Ensembl

AlphaGenome Variant Impact (AVI) scores, developed by Google DeepMind, predict how likely variants across the whole human genome are to impact gene regulation. AVI scores are available in the Ensembl Variant Effect Predictor to enable easy access into variant analysis workflows.

Due to a server issue, Ensembl tools are currently down. This affects tools such as BLAST and Ensembl VEP, on both new and legacy Ensembl sites. New jobs will not start and currently running jobs will fail. Fixes are in progress.Thank you for your patience in this regard.

Ensembl transition update - the Ensembl USEast and Asia mirrors are now retired. Both addresses will continue to work, but will serve content from the Ensembl 116 archive. For BioMart, update host config to use the e116 archive directly. Blog here - zurl.co/SbFuP

Are you attending #ASHG2026? Come visit booth 306, give our @impc-phenotypes.bsky.social, @gwascatalog.bsky.social and #Ensembl quiz a go, win prizes and talk to our colleagues!

For users of our new FTP space: ftp.ebi.ac.uk/pub/ensemblo... - reminder that we are retiring the species name based directory structure this week! More info on our blog www.ensembl.info/2026/10/08/r...

We are at EuropeanResearchersNight @embl.org An evening for all ages to meet researchers from different fields, try hands-on science (Including a coding workshop!) and see how research shapes our daily lives and our future. #STEM #EMBL

Want to know what’s next for variation data? Join us to explore the latest EVA developments, hear community insights, & help steer the EVA roadmap! 𝟮𝟮 𝗢𝗰𝘁 𝟮𝟬𝟮𝟲 | 𝟭𝟰:𝟬𝟬–𝟭𝟲:𝟬𝟬 𝗕𝗦𝗧 | 𝗙𝗿𝗲𝗲 𝗼𝗻 𝗭𝗼𝗼𝗺 Registration is now open: embl-org.zoom.us/meeting/regi...

Ensembl archive sites are currently under very heavy load, causing failures and slow performance. Sorry for the disruptions, we're working on it. Workaround for Ensembl 116 (June 2026): use the Ensembl 115 (Sep 2025) archive instead - sep2025.archive.ensembl.org/index.html

Are you a skilled and highly motivated Bioinformatics Developer looking for a new opportunity? Join the DECIPHER team - gain knowledge of clinical genomics and improved web development skills while creating tools to facilitate genomic medicine. embl.wd103.myworkdayjobs.com/EMBL/job/Hin...

The new Ensembl VEP web interface just got upgraded for human GRCh38 variants! Add scores from AlphaMissense, REVEL, CADD, and SpliceAI. Link gnomAD frequencies, ClinVar & GWAS Catalog phenotypes to your data. Try it at- ensembl.org/tools/vep  Blog- www.ensembl.info/2026/09/04/n...

Want a quick tour of the new Ensembl? Check out our new material on the EMBL-EBI Training site! It's free to access - give it a try and see what genomes are available on Ensembl now. 🧬

Exciting opportunity to work with Ensembl microbes! We are seeking a bioinformatician to help us develop and maintain high-quality genome resources for microbial research communities. More info: zurl.co/hdKpk #Jobs #bioinformatics

Explore genes & transcripts with the @Ensembl Feature Explorer! Using human BRCA2 as an example, learn how to explore transcripts, exon structure & sequences, external references and orthologues across species. zurl.co/Q5YoZ #Ensembl #Genomics #Bioinformatics

Open access means faster discoveries, new ideas and scientific growth #OpenAccess #Genomics

Ensembl has moved! We are ahead of schedule and all sites now point to the new Ensembl at ensembl.org. It is a major milestone in our 26 year long project! 🧬🧬🧬 Refresh your browser cache for our sites if you find an error this week ⚙️

Ensembl is moving this week! 🧬 Links will point you to the new Ensembl. The default site will be ensembl.org for all species from across the tree of life. We’re starting with the Ensembl Genomes sites, and we’ll end with the Ensembl 116 site.

Explore genomes with the new Ensembl Data Platform! In this demo, see how to: Select a genome Find information about your selected genome Watch the demo and start exploring: zurl.co/qtSwQ #Ensembl #Genomics #Bioinformatics

Big news for European biodiversity conservation. Three major scientific communities have signed a landmark agreement through the @biogeneurope.bsky.social (BGE+) project to build a continent-wide infrastructure for biodiversity genomics. www.embl.org/news/science... #biodiversity #EUPolicy

The annual DECIPHER user survey is now available ! Please, help us to improve DECIPHER by taking 5 minutes to answer. docs.google.com/forms/d/e/1F... This is a new survey so don’t hesitate to answer it even if you had completed it last year.

We're making some changes to our new Ensembl site in the lead up to transition! Two apps have been renamed: Species selector is now Genome selector; Entity viewer is now Feature explorer. Any saved links still work - so no worries for your bookmarked genomes and genes. 🧬

NMD predictions have been updated. The first 200bp of coding nucleotides on the protein browser are now highlighted as predicted to escape the NMD - 100-200bp is shaded in light grey to reflect the evidence of gradual decrease in NMD inhibition in this region #VariantClassification

DECIPHER version 11.40 has been released. See the new features at www.deciphergenomics.org #variantinterpretation

Join @training.ebi.embl.org webinar on 1 July: Transitioning to the new @ensembl.org platform for genome data and annotation. We will cover features in development and the access the current Ensembl site. Register: zurl.co/VNaw3 Qs?: zurl.co/asl8M #Genomics #Bioinformatics #Training

New Ensembl FTP users, heads up! 

