Bob Pellegrino

Bob Pellegrino

@kingfunk.bsky.social

Assistant Professor at Texas A&M University Human psychophysicist interested in all things smell and texture. 📸: @smellboi24_7

130 followers152 following26 posts

Pinned

20% of people have impaired smell. Almost no cookbooks account for that. #LongCOVID #anosmia Rediscovering Flavor, a new type of cookbook, changes that — science, practical guidance, and recipes co-created with smell loss patients. Preorder open now. 🧪 📖 🍽️

amazon.comRediscovering Flavor: A Practical Guide for Smell LossRediscovering Flavor: A Practical Guide for Smell Loss: 9783032080554: Medicine & Health Science Books @ Amazon.com

One of the better discussions on how LLMs work and can be used to understand cognition.

Sean Carroll@seanmcarroll.bsky.social

Mindscape 363 | Chandra Sripada on How LLMs and Humans are Cognitive Cousins. Food for thought here, whether you are biological or silicon! #MindscapePodcast preposterousuniverse.com/podcast/2026...

Bob Pellegrino reposted

Prime cat content brought to you by Current Biology! www.cell.com/current-biol...

cell.comSignatures of branched-chain fatty acids derived from a kidney reservoir confer stable chemical individuality on domestic catsIchizawa et al. show that cats maintain durable chemical individuality in urine through donor-specific branched-chain fatty acid (BFA) profiles stabilized by renal cortical lipid droplets. This kidney...
Science Magazine@science.org

Tiny fat droplets in cat kidneys—whose function has been mysterious for more than a century—encase chemical calling cards unique to each feline, allowing these messages to remain stable long after the cats themselves have left the vicinity. Learn more: https://scim.ag/46deS5C

Bob Pellegrino reposted

Hiring a postdoc to do something nobody has done: record oscillatory signals from the human olfactory epithelium in awake humans. PhD in neuroscience, biomedical engineering, or adjacent. Real electrophysiology experience: single-unit, intracranial, or peripheral. Olfactory background optional.

Howdy Y'all, I'm running a sensory lab now 👀 The lab focuses on smells (duh), textures (🤔), and their interactions using big data approaches to relate the physical to the perceptual. Lab manager posting linked here. Interested in a PhD? Just message me!

tamus.wd1.myworkdayjobs.comLab ManagerJob TitleLab Manager Agency Texas A&M Agrilife Research Department Animal Science Proposed Minimum SalaryCommensurate Job LocationCollege Station, Texas Job TypeStaff Job Description About Texas A...

Bob Pellegrino reposted

Call for chapter proposals - The OUP Handbook of Smell edited by Jessica Freiherr, Andreas Keller, Kathrin Ohla, Laiquan Zou, & Benjamin Young and published by Oxford University Press (under contract). Full details here: philevents.org/event/show/1... Please share widely.

philevents.orgThe OUP Handbook of Smell - Call for chapter proposalsCall for chapter proposals - The OUP Handbook of Smell We are seeking chapter proposals of The OUP Handbook of Smell. The handbook will be edited by Jessica Freiherr, Andreas Keller, Kathrin...

Bob Pellegrino reposted

Postdoc position in systems neuroscience! Excited to recruit a postdoc for my lab at the University of Bonn. 🔬 In vivo physiology (Neuropixels, 2P/miniscope) 🐭 Head-fixed & freely moving behaviour 💡 Optogenetics/chemogenetics ⏳ Start: ASAP | Application deadline: 28.02.2026 More info below ⬇️

1/3 The humble glass jar is a workhorse in olfactory research, but comes w/ hidden problems: - Unknown headspace concentration - Concentration dilution by ambient air These add noise to odor measurements. Our preprint introduces something new, something bag.🧪 @jmainland.bsky.social & Matt Andres

biorxiv.orgOdor Sampling Bags Enable Reliable Delivery of Controlled Odor ConcentrationsPrecise control of odorant concentration is essential for reliable olfactory research, yet existing odorant delivery methods often suffer from solvent interactions and dilution from ambient air, limiting stimulus consistency in olfactory research. We developed an odor sampling bag system using Nalophan plastic to create a closed headspace with air as the carrier medium, eliminating solvent-related variability and ambient air dilution. In two independent experiments, 15 trained panelists each rated the perceived intensity of seven concentrations of benzaldehyde and 2-heptanone using both gas-sampling bags and glass jars. Bags produced higher maximum perceptual intensities (p < 0.001) and greater test-retest reliability than jars (Experiment 1: r = 0.89 vs. 0.81, p < 0.001; Experiment 2: r = 0.86 vs. 0.72, p < 0.001). Notably, the two tested odorants showed different maximum intensities in bags (p < 0.001) but not jars (p = 0.85), suggesting bags better preserve odorant-specific concentration differences. Photoionization detector measurements confirmed stable headspace concentrations over time, comparable to industry-standard Tedlar bags. This cost-effective approach offers improved stimulus control for olfactory psychophysics research. ### Competing Interest Statement Joel D. Mainland serves on the scientific advisory board of Osmo Labs, PBC and receives compensation for these activities. National Institutes of Health, https://ror.org/01cwqze88, F32 DC020380, T32 DC000014, U19 NS112953, R01 DC017757, R01 DC021663

2/3 We’ve built and tested an odor sampling bag system with: - Known concentrations - Closed headspace - Air as the carrier (no solvent confounds) In head-to-head tests, bags produced more reliable results than jars and preserved odorant-specific differences.

