Raphael Laurenceau

Finally, my paper is out! It shows how bacteria can utilize their CRISPR immunity against transducing phages to turn them into "pollinators". This way bacteria can speed up their own adaptation through recombination by two orders of magnitude compared to mutations, and they do so when starving!

Very happy that this work found a good home at @pnas.org Thanks to the reviewers for their constructive comments. www.pnas.org/doi/10.1073/...

New @science.org A breakthrough in understanding why do we get fever and an inflammation response to vaccines. The gut microbiome chronic production of flagellin Paves the way to potentially prevent these acute phase side-effects in the future www.science.org/doi/10.1126/...

#plasmidbiology #plasmid Just out! 🚀 Thrilled by our discovery: the function of the C-terminal domain of MOBH1 relaxases! We uncovered this thanks to a fertility inhibitor encoded by a parasitic mobile genetic element. Congrats to Florence on a great piece of work! 👏 academic.oup.com/nar/article/...

@jihoon-han.bsky.social's new detectron technology -- out now in Nature Biotechnology. Toehold RNA sensing controls a retron-derived DNA barcode generator. Check it out!

www.quantamagazine.org/is-ai-the-en...

1/2 Here we report the activity of Arc, a 50-aa DNA-binding protein encoded within IS605-family transposons. www.biorxiv.org/content/10.6...

Pleased to share my first preprint from my postdoc, where I ask what drives mobile DNA movement between bacterial cells in complex communities like the gut microbiome. To answer this, we built a way to capture mobile DNA in the act of moving between cells, using short-read metagenomics. 🧵

🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET

Some of the smallest 😎 viruses on Earth are all around us. Three or four genes 😍 each, in nearly every environment. We keep finding thousands by sequencing, yet don't know who they infect, can't easily isolate them, or even how the few we have infect a cell. Our new preprint takes this on 🧵👇

Excited that our new paper with @henrylabsymbio.bsky.social and Kerry Oliver is out @pnas.org! We show that mobile genetic elements can spread adaptive host-benefiting traits across heritable insect symbionts on eco-evolutionary timescales.🧵 www.pnas.org/doi/10.1073/...

www.nature.com/articles/s41...

Clonal does not mean uniform. #MicroSky Our new review explores how genetically identical bacteria adopt different cell states, and how that diversity shapes survival, cooperation, antibiotic responses and gene transfer. 🧵 doi.org/10.1146/annu...

A Global Catalog of Microbial Symbionts 🌍🦠🧬🫨 New resource from @jgi.doe.gov, led by @astrogenomics.bsky.social and @fmschu.bsky.social with contributions by @emileyeloe-fadrosh.bsky.social @miferg.bsky.social and many more 🔓 www.nature.com/articles/s41... @biosci.lbl.gov @berkeleylab.lbl.gov

So happy to share that this work is finally out, now in @nature.com! Lots of new goodies since preprint so plz check it out (old thread below). Giant thank you to everybody involved + all @savitski-lab.bsky.social and @typaslab.bsky.social lab members 🙏🙏🙏 @embl.org nature.com/articles/s41...

academic.oup.com/nar/article/... 🦠

www.thelancet.com/journals/lan...

Yet another audacious origin of life theory www.pnas.org/doi/10.1073/...

That is one bold theory. Bacteria and Archaea would represent two independent events when life “freed metabolism from the crust” of a hydrothermal vent. www.science.org/doi/10.1126/...

www.nature.com/articles/s41...

www.nature.com/articles/s41...

www.nature.com/articles/s41...

www.nature.com/articles/s41... Wow. So complex, and yet so neat and simple at the same time. It feels like this type of regulatory efficiency could only be seen in bacterial genetics

Our pQBR plasmid paper is out! A model environmental plasmid collection that contains no known AMR genes and worldwide relatives! @jpjhall.bsky.social @ellieevolves.bsky.social @dwrivett.bsky.social and Rosanna Wright @microbiologysociety.org microbiologyresearch.org/content/journal/mgen/10.1099

Surface architecture of the bacterial envelope determines phage adsorption route in pathogenic Escherichia coli O157:H7 www.biorxiv.org/content/10.6...

