Ary Shalizi

Ary Shalizi

@unsequenced.bsky.social

Biologist, book nerd, parent, hype skeptic in no particular order. Phenotypic screening for cell and chemical biology. Also, random book reviews at link. unsequenced.life

193 followers214 following839 posts

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2026 book thread, pt. 25 I once heard @adambecker.bsky.social mention imposter syndrome when writing #MoreEverythingForever. An anthropologist might do it better? Such a book exists: On Not Dying is the 12th book of Critical Aging Summer. It's cool & different, but not better. 💙📚 #writingcommunity

unsequenced.lifeIce-y dead peopleSometimes it’s worthwhile to step out of your lane and look at things from a very different perspective. On Not Dying, by New School anthropologist Abou Farman, puts a very particular subculture of…
Ary Shalizi@unsequenced.bsky.social

2026 book thread, pt. 24 Working through the last books for Critical Aging Summer, some observations about the author as character, with particular reference to 2020’s “Age Later,” by Nir Barzilai. 💙📚 #writingcommunity

Because biology is squishy and its computational representations are thin? OpenAI has had almost 2 years to generate follow-up data on their improved Yamanaka factors, and still nothing peer reviewed has been released. Not even a biorXiv.

unsequenced.lifeIn God we trust; all others must bring dataDid OpenAI create an “AI model for longevity science”? Of course not. They did do something clever, but weren’t the first to think of it. Read on…
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The idea that we’re just around the corner from true control of biology follows almost every major technical advance. 50 years ago, people hyped recombinant DNA methods the way CRISPR was hyped in the 2010s. unsequenced.life/2025/05/23/d...

unsequenced.lifeDesigner GenesTaking inspiration from Dave Karpf’s occasional essay series, The Future, Now and Then (which is supposed to become a book I can’t wait to read!) I started reading older books on biotec…

Because biology is squishy and its computational representations are thin? OpenAI has had almost 2 years to generate follow-up data on their improved Yamanaka factors, and still nothing peer reviewed has been released. Not even a biorXiv.

unsequenced.lifeIn God we trust; all others must bring dataDid OpenAI create an “AI model for longevity science”? Of course not. They did do something clever, but weren’t the first to think of it. Read on…
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There’s a lot more we can do in the lab than 10, 20, 50 years ago, thanks in no small part to better computational tools and methods of statistical inference, but the notion that we’ll achieve “Moore’s Law for everything” is sheer fantasy.

unsequenced.lifeSuperwishful thinkingtl;dr → with all the “Dire wolf” hype recently, decided to share this longish review I wrote in a fit of pique about a recent popular press book about biotechnology and AI. Read on&#823…

Ary Shalizi reposted

Social investment in universities to independently pursue knowledge for its own sake is the greatest driver of innovation we've every known. That is *the* message, and our leaders aren't doing nearly enough to help policy makers understand it.

Fun fact, De Kruif was good friends with Sinclair Lewis, and was the model for the main character of Lewis’ 1925 novel “Arrowsmith.” unsequenced.life/2025/03/20/b...

unsequenced.lifeBooks to Read While the World Burns, Winter 2025Man, what a bleak season this has been. America gutted its administrative state and scientific community, and started a trade war with everyone. At least we’ve still got books! I started the …
Sorek Lab@soreklab.bsky.social

Just finished reading "Microbe Hunters" (1926). What a book! It brings to life the great discoveries of microbiology - and, even more, the people behind them: Leeuwenhoek, Pasteur, Koch, and others who revealed the invisible world shaping disease, wine, beer, and food 1/5

I have this imagined alternate history where Spalazzani meets Napoleon in French-occupied Pavia, and canned food is invented “ahead of schedule,” leading to very different outcomes in 1812/13.

If the alternate title for More Everything Forever is “These Fucking People,” the alternate title for this episode of @dreamingagainstthemachine.com is “These people, fucking.”

