Hesso Farhan

Hesso Farhan

@hessofarhan.bsky.social

Professor at the Medical University of Innsbruck, Austria. Interested in Endoplasmic Reticulum, Mechanobiology, Proteostasis, Organelles, Cell migration, Pseudoenzymes

500 followers432 following28 posts

Hesso Farhan reposted

John Stott
@jpsastro.bsky.social

Had a UKRI funded grant proposal rejected at the "AI triage stage". "This AI-based triage was used only to identify approximately 50% of the strongest proposals to take forward to full human review." 🧪 #academicsky

Hesso Farhan reposted

Maja Radulovic
@majarad.bsky.social

Our study on DFCP1 and lysosome membrane repair is live! We uncover a previously unrecognized role for omegasomes in the cellular response to lysosomal membrane damage, revealing another layer of regulation in how damaged lysosomes are repaired. www.nature.com/articles/s41...

nature.comDFCP1-containing ER microdomains mediate lysosomal membrane repair - Nature Cell BiologyRadulovic et al. show that phosphatidylinositol 3-phosphate (PI3P), produced by the phosphatidylinositol 3-kinase PIK3C3, is formed on ER domains after lysosome damage. ER domain PI3P helps to recruit...

Hesso Farhan reposted

Cell Biology J-Club
@cellclub.bsky.social

The ARLA1A-NAC089 module coordinates ER phagy with the unfolded protein response to maintain cellular homeostasis in plants: Developmental Cell www.cell.com/developmenta...

cell.comThe ARLA1A-NAC089 module coordinates ER phagy with the unfolded protein response to maintain cellular homeostasis in plantsYang et al. reveal that the ARLA1A-NAC089 module couples ER phagy with the UPR in plants. This dual regulatory axis fine-tunes cell survival versus death under stress, providing a mechanistic framework for maintaining ER homeostasis and enhancing environmental resilience.

Hesso Farhan reposted

Journal of Cell Biology
@jcb.org

Yang et al. show that the secretory pathway kinase Fam20C is retained in the #Golgi via Fam20A-mediated membrane anchoring. Mislocalizing Fam20C alters #secretome phosphorylation, leading to reduced milk quality and subsequent growth retardation in pups. rupress.org/jcb/article/...

Hesso Farhan
@hessofarhan.bsky.social

3/4 But why does high mTORC1 promote cell death under these conditions? High mTORC1 induces an anabolic state. However, when ER export is blocked, mitochondria become dysfunctional and cannot meet the metabolic demand. This energetic imbalance results in lower translation (despite high mTORC1 !!)

Hesso Farhan
@hessofarhan.bsky.social

4/4 Our work highlights ER proteostasis as a therapeutic vulnerability in myeloma. This extends our previous work showing that targeting LTK, a kinase that regulates ER export, kills myeloma cells (www.nature.com/articles/s41...) We propose ER export as an avenue for multiple myeloma therapy

nature.comTargeting proteostasis in multiple myeloma through inhibition of LTK - LeukemiaLeukemia - Targeting proteostasis in multiple myeloma through inhibition of LTK
Hesso Farhan
@hessofarhan.bsky.social

2/4 We show that targeting the ER export machinery induces death of MM cells. Surprisingly, cell death was unrelated to ER stress. Instead, we uncover this cascade: ER overload > activation of ERAD > proteasomal degradation > increase of free cytosolic amino acids > activation of mTORC1.

Hesso Farhan reposted

Österreichischer Wissenschaftsfonds FWF
@fwf-at.bsky.social

Wir gratulieren den 18 aufstrebenden Spitzenforscher:innen, die heute ihre #ASTRA-Preise und damit insgesamt 22 Millionen Euro für Ihre Forschung erhalten! 🪘👏 Unter den Ausgezeichneten sind elf Frauen. 💪 Alle Infos 👉 www.fwf.ac.at/aktuelles/de...

fwf.ac.at18 FWF-ASTRA-Preise 2026: Eine Million Euro für internationale Forschungstalente in ÖsterreichDer FWF vergibt 18 FWF-ASTRA-Preise an herausragende Postdocs. Die mit jeweils rund einer Million Euro dotierten Förderungen stärken Spitzenforschung und helfen, internationale Talente für den Forschu...

Hesso Farhan reposted

The EMBO Journal
@embojournal.org

How do cells control formation of Golgi stacks upon demand? Roman Polishchuk, Franck Perez and collaborators identify a ‘Golgi regulon’ under control of the CREB3L1 transcription factor link.springer.com/article/10.1...

link.springer.comA coordinated transcriptional program controls de novo Golgi biogenesis - The EMBO JournalThe Golgi apparatus expands during differentiation and increased secretory demand, yet the transcriptional mechanisms governing its biogenesis remain poorly defined. To investigate this process, we de...

Hesso Farhan reposted

David Teis
@teislab.bsky.social

We offer a PostDoc position for a fully funded project on lipid-encoded #lipidtime protein quality-control checkpoints at the Golgi: great collaborators, excellent working & living conditions & benchspace with a view ;) Please share and repost!

