Lew Lab @ WashU

Lew Lab @ WashU

@lewlab.com

Playing with #singlemolecules, bending light, and algorithms to see really small things. Led by Matthew Lew, Associate Professor @WashUESE @WashUengineers @WashU #superresolution #microscopy #SMLM #computationalimaging

660 followers478 following21 posts

Lew Lab @ WashU reposted

Science Magazine
@science.org

Proposed changes by the Trump administration to rules that govern how federal dollars are spent "would inevitably lead to unlegislated reductions in funding and damage US leadership in science, both in academia and industry," writes H. Holden Thorp in a new #ScienceEditorial. https://scim.ag/4uK0fBj

Lew Lab @ WashU reposted

Rohit V. Pappu
@rohitpappu68.bsky.social

Nuclear speckle associated RRM-containing proteins are block copolymers. They make size-limited, ordered microphases, tens of nm in size comprising tens of molecules. Speckles are likely clusters or emulsions of distinct microphases and not macrophases www.sciencedirect.com/science/arti...

sciencedirect.comNuclear speckle proteins form intrinsic and MALAT1-dependent microphasesPre-mRNA processing components in nuclear speckles encompass one or more folded RNA recognition motifs (RRMs) and disordered regions with specific seq…
Lew Lab @ WashU
@lewlab.com

Very happy to share this news of my election to become an #OpticaFellow. I'm grateful to my many students and mentors over the years. Happy Thanksgiving!

Optica@optica.org

Meet the new #OpticaFellows! The Optica Board of Directors is pleased to announce that 121 members from 23 countries have been elected as Fellows for their outstanding contributions and service to Optica and the community. Find the full class: https://bit.ly/4rgXHtn

Lew Lab @ WashU
@lewlab.com

Happy to share our recent review in @natphoton.nature.com on #singlemolecule #orientation #localization #microscopy, co-authored with Sophie Brasselet @cnrs.fr @institutfresnel.bsky.social. See molecule motions and rotations in action! doi.org/10.1038/s415... @washuengineers.bsky.social @washu.edu

doi.orgSingle-molecule orientation and localization microscopy - Nature PhotonicsThe Review discusses recent advances in single-molecule orientation and localization microscopy (SMOLM) along with remaining challenges and promises for future developments of the field.

Lew Lab @ WashU reposted

Stand Up for Science!
@standupforscience.net

Thx again ‪@joshtpm.bsky.social‬ for sharing to our feed...THIS is the critical data needed to fuel our fight to stop Trump regimists from killing millions of American w/ their criminal cuts to agencies like #CDC. zurl.co/uJUDQ Fight back with us here zurl.co/TLiCg #StandUpForScience #SaveCDC

cdcdataproject.orgThe CDC Data ProjectIn the proposed FY26 budget, programs that help Americans live safer, healthier, longer lives are on the chopping block.

Lew Lab @ WashU reposted

cancerconnector.bsky.social
@cancerconnector.bsky.social

Big shout out to rising M4 and CWRU MSTP student Eshan King - whose paper came out in @aaas.org Science Advances. connecting the fields of PK-PD and evolutionary modeling using fitness seascapes. #mathevo #mathonco @cbo.bsky.social @sandyanderson.bsky.social www.science.org/doi/10.1126/...

science.orgFitness seascapes are necessary for realistic modeling of the evolutionary response to drug therapyComputational and experimental studies of drug resistance evolution give insights into why some bacteria become resistant.
Lew Lab @ WashU
@lewlab.com

- Matt will speak at 8:00 AM on “ #SingleMolecule #Orientation #Localization #Microscopy: New Approaches and Applications” (NM1C.1). - Yiyang will speak at 9:15 AM on “Combining Excitation and Emission Modulation Resolves the Angular Separation between a Pair of #DipoleEmitters” (NM1C.4).

