Jeff Martin

Sooo.... I finally got around to making a logo for my SmolWeb project. It's a peer-to-peer network for the web. Like, host a website using the computer and internet you already have. Then people visit your website using the web browser they already have. No clouds needed! Sort of, it's complicated.

Devoting your social time to platforms where you control your own account and your own data, is the only real long term solution to hating billionaires controlling their own platforms.

Explore images that structural biologist Irina Bezsonova (UCONN Health) created for #inktober in PDB-101's #sciart gallery

Genentech Structural Biology is hiring a Principal Scientist - please share! We're looking for someone with expertise in solving structures and in computational techniques related to dynamics - MD, ensemble modeling, ensemble docking, and/or related methods.

Interested in a career in industry cryoEM? We're hiring! We seek a cryoEM/cryoET expert to join our team at Genentech advance our mission to provide high-resolution structural insights into biological macromolecules involved in health and disease. Apply at: careers.gene.com/us/en/job/20...

Me every time I get an error message from rustc

This is one of those jokes you make, then realize people in the field have probably been saying it verbatim for 20 years. COMIC ◆ www.smbc-comics.com/comic/ai-17 PATREON ◆ www.patreon.com/ZachWeinersm... STORE ◆ smbc-store.myshopify.com

who decided to call it speculative execution and not cache me if you can

Excited to share that my 2025 collection of science-inspired drawings is now live on the Protein Data Bank (PDB) website. Thank you @rcsbpdb.bsky.social! It is free to explore and download. I’d love to hear what you think! pdb101.rcsb.org/sci-art/bezs...

I’ve posted it before, but it feels evergreen The two hardest problems in Computer Science are 1. Human communication 2. Getting people in tech to believe that human communication is important

Here is an insane piece of lore inside SQLite's source code I am researching VACUUM and I was studying their code. In VACUUM, SQLite creates a temp file prefixed with `etilqs_` Here is why:

🚨🚨🚨JOB ALERT🚨🚨🚨 The Image Analysis Unit at Human Technopole in Milan is recruiting for two positions to join our growing team: 1) Bioimage Analyst 2) Research Software Engineer (RSE) Read on to learn why one of these two people should be you!

This is my entire $DayJob right now. Roundoff error is the absolute worst! ☹️

The employer class is trying to get rid of the employee class.

“think about whether some of the proprietary license money you’re currently spending could be spent instead on open solutions that would be yours forever, endlessly adaptable, and benefit the entire world. And please get in touch by emailing info@image.coop” 👏 👏 👏 Can’t wait to see where this goes

When someone says „Scientists do not want you to know“ you can dismiss everything from there on. Scientists want you to know. They are desperate that you know. They can’t shut up about what they found out and want you to know.

I had a number of CS people tell me this read just fine for them. www.smbc-comics.com/comic/language

its amazing how chatgpt knows everything about subjects I know nothing about, but is wrong like 40% of the time in things im an expert on. not going to think about this any further

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

I brewed my first homebrew beer in nine years today! Damn, it's been a while. It's a dark English mild. If breweries won't make the beers I like anymore, guess I'll do it myself. If you're interested, read more on my other account. Since I'm too lazy to copy it here. gladtech.social/@cuchaz/1160...

I just got this banger AI-generated spam: "We can potentially arrange for 2 million to 35 million ... Our consortium of single-family offices and HNW individuals are seeking fresh investment opportunities inside the minecraft modding category" There's not much money in Minecraft mods. I LOL'd.

If you're reading my posts or following me because of @altnoaa recommending Session over Signal and folks linking to my blog post criticizing Session: Hi, I'm Soatok. I'm a gay furry who gets angry at arrogant techbros that put people's lives and safety at risk with poor security advice.

Jane Richardson was born #OTD in 1941 + Developed the Richardson (ribbon) diagram to represent proteins' 3D structure (becoming a standard representation for protein structures) + MacArthur Fellow, 1985 + Elected, Nat'l Academy of Sciences, 1991 + President, Biophysical Society, 2012 #WomenInSTEM

First Scientific Computing in Rust monthly newsletter of 2026 is out. Enjoy! scientificcomputing.rs/monthly/2026...

LMAOOOOOO

CryoEM folks, If you want to handle huge STAR file efficiently in Python, please try starfile-rs! github.com/hanjinliu/star… Reading a motion data of a particle from a 15 MB file is just like this ↓🤩

Day 18: Function with fast & slow paths. Inline = code bloat. Don't inline = slow fast path. Can't have both—or can you? The compiler finds a surprising way out of this dilemma. xania.org/202512/18-pa... youtu.be/STZb5K5sPDs #AoCO2025

Computers are a gigantic sequence of interesting logic puzzles.

Take a look under the hood of the state of the art in grid interpolation in Rust and Python! Come for the compile-time loop unrolling, stay for the profile-guided optimization! jlogan.dev/blog/2025/11...

InterpN: Fast Interpolation, using Rust jlogan.dev/blog/2025/11... Cool story about how to go fast with numerical computing. And why many Pythonic approaches, even with native extensions, can be pretty slow. My first thought though: can we go faster in Mojo? 😅

Happy logical operator Halloween! 🎃

Really positive sign that open source projects are standing up to do the right thing. Kudos to the Python folks: www.theregister.com/2025/10/27/p...

We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated. mrc.tal.net/vx/appcentre...

PSA for my friends who play games on Windows: Microsoft now screenshots your games and sends the images to the cloud for AI stuff, and who knows what else. If this bothers you, you can turn it off (for now). Or you can switch to a different OS, like Linux or Mac. www.techspot.com/news/109983-...

October issue is now available! journals.iucr.org/d/issues/202... The cover highlights the article on categorizing prediction modes within low-pLDDT regions of AlphaFold2 structures from the Richardson lab @duke-university.bsky.social : doi.org/10.1107/S205... Image credit: Chistopher Williams

Welp. We've reached the part of the story where I get the Very Official Work Email that says: If the government shuts down, you should keep working. Because you'll still get paid. Probably.

Happy 10 year anniversary to this tweet! Has memory safety in C++ been solved yet? x.com/CppCon/statu...

A "fun" issue my professional communities are dealing with recently is where to hold conferences, if non-US people can't safely enter the US, and foreigners in the US can't safely leave it. There is no good answer, and the equilibrium is having fewer foreigners AND conferences in the US.

My bsky feed is slowly filling up with science and CryoEM posts. I never really found much of the tech crew here (guess they stayed on Mastodon?), but it's nice seeing a bunch of scientists now. 🔬

Woo! My lab's Nature Protocols paper is out today. In a nutshell, the protocol shows how to use our Cryo-ET software to solve high-res protein structures. I don't think any of the other authors are here, but congrats to Hsuan-Fu, Ye, and Wendy for all of their work! www.nature.com/articles/s41...

😍 Eng manager job working on storage APIs, workers, etc for Firefox. Relevant to improving local-first apps in the browser! www.mozilla.org/en-US/career...

Orion is coming to Linux early next year! 🙂