LabSoap

29 June

@labsoap.bsky.social #Summer #PlayList 🇧🇷🇮🇹🇯🇲 🎼 😱🤩🪘🪩🎸

science.orgBAK and BAX form a multiprotein complex to drive mtDNA efflux and caspase-independent cell deathThe apoptotic regulators BAX and BAK, once activated, form homo-oligomers to trigger mitochondrial outer membrane permeabilization (MOMP), activating the apoptosome and caspases. Activation of BAX-BAK...

This week #JournalClub @labsoap.bsky.social @science.org #Mitochondria #celldeath BAX BAK and co www.science.org/doi/10.1126/...

LabSoap reposted

Wiley Life Sciences

@wileylifesci.bsky.social

30 July

From new discoveries to emerging research themes. Traffic Lights offers expert commentary on topics driving discussion across cell biology. Read the latest contribution and see what's capturing attention in the field: https://bit.ly/4c1nNu7 @traffic-journal.bsky.social

Octobre rose @labsoap.bsky.social 🎀🌸👚

nature.comUbiquitination of glycogen and metabolites in cells and tissues - NatureIntegration of ubiquitin clippases with sortase-based labelling and mass spectrometry reveals that a wide range of non-peptide molecules are ubiquitinated in vivo, and points to a potential role for u...

This #JournalClub @labsoap.bsky.social @nature.com @komanderlab.bsky.social www.nature.com/articles/s41...

Happy Birthday #societefrancaiseducancer

cell.comCancer stem cells orchestrate immune evasion through extracellular vesicle-mediated non-canonical signaling pathwaysTumor cells evade anti-tumor immunity by reprogramming TME. Fan et al. uncover that cancer stem cells of TNBC drive regulatory T cells differentiation and expansion via a paracrine signaling mediated ...

This week #JournalClub @labsoap.bsky.social #extracellularvesicles #TNBC #cancerstemcells www.cell.com/cancer-cell/...

science.orgTumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen speciesReactive oxygen species (ROS) promote genomic instability and fuel oncogenic signaling in cancer, but antioxidant therapies have so far failed to improve, or worsen, cancer outcomes. Emerging data sug...

This week #JournalClub @science.org #antioxidant #Tcell #immunity www.science.org/doi/10.1126/...

nature.comTRI-611, a selective, brain-penetrant molecular glue degrader of ALK - NatureTRI-611 induces the degradation of ALK fusion proteins via a previously undescribed CRBN recruitment motif, and its preclinical anti-tumour activity highlights TRI-611 as a potential new way of treati...

14 Sept

This week #JournalClub @labsoap.bsky.social @nature.com #protac #glue #ALK www.nature.com/articles/s41...

cell.comPersistent and transient senescent cells contribute to brain-barrier developmentSenescent cell states arise across brain-barrier cell types during development but diverge in duration and function. Endothelial cells and macrophages enter a transient, inflammatory state, whereas ch...

7 Sept

This week #JournalClub @labsoap.bsky.social #BloodBrainBarrier #endothelialcells @cellpress.bsky.social www.cell.com/cell/fulltex...

1 Sept

Summer @labsoap.bsky.social papers : all about cell deaths 1. LUBAC and pyroptosis @cp-iscience.bsky.social www.cell.com/iscience/ful... 2. CYLD and mitochondrial death @emboreports.org link.springer.com/article/10.1... 3. CK1a and cGAS/STING #CellDeathDiff www.nature.com/articles/s41...

nature.comPartial downregulation of platelet glycoprotein VI by low affinity antibodies confers sustained and safe antithrombotic protection - Signal Transduction and Targeted TherapySignal Transduction and Targeted Therapy - Partial downregulation of platelet glycoprotein VI by low affinity antibodies confers sustained and safe antithrombotic protection

1 Sept

This week #JournalClub @labsoap.bsky.social #Platelet #antibodies #thrombosis www.nature.com/articles/s41...

LabSoap reposted

onlinelibrary.wiley.comTraffic Light Commentary—Src in the Upside Down: A Kinase Turned Inside OutJust as Antelope Canyon transforms familiar rock into an unexpected hidden landscape, the topological inversion of Src reveals an unforeseen extracellular facet of kinase signaling in cancer. Antelop...

