ancient resistome, antimicrobial potential, and enzymatic activi...IntroductionAncient cryospheric environments may preserve overlooked reservoirs of antimicrobial resistance (AMR) and bioactive potential. This study reports...

Jay Hinton reposted

Vivek Mutalik
@vivekmutalik.bsky.social

📣Huge preprint 🔔 Today we share something our group has been working toward for a long time, led by @lucasmoriniere.bsky.social We asked can we predict which receptor a phage targets from its genome sequence alone? For most phages, we couldn’t. So Lucas set out to do something I had only dreamed of.

Jay Hinton reposted

Victor de Lorenzo (CNB, Madrid)
@vdlorenzo.bsky.social

The list of new (2026) elected members of the @femsmicro.org European Academy of Microbiology is out 👏 Congrats to the newcomers, most of them very well-known names incl many friends & close colleagues 😀 fems-microbiology.org/european-aca...

fems-microbiology.orgFellowsThe European Academy of Microbiology (EAM) proudly brings together a distinguished community of leading scientists whose contributions have shaped and advanced the field of microbiology. Below, you wi...

Jay Hinton reposted

Victor de Lorenzo (CNB, Madrid)
@vdlorenzo.bsky.social

Great time in Segovia with Jay Hinton—one of my favourite microbiology colleagues. The castle of the background (El Alcazar) hosted the first chemistry lab in Spain in the XVIII century. While working there, Joseph Proust discovered the Law of Definite Proportions that every Chemistry student knows

Jay Hinton reposted

Andreas Bäumler
@abaumler.bsky.social

Does an imbalanced gut microbiome worsen chronic kidney disease? By elucidating the ecological causes for changes in the gut microbiota composition and its consequences for disease progression we were able to answer this question. Read more at: www.eurekalert.org/news-release...

eurekalert.orgHow an imbalanced gut microbiome worsens chronic kidney diseaseResearchers have identified how chronic kidney disease turbocharges E. coli toxin production, worsening the disease. An investigational drug might break the destructive feedback loop.

Jay Hinton reposted

Cara - the Council for At-Risk Academics
@cara1933.bsky.social

📰 𝐉𝐎𝐈𝐍𝐓 𝐒𝐓𝐀𝐓𝐄𝐌𝐄𝐍𝐓 𝐨𝐧 𝐔𝐊 𝐇𝐢𝐠𝐡𝐞𝐫 𝐄𝐝𝐮𝐜𝐚𝐭𝐢𝐨𝐧 𝐀𝐜𝐜𝐞𝐬𝐬 𝐟𝐨𝐫 𝐒𝐭𝐮𝐝𝐞𝐧𝐭𝐬 𝐟𝐫𝐨𝐦 𝐀𝐟𝐠𝐚𝐧𝐢𝐬𝐭𝐚𝐧, 𝐌𝐲𝐚𝐧𝐦𝐚𝐫, 𝐒𝐮𝐝𝐚𝐧, 𝐚𝐧𝐝 𝐂𝐚𝐦𝐞𝐫𝐨𝐨𝐧

Jay Hinton reposted

FEMS
@femsmicro.org

95 new Fellows join the European Academy of Microbiology 🔬 The newly elected Fellows represent a wide range of expertise across microbiology and related disciplines , spanning institutions across Europe and beyond. Read the full announcement📄https://buff.ly/CdRK14U

Jay Hinton reposted

Vivek Mutalik
@vivekmutalik.bsky.social

www.biorxiv.org/content/10.6... #phage #phagesky

biorxiv.orgCross-family and phage-specific gene requirements for Klebsiella infection revealed by scalable RB-TnSeq genetic screensBacteriophages (phages) are being cataloged at unprecedented rates and are recognized as key players in nutrient and energy cycling across ecosystems. Yet, the biological determinants of phage-host specificity and infection success remain poorly understood. Here, we used a randomly barcoded, genome-wide, loss-of-function transposon mutant library (RB-TnSeq) of Klebsiella sp. M5al, a plant-associated, nitrogen-fixing rhizobacterium, to identify bacterial genetic determinants necessary for the infection of 25 double-stranded DNA phages spanning five viral families. This approach identified 42 bacterial genes associated with phage infection, encompassing genes involved in receptor biosynthesis, regulatory pathways, electron transport, and unknown functions. Disruption of genes involved in receptor biosynthesis, such as glycosyltransferases involved in lipopolysaccharide (LPS) production, conferred cross-resistance to half of the phages, while intracellular gene disruptions had phage-specific effects. Taxonomically, we found significant differences in RB-TnSeq profiles across phage families and genera. While bacterial gene requirements are generally clustered by phage genus, we also observed notable divergences within genera. These differences were associated with variation in receptor usage, likely driven by divergence in tail fiber or other host recognition proteins. In some cases, differential reliance on bacterial intracellular factors suggested that even closely related phages may depend on distinct infection strategies, potentially involving phage-specific genes of unknown function. Our findings reveal key genetic dependencies shaping phage-host interactions and offer a framework for predicting infection outcomes in natural and applied settings. ### Competing Interest Statement The authors have declared no competing interest. Department of Energy and Environment, https://ror.org/05d5hbz44, #DE-SC0020173, #DE-SC0023307
Vivek Mutalik@vivekmutalik.bsky.social

New paper 🔔 Collaboration @sullivan-lab.bsky.social Marissa Gittrich led the work Klebsiella phage biology has focused almost entirely on capsulated strains, but capsule loss is the #1 resistance mechanism under phage predation. We used a naturally acapsular host to reveal the receptor landscape

Jay Hinton
@jayhinton.bsky.social

🦠 “𝗧𝗵𝗲 𝘃𝗶𝗿𝘂𝘀𝗲𝘀 𝘁𝗵𝗮𝘁 𝗲𝗮𝘁 𝗯𝗮𝗰𝘁𝗲𝗿𝗶𝗮 𝗰𝗼𝘂𝗹𝗱 𝘀𝗮𝘃𝗲 𝘂𝘀 — 𝗯𝘂𝘁 𝗵𝗼𝘄?” Historian @kirchhelle.bsky.social chats with 𝗠𝗮𝗿𝘁𝗵𝗮 𝗖𝗹𝗼𝗸𝗶𝗲 & 𝗝𝗮𝗺𝗲𝘀 𝗘𝗯𝗱𝗲𝗻 about revival of phage biology & phage therapy as antibiotics fail. 🎧 2024 BBC Radio 4 — listen worldwide: www.bbc.co.uk/sounds/play/... #phage #phagesky #microsky

bbc.co.ukIn Our Time - Bacteriophages - BBC SoundsMelvyn Bragg and guests discuss how viruses can help us track and cure bacterial illnesses

Jay Hinton reposted

Vivek Mutalik
@vivekmutalik.bsky.social

😮👀 The metabolome of an E. coli CRISPRi library identifies benefits of minimal metabolite levels and targets for engineering: Cell Systems www.cell.com/cell-systems...

cell.comThe metabolome of an E. coli CRISPRi library identifies benefits of minimal metabolite levels and targets for engineeringRapp et al. combine genome-scale CRISPRi and metabolomics in E. coli. CRISPRi of enzymes enforces metabolite accumulation, which leads to regulatory crosstalk and side reactions. This suggests that ma...