PyrexCorex

PyrexCorex

@pyrexcorex.bsky.social

Following advances in cellular, molecular & structural biology in a mercifully bot-free space.

482 followers1.4K following3.4K posts

PyrexCorex reposted

Nature Reviews Molecular Cell Biology
@natrevmcb.nature.com

ICYMI: New Online! Atomic, structural and molecular insights into GPCR ligand binding and signalling

dlvr.itAtomic, structural and molecular insights into GPCR ligand binding and signallingNature Reviews Molecular Cell Biology, Published online: 13 October 2026; doi:10.1038/s41580-026-01030-7This Review explores the atomic, structural and molecular basis of G-protein-coupled receptor (GPCR)-mediated signalling, highlighting recent insights into conformational changes associated with ligand recognition and interaction with downstream adaptors, and underscoring their importance for the development of therapeutics.

PyrexCorex reposted

GlycoShape
@glycoshape.org

Phenomenal #glycotime by Meg Lunn-Halbert, Joel Allen and colleagues demonstrates through de novo protein design how steric hindrance controls N-glycan maturation ⬇️ doi.org/10.64898/202... Protein design with RFdiffusionAA coupled with glycosylation with GlycoShape 🧪

PyrexCorex reposted

Scott McGrath
@smcgrath.phd

🧪 Google DeepMind's SynthIDBio embeds a statistical watermark into both the amino-acid sequence and 3D structure of AI-designed proteins. While it preserves biological function, the tag can still be scrubbed by running sequences through another tool, leaving detection keys in dispute. 💻🧬

nature.comSecret watermark labels proteins as ‘made by AI’An innovative safeguard could help to flag proteins devised by artificial-intelligence tools such as AlphaFold, but the digital marker can be erased.

PyrexCorex reposted

Rasmus Jensen
@rasmusjensen.bsky.social

🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET

PyrexCorex reposted

Science Magazine
@science.org

A recent Science Translational Medicine Review synthesizes the translational pipeline of research decoding how tumors interact with both the central and peripheral nervous systems to fuel their growth. Learn more on #WorldCancerResearchDay: https://scim.ag/3V3HaNK

scim.agCancer neuroscience: Mechanisms to medicineBidirectional cross-talk between neural circuits and tumors drives cancer progression and can be therapeutically targeted through drug repurposing.

PyrexCorex reposted

EMBL Events
@events.embl.org

🧬 Ready to dive into the world of RBPs? The #EMBLRBP Conference is back in 2027! Submit your abstract by 6 December 2026 to present your work to our global community of researchers: s.embl.org/rbp27-01-bl Date: 15 – 18 March 2027 EMBL Heidelberg and Virtual Organised with the support of KAUST.

PyrexCorex reposted

Journal of Evolutionary Biology
@jevbio.bsky.social

Our study shows that mutation-rate differences between daughter DNA strands persist throughout evolution rather than converging to equal fidelity. Evolution maintains asymmetric replication fidelity through self-organisation of mutation rates: doi.org/10.1093/jeb/... Akashi and Furusawa 2026

doi.orgReplication fidelity difference between daughter chains persists during evolutionAbstract. While mutations are the engine of evolution, how mutation rates themselves evolve remains poorly understood. Previous simulation and experimental

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Krishna Shrinivas
@shrinivaslab.bsky.social

This is now published in PNAS! And double-treat, we also made the cover :) www.pnas.org/doi/10.1073/...

Krishna Shrinivas@shrinivaslab.bsky.social

Preprint! Inspired by condensates that form on specific DNA, we ask: can we design multicomponent fluids to form distinct condensates on diff. surfaces? i.e. perform classification by condensation ⚛️ 💻 exploiting phase transitions beyond compartmentalization! arxiv.org/abs/2509.08100 (1/2)

PyrexCorex reposted

Turner Lab
@lab-turner.bsky.social

New preprint 📢 Thrilled to share our long-awaited work on the role of RSX in marsupial X-inactivation. This was a huge team effort over the years, led by @aureliencourtois.bsky.social @sermenchero.bsky.social Sugako Ogushi and Waz Varsally, that allowed us to set up genome editing in opossum embryos

biorxiv.orgGenome editing of marsupial RSX reveals conserved and divergent principles in mammalian X-inactivationX-chromosome inactivation balances X-gene dosage between the sexes in eutherians and marsupials. The lncRNA Xist mediates X-inactivation in eutherians but is absent from marsupials. An evolutionarily ...

PyrexCorex reposted

Robert Arkowitz
@robertarkowitz.bsky.social

Manipulation of protein translation and stem cell self-renewal by CRISPR activation of rRNA transcription | Science www.science.org/doi/10.1126/...

science.orgManipulation of protein translation and stem cell self-renewal by CRISPR activation of rRNA transcriptionRibosomal RNA (rRNA) transcription rates vary during development, and their dysregulation is linked to diseases such as cancer and ribosomopathies. Owing to their high abundance and genomic redundancy...

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Thiago Carvalho
@cyrilpedia.bsky.social

'(...) gene regulatory network inference methods largely neglect the dynamic nature of biological systems. To overcome this conceptual disconnect, we present RegVelo, a bottom-up, actionable & interpretable deep learning framework that jointly models splicing kinetics & gene regulatory interactions'

cell.comRegVelo: Gene-regulatory-informed dynamics of single cellsRegVelo introduces an end-to-end generative framework that jointly infers gene regulatory networks and developmental dynamics. It serves as an actionable in silico “cell,” enabling researchers to simu...