23 June

#Traffic is proud to inaugurate its #TrafficLights commentary section in a #JournalClub report format... it starts now with @JulieGavard onlinelibrary.wiley.com/doi/10.1111/...

nejm.orgDaraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer | NEJMCurrent therapies offer limited benefit for patients with previously treated metastatic pancreatic ductal adenocarcinoma (mPDAC). Aberrant activation of the RAS pathway is the key driver of PDAC, w...

30 June

This week #JournalClub @labsoap.bsky.social #pancreas @nejm.org www.nejm.org/doi/full/10....

22 June

Traffic Light Commentary—Src in the Upside Down: A Kinase Turned Inside Out - Gavard - 2026 - Traffic - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...

link.springer.comGlobal analysis of cancer cell responses to USP9X inhibition - The EMBO JournalThe ubiquitin-specific protease (USP) USP9X is a human deubiquitinase (DUB) with a large number of described targets and cellular roles. In cancer, USP9X is found as an oncogene or as a tumour suppres...

15 June

This week #JournalClub @labsoap.bsky.social @embojournal.org @komanderlab.bsky.social #ubiquitin #DUB #USP9X link.springer.com/article/10.1...

nature.comTargeted degradation of endogenous YAP by nanobody bioPROTAC inhibits tumor progression - Nature CommunicationsYAP is a key oncogenic driver that has long been considered undruggable. Here, the authors present the development of a nanobody-based bioPROTAC that efficiently degrades endogenous YAP, demonstrating...

9 June

This week #JournalClub @labsoap.bsky.social #YAP #PROTAC #cancers @natureportfolio.nature.com www.nature.com/articles/s41...

LabSoap reposted

onlinelibrary.wiley.comA Toolbox for Quantifying Nuclear and Nucleolar Protein Accumulation Using NLS and NoLS Fusion ReportersFluorescent proteins fused with nuclear (NLS) or nucleolar (NoLS) localization signals are commonly used for live assessment of protein accumulation in the nucleus and nucleolus. We present a standar...

4 May

Just Published ! onlinelibrary.wiley.com/doi/10.1111/...

LabSoap reposted

onlinelibrary.wiley.comThe Lack of a COPII Cargo Receptor Erv14 Impacts Physiological Functions of the Vacuole in Saccharomyces cerevisiaeLoss of the cargo receptor Erv14 in Saccharomyces cerevisiae results in sensitivity to calcium, zinc, neutral extracellular pH, and elevated temperature. Furthermore, cells deleted in the ERV14 exhib...

4 May

Just Published ! onlinelibrary.wiley.com/doi/10.1111/...

science.orgStem cell control in the lung by an autocrine injury-activated Igf complexStem cells proliferate after injury to repair damaged tissue, and chronic injury can promote cancer. However, the injury-activated signals and regulatory mechanisms, and their relationship to cancer, ...

18 May

This week #JournalClub @labsoap.bsky.social #stemcell #lunginjury #cancer #IGF @science.org www.science.org/doi/10.1126/...

cell.comDeltaviruses spread through a viral Trojan HorseMcKellar et al. have discovered that some satellite viruses act as the ultimate hitchhikers. They physically become a virus inside a virus, hiding within helper virus particles by hitching a ride as a...

20 Apr

This week #JournalClub @labsoap.bsky.social @cellpress.bsky.social @karimaj.bsky.social #virusinavirus #virus #spreading www.cell.com/cell/fulltex...

cell.comCell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorderThis study describes the cell-type-specific lysosomal proteome across the major brain cell types and identifies SLC45A1 as a neuron-specific lysosomal sugar exporter linked to lysosomal storage diseas...

13 Apr

This week #JournalClub @labsoap.bsky.social #lysosome #brain @cellpress.bsky.social @abu-remaileh.bsky.social www.cell.com/cell/fulltex...

LabSoap reposted

onlinelibrary.wiley.comUnraveling the Dynamics of Oxytocin in Hypothalamic NeuronsOxytocin (OT) plays an important role in regulating social behavior, and dysregulation of the oxytocinergic system leads to social impairments, such as autism spectrum disorder. Central OT release is...

9 Apr

Just Published ! onlinelibrary.wiley.com/doi/10.1111/...

nature.comMitochondrial transfer from glia to neurons protects against peripheral neuropathy - NatureMitochondria that are transported from satellite glial cells in dorsal root ganglia to peripheral sensory neurons through tunneling nanotube-like structures provide protection against peripheral neuro...

