Science Magazine

Science Magazine

@science.org

Cutting-edge research, news, commentary, and visuals from the Science family of journals. https://www.science.org

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The new issue of #ScienceSignaling has arrived! The humble sea slug reveals how transfer RNAs become modified during behavioral habituation and learning, new work shows how a mutant form of STAT3 causes a genetically dominant immunodeficiency, and more. https://scim.ag/4ily0Eo

"What mattered, I realized, was not to be some imaginary perfect mentor with all the answers, but to get to know my mentee ... and offer whatever guidance and support I could based on my own experiences." #NationalMentoringDay https://scim.ag/47mSs29

Malaria-carrying Anopheles coluzzii mosquitoes are skillful foragers, speedily biting the skin and efficiently probing for blood vessels before feeding, then retracting and withdrawing their mouthparts—all in five distinct steps, according to a new #ScienceAdvances study. https://scim.ag/3U8ETki

Last chance: Apply for the BioInnovation Institute & #ScienceTranslationalMedicine Prize for Innovations in Women’s Health The Grand Prize winner will receive a cash prize of USD 25,000 and have their winning essay published online in STM. Apply by 1 November 2026: https://bit.ly/4AOij0W

A #ScienceTranslationalMedicine analysis of data from stem cell transplant recipients shows how immune suppression with either cyclophosphamide or tacrolimus shapes T cell reconstitution—and has opposing effects on the risk of GVHD or infection post-transplant. https://scim.ag/4szzNuh

scim.agGraft-versus-host disease prophylaxis shapes T cell biology and immune reconstitution after hematopoietic cell transplantLarge-scale longitudinal analysis of posttransplant immune reconstitution reveals how T cell–directed immunosuppression shapes transplant outcomes.

Researchers have developed a single-cell–level digital twin to simulate how different treatments can alter maternal immune pathways and affect the time to labor of individual patients. Learn more this week in #ScienceAdvances: https://scim.ag/3TSbLO9

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A newly uncovered fossil of a turkey-sized dino reveals it likely munched fruit like a parrot—the first-ever evidence of a dinosaur frugivore. It would have dined on the Cretaceous equivalent of cherries and peaches. #Paleontology #FossilFriday 🧪🧪 New for @science.org

science.orgThe first dinos that only ate fruit munched like parrotsToothless, turkey-size oddity may have evolved alongside the emergence of flowering plants

Researchers in Science report that many birds use vertical winds or gradual changes in wind speed or direction (wind shear) to soar, thereby reducing their cost of transport by switching from costly flapping flight to gliding flight. Learn more: https://scim.ag/4yVNGFd

scim.agAirflows redefine the cost of aerial transport in the wildFuel economy matters to both animals and machines, as the cost of transport can determine where, when, and how far locomotion is possible. However, established estimates of these values for animal fli...

Exclusive: A physician-scientist recommended by NIH Director Jay Bhattacharya to lead the agency’s mental health institute is no longer in the running. Instead, HHS Secretary Robert F. Kennedy Jr. favors a researcher who studies treating mental illness with diet. https://scim.ag/4BvmHlN

scim.agKennedy to select MAHA-aligned researcher to head mental health institute, overruling NIH directorHealth secretary wants a leader of “metabolic psychiatry” movement to direct $2.2 billion agency

A new device can detect scents and transmit them between people across distances, with the potential for long-range transmission. It marks another stage in the development of human-machine interfaces: enabling the sharing of smell. Learn more in #ScienceAdvances: https://scim.ag/4jRRN0D

scim.agScentronic: An artificial intelligence–assisted olfactory interface for remote odor sharing and transmissionRecent years have witnessed the surge of human–machine interfaces (HMIs) for various applications. Olfaction is a fundamental chemical sense crucial to perception, memory, and emotion. Current limitat...

The Advanced Research Projects Agency for Health, whose mission is to fund bold, edgy biomedical research, is making a $41 million bet on repurposing drugs approved for other conditions and natural products such as supplements to stave off Alzheimer’s. https://scim.ag/4kaIZCP

scim.agWith blood test looming, government puts $41 million into clinical trials to ward off Alzheimer’s diseaseFunding from Advanced Research Projects Agency for Health will expand testing of supplements and approved drugs to prevent dementia in people at risk

A new slate of optogenetic tools enables scientists to finely control G protein signaling in excitable cells—providing a flexible method that might also be used therapeutically for disorders that disrupt the excitability of cells. #ScienceSignaling https://scim.ag/4z2tPV2

scim.agImproving optogenetic control over Gi/o-coupled receptor signaling by optimized GIRK channel expressionOptogenetically coupling GIRK channel activation to an opsin switches G protein signaling.

Science Magazine reposted

Some good news today: A clinical trial to test Ebola Bundibugyo vaccines candidates has started. The first participant was vaccinated in Bunia in the DRC today. 🧪 #IDsky I wrote about the plans and the background a few days ago in @science.org: www.science.org/content/arti...

science.orgAs Ebola epidemic rages, Congo bets on high-stakes ‘hope’ vaccine trialStudy will first test a “mismatched” vaccine, but Bundibugyo-specific shots may be added as early as next month

Last call: Apply for the BioInnovation Institute & Science Prize for Innovation The Grand Prize winner will receive a cash prize of USD 25,000 and have their winning essay published in Science, in print and online. Apply by 1 November 2026: https://bit.ly/4jEqg2e

Science Magazine reposted

My latest for @science.org: Much depends on the structure of iron in the inner core -- the maintenance of Earth's protective magnetic field and the escape of heat, to start. After decades of debate, scientists thought they finally had it down. But a surprising new result is throwing that in doubt.

science.orgIron at Earth’s heart may take a surprising formX-ray experiments reveal cubic crystals that could complicate the picture of the inner core

Researchers find in mice that cells in the brain’s network of blood vessels also support neural circuits in the cerebellum that govern motor coordination—expanding current paradigms of the role of the brain’s vasculature in neurodevelopment. #ScienceSignaling https://scim.ag/4jxuatU

scim.agA PRMT5-ANGPTL4 axis in brain endothelial cells regulates cerebellar inhibitory synaptogenesis and motor coordinationVascular PRMT5 restricts inhibitory input to the cerebellum to support fine motor coordination.

By applying a unique polyene scaffold, a team engineers a next-generation, broad-spectrum antifungal that selectively targets ergosterol without binding to cholesterol, avoiding severe toxicity linked to drugs like amphotericin B. #ScienceTranslationalMedicine https://scim.ag/4BhdvkB

scim.agA 5 + 1 polyene scaffold that selectively recognizes ergosterol’s conjugated diene uncouples antifungal potency from host toxicityMandimycin M16, a next-generation polyene antifungal, shows broad-spectrum activity against drug-resistant fungi with favorable preclinical safety.

In the 1950s, scientists tried to define "normal" humans. The problem? They couldn't find any. The Normals, a #SciencePodcast series that explores this story, has won Silver in the Science & Education: Limited Series and Specials category at The Signal Awards! Learn more: https://scim.ag/4mj0bVY

A new antifungal drug architecture combats infections in mice without the usual toxicity, a fluorescent imaging agent could enable more pinpointed removal of lung cancer tumors, and more in this week's new issue of #ScienceTranslationalMedicine. https://scim.ag/47sabFV