Claudia Matthaeus

Hello new followers 🖖 I like looking at the plasma membrane by high res microscopy. Here, you see a platinum replica EM of a fibroblast plasma membrane with clathrin dome (in the center) and caveolae (small invaginations on the side)

1/5 🚨 🔬 PhD opportunities in my lab at @uni-of-warwick.bsky.social What is the role of plasma membrane organisation in tissue formation? Let’s find out! www.findaphd.com/phds/project... I’m recruiting for several interdisciplinary PhD projects. #PhD #Biophysics #Microscopy ⬇️ Details below 🧵⬇️

Why use many lipids when few will do? www.nature.com/articles/s41...

💥 Post-doc opportunity! 💥 Come join our team (www.thelowlab.org) at Imperial, London, working on the cryo-EM structure and mechanism of bacterial secretion systems. 48 months. Please RT. For more details and to apply: www.imperial.ac.uk/jobs/search-...

Made it! I am delighted to share that I got tenured as Full Professor for Cellular Physiology of Nutrition @unipotsdam.bsky.social A dream comes true! I want to thank all my lab members, all the mentors along the way, my collaborators and my family & friends for their emotional support. 🎉

Learn about lipid droplet dynamics and #LipidMetabolism at the EMBO Workshop "Lipid droplets and metabolism: From cell physiology to disease" in Sant Feliu de Guixols, Spain, 26 Sep–1 Oct 2027. Deadline: 10 Jun 2027 https://meetings.embo.org/event/27-lipid-droplets #EMBOlipidDroplets #EMBOevents 🧪

Study today in @natcellbio.nature.com by @mathilda95.bsky.social @nadlerlab.bsky.social @mpi-cbg.de, Honigmann group @biotec-tud.bsky.social & @carldmodes.bsky.social reveals that clathrin-mediated endocytosis sorts proteins but not lipids. Lipids use different routes. www.mpi-cbg.de/news-outreac...

www.biorxiv.org/content/10.6...

#membranetrafficking seminars are back for the fall session! This Thursday two exciting talks from Roger Pons Lanau from @felixmendu.bsky.social lab and @veijosalo.bsky.social #ER #lipiddroplets and lots of wonderful imaging! From single molecules to cryo EM! Please repost

Perspective: Harriet Lo, Robert Parton et al. provide a perspective on the role of #skeletalmuscle #caveolae, focusing on the cellular processes impaired by caveola dysfunction in muscle disease. They propose a new classification for disease-associated CAV3 variants. rupress.org/jcb/article/...

☕This Review highlights advanced imaging methods and available biosensors that can be used to elucidate the composition and dynamics of membrane contact sites. 👉https://rdcu.be/4uDgJ3upkD1a www.nature.com/articles/s41...

Happy 50th anniversary, Clathrin! onlinelibrary.wiley.com/doi/full/10.... @effc.bsky.social

www.biorxiv.org/content/10.6...

Lipids build the membranes of all cells, but identifying their precise functions is extremely challenging. Here’s our attempt to change that: How to find and understand lipid-protein interactions, by Katelyn Cook & company. www.biorxiv.org/content/10.6...

💡New Preprint! How does a cell control which way a membrane bends? ESCRT-III has the remarkable ability to reshape membranes and drive reverse-topology fission, yet a fundamental question has remained: what determines the direction of membrane remodeling? www.biorxiv.org/content/10.6...

Identification of lipid specificity in membrane organizing protein complexes https://www.biorxiv.org/content/10.64898/2026.07.24.740489v1

Free and open-source images, icons, and tools for creating scientific illustrations doi.org/10.59350/5zt... 🧪

How do liver cells determine whether lipids are stored or secreted? doi.org/10.1172/JCI2... Bo Wang & team report SEC16B helps manage lipids by balancing lipid release and storage—and its inhibition in mice lowers blood lipids and reduces atherosclerosis.

Online now: Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism

link.springer.com/article/10.1...

New preprint from the lab, led by the ever-talented grad student Tessa Lochetto @tlochetto.bsky.social! We find that loss of our favorite phosphatase Pptc7 decreases lean mass, induces skeletal muscle dysfunction, and causes metabolic derangements in adult mice: doi.org/10.64898/202... /1

Save the date! Club Exocytose-Endocytose half-day scientific meeting is planned 📅 1 Dec 2026, 2 pm 📍 Centre Broca Nouvelle-Aquitaine, Bordeaux Neurocampus 🎤 ~8 talks 💻 Hybrid: in person or online Registration & abstract submission open in September. Stay tuned !!

Online now: Competitive catabolism drives hyperglycemia and hyperinsulinemia in obesity

Analyzing large datasets is one of the messiest, most complicated parts of lipid research. So #HHMIInvestigator Tobias Walther's lab @mskcancercenter.bsky.social built LipidCruncher: a free, open-source, step-by-step platform that makes results easier to reproduce & share: bit.ly/3QWca0o.

