Mark Histed

Mark Histed

@markhisted.org

Lincoln liberal, 2nd inaugural enthusiast. Information processing in networks. Brains, models, lasers. Prev: media policy for democracypolicy.network. Personal views, not speaking for NIH linktr.ee/markhisted neuro: 🧠 /🧪

14.7K followers2.4K following8.1K posts

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The Battle over the Constitution Has Spread to American Science. I'm out in the @theatlantic.com today about the new OMB proposed rule. It's just the longtime agenda of the the Supreme Court. US science and cancer cures now all depend on us picking up a fight with the Roberts Court.

theatlantic.comThe Unitary Executive Takes Over New TerritoryThe Trump administration’s theory of how the federal government should work is a threat to American science.

Dear Very Important Officials in DC: it is after 2am on a Wednesday, do you really need to be flying a helicopter low over my house?

I fully get the frustration. However this overestimates how much the average (busy) person pays attn to politics. When @vanhollen.senate.gov went to El Salvador it created a media event and gt information out to the public, and we know that b/c polls shifted significantly afterward. That’s what is

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We should get to the point where NFL and crime drama ratings go down — because the whole country is on the edge of their seats waiting for the next installment of the true crime Trump Family Corruption Show, presented by Congressional Majority Oversight, Inc.

Can start with dramatic hearings about Bolsonaro family coups and the State dept process that led to these visas. Run the compelling footage of Brazilian coup effort, talk about how Brazil held the insurrectionists accountable. Two birds, one stone.

Phil Lewis@phillewis.bsky.social

WASHINGTON (AP) — State Department says it will give US visas to defeated Brazilian presidential candidate Flávio Bolsonaro and his family.

Mark Histed reposted

Replying to @markhisted.org

We should get to the point where NFL and crime drama ratings go down — because the whole country is on the edge of their seats waiting for the next installment of the true crime Trump Family Corruption Show, presented by Congressional Majority Oversight, Inc.

I fully get the frustration. However this overestimates how much the average (busy) person pays attn to politics. When @vanhollen.senate.gov went to El Salvador it created a media event and gt information out to the public, and we know that b/c polls shifted significantly afterward. That’s what is

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needed now and in 2027: a sustained effort, using the bully pulpit of the Congressional investigatory and media-attention power, to drive information about crimes out to every corner of the mass public.

‘The docs reveal: - Explicit plans by Meta to discredit [scientists]… - Explicit plans to work w [science orgs] on social media and youth mental health with goals to “get credit” for proposing the assessment and “greatly shape the nature of the questions they will explore.”’ This is one playbook…

J. Nathan Matias@natematias.bsky.social

This release of Meta documents is a deeply shocking look at how tech tries to steer & control science. It's normal for crisis comms teams to ask how to counter scientists who criticize their employers. But here's what's especially shocking in these docs: cailinoconnor.substack.com/p/its-now-of...

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‘The docs reveal: - Explicit plans by Meta to discredit [scientists]… - Explicit plans to work w [science orgs] on social media and youth mental health with goals to “get credit” for proposing the assessment and “greatly shape the nature of the questions they will explore.”’ This is one playbook…

J. Nathan Matias@natematias.bsky.social

This release of Meta documents is a deeply shocking look at how tech tries to steer & control science. It's normal for crisis comms teams to ask how to counter scientists who criticize their employers. But here's what's especially shocking in these docs: cailinoconnor.substack.com/p/its-now-of...

… the “co-opt” playbook to use their money to change science. And to play PR games. And limit the freedom of internal scientists. But there’s another playbook that oligarchs are also running now on biomedical science; the “law and economics” playbook.

Literal emails from inside Meta proposing a “whisper campaign” against Jonathan Haidt. Between climate denial, asbestos cancer denial, smoking cancer denial, COVID harm denial, COVID zoonotic origin denial, and now social media harm denial, it seems like there may be a corporate playbook

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Mark Histed reposted

this summary does Harris dirty. her first argument is that impeaching Trump is a waste of investigative resources that should go elsewhere- presumably at cabinet members- instead

Acyn@acyn.bsky.social

Kamala Harris: I think that going in the direction of impeachment is not a good idea. I was in the Senate for the last go-round, and the votes aren’t there. I think after the election, we all have to just also agree that our attitude has to be to get stuff done…

Mark Histed reposted

As a PI who has used both private and public money to do science, the only times anybody has tried to interfere with the science were when it was done with private money

Colette Delawalla, PhD@cdelawalla.bsky.social

I am pushing back against Varmus’ claim that philanthropic dollars come with fewer strings attached, compared to federal dollars. The strings are established in what they will fund: work that DIRECTLY benefits them, can be rolled over into an IPO, and promoted their ideologies.

