Lamming Lab

onlinelibrary.wiley.comSleeve Gastrectomy Improves Metabolic Health, Cognition, and Alzheimer's Disease Pathology in <fc>3xTG</fc> MiceThrough a single metabolic intervention, Sleeve Gastrectomy improves metabolic health and attenuates Alzheimer's pathology in 3xTg-AD mice across dietary contexts. It reduces cortical amyloid and neu....

Very cool story from @wiscosurgicalmetab.bsky.social about the surprisingly protective effects of sleeve gastrectomy on the development and progression of Alzheimer’s disease in a mouse model! Glad to have been able to assist with this project.

WiSLiM@wiscosurgicalmetab.bsky.social

It is hard to imagine that cutting away a portion of the stomach could prevent future Alzheimer’s Disease but here, in our first of many stories to come, we show just that! SG’s effects on the brain are profound and long lasting! @lamminglab.bsky.social onlinelibrary.wiley.com/doi/10.1111/...

25 Aug

Check out the latest pre-print from our lab, the work of star graduate student Shelly Sonsalla! If you (an extremely online mouse) reduce dietary protein and increase dietary carbohydrates, does it matter what type of carbohydrates you are eating? Find out from our paper:

bioRxiv Physiology@biorxiv-physio.bsky.social

Dietary sugar type determines the response to protein restriction in females, but not males https://www.biorxiv.org/content/10.64898/2026.08.18.745207v1

18 Aug

For those who wonder about the human relevance of our BCAA work, a new paper showing dietary BCAAs are associated with plasma BCAAs and plasma BCAAs are associated with multiple Cardiometabolic risk factors. www.oaepublish.com/articles/mto...

31 July

Great discussion of dietary protein and aging in @sciencenews.bsky.social today "The protein craze may not be for everyone", spurred in part by @baileyknopf.bsky.social 's new review article entitled "The hallmarks of protein and amino acid restriction in aging and longevity"

cell.comThe hallmarks of protein and amino acid restriction in aging and longevityDietary protein is a key regulator of health and longevity across species, and restriction of proteins or other specific amino acids has emerged as a potential strategy to promote healthy aging. Here,...

31 July

Here's a direct link to the open access review in @cellpressblue www.cell.com/cell-press-b...

sciencenews.orgThe protein craze may not be for everyoneGetting more protein has been all the rage. In sedentary people, that advice could accelerate aging.

31 July

And here is the article in Science News: www.sciencenews.org/article/prot...

Lamming Lab reposted

nature.comLifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice - Nature AgingCalubag et al. report that reduced dietary intake of the branched-chain amino acid valine is sufficient to improve healthspan in both male and female mice, as well as to extend lifespan in male mice.

I am delighted to be able to share the latest study from the @LammingLab, “Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice” led by former graduate student Dr. Mariah Calubag www.nature.com/articles/s43...

With the Wisconsin Nathan Shock Center, we analyzed multi-tissue transcriptomic profiling data, which hinted at an essential role for liver mitochondria in the molecular response to Val-R across tissues. We validated these results, identifying Val-R induced changes in liver mitochondrial function.

We thank all of our great collaborators within and outside the lab, including @drcaragreen.bsky.social (who now has her own lab at U. Bath), Ryan Marshall, Michelle Sonsalla, Chung-Yang Yeh, @baileyknopf.bsky.social Shoshana Yakar, Teresa Liu, Alan Attie, and @sadagurski.bsky.social

We find that Val-R improves metabolic health and reduces frailty in both sexes, while specifically increasing male lifespan by 23% – suggesting that decreasing dietary valine may be a robust way to promote healthy aging and extend longevity.

Other benefits of Val-R include a reduction in senescent cell burden and less cancer in both sexes, and in males, reduced neuroinflammation.

We recently identified a critical role for the branched-chain amino acids – leucine, isoleucine, and valine – in regulating metabolic health. We previously showed that restriction of isoleucine by itself is sufficient to promote metabolic health and extend lifespan, but what about the other BCAAs?

Here, we examined the effect of lifelong valine restriction on metabolism, health, and aging in both male and female C57BL/6J mice, a commonly used mouse strain.

Over the last decade the research of many, including our lab, as well as Drs. Luigi Fontana, Steve Simpsons and Samantha Solon-Biet, has demonstrated that a calorie is not just a calorie – and that eating less dietary protein promotes metabolic health in both mice and humans.

Lamming Lab reposted

Nature Aging

@nataging.nature.com

24 July

Online now!✨Calubag et al report that reducing dietary valine extends healthspan in male and female mice, and lifespan in male mice @lamminglab.bsky.social www.nature.com/articles/s43...

13 May

Please enjoy my new review article "Bench to bedside: is rapamycin headed for the docTOR?" Open access at: link.springer.com/article/10.1...

1 May

Terrific Department of Medicine Research, and congratulations to Dr. Yang Yeh and Bailey Knopf for winning poster awards and Dr. Mariah Calubag for receiving the DOM Outstanding Graduate Student Award!

17 Apr

Three amazing award winners from the Lamming Lab at the 7th Annual Midwest Aging Consortium Meeting! Congratulations to all the winners and all participants! @baileyknopf.bsky.social Yang Yeh and Amirah Nieves Medina!

advanced.onlinelibrary.wiley.comRestriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg MiceProtein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched-chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with...