7 Apr

This week #JournalClub @LabSoap @nature.com #mitochondria transfer #astrocyte #neuron #nanotube Mitochondrial transfer from glia to neurons protects against peripheral neuropathy www.nature.com/articles/s41...

science.orgAutophagolysosomal exocytosis inverts Src kinase onto the cell surface in cancerOverexpression of the proto-oncogene Src is common to a wide variety of cancers. In this work, we found that Src is noncanonically translocated and inverted onto the cell surface in cancer, both in vi...

31 Mar

This week #JournalClub @labsoap.bsky.social #Src #lysosome #autophagy #exocytosis welcome to the upside-down 😱 @science.org www.science.org/doi/10.1126/...

nature.comAgeing promotes metastasis via activation of the integrated stress response - NatureAgeing reprograms the evolutionary trajectory of KRAS-driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic activation of the integrate...

23 Mar

This week #JournalClub @labsoap.bsky.social @nature.com #ageing #metastasis #stressresponse www.nature.com/articles/s41...

19 Mar

@labsoap.bsky.social proud to take part in #BrainAwarenessWeek @semaineducerveau.bsky.social , where we engaged with the public on the topic of #brain #tumors It was a great opportunity to share our research and raise awareness about the challenges and advances in this field.

science.orgDNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethalityDNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...

18 Mar

This week #JournalClub @labsoap.bsky.social @science.org #cGAS_STING @idikic.bsky.social www.science.org/doi/10.1126/...

12 Mar

💪 the almost final program is now available 📍https://btmbts26.sciencesconf.org/data/pages/PgBTMBTS_27.pdf 🕐 still time to register and present a poster

Eric Chevet@ericchevet.bsky.social

🗣️You can NOW (at last) register for the Brain Tumor Meeting By The Sea which will be held in #StMalo from March 23 to March 25 here btmbts26.sciencesconf.org 🤩The keynote speakers are @annagolebiewska.bsky.social, #David_Castel and @benjaminwerner.bsky.social poke @labsoap.bsky.social

3 Mar

fantastic venue, fantastic program, just apply and spread the word 🧠 🌊💺

Eric Chevet@ericchevet.bsky.social

12 Mar

💪 the almost final program is now available 📍https://btmbts26.sciencesconf.org/data/pages/PgBTMBTS_27.pdf 🕐 still time to register and present a poster

sciencedirect.comA lysosomal requiem for glioblastoma cellsOnce viewed solely as degradative compartments, lysosomes shape cell fate through signaling, metabolism, and communication. In glioblastoma, their rew…

11 Mar

take a look to our #forum on #lysosome #glioblastoma out @cp-trendscancer.bsky.social 🧠 "A lysosomal requiem for glioblastoma cells" lnkd.in/e3Zcb46y 🙌 Laura Merlet Margaux LE GUYON Julie Gavard www.sciencedirect.com/science/arti...

nature.comAgonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity - NatureThe ALPK1 agonist UDSP-Hep stimulates tumour-cell antigen presentation, macrophage–DC cross-priming and differentiation of protective memory T cells.

9 Mar

This week #JournalClub @labsoap.bsky.social #immunotherapy #inflammation #cGAS-STING @nature.com www.nature.com/articles/s41...

LabSoap reposted

Eric Chevet

@ericchevet.bsky.social

3 Mar

LabSoap reposted

Eric Chevet

@ericchevet.bsky.social

3 Mar

Replying to @ericchevet.bsky.social

poke @elodie-lafont.bsky.social @tonyavril.bsky.social @xguillory.bsky.social @insermgrandouest.bsky.social @labsoap.bsky.social @rennesuniv.bsky.social @inserm.fr

nature.comThe integrated stress response promotes immune evasion through lipocalin 2 - NatureThe transcription factor ATF4 and its effector lipocalin 2 (LCN2) have a key role in immune evasion and tumour progression, and targeting the ATF4–LCN2 axis might provide a way to treat several t...

2 Mar

This week #JournalClub @labsoap.bsky.social #immunotherapy #resistance #evasion @nature.com www.nature.com/articles/s41...

24 Feb

Here’s the classic lab SOAP-box picture, sometimes copied but un-equalized, and full of memories. Sad to see some familiar faces leaving, but so excited to welcome new colleagues, and sometimes old friends we are hoping to see back to @labsoap.bsky.social

cell.comTumor-derived arachidonic acid reprograms neutrophils to promote immune suppression and therapy resistance in triple-negative breast cancerHow tumor cells overcome anti-tumor immune responses and drive cancer recurrence is not well understood. Yu et al. demonstrate how therapy-resistant breast cancer cells synthesize and secrete arachido...

