EMBO Reports

The second October issue is online. link.springer.com/journal/4431... The cover features the article "Maternal microbiome promotes offspring ovarian reserve via bile acid metabolism" by Han Wang, Wei Shen, Wei Ge and colleagues. link.springer.com/article/10.1...

Very excited to share our latest work! We identify Gαi2 as a key regulator that promotes microtubule-driven neurofilament incorporation into nascent axons, helping convert transient protrusions into stable axons in vivo. link.springer.com/article/10.1... @mcf-uom.bsky.social @emboreports.org

#iPSC 20th anniversary @isscr.org conference in Kyoto off to a roaring start with Wagner - in the very hall where I saw the Yamanaka factor paper first presented two decades ago. The excitement was clear already back then and remains undiminished. @emboreports.org @embojournal.org

Our first October issue is online. link.springer.com/journal/4431... The cover features work by Taichiro Iki, Toshie Kai and co-workers, revealing a new role for Set1-mediated piRNA biogenesis in transposon silencing at telomeres. link.springer.com/article/10.1...

The end of a fantastic meeting on NF-kB @prbb.org. -> nfkbcongress.com Congratulations to Hanna Norbäck from the group of Judith Zaugg @unibas.ch for winning the EMBO Reports poster prize for her work "Cell-type-specific immune dysregulation in NFKB1-associated CVID" and the other prize winners.

A new review is online. link.springer.com/article/10.1... Christina Maria Schuh and Joshua Mark Brickman @josh-brickman.bsky.social @novo-nordisk.bsky.social discuss the nature and function of transcription factors beyond the simple view of DNA recognition and transcription activation.

Are you at the 7th International NF-kB Congress held at PRBB (Barcelona Biomedical Research Park) @prbb.org? nfkbcongress.com If yes (or work at PRBB), talk to our editor Achim Breiling there about your research, your manuscript looking for a home or any other publishing-related topic!

Today, the #NobelPrize in Physiology or Medicine was announced. Interested in how the #research developed? 🧪 In 2017, @emboreports.org @embopress.org interviewed Karl Deisseroth, one of the Nobel Prize winners, about his work on #optogenetics and more: link.springer.com/article/10.1...

Have a look at our second September issue: link.springer.com/journal/4431... The cover features work by Jean-Michel Cioni and co-workers identifying LC3B mRNA as a component of the endosome-associated mRNA pool. link.springer.com/article/10.1...

Can light build centrosome-like activity? 💡🔬 Yes! We introduce LISA (Light-Induced Spindle Assembly), now in @emboreports.org. By clustering Aurora A with optogenetics, we build centrosome-like activity that nucleates microtubules and rescues spindle defects after centrosome loss. shorturl.at/9h3VQ

First September issue is live: link.springer.com/journal/4431... Cover features work by Ken-Ichi Takemaru and colleagues @stonybrooku.bsky.social showing that basal body docking failure triggers centriole clustering and elimination in mammalian spermatogenesis. link.springer.com/article/10.1...

Summer @labsoap.bsky.social papers : all about cell deaths 1. LUBAC and pyroptosis @cp-iscience.bsky.social www.cell.com/iscience/ful... 2. CYLD and mitochondrial death @emboreports.org link.springer.com/article/10.1... 3. CK1a and cGAS/STING #CellDeathDiff www.nature.com/articles/s41...

A new review is online! Liang Ge and colleagues provide a comprehensive review of the ER-Golgi intermediate compartment (ERGIC) and position it as a central hub integrating membrane trafficking and stress responses. #endoplasmic #Golgi -> link.springer.com/article/10.1...

Have a look into our second August issue: link.springer.com/journal/4431... The cover features work by Marco Milán and co-workers showing that a tumour-host feed-forward loop contributes to the growth of chromosomal instability-induced tumours in Drosophila. link.springer.com/article/10.1...

See our first August issue: link.springer.com/journal/4431... The cover features work by Tony Ly and co-workers @edinburgh-uni.bsky.social @dundee.ac.uk showing that CD8 T lymphocytes deploy embryonic cell cycle control mechanisms for rapid cell proliferation. link.springer.com/article/10.1...

🥳 Very happy to see this collaborative work now published in @emboreports.org ! From T cells to Dictyostelium, it reveals a conserved pathway controlling amoeboid migration speed. Many thanks to @pdehio.bsky.social , Christoph and colleagues for involving our lab! doi.org/10.1038/s443...