Hesso Farhan reposted

Ishier Raote
@ishier.bsky.social

Postdoc job alert at Institut Jacques Monod in Paris! Interested in fundamental membrane trafficking? We seek a postdoc to study collagen secretion as a model for core principles of how cells and their environment build each other. emploi.cnrs.fr/Offres/CDD/U...

emploi.cnrs.frPortail Emploi CNRS - Offre d'emploi - Poste de chercheur postdoctoral en trafic membranaire fondamental et sécrétion du collagène (H/F)Assurez-vous que votre profil candidat soit correctement renseigné avant de postuler

Hesso Farhan reposted

PLOS Biology
@plosbiology.org

Cdc42 is a small GTPase crucial for #CellPolarity, but how does it contribute to #aging when upregulated? This study shows that the ER-anchored chaperone Ydj1 interacts with Cdc42, enhancing its stability & partitioning during asymm #CellDivision & aging in yeast @plosbiology.org 🧪 plos.io/4qz7WaM

Hesso Farhan
@hessofarhan.bsky.social

Camouflaged nanorobots target and regulate macrophage subcellular organelle crosstalk patterns to promote neural regeneration. Interesting paper on tagelang Ero1 in macrophages by nanorobots. 🤔 rdcu.be/e3Uxw

rdcu.beCamouflaged nanorobots target and regulate macrophage subcellular organelle crosstalk patterns to promote neural regenerationNature Communications - Macrophages play an important role in repair and regeneration of damaged nerves in spinal cord injury (SCI). Here, Guo et al. investigate effects of endoplasmic...

Hesso Farhan reposted

Avezov lab
@avezovlab.bsky.social

Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule rdcu.be/e3Ris

Hesso Farhan reposted

Nature Cell Biology
@natcellbio.nature.com

☕Donahue et al. show that #aging is associated with changes in ER morphology. ER-phagy drives age-associated ER remodeling through tissue-specific factors. #autophagy #longevity bit.ly/40dNHEE

bit.lyER remodelling is a feature of ageing and depends on ER-phagy - Nature Cell BiologyDonahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.

Hesso Farhan reposted

Christophe 🔬 Leterrier
@christlet.bsky.social

ERC success rates are tanking and the move is... even bigger grants for fewer people? smh

Katherine Stiles@katherinestiles.org

· #AcademicSky · The European Research Council is launching €7m Plus Grants for ambitious, long‑term research — open to researchers at any career stage but limited to about 30 awards; current ERC grantees and applicants are ineligible, reports @clanicholson.bsky.social.

researchprofessionalnews.comERC’s new €7m Plus Grants open to researchers at any career stage - Research Professional NewsEuropean Research Council president describes scheme as part attempt to lure US talent

Hesso Farhan reposted

Österreichischer Wissenschaftsfonds FWF
@fwf-at.bsky.social

Bei #Grundlagenforschung kürzen? Keine gute Idee! so die Philosophin @asmeincke.bsky.social in ihrem Gastkommentar in @diepressecom.bsky.social. Denn Österreich brauche eine starke und vielfältige Wissenschaft. @fwf-at.bsky.social @oeaw.bsky.social Bessere Ideen 👉 www.diepresse.com/20152064/bei...

diepresse.comBei Grundlagenforschung kürzen? Keine gute Idee!Kein Geist, kein Sinn. Österreich braucht keine männliche MINT-Monokultur, sondern eine starke und vielfältige Wissenschaft.

Hesso Farhan reposted

Lisa Heinke
@lisaheinke.bsky.social

Check out this new Roadmap, a fantastic team effort by a consortium of ER researchers. Glad we could provide the space for this synthesis, which came out of discussions at a fruitful meeting, see below:

Ishier Raote@ishier.bsky.social

ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions. www.nature.com/articles/s41...

nature.comTowards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell BiologyEndoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.
Hesso Farhan
@hessofarhan.bsky.social

It was a great pleasure to work on this paper. What started as a small meeting in January this year resulted in this beautiful piece of work.

Ishier Raote@ishier.bsky.social

ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions. www.nature.com/articles/s41...

nature.comTowards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell BiologyEndoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.
Hesso Farhan
@hessofarhan.bsky.social

The microbial metabolite preQ1 modifies tRNA, reduces cell proliferation, and decreases protein translation. This is mediated by IRE1-dependent cleavage of preQ1-modified tRNAs. rdcu.be/eHw46

rdcu.beTwo microbiome metabolites compete for tRNA modification to impact mammalian cell proliferation and translation quality controlNature Cell Biology - Zhang, Lahry, Cipurko et al. show that the microbial metabolites queuine and preQ1 modify the same host tRNA. PreQ1-tRNA reduces cell proliferation, slows tumour growth,...
Hesso Farhan
@hessofarhan.bsky.social

Beautiful work which supports a role for the ER in mechanobiology.