Mark Histed reposted

“Doctors and scientists don’t have a clear understanding of [how antidepressants work.]” Right. Because the human brain is an incredibly complex network w/ trillions of connections. My team at NIMH, along w/ thousands of other NIH-funded scientists, is doing the basic science to understand this. 1/

Awais Aftab@awaisaftab.bsky.social

In my latest “Therapeutic Window” piece for the @nytimes.com, I discuss our current scientific understanding of how antidepressants work (Gift link but NYT requires an email sign up to read for free) www.nytimes.com/2026/10/27/s...

Mark Histed reposted

"In my opinion, this Article is a deathblow to the unitary executive theory..." And, relevant to science: "Lawmakers throughout US history have [shielded from political control] modes of administration that ... handled sensitive money-related tasks." I'd say science grantmaking is exactly that.

Beau Baumann 🍎@beaubaumann.bsky.social

New Substack celebrating the publication of "Quasi-Judicial: A History and Tradition" with @columlrev.bsky.social

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"In my opinion, this Article is a deathblow to the unitary executive theory..." And, relevant to science: "Lawmakers throughout US history have [shielded from political control] modes of administration that ... handled sensitive money-related tasks." I'd say science grantmaking is exactly that.

Beau Baumann 🍎@beaubaumann.bsky.social

New Substack celebrating the publication of "Quasi-Judicial: A History and Tradition" with @columlrev.bsky.social

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"In my opinion, this Article is a deathblow to the unitary executive theory..." And, relevant to science: "Lawmakers throughout US history have [shielded from political control] modes of administration that ... handled sensitive money-related tasks." I'd say science grantmaking is exactly that.

Beau Baumann 🍎@beaubaumann.bsky.social

New Substack celebrating the publication of "Quasi-Judicial: A History and Tradition" with @columlrev.bsky.social

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And it makes sense to insulate: scientific project selection is exactly the kind of function that benefits from independent pursuit of many ideas and should be set a step away from hierarchical political control. That was the (informal) system at NIH for decades, now changed by the Trump admin.

"In my opinion, this Article is a deathblow to the unitary executive theory..." And, relevant to science: "Lawmakers throughout US history have [shielded from political control] modes of administration that ... handled sensitive money-related tasks." I'd say science grantmaking is exactly that.

Beau Baumann 🍎@beaubaumann.bsky.social

New Substack celebrating the publication of "Quasi-Judicial: A History and Tradition" with @columlrev.bsky.social

I'd argue the NIH structures that long decided which science projects get funded are indeed 'quasi-judicial'. Scientists write long applications [like briefs]; panels of scientists sit in judgement and write reviews [opinions]; they work with Art I officials to do final adjudication.

“Doctors and scientists don’t have a clear understanding of [how antidepressants work.]” Right. Because the human brain is an incredibly complex network w/ trillions of connections. My team at NIMH, along w/ thousands of other NIH-funded scientists, is doing the basic science to understand this. 1/

Awais Aftab@awaisaftab.bsky.social

In my latest “Therapeutic Window” piece for the @nytimes.com, I discuss our current scientific understanding of how antidepressants work (Gift link but NYT requires an email sign up to read for free) www.nytimes.com/2026/10/27/s...

View full thread

“Doctors and scientists don’t have a clear understanding of [how antidepressants work.]” Right. Because the human brain is an incredibly complex network w/ trillions of connections. My team at NIMH, along w/ thousands of other NIH-funded scientists, is doing the basic science to understand this. 1/

Awais Aftab@awaisaftab.bsky.social

In my latest “Therapeutic Window” piece for the @nytimes.com, I discuss our current scientific understanding of how antidepressants work (Gift link but NYT requires an email sign up to read for free) www.nytimes.com/2026/10/27/s...

View full thread

This is a project that requires people to work together to advance the leading edge of knowledge. That requires diversity, equity, and inclusion.

