Mel Eckersley-Maslin

We often say cancers reactivate embryonic programs, but how often does this happen? and is it always bad? In this study, we develop EmbryoRadar to detect widespread expression of preimplantation transcriptional programs across all cancers, with varied patient outcomes www.biorxiv.org/content/10.6...

I had fun chatting with Stefan on this Epigenetics podcast, thanks for the invitation!

Thrilled to share my freshly "baked" Baker lab paper. We took a bottom-up approach to designing transcriptional regulators. Instead of relying on natural activation domains, we designed compact proteins that recruit specific cofactors. Activators for now, repressors to come!

Thoroughly enjoying the 6th Danube #epigenetics meeting in Budapest. Lots of great talks so far. Come fine me over coffee if you want to learn about our work on bivalent chromatin our our latest EmbryoRadar preprint www.biorxiv.org/content/10.6..., or to talk about #chronatin more generally!

Had a great time last week at the #CancerEpigenetics meeting in Paris where I had the opportunity to share our latest work on bivalent chromatin dynamics in cancer. Thanks Pierre-Antoine Defossez for organising and ensuring the conference success despite all the protests!

(1/9) Excited to share my preprint on Polycomb 3D chromatin interactions from my postdoc with @andersshansen.bsky.social! We were surprised to find that canonical PRC1 doesn't seem to be the only contributor to these interactions: www.biorxiv.org/content/10.6...

1/ Most genes and variants matter somewhere but look silent in any one cell model. Can we build conditions that reveal phenotypes? With @kanishkadey.bsky.social, we engineer cell states to expose hidden disease biology and trace how genetic risk reaches disease genes. www.biorxiv.org/content/10.6...

Pathway to Independence – an interview with Evan Healy In this interview, we learn about @evhealy.bsky.social's career path, what he hopes to gain from the Pathway to Independence programme, and what questions he hopes to tackle with his own group. doi.org/10.1242/dev....

1\ We know a bit about how 3D chromatin interactions are formed, but what do we know about how they are disrupted? We asked this question in our latest preprint: doi.org/10.64898/202..., focusing on the massive loss of promoter interactions during neuronal differentiation.

Sad to hear about Terri’s passing. I have fond memories of her from my graduate student days at CSHL. and am grateful for some rather direct career advice she gave me at the time. My thoughts are with all those close to her. She will be missed

🚨 #Postdoc position open. Want to understand non-canonical #epigenetic regulation of mammalian transcription? Come work @uoe-igc.bsky.social in Edinburgh! We’re looking for a motivated & collaborative colleague with a strong track record. 📅 14 October 2026 📢 Please share Apply here 👇

Reposting this ongoing search (any discipline of biology) for an Assistant to Associate level colleague in the Division of Basic Sciences at Fred Hutch. Great city, great colleagues, great core facilities, great trainees.

Ready to take the next step in your research career? 👨‍🔬 We're seeking an outstanding researcher to establish an independent research program as an EMBL Australia Group Leader at the Australian Regenerative Medicine Institute (ARMI) @monashuniversity.bsky.social 🗓️ Apply by 2 October 🔗 bit.ly/4qHYtjb

Had a great time visiting @vonmeyenn.bsky.social at ETH Zürich yesterday and sharing some of the labs latest work. Thanks for the invite, lively discussions and good food! Next stop Heidelberg for the #EMBLTranscript meeting that starts later today

Our lab had an international brunch where everyone brought in something from their culture to share. They even printed out little place-cards with flags and ingredients. So much delicious food!

Preprint from Katerina Gurova's group looking at oncogenic competency. Using barcoding and scRNAseq, suggest all cells respond to oncogenic insults, yet only some stabilise as transformed. Explores many of the concepts we regularly discuss in the lab. www.biorxiv.org/content/10.6...

Latest from @arnaudkr.bsky.social on TF cooperation at enhancers, liked the combination of single-molecule footprinting at ectopic vs endogenous loci in mESCs. Curious if the cumulative activation frequency model holds for other less proliferative/plastic cell types? www.nature.com/articles/s41...

Intestinal stem cells count divisions and Polycomb/trithorax proteins are involved in the counting, implicating chromatin control. Love the model but would be great to know if it’s truely counting and not time, and how mechanistically replication dilution of histone mods ensures 9 cell cycles?