Nature Cell Biology@natcellbio.nature.com

💫NEW: Das, @fabianspill.bsky.social & co combine intracellular cartography and biophysical modelling to reveal how edge curvature governs endoplasmic reticulum (ER) morphology, showing that curvature-dependent ER reorganization directs distinct modes of epithelial cell migration. bit.ly/3HFAQ8S

bit.lyEdge curvature drives endoplasmic reticulum reorganization and dictates epithelial migration mode - Nature Cell BiologyRawal et al. combine intracellular cartography and biophysical modelling to reveal how edge curvature governs endoplasmic reticulum (ER) morphology, showing that curvature-dependent ER reorganization ...
Hesso Farhan
@hessofarhan.bsky.social

New paper by the Reggiori and Ungermann Labs showing using a yeast model that contact sites between the phagophore and ERES are important for phagophore elongation. rdcu.be/ezUeZ

rdcu.beEstablishment of the phagophore–ERES membrane contact site initiates phagophore elongationNature Structural & Molecular Biology - Gómez-Sánchez et al. show that generation of phagophore–endoplasmic reticulum exit sites (ERES) membrane contact sites, mediated by Atg2...
Hesso Farhan
@hessofarhan.bsky.social

Great preprint showing that COPII vesicles do exist in vicinity of ERES. Very interesting.

Liz Miller@lizmillercu.bsky.social

Go check out the latest preprint from Giulia Zanetti's lab. @dr-downes.bsky.social used cryo-tomography to directly visualize COPI and COPII coated vesicles in situ at unprecedented resolution in human cells. Amazingly beautiful, rigorous, insightful work. www.biorxiv.org/content/10.1...

biorxiv.orgMulti-scale Molecular Imaging of Human Cells reveals COPI and COPII Vesicles at ER Exit SitesTrafficking from the endoplasmic reticulum to the Golgi apparatus comprises the first steps toward the correct localization of 30% of eukaryotic proteins. Coat protein complexes COPII and COPI are inv...

Hesso Farhan reposted

MolinariLab-ER
@molinarilab-er.bsky.social

Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉 rdcu.be/ey8iL

rdcu.beThe intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy fluxNature Cell Biology - Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite...

Hesso Farhan reposted

Hellerschmied Lab
@hellerschmiedlab.bsky.social

Very happy to see our contribution to a better understanding of Hsp70/90 #chaperones online! Congrats and a big thank you to all co-authors, collaborators and reviewers! #proteostasis @poepsel-lab.bsky.social @crc1430.bsky.social @unidue-zmb.bsky.social

Nature Structural & Molecular Biology@natsmb.nature.com

New online: Conformational plasticity of a BiP–GRP94 chaperone complex

go.nature.comConformational plasticity of a BiP–GRP94 chaperone complexNature Structural & Molecular Biology, Published online: 14 July 2025; doi:10.1038/s41594-025-01619-0BiP–glucose-regulated protein 94 chaperones are critical to the proper folding of secretory and transmembrane proteins. Brenner et al. provide biochemical and structural insight into a conserved mechanism of chaperone cooperation underlying this quality control process.

Hesso Farhan reposted

Agostinis Lab
@agostinislab.bsky.social

🚨 Where does #lipid peroxidation kick off in #ferroptosis? 🔥Excited to reveal #ER- #mitochondria #contactsites as the ignition point of the lipid peroxidation cascade! Huge kudos to our Maria Livia Sassano @mariamls.bsky.social & our amazing collaborators who made this breakthrough possible!

doi.orgEndoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis - Nature Cell BiologySassano et al. identify endoplasmic reticulum–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact s...

Hesso Farhan reposted

Cahir O'Kane
@cahirokane.bsky.social

ER needs ATP for processes like protein quality control, but can't make its own. Here, how ATP is imported into the ER lumen and exchanged for ADP.

Cell Biology J-Club@cellclub.bsky.social

Stepwise ATP translocation into the endoplasmic reticulum by human SLC35B1 www.nature.com/articles/s41...

nature.comStepwise ATP translocation into the endoplasmic reticulum by human SLC35B1 - NatureSLC35B1, initially thought to be a nucleotide sugar transporter, is an essential ATP/ADP exchanger that imports ATP into the endoplasmic reticulum through a unique stepwise translocation mechanism.
Hesso Farhan
@hessofarhan.bsky.social

Excited to present our unpublished data tomorrow on how Mechanosesing at the Endoplasmic Reticulum regulates Proteostasis. #Organelles #Mechanobiology

Ishier Raote@ishier.bsky.social

Join @felixmendu.bsky.social, @franbottanelli.bsky.social, @hessofarhan.bsky.social, Kelly Ten Hagen, and me for exciting #MembraneTrafficking science and great discussions. Details on the website felixcampelo.wixsite.com/membranetraf... or Slack join.slack.com/t/membranetr...

join.slack.comJoin Membrane trafficking virtual community on SlackSlack is a new way to communicate with your team. It’s faster, better organized, and more secure than email.