Out @cp-cellhostmicrobe.bsky.social, natural products meet bacterial immunity! We used genomics to identify lanthivirins: a family of >2,000 lanthipeptide BGCs that protect Actinobacteria against phages. Led by @hshomar.bsky.social & @mariegllm.bsky.social www.sciencedirect.com/science/arti...

www.cell.com/cell-reports... #phage #phagesky

www.science.org/doi/10.1126/...

7/10 Our model 🧬👇 🔴OFF: RT-synthesized DNA scaffolds the ring and restrains the toxic RNase. 🟢ON: phage nucleases cut msDNA → ring collapses → RNase fires → host tRNAs shredded → infection blocked! 🛡️

🧬 Thrilled to share our latest @biorxiv-microbiol.bsky.social preprint! Here we find that Retron-IX build crazy supramolecular rings scaffolded by DNA molecules that sense phage infection! www.biorxiv.org/content/10.6... Read more below🧵! (1/X)

www.nature.com/articles/s41...

The type and amount of bacterial DNA carried by virus-like particles in the gut microbiome is simply mind-boggling. Amazing work by PhD candidate Jessie Maier in my group and collaborators @duerkoplab.bsky.social and Ben Callahan www.biorxiv.org/content/10.6...

#microsky New preprint from the lab! Widespread immune systems protect bacteria against conjugative plasmids www.biorxiv.org/content/10.6... Kudos to the extremely talented lead author Ludovic Poiré! Key contributions by @francoisrousset.bsky.social and also help from C. Lesterlin/TacC lab. 🧵⬇️

Californians, please make it count! Of all places, this is where it should start www.nytimes.com/2026/06/25/u...

The internet’s largest stockpile of free knowledge is under threat from MAGA, A.I. and foreign autocrats. www.nytimes.com/2026/07/05/b...

The Common Good Economy: a new compass ➡️ marianamazzucato.com/books/the-co...

🚨New paper alert 🚨 Here we tried to leverage an (incredible) metagenome time-series to better understand MGE diversity and activity in soil across decade(s). @scbagby.bsky.social has an amazing thread about this work with all the details - bsky.app/profile/scba...

www.science.org/doi/10.1126/... 🦠💫💫💫

www.sciencedirect.com/science/arti... #microbiomesky #microsky

Spotlight on our recent work by @emmajbanks.bsky.social @pavol.bsky.social and team!!! @johninnescentre.bsky.social Thank you very much, @fnobrega.bsky.social, for this great piece!!!

This Visual-omics approach is kind of amazing: "We resolved each to sufficient resolution (2.8 and 3.6 Å) to predict the amino acid composition directly from the 3D electrostatic potential map"

new pili for the lilliputians (CPR/Patescibacteria) 👇 #MicroSky

😲.

Cheap and easy method for nanopore sequencing phage DNA directly from plaques. Proud of lab members Brenna and Patrick for doing this work *with absolutely no help from me* !! www.nature.com/articles/s41...

Catalogue entries for more than 100 antibodies sold by the research services and supply company Thermo Fisher Scientific contain images that have apparently been manipulated, according to a pair of science sleuths. go.nature.com/4wX4yej

www.prnewswire.com/news-release...

New preprint. In S. sanguinis, a C5a peptidase-like protease (ScpH) polymerizes along eDNA, turning it into a catalytic biofilm scaffold. Great work from @robinanger.bsky.social in our lab, with Pelicic lab @lcbofficiel.bsky.social www.biorxiv.org/content/10.6...

Beyond thrilled that our paper ‘Co-migration of hundreds of microbial species over metres drives selection and promotes non-motile hitchhikers’ has been accepted in Nature Communications! 🎉🦠 (1/n) www.nature.com/articles/s41...