The ARC has released their new set of grant schemes ▶️ www.arc.gov.au/news-and-pub... Before implementing them, they’re now going to “consult with the sector”. Hopefully genuinely, not just with a few disengaged DVCRs. In the meantime, there’ll be another round of Discovery Projects (DP28).

New paper 🧵 What if the "landscape" that guides cell differentiation isn't fixed, but is sculpted, in real time, by the very cells moving through it? We call this a 'sandscape' : grains of sand that carve dunes as they move, while the dunes' shape simultaneously steers where the grains go next.

1/ Very excited to share the first publication from my lab! In this work, we developed an efficient strategy to precisely mutate mammalian histone genes in their native genomic context using CRISPR prime editing: www.nature.com/articles/s41...

We just started our summer break, but we're also planning our September-December seminar schedule! If you have an exciting chromatin/transcription story that will be ready for the spotlight by then, use the survey below to nominate yourself to give a #FNucleosome talk 🧬🧬 forms.gle/1EKYN2Nt79ar...

Please join us for the next edition of the GOA monthly seminar series Dr Karissa Hansen Registration link: unimelb.zoom.us/webinar/regi...

If you're in Melbourne and interested in genomics and epigenetics, come along to the #Melbourne #Epigenetics club 4pm today. Visit the website to get club email updates: https://www.eckmaslab.com/melbourne-epigenetics-club

Our story about the poising and connectivity of human developmental enhancers is out! www.cell.com/cell-reports...

📢 We are looking for a Junior Group Leader to join us at @institutcurie.bsky.social! Having joined the department just over a year ago, I can honestly say that it is an exceptionally stimulating and supportive scientific environment, filled with outstanding colleagues — all in the heart of Paris.

Exciting breakthrough technology from the lab, now live in @cellcellpress.bsky.social ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!

TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...

You can now read this in the latest issue of @genesdev.bsky.social. It should be open access, but please reach out if you need an access code genesdev.cshlp.org/content/40/9...

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Embryonic stem cell factors DPPA2/4 amplify active H3K4me3–H2AK119ub chromatin domains in non-small cell lung cancer By Seneviratne et al. and Melanie A. Eckersley-Maslin ➡️ https://ow.ly/ybJl50YNzz0 Mel Eckersley-Maslin Peter MacCallum Cancer Centre #lungcancer

Please join us for the next edition of the GOA monthly seminar series A/Prof. R. Babak Faryabi @faryabi.bsky.social! Registration link: unimelb.zoom.us/webinar/regi...

𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀 𝗮𝗿𝗲 𝗻𝗼𝘄 𝗼𝗽𝗲𝗻 𝗳𝗼𝗿 𝘁𝗵𝗲: 𝗔𝗘𝗽𝗶𝗔 𝗦𝘂𝘀𝗮𝗻 𝗖𝗹𝗮𝗿𝗸 𝗔𝘄𝗮𝗿𝗱 𝗳𝗼𝗿 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗘𝘅𝗰𝗲𝗹𝗹𝗲𝗻𝗰𝗲 @aepia.bsky.social is excited to open applications for the Susan Clark Award for Research Excellence, recognising outstanding contributions in epigenetics research, leadership, and advocacy.

ChromSMF preprint is out!🚀 tinyurl.com/ChromSMF We often piece together chromatin regulation layer by layer from separate assays. But this can be limiting! In @arnaudkr.bsky.social's lab, we developed a method to directly study multiple layers on the same DNA molecule! 🧬 What does this unlock? ⬇️

𝗢𝘂𝘁 𝘁𝗼𝗱𝗮𝘆: Research at Peter Mac led by @meleckmas.bsky.social has uncovered a surprising driver behind aggressive lung cancer — embryonic proteins that are normally only active before birth. Read more: www.petermac.org/about-us/new... #LungCancerResearch #LungCancer

We are looking for a new group leader to join the IGH (Montpellier, France). I can’t wait to meet my future colleague! Apply :-) More infos here: igh.cnrs.fr/join-igh-as-...

We;re hiring Junior Group Leaders! 🔬✨ We’re looking for researchers in immunology, chemical biology, AI in biology, or protein design to launch their own independent groups in our collaborative, international environment. www.nki.nl/news-events/...

Eliminating the confounding effects of human pluripotent #stemcell co-culture with MEFs: @grazianomartello.bsky.social @leeboratory.bsky.social @jzylicz.bsky.social and collaborators describe a serum coating approach for feeder-free culture of naïve hPSCs link.springer.com/article/10.1...