23 Feb

This week #JournalClub from @LabSoap @cp-immunity.bsky.social #lipid #neutrophils #TNBC #breastcancer #resistance www.cell.com/immunity/abs...

cell.comMeningeal blood vessel blockage enhances anti-glioblastoma immunityMeningeal blood vessel blockage enhances anti-tumor immunity against GBM in preclinical models by expanding dural resident border-associated macrophages, which are equipped with an elevated antigen-pr...

9 Feb

This week #JournalClub @labsoap.bsky.social @cellpress.bsky.social #glioblastoma #immune_responses #meningeal_vessels www.cell.com/cell/abstrac...

science.orgPlatelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammationPlatelet integrin αIIbβ3 is essential for hemostasis, thrombosis, and inflammation. We found that ligation of αIIbβ3 by von Willebrand factor or fibrin under flow triggered its accumulation in plasma ...

2 Feb

This week #JournalClub @labsoap.bsky.social @nature.com #integrin #tetraspanin #migration www.science.org/doi/10.1126/...

science.orgIDH-mutant gliomas arise from glial progenitor cells harboring the initial driver mutationIdentifying the cell of origin that harbors an initial driver mutation is key to understanding tumor evolution and for the development of new treatments. For isocitrate dehydrogenase (IDH)–mutant glio...

26 Jan

This week #JournalClub @labsoap.bsky.social @science.org #glioblastoma #IDH1 www.science.org/doi/10.1126/...

nature.comSecretome translation shaped by lysosomes and lunapark-marked ER junctions - NatureLive-cell imaging of mRNA encoding secretome proteins and translated nascent peptide markers show that secretome translation occurs at endoplasmic reticulum junctions near lysosomes, requires lun...

19 Jan

This week #JournalClub @labsoap.bsky.social #lysosomes #ER #secretion @nature.com www.nature.com/articles/s41...

nature.comClient Challenge

12 Jan

This week #JournalClub @labsoap.bsky.social @nature.com #celldeath #plasmamembrane #rupture #MLKL #necroptosis www.nature.com/articles/s41...

nature.comMicrobial signals in primary and metastatic brain tumors - Nature MedicineA combination of high-resolution spatial imaging, spatial proteomics and transcriptional data reveals sparse and heterogeneous bacterial signals in gliomas and brain metastases.

6 Jan

This week #JournalClub @labsoap.bsky.social #glioblastoma #microbiota @natureportfolio.nature.com www.nature.com/articles/s41...

15 Dec 2025

This week no #JournalClub @LabSOAP - it's #SOAPosium celebrating a decade in #Nantes 🎂🎁🎈🎄⛄

sciencedirect.comMembrane potential mediates the cellular response to mechanical pressureMechanical forces influence cellular decisions to grow, die, or differentiate, through largely mysterious mechanisms. Separately, changes in resting m…

9 Dec 2025

This week #JournalClub @cellpress.bsky.social #membrane #pressure #Hippo #density www.sciencedirect.com/science/arti...

LabSoap reposted

onlinelibrary.wiley.comFrom Mechanisms to Therapy: Exploring the Role of Ferroptosis in Cervical Cancer Transformation and TreatmentThis review mainly discusses the role of ferroptosis in cervical cancer from four aspects: underlying mechanisms, stage-specific sensitivity, ferroptosis-related targets and biomarkers, and clinical ...

24 Sept 2025

Just published ! onlinelibrary.wiley.com/doi/10.1111/...

LabSoap reposted

onlinelibrary.wiley.comStrain‐Dependent Immune Signaling by Small Extracellular Vesicles Derived From Trypanosoma cruzi‐Infected MacrophagesChagas disease, caused by Trypanosoma cruzi, remains a major treatment challenge due to variations in host immunity and parasite strains. We found that small extracellular vesicles (EVs) from infecte...

24 Sept 2025

Just published ! onlinelibrary.wiley.com/doi/10.1111/...

LabSoap reposted

onlinelibrary.wiley.comonlinelibrary.wiley.com

23 Oct 2025

Just Published! Spatiotemporal Analysis of Glucagon Secretory Granule Dynamics - Ghignoli - 2025 - Traffic - Wiley Online Library onlinelibrary.wiley.com/doi/abs/10.1...

LabSoap reposted