Lew Lab @ WashU
@lewlab.com

A wonderful collaboration between us, @rohitpappu68.bsky.social and the Knowles lab is now online, exploring anisotropies of molecules at the interfaces of RNA condensates! Congratulations Nadia, Mina, and Yuanxin! @washuengineers.bsky.social @washu.bsky.social

Rohit V. Pappu@rohitpappu68.bsky.social

We investigated the interfacial orientations of scaffold molecules vs. adsorbents in model condensates formed by pairs of RNA molecules with PEG. Experiments identify purine-rich RNAs as scaffolds & pyrimidine-rich RNAs as adsorbents that undergo wetting transitions. www.nature.com/articles/s41...

nature.comDifferential interactions determine anisotropies at interfaces of RNA-based biomolecular condensates - Nature CommunicationsExperiments and computations show that the organization and dynamics of molecules within and at interfaces of biomolecular condensates are governed by differential interaction strengths leading to the...

Lew Lab @ WashU reposted

WUSM BMB
@wusm-bmb.bsky.social

This semesters Biophysical Evening seminar will be given by Matthew Lew, Professor in Electrical & Systems Engineering at WashU "Single-Molecule Orientation-Localization Microscopy: New Challenges and Biophysical Insights" Thurs, March 20th 4-5 PM, Connor Auditorium

Lew Lab @ WashU reposted

Leah
@leah.myatproto.social

Replying to @leah.myatproto.social

"Single-flurogen" is key, allows them to view condensate hubs that are normally a needle in a haystack to find. The use of a single chemical probe means they don't get conflicting signals. 🧪 www.nature.com/articles/s41...

nature.comSingle-fluorogen imaging reveals distinct environmental and structural features of biomolecular condensates - Nature PhysicsExperiments confirm the prediction that fluid-like biomolecular condensates are defined by spatially inhomogeneous organization of the underlying molecules.

Lew Lab @ WashU reposted

Reuven Gordon
@reuven-gordon.bsky.social

Label-free Single Molecule Sensing -- the first conference in this Gordon Research Conference series. Outstanding distinguished invited speaker program just announced: www.grc.org/label-free-s... Submit your applications early! #singlemolecule #labelfree

grc.org2025 Label-Free Single Molecule Sensing Conference GRCThe 2025 Gordon Research Conference on Label-Free Single Molecule Sensing will be held in Easton, Massachusetts. Apply today to reserve your spot.

Lew Lab @ WashU reposted

Nature Human Behaviour
@nathumbehav.nature.com

In this Q&A, we asked why they organized Stand Up for Science. Here are the answers: www.nature.com/articles/s41... @leslie-bern.bsky.social @emmalovesscience.bsky.social @cdelawalla.bsky.social @jpflores.bsky.social @samschuelstein.bsky.social @standupforscience.bsky.social

nature.comWhy we organized ‘Stand Up For Science’ - Nature Human BehaviourIn the USA, the Trump administration has signed executive orders that impose censorship on key areas of scientific research, strip government scientists of their jobs and reduce federal funding for sc...
Lew Lab @ WashU
@lewlab.com

Scary statistics: Fake papers are contaminating the world’s scientific literature, fueling a corrupt industry and slowing legitimate lifesaving medical research theconversation.com/fake-papers-...

theconversation.comFake papers are contaminating the world’s scientific literature, fueling a corrupt industry and slowing legitimate lifesaving medical research‘Paper mills’ are contaminating the world’s scholarly output with fake papers that hinder research. Lifesaving biomedical fields are especially hard hit.
Lew Lab @ WashU
@lewlab.com

The bottom image is from our multi-view microscope work, showing amyloid aggregate infiltration of a spherical lipid bilayer: doi.org/10.1038/s415...

doi.orgSix-dimensional single-molecule imaging with isotropic resolution using a multi-view reflector microscope - Nature PhotonicsA multi-view reflector microscope based on polarization modulation and pupil splitting enables single-molecule orientation-localization microscopy with precisions of 10.9 nm and 2.0°.

Lew Lab @ WashU reposted

bioRxiv Biophysics
@biorxiv-biophys.bsky.social

Single-Molecule Orientation Imaging Reveals the Nano-Architecture of Amyloid Fibrils Undergoing Growth and Decay https://www.biorxiv.org/content/10.1101/2024.03.24.586510v1

biorxiv.orgSingle-Molecule Orientation Imaging Reveals the Nano-Architecture of Amyloid Fibrils Undergoing Growth and Decay https://www.biorxiv.org/content/10.1101/2024.03.24.586510v1 Amyloid-beta (A{beta}42) aggregates are characteristic signatures of Alzheimer's disease, but probin

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