Weekend reading: this back and forth about a p16 reporter mouse for senescence and aging research. Read here in @emboreports.org and many more comments PubPeer. It seems to me that many journals are quite reluctant to publish these correspondences, to their great detriment.

What if you could hear scientific data instead of see it? 🧪 A Science & Society article in EMBO Reports explores how #sonification, the use of sound to represent data, could interpret complex datasets and make #science more accessible: https://link.springer.com/article/10.1038/s44319-024-00230-6

Aflah Hanafiah, Zhonghua Gao et al show that cPRC1.2 complex forms #chromatin loops at poised bivalent promoters. A switch from cPRC1.2-mediated to CTCF-mediated active loops enables differentiation to #neuronal progenitors and activation of lineage-specific genes. link.springer.com/article/10.1...

“… the most impactful publications in modern science are increasingly not primary theoretical or experimental findings, but the methodological innovations that enable and support them.” Read the full Science & Society article by Krauss, Rosenfeld & Bornmann -> link.springer.com/article/10.1...

The second July issue is online: link.springer.com/journal/4431... The cover features work by Naoyuki Inagaki, Kio Yagami and colleagues from NAIST describing spontaneous membrane protrusion and cell morphogenesis via self-propelled #actin filaments. -> link.springer.com/article/10.1...

A new review is online! Monja Müller, Konstanze Winklhofer @ruhr-uni-bochum.de and Fulvio Reggiori discuss the role of E3 #ubiquitin ligases in selective types of #autophagy. -> link.springer.com/article/10.1...

A new review is online! Umut Sahin and Elif Nur Firat-Karalar @cytolabkoc.bsky.social describe the role and alterations of the #centrosome - #cilium - satellite axis in neurodegenerative disease and discuss potential mechanism-based therapeutic strategies. -> link.springer.com/article/10.1...

This knowledge, published in @emboreports.org, has potential in the design and improvement of #immunotherapy treatments. 5/ link.springer.com/article/10.1...

A beautiful image (and study), indeed! A similar image was featured on the Cover of our June issue, Volume 27, issue 12! => link.springer.com/journal/4431...

A Science & Society article reflects on 100 years of the theory of the gene – from its role in explaining inheritance to how it laid the foundation for modern #genetics and continues to evolve with discoveries: https://link.springer.com/article/10.1038/s44319-026-00770-z 🧪 #LifeSciences #research

Francesca Pappacena, Jean-Michel Cioni and co-workers show that lc3b mRNA is translated on #endosomes in #axons and that this local synthesis is vital for clearance of dysfunctional endosomes by #autophagy. #ProteinSynthesis #neurons -> link.springer.com/article/10.1...

Yanis Macé, Nicolas Bidère and co-workers show that CYLD is a target of #caspase -3. CASP3-induced cleavage of CYLD tempers inflammatory signaling and heps maintain #apoptosis silence. #inflammation #CellDeath #ubiquitin -> link.springer.com/article/10.1...

The first July issue is online: link.springer.com/journal/4431... The cover features work by Hsiao-Ying Kuo from NYCU Taipei describing activity-dependent #development of #vocal circuits in the neonatal rodent #forebrain. -> link.springer.com/article/10.1...

Philippe Dehio @pdehio.bsky.social, Christoph Hess and co-authors describe a conserved VPS34-PIKfyve pathway regulating #T cell and amoeboid cell migration speed via #lysosome Ca2+ efflux, #myosin IIA activation and retrograde #actin flow. -> link.springer.com/article/10.1...

Mindong Ren, Michael Schlame and co-authors show that cardiolipin de novo synthesis, but not remodeling, is essential for mouse postnatal maturation of cardiac mitochondria, respiratory chain biogenesis and cardiac function. #lipid #mitochondria -> link.springer.com/article/10.1...

Gayatri Rai, Bama Charan Mondal and co-authors show that the COP9 signalosome and Cullin-RING #ubiquitin ligases regulate the cell fate of myeloid-type blood progenitors in Drosophila via EGF and #WNT #singaling. -> link.springer.com/article/10.1...

Academic independence after the USA's 250th anniversary of the Declaration of Independence? Read why the proposed #OMB policies would undermine research & economic leadership + comment by July13th shorturl.at/2s6f8). At the same time we must get our house in order. link.springer.com/article/10.1...