DreamingAgainstTheMachine@dreamingagainstthemachine.com

The AI Doomers have a sex cult and @adambecker.bsky.social has the details on this week’s episode. Listen Now! www.youtube.com/watch?v=A7BT... #datmpodcast #ai #science #noai #cult #doomers #aidoomers #datacenter #siliconvalley @multitudeshows.com

My brother and his long-time collaborator @himself.bsky.social turned me on to James Scott, and I've found Scott's ideas about legibility and control explain a great deal about projects like Colossal, and connect them to a very long history.

unsequenced.lifeHopemaxxing, Hypemaxxing, FearmaxxingDid you know that synthetic biology is going to save the world? Or possibly destroy it? Maybe both! Or neither, you know, whatever. It depends. But it’s going to change everything, and you be…
Amy Feldman@amyfeldman7.bsky.social

*NEW* Colossal Biosciences’ Ben Lamm and Anduril’s Palmer Luckey team up on a new startup to genetically engineer war dogs for the military. Warhound comes out of stealth at $1.2B valuation For @forbes.com with @iainmartin.bsky.social and @mhunterhart.bsky.social www.forbes.com/sites/amyfel...

I could just as easily have written that it about George Church's book, or either of Shapiro's. Here, is what she wrote in 2023's "Life as We Made It." The twin goals of progress and control have informed a strain of biological thinking for over a century.

I think I WAAAY am more excited about my 6th grader’s science assignment “how is your bedroom like a cell? what are the different organelles?” than she is… 🧪 🧫

So Ben Lamm of Colossal and Palmer Luckey of Anduril team up for the most dystopian TX company possible… Fun fact, one of the early investors in Colossal was InQTel. I always assumed that was to get on the ground intelligence about Russia, but maybe the CIA just wants demon dogs?

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Before Colossal shifted interest to Alaska, Siberia was where they envisioned repatriating the mammoths they planned to make. I kid you not, George Church thinks this could be a way to solve climate change (read his book, or either of Beth Shapiro’s, or Jamie Metzl’s “Hacking Darwin”).

It won’t work, since scale-wise you’d need a population of a few million mammoths, and other megafauna, but I guess the investors never bothered to read the Zimov’s papers…

So Ben Lamm of Colossal and Palmer Luckey of Anduril team up for the most dystopian TX company possible… Fun fact, one of the early investors in Colossal was InQTel. I always assumed that was to get on the ground intelligence about Russia, but maybe the CIA just wants demon dogs?

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For those who don’t know, there is (was? i haven’t been keeping up) a Russian scheme to restore a large swathe of land to the “Mammoth Steppe” biome that existed during the last ice age, called ”Pleistocene Park,” the fever dream of father-son duo Sergey and Nikita Zimov.

Paradoxically, it’s because of stories like this that I don’t worry so much about Anthropic or other AI companies having a biological wet lab. It’s so easy to break things like incubators or liquid handlers, the vastly more likely outcome is spoilage, not an outbreak.

Joanna Bryson@j2bryson.bsky.social

Hundreds of French supermarkets hit by a cyberattack that turned up the heat in refrigeration systems Hundreds of French supermarkets saw their refrigeration systems defrosted, spoiling tons of frozen food. The unprecedented attack has raised serious questions about food security across Europe.

I’ve always been partial to the “argument from Einstein’s cat…” idlewords.com/talks/superi...

idlewords.comSuperintelligence: The Idea That Eats Smart People
Adam Becker@adambecker.bsky.social

It's important to remember that the AI doom scenario assumes not only that intelligence is a single well-defined thing, but also that intelligence solves literally every single problem, and that in every conflict overwhelming intelligence always wins. This is just not how anything works.

2026 book thread, pt. 24 Working through the last books for Critical Aging Summer, some observations about the author as character, with particular reference to 2020’s “Age Later,” by Nir Barzilai. 💙📚 #writingcommunity

unsequenced.lifeThe Adventures of Buckaroo BarzilaiUnless you’ve lived for 100 years, odds are you’re not a centenarian. Age Later looks at how the very old are different from you and me.
Ary Shalizi@unsequenced.bsky.social

2026 book thread, pt. 23 Back to the biology of aging with what is, hands down, the best book about the biology of aging: “How We Age,” by @ctmurphy1.bsky.social. Lucidly written, meticulously researched, hype-free. #💙📚, #WritingCommunity

I’m generally not a “one weird trick” kind of guy, but… Don’t these people love exponential curves? Steep progressive taxation _is_ one weird trick for making a more equitable society and more functional democracy. Remember to vote!