RESEARCH | @alquierthierry.bsky.social @ejrideout.bsky.social et al.: Neuronal lipid droplet formation mediates energy homeostasis in a sex-specific manner in Drosophila and mice 🧪

🚨🚨Last day to register for the next annual meeting of Club Exocytose-Endocytose !!!🚨🚨 Invited speakers: M. Stroeber, G. D'Angelo and @christlet.bsky.social 📍 Centre Paul-Langevin, Aussois, France 📅 May 27–29, 2026 Get ready for exciting science!! Registration here exoendo.org/evenement/28...

It was fun writing this with David @dgershlick.bsky.social! Check it our if you want to hear our view on small #GTPases networks in endosomal trafficking :) part of the themed issue on Membrane trafficking edited by @fromme-lab.bsky.social and Philippe Chavrier www.sciencedirect.com/science/arti...

Preprint 🧵! I’m really excited to introduce BIGSMALL, an interleaved multi-magnification cryo-ET scheme bridging molecular and cellular scales in a single acquisition! BIGSMALL = 𝐁road 𝐈nformation 𝐆athering 𝐒trategy by 𝐌ultiscale 𝐀cquisition of lame𝐋𝐋a www.biorxiv.org/content/10.6... (1/6)

Interested in caveole and/or lipid metabolism? We have two master thesis projects available in the lab @unipotsdam.bsky.social starting September or October. For more details 👇 www.matthaeus-lab.de/post/04-2026...

1/9 🚨 New paper out in Nature Metabolism! Chapter 2 of our mitochondria zonation story (following our 2024 Nature Communications work). We asked how zonated liver mitochondria adapt when lipid flux surges. 🧵👇 www.nature.com/articles/s42...

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density. Lipid-CLEM, now out in @natcellbio.nature.com brought to you by @mathilda95.bsky.social changes that: www.nature.com/articles/s41...

Methods in Enzymology, Vols 726-728: Lipids & Membranes Vol 726: Detection by Imaging & Lipidomics www.sciencedirect.com/bookseries/m... Vol 727: Dynamics & Interorganelle Transport www.sciencedirect.com/bookseries/m... Vol 728: Metabolism, Lipidation, & Lipid-Protein Interactions: coming soon!

Awesome paper and super useful resource of CRISPR-based screens to identify regulators of #LipidDroplet biology under different metabolic conditions: crisprlipid.org

Final week to apply: GSO Leadership Academy 10 The GSO Leadership Academy is an interactive program designed to support researchers who want to develop leadership skills for academia and beyond. 📅 Application deadline: March 1, 2026 🔗 More information: gsonet.org/foerderprogr...

Join us next Tuesday for the next @dgz.bsky.social workshop on #trafficking and EVs! Spread the word please!

Structural basis of caveolin-driven membrane bending www.biorxiv.org/content/10.6...

Lipids challenge ligands to control receptors The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in. 🔗 buff.ly/G1Zl6cZ

Methods should be used as widely as possible, so here is our detailed lipid imaging protocol, written with @martinba99.bsky.social and Chia-Yi (Christine) Chou authors.elsevier.com/a/1mU4XHRzCb... in Methods in Enzymology. Everything you need to know to do it yourself is in there -

Triglyceride/Cholesterol Ester Ratio Encodes Lipid Droplet Size and Diversity https://www.biorxiv.org/content/10.64898/2026.01.21.700800v1

Distinct neurons, distinct functions 🧠🟤 Our Nature Metabolism paper (now out!) shows that separate sympathetic projections to brown adipose tissue independently control thermogenesis and glucose tolerance. Congrats Daniele Neri and team 🥳 www.nature.com/articles/s42...

With so many great reviews on LDs already out, do we need another? Sarah @cohenlaboratory.bsky.social and I were approached by @natrevmcb.nature.com to do a review on LD heterogeneity and inter-organelle contacts...topics in reviews, but not a focus. Fun project! www.nature.com/articles/s41...

Happy to finally share the amazing results of our long-term collaboration with Karin Reinisch’s lab on how bridge lipid-transfer proteins (BLTPs) cooperate with partner proteins to orchestrate lipid delivery. A quick thread (1/7) www.biorxiv.org/content/10.6...

I was part of the GSO Leadership Academy in 2023 and learned a LOT! I can highly recommend to apply. Still using techniques & advices in my everyday young PI life. And the best - it comes with an amazing peer group!

I've been waiting for this Titeca et al. story from Anne-Claude Gavin's lab to come out: A systematic, comprehensive analysis of lipid transfer protein cargo selection, a truly massive undertaking. What a time to work in lipid biology. Cool stuff every few days. www.nature.com/articles/s41...

Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance? www.nature.com/articles/s41... More info 👇

Registration is open for the FASEB #LipidDroplet meeting in Scottsdale, July 26-30! This is THE premier North American conference on LDs, you do not want to miss it!

Great Thread/ summary about interesting lipid related papers of 2025 👇