Timo-Daniel Voss @unihohenheim.bsky.social and co-authors show that C-terminal lysine residues localise NLRP10 at lipid droplets and govern #NLRP10 oligomer formation. link.springer.com/article/10.1... Press releases: www.uni-hohenheim.de/index.php?id... idw-online.de/de/news873496

Schistosomiasis affects 110 million African children. Its control demands an urgent shift from drug treatments to permanent transmission interruption. Read the article by Francisca Mutapi and Mark EJ Woolhouse here: -> link.springer.com/article/10.1...

Margot Sahnine, Dorian Obino and co-workers @pasteur.fr show that N. meningitidis induces membrane protrusions with distinct #F-actin networks in epithelial and endothelial cells. The branched network in endothelia depends on Arf1. #Host-pathogen #membrane -> link.springer.com/article/10.1...

Naoyuki Inagaki at Nara Institute of Science and Technology (NAIST) and co-workers show spontaneous #membrane protrusion and cell morphogenesis happens via self-propelled #actin filaments. link.springer.com/article/10.1... Read the press release here: www.naist.jp/en/research_...

See our second June issue! link.springer.com/journal/4431... The cover features work by Xin Zhang, Xiaozhi Rong, Jianfeng Zhou and co-workers showing that CST complex subunit Stn1 amplifies #Wnt/beta-catenin signaling and ensures proper #oocyte development. -> link.springer.com/article/10.1...

A new review is online! Wassim Daher, Laurent Kremer and co-authors @umontpellier.bsky.social @inserm.fr @irim-life.bsky.social tell you all you need to know about organelle interplay in host responses and #mycobacterial #resilience. -> link.springer.com/article/10.1...

Elena Sindram, Laura Gámez-Díaz and colleagues @uni-freiburg.de show that LRBA interacts with non-muscle myosin IIA and regulates the #actin #cytoskeleton and #immune synapse formation in #BCells #Lymphocyte #antigen -> link.springer.com/article/10.1...

Philipp Rieche, Marten Exterkate, Arnold Driessen et al show that the #lipid divide between #bacteria and #archaea is not as strict as previously thought as bacterial lipid synthesizing enzymes can use both stereo-forms of glycerol-phosphate. #MembraneBiology -> link.springer.com/article/10.1...

Emmanuel Amzallag, Eran Hornstein and colleagues show that the E3 #ubiquitin ligase MKRN2 maintains granulostasis by preventing the accumulation of misfolding-prone DRiPs into #StressGranules. -> link.springer.com/article/10.1...

See our first June issue! link.springer.com/journal/4431... The cover features work by Daniel Ríos @yosoyden.bsky.social at UNAM in Mexico City and co-workers showing that the #ECM scaffolds interdependent #tissue morphogenesis in #Drosophila. link.springer.com/article/10.1...

Congratulations to Mayra Aguirre-Garcia from Annemarie Meijers lab @unileiden.bsky.social for receiving the EMBO reports poster prize at #EMBOpathogenSignalling for her work "GBP1 recruitment to Mycobacteria-containing vesicles through calcium signalling drives #macrophage lysosomal defenses".

A new review on #evolution is online! Pavithra Venkataraman and Christian Landry @christianlandry.bsky.social discuss a conceptual framework for the joint influence of coding and regulatory mutations in shaping fitness and impacting molecular #evolution. -> link.springer.com/article/10.1...

Attending the GRC conference “Endosomes and Lysosomes in Action Across Cells, Tissues and Disease States” in Andover, NH? www.grc.org/lysosomes-an... Talk to our editor Martina Rembold who is attending the meeting about your work or publishing-related topics! #lysosome #endosome

Lee Armstrong, Yogesh Kulathu @kulathu.bsky.social and co-workers show that MINDY3's EF-hand domain is a novel #ubiquitin binding domain. It not only enables chain-length-dependent deubiquitination but also binds to DNA repair factors RAD23A/B. -> link.springer.com/article/10.1...

Great EMBO YIP @embo.org lecture by Teresa Thurston @thurstonlab.bsky.social @ox.ac.uk at "Pathogen Immunity and Signalling" #EMBOpathogenSignalling. Bacterial effectors mediate kinase reprogramming through mimicry of conserved eukaryotic motifs. See also: -> link.springer.com/article/10.1...

Attending the EMBO @embo.org workshop "Pathogen Immunity and Signalling" #EMBOpathogenSignalling in Leiden? meetings.embo.org/event/26-pat... Talk to our editor Achim Breiling who is attending the meeting about you work or publishing-related topics!

A tumour-host feed-forward loop contributes to the growth of chromosomal instability-induced tumours. -> link.springer.com/article/10.1...