Adam Becker@adambecker.bsky.social

1. They're not "fleeing," they're just pretending they don't live here, as the article itself makes clear. 2. If you live in CA, please vote for Prop 40! Billionaires shouldn't exist and we can live in a world without them if we tax their wealth away 3. They're afraid. That's good.

Today my 11yo fully grasped the concept of inflation. Visiting home to mark 1y since my mom passed, found my old LoTR paperbacks. Disgusted, she asks "why is the paper so... yellow?!" "Because these are 42 years old." "Ugh, so gross." "Yeah, look: 1984 edition, $3" "You could buy a book for $3?" 💙📚

Ary Shalizi reposted

Wow. I really appreciate this review! (So detailed and well-written)

Ary Shalizi@unsequenced.bsky.social

2026 book thread, pt. 23 Back to the biology of aging with what is, hands down, the best book about the biology of aging: “How We Age,” by @ctmurphy1.bsky.social. Lucidly written, meticulously researched, hype-free. #💙📚, #WritingCommunity

2026 book thread, pt. 23 Back to the biology of aging with what is, hands down, the best book about the biology of aging: “How We Age,” by @ctmurphy1.bsky.social. Lucidly written, meticulously researched, hype-free. #💙📚, #WritingCommunity

unsequenced.lifeBless the Maker, and His WaterColeen T. Murphy’s lucidly written and meticulously researched How We Age wins Critical Aging Summer. Comprehensive but still accessible, and free of unnecessary hype.
Ary Shalizi@unsequenced.bsky.social

2026 book thread, pt 22. Taking a break from the biology of aging with a suggestion iof my daughter's: Chelsea Sedoti's backwoods mystery, "Tell Me What Really Happened." #booksky #WritingCommunity

This time, I had so many open tabs — from 66 year old warnings about AI doom, to 20 years of claims that robots are about to do ALL the laboratory science — I gave them in their own entry. @chorye.bsky.social, if you want more of these for your automation classes, lmk!

unsequenced.lifeOne day, I’ll have time to read all of it?Open tabs get their own post today. This approach to note taking might become a regular feature. It’s positively cathartic to close tabs this way.
Ary Shalizi@unsequenced.bsky.social

Every change of season, I like to take stock of what's been happening in the world, what I've been reading, and make a list of tabs I'll get back to and read, I swear...

Cell culture is hands on/brain off, and before podcasts I'd listen to the classes I didn't get to in undergrad. One UC course on the History of Information changed my ideas about information, and this 1965 thing about international paper sizes reminded me how physical an abstract concept can be.

2026 book thread, pt 22. Taking a break from the biology of aging with a suggestion iof my daughter's: Chelsea Sedoti's backwoods mystery, "Tell Me What Really Happened." #booksky #WritingCommunity

unsequenced.lifeOk, Zoomer?Chelsea Sedoti’s Tell Me What Really Happened is a kinetic high school mystery that hits all the hot issues: Guns, race, class, social media… … and Sasquatch!
Ary Shalizi@unsequenced.bsky.social

2026 book thread, pt 21. So, I read “Outlive” because it was relevant to my summer project of “popular books about aging.” For a book whose central message boils down to “better living through KPIs,” it was … better than I expected? #booksky #WritingCommunity

2026 book thread, pt 21. So, I read “Outlive” because it was relevant to my summer project of “popular books about aging.” For a book whose central message boils down to “better living through KPIs,” it was … better than I expected? #booksky #WritingCommunity

unsequenced.lifeDeath of the authorLongevity gurus are unavoidable, but Peter Attia and Bill Gifford’s Outlive was better than I expected. Leaving aside the author’s personal failings, it does a good job of explaining co…
Ary Shalizi@unsequenced.bsky.social

2026 book thread, pt. 20. Margareta Magnusson's charming essay collections embrace the role of community and connection for healthy aging. Also, it helps to have an intact welfare state... #booksky

I mean, ”we’ve got to slow down” is a banger way to stop spending billions on training marginally better models, and make your business appear more sustainable. Maybe I am too cynical?