View full thread

4/5 Using this information, we can predict perceived odor intensity from molecular structure + concentration with high accuracy for both: • Single molecules (RMSE = 7.1 on a 100 point scale) • Complex mixtures (RMSE ~ 7.5)

This isn’t just theory! These models can replace slow, expensive “omission tests” in flavor chemistry to find the handful of molecules that actually matter in a food’s aroma. For instance, what molecules really make coffee smell like coffee. ☕

2/5 It’s a trick question. At a lower concentration, acetophenone (left molecule, red, smells like urinal cake) is stronger than 2-heptanone (right molecule, green, smells like blue cheese). So concentration ≠ intensity. That’s been a major roadblock for neuroscience and fragrance / food industries

3/5 Using a very cool bag system to tightly control the concentration, we measured: • 62 molecules, each at ≥7 concentrations • 260 mixtures (2–10 components) • >7,000 intensity ratings from trained human panels

Bob Pellegrino reposted

Large language models (LLMs) can mirror human thinking in vision and language, but can they smell and taste? New study with @rbrainengineer.bsky.social show stochastic LLMs rate creative flavor pairings like humans, prioritizing novelty over taste. #AI #creativity #foodscience

sciencedirect.comAutomating chemosensory creativity assessment with large language modelsChemosensory creativity, the ability to innovate using taste and smell, is a crucial yet understudied aspect of human ingenuity. This study explores t…

Bob Pellegrino reposted

ACOG is deeply disappointed by HHS’s move to drop COVID-19 vaccine recommendations in pregnancy. The science is clear: COVID-19 remains dangerous in pregnancy and vaccination protects both patients and newborns. The vaccine is safe and protects families. Read our full statement: buff.ly/OGue7sO

Bob Pellegrino reposted

Bob Pellegrino reposted

Excited to share the sequel to our 2022 paper! In this follow-up, we show that the stable head direction (HD) signals we reported in blind mice rely on stereo olfaction—that is, the comparison of odor info. between the two nostrils. Link: www.nature.com/articles/s41... 🧵highlights below

nature.comStereo olfaction underlies stable coding of head direction in blind mice - Nature CommunicationsStereo olfaction involves comparing odor differences between the two nostrils. Here, using neuronal recordings and a behavioral test, the authors demonstrate that blind mice use stereo olfaction to fo...

Bob Pellegrino reposted

Welcome to the Bluesky account for Stand Up for Science 2025! Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide! #scienceforall #sciencenotsilence

Bob Pellegrino reposted

One more day to get your paper in.

Ben Young@benyoung.bsky.social

CFP: Olfactory Philosophy Workshop at UNR Lake Tahoe philevents.org/event/show/1... Please spread the CFP widely to PhD students and ECRs - the deadline is January 31

Bob Pellegrino reposted

Learning the language of life with A.I. @science.org In today's essay, I review the phenomenal progress in foundation models of DNA, RNA, proteins, ligands, cells, their interactions, the Virtual Lab, and the aspiration for the Virtual Cell www.science.org/doi/10.1126/...

science.orgLearning the language of life with AIIn 2021, a year before ChatGPT took the world by storm amid the excitement about generative artificial intelligence (AI), AlphaFold 2 cracked the 50-year-old protein-folding problem, predicting three-...

Bob Pellegrino reposted

Interested in understanding how things work? In particular the tools you use to study the brain? Join us at TENSS 2025 where we brainstorm ideas, build and debug microscopes, electrophysiology and behavior rigs amidst the picturesque Transylvanian hills! tenss.ro Apply by: February 16th!

Alexander Fjaeldstad and I have a new chapter in the book Smell, Taste, Eat: The Role of the Chemical Senses in Eating Behaviour, edited by @LorenzoDStafford. Lots of great insights here. From our chapter, it’s clear that smell loss and its impact on ingestion remain vastly underexplored."

link.springer.comThe Effect of Olfactory Disorder (and Other Chemosensory Disorders) on Perception, Acceptance, and Consumption of FoodPeople with changes in the overall sensory experience of food often complain of taste disturbances, although the problem is normally caused by the loss of aroma in the food (thus an olfactory disorder...

Bob Pellegrino reposted

We have a fresh new paper! The PhD project of the talented Mark Conway. A learning-induced change in the sensitivity of olfactory receptor neurons enables consistent perception of an odor. #olfaction #neuroscience www.science.org/doi/10.1126/...

science.orgPerceptual constancy for an odor is acquired through changes in primary sensory neuronsLearning-induced changes in primary sensory neurons support concentration-invariant perception of an odor.