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Kurianlab
@kurianlab.bsky.social

What a beautiful piece of work. Congrats @jomaalab.bsky.social Inspirational

Ahmad Jomaa@jomaalab.bsky.social

Excited to share our work uncovering SNOR, a ribosome-associated factor that promotes translation restart after dormancy published in Nature!! This was, as usual, a wonderful collaborative effort between our group and the Mattei Lab @simonemattei.bsky.social @embl.org www.nature.com/articles/s41...

PyrexCorex reposted

Max Renner
@maxrenner.bsky.social

Super happy to see the final version of our paper out now 🎉🎉🎉 www.science.org/doi/10.1126/... Proud of PhD student Rupesh @rupeshjayachandran.bsky.social and postdoc Erwan for doing really nice work on this 😊

science.orgOpen and closed forms of assembled henipavirus nucleoprotein suggest structural basis of genome accessHenipavirus nucleoprotein assemblies exist in different conformations, indicating temporary release of genome for RNA synthesis.
Max Renner@maxrenner.bsky.social

Our new preprint is out 🥳🥳🥳 Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence? 👇

PyrexCorex reposted

Yale MB&B
@yalembb.bsky.social

Yale MB&B's Karla Neugebauer and Guillermina Kubaczka have been featured in a new @natmethods.nature.com piece 🌍🔬 The article spotlights researchers bridging the molecular and planetary scales to address global health challenges. @karlaneugebauer.bsky.social www.nature.com/articles/s41...

nature.comCell biology’s fantastic voyage to Planet Earth - Nature MethodsA nascent group of researchers sees planetary health as an urgent reason to bridge the molecular and planetary scales. This is shaping their strategies, methods, collaborations and outlook about their...

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Daniel Hurdiss
@danielhurdiss.bsky.social

Our paper describing the #cryoEM structures of unusual spike proteins from marine mammal–infecting gammacoronaviruses is now published in PLOS Pathogens! 🐬 journals.plos.org/plospathogen...

journals.plos.orgCetacean coronavirus spikes highlight S glycoprotein structural plasticityAuthor summary Coronaviruses are well known for their ability to jump between species, a process driven mainly by the spike protein on their surface. In this study, we examined spike proteins from coronaviruses found in marine mammals (whales and dolphins) to better understand how these viruses evolve and interact with their hosts. Using structural biology and mass spectrometry, we discovered several unusual features of the cetacean spike proteins. These spikes contain an extra domain within their receptor-binding region that resembles cupin proteins, assemble into trimers in a novel way that hides the receptor-binding domains, and show clusters of sugars (O-linked glycans) near the sites thought to interact with host receptors. These distinctive features suggest that cetacean coronaviruses may use a different entry mechanism, in which the extra domain acts as a switch to reveal the hidden receptor-binding regions. Such a mechanism could affect which species these viruses can infect, how easily they cross species barriers, and how they evade the immune system. Our findings emphasize the structural diversity and modularity of coronavirus spike proteins, highlight the unique adaptations of coronaviruses in marine mammals, and provide insight into their potential to give rise to new diseases in other species.
Daniel Hurdiss@danielhurdiss.bsky.social

Think coronavirus spikes have run out of surprises? Think again. Our latest preprint dives into the highly unusual spikes of marine mammal coronaviruses. www.biorxiv.org/content/10.1... This #cryoEM study was led by @viralfusion.bsky.social, with key contributions from an amazing team.

PyrexCorex reposted

Karim Majzoub
@karimaj.bsky.social

We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it. A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !

sciencedirect.comDeltaviruses spread through a viral Trojan HorseHepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…

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Alejandro Montenegro
@aemonten.bsky.social

"we propose that the protoribosome was a parasite (...). If this view is correct, then like the spliceosome in the stem eukaryote, a repurposed host-parasite interaction led to a dramatic change in cell biology at the base of the tree of life, in this case leading to the exit from an RNA world"

academic.oup.comA symbiotic origin of the ribosome?Abstract. The origin of life is one of the great mysteries of science. Of the multiple unsolved problems, the origin of the translation system (the means b

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The Groth lab
@grothlab.bsky.social

DNA replication globally disrupts the epigenome. But does this create a chromatin-access opportunity for TF binding to facilitate cell identity change? Now 𝐫𝐞𝐩𝐥𝐢-𝐀𝐓𝐀𝐂-𝐬𝐞𝐪 shows 𝘥𝘦 𝘯𝘰𝘷𝘰 chromatin opening & TF binding occurs specifically post-replication, in cellular differentiation & reprogramming!

cell.comPost-replicative chromatin accessibility predicts cell fate changeKnudsen and colleagues use repli-ATAC-seq to compare replicated and unreplicated chromatin in two models of cell identity change. They find that lineage-specific elements are accessible earlier in rep...

PyrexCorex reposted

Darío Lupiáñez
@dariloops.bsky.social

🤩💪 Out now! 3D regulatory hubs in sex determination With @mamartirenom.bsky.social & Capel labs, led by @imotagom.bsky.social & @jrotwitguez.bsky.social 1️⃣ METALoci – explore #3DGenome 🧬 2️⃣ Non-coding region controlling Fgf9 🧩 3️⃣ Meis genes = new key players 🌟 👉 rdcu.be/e5sm2 1/n Bluetorial 👇

rdcu.beChromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubsNature Structural & Molecular Biology - METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining...

PyrexCorex reposted

Faraz Mardakheh
@mardakheh.bsky.social

🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41... RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10 #RNA #IDR #RBP

nature.comAn intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6 - Nature CommunicationsLARP6 is an EMT-associated RNA-binding protein with diverse RNA targets. Here, the authors show that the N-terminal disordered region of LARP6 promotes RNA-binding selectivity by modulating the adjace...