2026 book thread, pt. 20. Margareta Magnusson's charming essay collections embrace the role of community and connection for healthy aging. Also, it helps to have an intact welfare state... #booksky

unsequenced.lifeSwedish massageMargareta Magnusson’s delightful diptych about growing old and letting go shows that healthy aging is all about attitude… if you’re lucky enough to do it in a robust welfare state.
Ary Shalizi@unsequenced.bsky.social

Forgot to add #booksky when I posted last week. 2026 book thread, pt. 19. "Cracking the Aging Code" is a reminder that you don't need AI to produce slop. The central argument is that aging is adaptive and arose via group selection, but we should still try to stop it, because getting old is scary.

Forgot to add #booksky when I posted last week. 2026 book thread, pt. 19. "Cracking the Aging Code" is a reminder that you don't need AI to produce slop. The central argument is that aging is adaptive and arose via group selection, but we should still try to stop it, because getting old is scary.

unsequenced.lifeI have no need of that hypothesisHave we got aging all wrong? Josh Mitteldorf and Dorion Sagan sure think so! Cracking the Aging Code is a book whose central argument boils down to “aging is good for the species and the plan…
Ary Shalizi@unsequenced.bsky.social

2026 book thread, pt. 18. An ambitious but flawed polemic about how Americans approach health and aging and so much more. Barbara Ehrenreich’s “Natural Causes.” #booksky

After soccer practice today, the 8yo says out of nowhere: “Dad, I have an idea! Boba [long pause]… … Topped with cotton candy! I bet they have it in New York.”

I am so curious about the other 6/7ths of this thread. Does he share a structure? Is there some analytical chemistry to determine purity? What, exactly, does he mean by “improved”?

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OMG, he has another lead compound, PAC-832. And it appears that the other 6/7ths of the original thread about PAC-3-3-10 are additional supporting data, like concentration of compound in the brain and open-field behavior tests.

All of which can, I suppose, be handled by a CRO, because he definitely ain't doing that stuff in a garage. But it seems exceedingly reckless. How is he disposing of his chemical waste? He's using a box fan for ventilation, ffs!

2026 book thread, pt. 19. "Cracking the Aging Code" is a good reminder that people can produce slop without AI. The central argument is that aging is adaptive and arose via group selection, but we should still try to stop it, because getting old is scary.

unsequenced.lifeI have no need of that hypothesisHave we got aging all wrong? Josh Mitteldorf and Dorion Sagan sure think so! Cracking the Aging Code is a book whose central argument boils down to “aging is good for the species and the plan…
Ary Shalizi@unsequenced.bsky.social

2026 book thread, pt. 18. An ambitious but flawed polemic about how Americans approach health and aging and so much more. Barbara Ehrenreich’s “Natural Causes.” #booksky

I work in drug discovery, and mine was after our daughters’ preschool closed in March 2020. My wife asked if the pandemic would really be done by summer like the news was saying. I said “no way, at least 500 days to develop and widely distribute anything effective enough.”

Kath Barbadoro@kathbarbadoro.bsky.social

What is the most vindicated you have be ever been for a hot take

YT served me this video, which has nearly 1M views. The audio is just the content creator reading a 24-year-old book review, word-for-word. The author of that review is still alive, and the content creator never asked for permission to use the text!

Laboratory automation does not make science easier. It makes it a different kind of difficult.

Riley Bruce@rileybruce.bsky.social

What’s a thing from your area of expertise (or special interest) that you think it would behoove everyone else to know?

Hi, I'm looking for some basic advice on filing a #FOIA request. The NIH used to post their Wednesday Afternoon Lecture Series on a public website, with lectures dating back to the late 1990s. I've been planning a research project on how scientific presenting styles have changed, . : 1/n

but the videocast site for NIH has been changed and all lectures prior to 2012 are gone. There was a temporary videocast-b website, which had the old lecture directory, but the recordings were no longer publicly available, and the alternate site now seems to have been deactivated. . : 2/n

Would love to know from anyone with experience in recovering government records if a FOIA request is the right way to try to get access to previously public lectures, or if there is another method, or if those lectures are just gone now? Thanks! 3/3