Sonya

Sonya

@sonyahanson.bsky.social

Research Scientist at the Flatiron Institute | biological temperature sensors 🌡️ cryo-EM 🔬computational biophysics 👩🏼‍💻

181 followers117 following21 posts

Sonya reposted

Sonya reposted

I'm giving a poster on MIMIC at #ISMB2026 today (C-211)! Drop by and chat with me about multimodal modeling for DNA, RNA, and protein biology. Inference code + checkpoints + sample data are all now available on GitHub/HuggingFace. github.com/PolymathicAI...

github.comGitHub - PolymathicAI/MIMIC: A Generative Multimodal Model for BiomoleculesA Generative Multimodal Model for Biomolecules. Contribute to PolymathicAI/MIMIC development by creating an account on GitHub.

Introducing MIMIC: a new foundation model trained natively across DNA, RNA and proteins. MIMIC is multimodal and generative: it can use structure, regulation, evolution, and experimental context to infer missing biology or design new sequences. 🧵⬇️

Sonya reposted

Sonya reposted

Introducing MIMIC: a new foundation model trained natively across DNA, RNA and proteins. MIMIC is multimodal and generative: it can use structure, regulation, evolution, and experimental context to infer missing biology or design new sequences. 🧵⬇️

This was fun to pull together! Such a fast moving field!

Our review on ML for modeling conformational ensembles is out now in Current Opinion in Structural Biology (w/ @sonyahanson.bsky.social)! It's been exciting to follow all the progress in this field recently, and I'm equally excited to see where it goes! www.sciencedirect.com/science/arti...

Congrats!! 👏🥳🎉

Alisia Fadini@alisiafadini.bsky.social

ROCKET 🚀 inference-time optimization of AlphaFold to fit structural data is published! rdcu.be/fa9YH Since our preprint, we’ve pushed it to regimes where other methods break: low resolution, weak signal, real experimental edge cases. Here’s what we learned: 1/15

Sonya reposted

ROCKET came out on Nature Methods today. It takes a tremendous amount of effort to translate a research concept into a practical tool—one that researchers can seamlessly drop into their existing pipelines. We learned a lot along the path and will carry that spirit forward.

Alisia Fadini@alisiafadini.bsky.social

ROCKET 🚀 inference-time optimization of AlphaFold to fit structural data is published! rdcu.be/fa9YH Since our preprint, we’ve pushed it to regimes where other methods break: low resolution, weak signal, real experimental edge cases. Here’s what we learned: 1/15

What a treat! What do you think is the future of Biophysics?

pilarcossio.bsky.social@pilarcossio.bsky.social

Celebrating #BiophysicsWeek T&C partnered with Phase Space Invaders podcast: Robert Best @sonyahanson.bsky.social @xuhuihuangchem.bsky.social and host @milosz-wieczor.bsky.social Episode 32: Driving the Future of Biophysics: What’s Next in Theory and Computation? www.buzzsprout.com/2313153/epis...

This was so fun!

Simons Foundation@simonsfoundation.org

Last Saturday, over 8.5K people showed up to the @bklynlibrary.bsky.social for "Night in the Library: The Philosophy of Mathematics," part of our Infinite Sums #PiDay celebrations. Learn more about our #InfiniteSums initiative: https://infinitesums.simonsfoundation.org/ #math

So excited for this!

Matthieu Chavent@matthchavent.bsky.social

Looking forward welcoming next week all the participants of the CECAM workshop organized with @sonyahanson.bsky.social , Celia Plisson-Chastang, and @bonomimax.bsky.social at the Museum of Toulouse Full program: www.cecam.org/workshop-det...

A great start to the Biophysical Society Annual Meeting in San Francisco! Check out the various projects being presented on work from Flatiron Institute people! #bps2026

Thanks @fraserlab.com ! It was great to have your feedback during the journey that was this paper!

James Fraser@fraserlab.com

Nice to see an acknowledgement (and citation!) of our @prereview.bsky.social in the final version of this awesome paper (www.nature.com/articles/s41...) from @pilarcossio.bsky.social @sonyahanson.bsky.social investigating the promise and limitations of conformational heterogeneity analyses in CryoEM

Announcing cryo-EM heterogeneity challenge #2, now dubbed the 2025 Community-Wide Assessment of Cryo-EM Heterogeneous Reconstruction Algorithms (CAHRA)! Join us for a webinar next Friday (Nov 14th) to learn more. Datasets already posted here: heterogeneity.notion.site/challenge #cryoem

heterogeneity.notion.siteCAHRA 2025: Community-Wide Assessment of Cryo-EM Heterogeneous Reconstruction AlgorithmsA community-wide data processing challenge for cryo-electron microscopy.

Sonya reposted

From a Twitter research project to an independent rival — Bluesky’s journey under CEO Jay Graber shows how a decentralized, user-first platform gained millions users by prioritizing control & openness in social media. A true alternative in a billionaire-dominated space. www.cnbc.com/2025/08/29/b...

cnbc.comBluesky CEO: I turned a Twitter research project into a rival company—'we've achieved what a lot of people said was impossible'Under CEO Jay Graber, social media company Bluesky has grown to 38 million registered users while weathering large-scale challenges over the past few years.

Super excited our preprint on the Inaugural Flatiron Institute Cryo-EM Conformational Heterogeneity Challenge is up! 🎉 🥳 Check out Miro's thread below for more details!

Miro Astore@miroastore.bsky.social

That's a wrap! The results of the first #cryoEM heterogeneity challenge are up on biorxiv! biorxiv.org/content/10.110

Sonya reposted

You are a scientist or an engineer (with a PhD) and you want to upskill to learn about delivering scientific infrastructure for the lifesciences (experimental or computational)? You want to work in Europe, in an internationally excellent service delivery team? ARISE2 is for you!

EMBL@embl.org

Interested in research infrastructures career? The #ARISE2 Fellowship Programme might be right for you. MSCA funded, the programme supports STEM researchers in becoming leaders in research infrastructures, driving innovation in life sciences 🧪 🗓️ Call opening: 30 June www.embl.org/training/ari...

Sonya reposted

The EMBL #ARISE2 Fellowship Programme, funded by MSCA, will open for applications on 30 June. This unique opportunity trains researchers to lead #ResearchInfrastructures & innovate in the #LifeSciences. 🧪 🗓️ Join our webinar on 17 June at 15:00 CET: embl-org.zoom.us/meeting/regi... #careers

I was asked an interesting question at a (worky/networky) dinner this week. "What percentage of the human proteome has experimentally determined structures?" - Do you know the answer off the top of your head?

Sonya reposted

Science is an economic driver in Hamilton, Mont., thanks to Rocky Mountain Laboratories, a federal research lab. Now, layoffs and funding cuts are having an impact in this town far from Washington.

npr.orgA small Montana town grapples with the fallouts from federal worker cutsScience is an economic driver in Hamilton, Mont., thanks to Rocky Mountain Laboratories, a federal research lab. Now, layoffs and funding cuts are having an impact in this town far from Washington.
Lander Lab@landerlab.bsky.social

That’s a wrap on the 2025 Cold Spring Harbor CryoEM course! Huge thanks to the amazing students for your enthusiasm, the TAs for your dedication, and the invited lecturers for sharing your expertise. Keep pushing the boundaries of single particle EM - excited to see what you all accomplish next!

Sonya reposted

Welcome to the Bluesky account for Stand Up for Science 2025! Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide! #scienceforall #sciencenotsilence

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