Vanni Lab at UNIFR, Switzerland

This amazing work by @danialv.bsky.social and Bodan Hu is now out in peer-reviewed form at @cp-cell.bsky.social with a lot of new simulations! Check it out if interested in lipid transport!

We found that cells survive a proteostasis defect, but not the lipid imbalance it causes. Rer1 & the Dsc complex triage orphan membrane proteins at the Golgi. Lose both & DAG-rich multilamellar compartments (DMCs) form. Drain DAG & cellular architecture recovers. www.biorxiv.org/content/10.6...

Please share widely (and wildly)!!! If you are a computational/AI scientist in biology and plan to apply your research to frontier biology questions across different methods and communities, you shouldn't miss this!

People!!! This workshop will be ACE - please share, please apply!

Played around a bit with Blender over the weekend and made a movie of a computational assay I had set up a while ago. Gasdermin-D binds to PIP lipids and I wanted to know what impact it has to just populate the most prominent binding site. PIP3, even more than PIP2, stabilizes GSDMD oligomers!

This my friends, this is the big one. A long time coming. Lipid Cell Biology is coming of age and even for a hot field, this is a true game changer. This dataset will keep us all busy for years to come. Congrats to everybody on this amazing crew!!! Go party!!

#lipidtime: It's a lipid universe. Today in Nature we publish the Lipid Brain Atlas, the first map of membrane lipid composition across the entire mouse brain, a layer of organisation that cell-type and transcript maps had left out. #lipidomics #neuroscience #BrainAtlas

Do not miss this fantastic symposium #lipidtime

Open postdoctoral fellow position in our lab on "𝐌𝐨𝐥𝐞𝐜𝐮𝐥𝐚𝐫 𝐇𝐨𝐬𝐭-𝐏𝐚𝐭𝐡𝐨𝐠𝐞𝐧 𝐈𝐧𝐭𝐞𝐫𝐚𝐜𝐭𝐢𝐨𝐧𝐬". Are you interested in macromolecular interactions during host-pathogen interactions both 𝐞𝐱𝐩𝐞𝐫𝐢𝐦𝐞𝐧𝐭𝐚𝐥𝐥𝐲 𝐚𝐧𝐝 𝐜𝐨𝐦𝐩𝐮𝐭𝐚𝐭𝐢𝐨𝐧𝐚𝐥𝐥𝐲? Want to join our team? apply here 👇 ki.varbi.com/what:job/job...

We are excited by the publication of our work on Torsin1A, its interaction partner CLCC1, and their role in membrane fusion during NPC biogenesis! A fantastic collaboration with @jagannathan-lab.bsky.social @labvanni.bsky.social @gautamdey.bsky.social and the Korkhov and Antonin labs!

A long-standing mystery in cholesterol biology: why is ER cholesterol sensing so switch-like rather than gradual? Our answer: cholesteryl ester phase separation in the ER membrane, which converts small lipid changes into a cooperative transcriptional response. www.biorxiv.org/content/10.6...

Lipids build the membranes of all cells, but identifying their precise functions is extremely challenging. Here’s our attempt to change that: How to find and understand lipid-protein interactions, by Katelyn Cook & company. www.biorxiv.org/content/10.6...

It's nice when you benchmark your own method and find it good. But its even nicer when others benchmark your method and find it good. Figure from: Coarse-grained simulations of long intrinsically disordered proteins: a benchmark of Martini 3 force-fields doi.org/10.64898/202...

Team science preprint, exploring the capabilities and limitations of Alphafold3 across different application areas, including protein-RNA, protein-lipid, ubiquitination,TCR and antibody recognition with @ninjani.bsky.social @labvanni.bsky.social @dgfeller.bsky.social www.biorxiv.org/content/10.6...

Happy to share that this beautiful work by @mudgal17.bsky.social in collaboration with the Weis lab @eth-dbiol.bsky.social, discovering a new membrane fusion mechanism in eukaryotes, is finally out in peer-reviewed form at @cp-molcell.bsky.social. www.cell.com/molecular-ce...

Check this mind-blowing story! How can a transmembrane protein adapt to a hugely diverse membrane topology to perform his job? Truly amazing in situ and integrative structural biology, and a great collaborative work by @veijosalo.bsky.social @yoelklug.bsky.social and @jennifersapia.bsky.social!

Beautiful cover on our Atg2-Atg18 work (with @ungermannlab.bsky.social, @arnemoeller.bsky.social and reggiori lab) by lab PhD student @yarasayed1.bsky.social. Congrats Yara! #lipidtime

Please help me share this amazing opportunity: our neighbours at @merkleinstitute.bsky.social are hiring a professor in data-driven materials discovery. This is a truly excellent (teaching, budget, infrastructure...) position. Deadline is close: 31/05/26. jobs.sciencecareers.org/job/677463/p...

Happy to share our latest work on bridge lipid transfer proteins, by PhD student @yarasayed1.bsky.social. A great collaboration with @ungermannlab.bsky.social @arnemoeller.bsky.social and Reggiori lab!