“Doctors and scientists don’t have a clear understanding of [how antidepressants work.]” Right. Because the human brain is an incredibly complex network w/ trillions of connections. My team at NIMH, along w/ thousands of other NIH-funded scientists, is doing the basic science to understand this. 1/

Awais Aftab@awaisaftab.bsky.social

In my latest “Therapeutic Window” piece for the @nytimes.com, I discuss our current scientific understanding of how antidepressants work (Gift link but NYT requires an email sign up to read for free) www.nytimes.com/2026/10/27/s...

View full thread

And the neuroscientists in the US working on this are from many backgrounds and cultures. Many are immigrants. Many are Arabs.

The Bulwark@thebulwark.com

RFK: "There's five hundred million Arabs in the world. And yet they don't produce science. They don't win the Nobel Prize. They don't win the Fields Prize. They don't win the Wolf Prize. They don't produce literature."

“Doctors and scientists don’t have a clear understanding of [how antidepressants work.]” Right. Because the human brain is an incredibly complex network w/ trillions of connections. My team at NIMH, along w/ thousands of other NIH-funded scientists, is doing the basic science to understand this. 1/

Awais Aftab@awaisaftab.bsky.social

In my latest “Therapeutic Window” piece for the @nytimes.com, I discuss our current scientific understanding of how antidepressants work (Gift link but NYT requires an email sign up to read for free) www.nytimes.com/2026/10/27/s...

This is why the next NIMH institute director choice is so important. The public needs someone who understands tha broad scope of basic brain science and will nurture lots of different ideas. Not a new director who’s focused on one or a few ideas.

Neuroscience has known for decades that antidepressants change serotonin levels in hours, but mood changes take days to weeks to develop. That argues antidepressants don’t just fix a chemical imbalance — they create changes in your complex brain synaptic networks. How? We don’t yet know.

We can hope that after the midterms there will be a public transparent oversight process that turns this report into a series of high-profile hearings. Much of the public now gets news via video; Congress can use oversight to make compelling video so the country pays attention.

Prem Thakker ツ@premthakker.bsky.social

NEW: "Donald Trump was an active participant in Jeffrey Epstein’s sexual abuse of young women during the mid-to-late 1990s," per new House Judiciary Dem report. Report has new allegation that Trump raped a 24-year-old and then promised the victim a visa & NYU admission, demanding she stay quiet.

And having a major public oversight process is important for science because there are many attacks on cancer cures that we need accountability for if we want to rebuild. Public and transparent oversight is needed to chart a new future for US science

Mark Histed reposted

The Trump Administration's below-the-radar gutting of the Agency for Healthcare Research and Quality is truly flabbergasting -- and is the kind of thing that will lead to avoidable illness and death down the line, even if we won't be able to trace it discretely. www.washingtonsun.com/health/insid...

washingtonsun.comInside the Trump Administration's Dismantling of a Health Care Research OfficeThe Agency for Healthcare Research and Quality has few remaining grant officers and has redirected millions in taxpayer dollars without telling Congress.

Mark Histed reposted

A 2025 Nobel Prize winner in chemistry, Omar Yaghi is the son of Palestinian refugees who grew up in Jordan. He just left the US to move to China after raising concerns about rising anti-immigrant sentiment, like the kind shown here. donmoynihan.substack.com/p/china-than...

The Bulwark@thebulwark.com

RFK: "There's five hundred million Arabs in the world. And yet they don't produce science. They don't win the Nobel Prize. They don't win the Fields Prize. They don't win the Wolf Prize. They don't produce literature."

Mark Histed reposted

Everyone should read these threads I did about industry lobbyists and the EPA and understand them. Take the time to see the unambiguous evidence of what's happening now at this moment inside the EPA. Please retweet them. Please read them. Each one of the threads. It's happening in slow motion.

Also true for US civil servants as well. They are asked to be nonpartisan, but also take an oath to the Constitution (that is, to liberal democracy). The bounds of a nonpartisan civil service should encompass any political leadership that respects democracy.

Stan Oklobdzija@stano.bsky.social

If we can solve our disagreements within the bounds of liberal democratic governance, then you're my ally in the fight against authoritarianism both in America and overseas.

When civil servants oppose the Trump administration for rejecting the constitution, that is what we should expect; the challenge is explaining how that intersects today’s party alignment. It’s not fair to civil servants to expect them to remain neutral in the face of fascism.

“I have stopped sending paper greeting cards because of the unpredictable delays. One card took a month to arrive.” That was a relative talking to me on the phone tonight. USPS is worth some investigation.