The FTP structure for the new site has been updated. The species name-based structure will be retired in August 2026. Overlap dumps are provided to help while you rework existing pipelines. Read more on our blog: zurl.co/sSbPj

We’ve updated human variant pathogenicity predictions on #Ensembl 116, which now features #AlphaMissense and #ESM1b predictors across variant and transcript views, alongside a fix to improve #REVEL score accuracy. Read more in our blog: zurl.co/EoRmm

The #Ensembl Transition webinar series starts tomorrow. If you would like to know how the transition will affect you, please join us and the @training.ebi.embl.org team! Registration for each webinar is free but essential to secure your place: www.ebi.ac.uk/training/eve...

Visit us at #eshg2026 F4-5 at 14:00 CEST I07 Adam Frankish (Manual Genome Annotation Coordinator) and Likhitha Surapaneni, Senior Bioinformatics Developer (Ensembl Variation)

Join us at #eshg2026 for Interactive Session I07: @genomebrowser.bsky.social and @ensembl.org Browsers! Sunday, 14 June 2026 14:15-15:45 CEST Suitable for anyone with a degree-level understanding of molecular biology, bioinformatics, or genetics, and comfortable using web browsers.

DECIPHER version 11.39 has been released. See the new features at www.deciphergenomics.org #variantinterpretation

Ensembl 116 + Ensembl Genomes 63 are out! Explore new pig, cattle, and oat genomes, updated alignments and new VEP plugins It’s a milestone! Our last on the current platform. New data from here on is via beta.ensembl.org More info on our blog: zurl.co/MrJ2A

We're excited for our webinar tomorrow where we'll demonstrate our new Alignments viewer tool and how to explore genomic structural variants! Registration is free but essential www.ebi.ac.uk/training/eve...

Explore genomic #StructuralVariants and #GenomeAlignments in our upcoming #webinar on the new Alignments viewer in the Ensembl Data Platform. It includes a live demo comparing human reference and alternative assemblies. Registration free but essential www.ebi.ac.uk/training/eve... @ensembl.org

Open genomic data powers modern life science research, and Ensembl plays a key part in this ecosystem. Developed by @ebi.embl.org we helps researchers explore genomes, variation, and comparative genomics across species. Our latest report here: zurl.co/aKKpF #Genomics #OpenScience #Bioinformatics

What is the value of open data for the life sciences? 📈 New report by Frontier Economics shows that EMBL-EBI data resources save users an average of 11 hours/week/person, leading to £11.8bn/year in research productivity gains. s.embl.org/EMBL-EBI-202... #opendata

Join our colleagues on 21 May 2026 to learn about Ensembl's new Alignments viewer tool!

Working with structural variants in human genomes? Try our new Alignments viewer with the GRCh38 and T2T-CHM13 genomes on the new Ensembl: zurl.co/LlemO   Built in collaboration with the HGSVC! Read more on on the Ensembl blog: zurl.co/98juQ

Our webinar series continues with next week's webinar 'How to fetch data from the Protein Data Bank using PDBe API'. Speaker: Ibrahim Roshan Kunnakkattu, Senior Bioinformatician with @pdbeurope.bsky.social at EMBL-EBI. Registration is free but essential: www.ebi.ac.uk/training/eve...

30 years ago, the yeast genome was completed by an international team of scientists. Since then, S.cerevisiae has become a key model for understanding conserved biological processes and driving discoveries. Explore the annotated Baker’s yeast R64-1-1 genome in @ensembl.org @yeastgenome.bsky.social

DECIPHER version 11.38 has been released. See the new features at www.deciphergenomics.org #variantinterpretation

From delivering genomics training across 16 countries to making bioinformatics more accessible worldwide, Aleena connects science, people, and cultures. www.embl.org/news/people-... #Bioinformatics #Genomics @ensembl.org

Want to level up your fungal genomics skills? Join our hands-on virtual training in Fungal Pathogen Genomics, covering Ensembl Fungi and other top web-resources for the field. Apply today! coursesandconferences.wellco... Applications close: 28 March 2026 Course runs: 1-5 June 2026

Our #Ensembl colleague, Leanne Haggerty, along with scientists around the globe, recently spoke to Nature Methods (@natureportfolio.nature.com) about the human pangenome and its importance in research. You can read the full article at www.nature.com/articles/s415...

Dr. Jorge Batista Da Rocha ( @ensembl.org ) will demonstrate how researchers can access, explore, and analyze genomic data using the Ensembl genome browser, while Dr. Jen Kong (VectorBuilder) will show how those genomic insights can translate directly into practical vector design using VectorBee.

Excited to build cutting-edge web tools for genomic research? Join us at @ensembl.org as a Web Developer. Apply here: www.ensembl.info/2026/03/04/... Closing date: 25th March 2026