Three PhD positions available to work on yeast lysosome biogenesis and reconstitution of membrane fusion as of July or September 2026. Details can be found here: myshare.uni-osnabrueck.de/f/76c16d1fcc...

I am looking for a postdoctoral fellow to join my team to work on the interplay between endocytosis and autophagy. The 3-year project runs in collaboration with the Dagdas lab @plantophagy.bsky.social and can start asap. Interested candidates can apply via the link below. jobs.vib.be/apply/134365

The molecular basis of tricalbin-mediated membrane contact site organization in cells url: journals.biologists.com/jcs/article-...

We offer a PostDoc position for a fully funded project on lipid-encoded #lipidtime protein quality-control checkpoints at the Golgi: great collaborators, excellent working & living conditions & benchspace with a view ;) Please share and repost!

Wee thread 🧵⬇️ on our new #glycotime with @siglecdude.bsky.social John Klassen and @glycocode.bsky.social 🥳 where we show Siglecs as molecular precision tools, able to recognise sialylated glycans with surgical precision in their natural environment, not bad for a lectin! 😎 doi.org/10.1038/s420...

I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗 beta.ideas.lego.com/product-idea...

Congratulations @olzmannlab.bsky.social @arrudalab.bsky.social! Really outstanding and important work!

Amazing PhD @cristianrocharoa.bsky.social and I have collected our thoughts and questions (many!) on lipid scramblases in this review: www.sciencedirect.com/science/arti... If you are interested in lipid transport and metabolism, membrane asymmetry and membrane protein function, give it a read!

New preprint from the lab together with @labvanni.bsky.social. We looked what happens to ER generated free very long chain fatty acids.. VLCFAs are partionig into lipid droplets and are extracted from the hydrophobic core by Fat1. www.biorxiv.org/content/bior...

PhD positions in my lab (AI for Science), but with special preference for people who complement our current activities or are enthusiastic about contributing to our on going work. Looking for technically strong, independent and proactive candidates. www.chalmers.se/en/about-cha...

Please REPOST (“likes” don’t help in diffusion!) and consider applying: we work in such a fantastic context, we ask so interesting questions, and we have such a collegial and best-willing atmosphere… CRBM = Happy & Good Science

Please share!!! I am looking for a postdoctoral researcher to join us. Focus will be on exciting collaborative projects on lipids and membrane biology, pushing the boundaries of in silico "reconstitutions". Previous experience with molecular dynamics simulations of biological systems a strong plus!

We have several Master’s thesis projects available in the D’Angelo lab, spanning different areas of lipid biology/biochemistry. If you know someone who might be interested, we’d really appreciate you sharing this. #lipidtime www.epfl.ch/labs/dangelo...

Please share🙏: Our lab opens 2 PhD positions to investigate fungi's evolution: #Barcelona Wet lab in Biochemistry/Structural Biology of cryo-tolerant fungi www.upf.edu/documents/d/... Computational in Physical Chemistry of cellular processes under extrem environments www.upf.edu/documents/d/...

I finally made my webpage, check it out: pilarcossio.org

New preprint from the lab! Triglycerides act like salt on ice: they solubilize cholesterol esters and drive lipid droplet growth. The TG/CE ratio shapes both droplet size and proteome, mirroring lipoprotein organization. www.biorxiv.org/content/10.6...

The work by @danialv.bsky.social is now out in @pnas.org with a few changes after peer-review. Have a look if you are interested in lipid transport by bridge lipid transfer proteins (BLTPs)... www.pnas.org/doi/10.1073/...

Experimental tour-de-force from Anne-Claude Gavin's lab: selectivity mapping of 39 lipid transfer proteins reveals ~500 new LTP-lipid pairs. Molecular modeling by @mahmoudmoqadam.bsky.social, @rezatalandahti.bsky.social & Florian Echelard. @cbubergen.bsky.social www.nature.com/articles/s41...

Join us for the 2026 Glycolipid & Sphingolipid Biology Gordon Research Conference (GRC). 📍 Renaissance Tuscany Il Ciocco (Italy) 🗓️ March 22 - 27, 2026 Theme: "Molecular Codes of Cell Identity and Recognition" #LipidResearch #Sphingolipids #GRC2026 #ScienceConference #Lipidtime

Join us for a two-and-a-half-day meeting in the scenic Wye Valley, to discuss how membrane contact sites shape cellular homeostasis across organelles, organisms, and approaches. 📍 Chepstow, South Wales, UK | 🗓️ 28–30 September 2026 👉 : www.eventsforce.net/biochemsoc/f...

TT in Experimental Biophysics The Danish Institute for Advanced Study and the Dept of Physics, Chemistry and Pharmacy at the University of Southern Denmark is hiring a tenure track Assistant Professor in Biophysics or a related discipline fa-eosd-saasfaprod1.fa.ocs.oraclecloud.com/hcmUI/Candid...