Please enjoy the latest publication from our lab "Restriction of Individual Branched-Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice" advanced.onlinelibrary.wiley.com/doi/10.1002/...

This work was made possible with the support of many collaborators in and outside the lab, including @drcaragreen.bsky.social @wiscosurgicalmetab.bsky.social Alan Attie, Luigi Puglielli and Cholsoon Jang!

With help from Alan Attie's lab we also made a data visualization and analysis tool - we hope to make this tool more broadly available soon: connect.doit.wisc.edu/dlamming_BCA...

In this terrific publication, Dr. Reji Babygirija shows that restriction of dietary leucine or isoleucine in males, and restriction of valine in females, preserves cognitive function in a mouse model of AD

Each BCAA has distinct effects on aspects of AD pathology and engages overlapping and distinct molecular pathways

29 Jan

Had a fantastic metabolism and aging retreat yesterday with the @judisimcox.bsky.social and @wiscosurgicalmetab.bsky.social labs!

With the end of the year upon us, it's time for the 2025 @lamminglab.bsky.social year in review! Some of our accomplishments and successes are described in the thread below.

We celebrated the graduation of two of our graduate students, Dr. Reji Babygirija and Dr. Mariah Calubag! Reji is now a postdoc with @WiscoSurgMetab while Mariah is looking for a postdoc – snap her up soon!

Thanks to all of the @lamminglab.bsky.social members past and present for another terrific year, all our collaborators and colleagues for their help and friendship, and thanks as well to everyone who has participated in great conversations online and off about healthy aging, diet and mTOR!

With the end of the year upon us, it's time for the 2025 @lamminglab.bsky.social year in review! Some of our accomplishments and successes are described in the thread below.

onlinelibrary.wiley.comRapamycin Does Not Compromise Exercise‐Induced Muscular Adaptations in Female MiceRapamycin is largely compatible with the physical and skeletal muscle benefits of progressive weighted wheel running (PoWeR). The detrimental effects of rapamycin on glucose metabolism in the context...

Working with Adam Konopka and colleagues we continued to study rapamycin, showing that “Rapamycin Does Not Compromise Exercise-Induced Muscular Adaptations in Female Mice” onlinelibrary.wiley.com/doi/10.1111/...

nature.comDietary lipids are largely deposited in skin and rapidly affect insulating properties - Nature CommunicationsThe mechanisms underlying the regulation of the skin thermal barrier are poorly understood. Here the authors show that the thermal properties of the skin are reactive to diet and that skin is a target...

And we helped push a fascinating story over the finish line, “Dietary lipids are largely deposited in skin and rapidly affect insulating properties” www.nature.com/articles/s41...

With the end of the year upon us, it's time for the 2025 @lamminglab.bsky.social year in review! Some of our accomplishments and successes are described in the thread below.

jbc.orgDepletion of individual dietary amino acids induce distinct metabolic and chromatin statesReducing dietary levels of protein or specific essential amino acids (EAAs) promotes favorable metabolic reprogramming, including improved glucose tolerance, increased insulin sensitivity and reduced ...

Finally, our fifth manuscript of the year, a collaboration between Spencer Haws, Yang Liu, @drcaragreen.bsky.social and @johndenu.bsky.social, "Depletion of individual dietary amino acids induce distinct metabolic and chromatin states" www.jbc.org/article/S002...

sciencedirect.comA low-protein diet drives short- and long-term improvements in metabolic health in a mouse model of sleeve gastrectomyDespite the beneficial impact of bariatric surgery on obesity and metabolic disease, continued post-surgical obesity and weight recurrence are common,…

We also participated in several collaborative publications, including the amazing “A low-protein diet drives short- and long-term improvements in metabolic health in a mouse model of sleeve gastrectomy” from @wiscosurgicalmetab.bsky www.sciencedirect.com/science/arti...

With the end of the year upon us, it's time for the 2025 @lamminglab.bsky.social year in review! Some of our accomplishments and successes are described in the thread below.

Thanks to all our collaborators and colleagues who helped make this possible, including @drcaragreen.bsky.social @mikemacarthur.bsky.social Cholsoon Jang @judisimcox.bsky.social Kristen Malecki and many more!

onlinelibrary.wiley.comKetogenesis is Dispensable for the Metabolic Adaptations to Caloric RestrictionIn this study, we demonstrated that metabolic responses to a daily-fed caloric restriction (CR) protocol remain robust in mice that cannot engage in canonical ketogenesis. This surprising finding is ...

That brings us to our fourth manuscript of the year, “Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction”, by lab postdoc Dr. Chung-Yang Yeh, onlinelibrary.wiley.com/doi/10.1111/...

With the end of the year upon us, it's time for the 2025 @lamminglab.bsky.social year in review! Some of our accomplishments and successes are described in the thread below.

Many current lab members collaborated on this paper, including Michelle Sonsalla, Mariah Calubag, @drcaragreen.bsky.social, Dr. Chung-Yang Yeh, and more, and it was done in collaboration with @johndenu.bsky.social, @wiscosurgicalmetab.bsky.social and Luigi Puglielli!

The third was the final paper of former graduate student Dr. Michaela Trautman, other lab members, and collaborators, “Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice”: www.clinicalkey.com#!/content/pl...

With the end of the year upon us, it's time for the 2025 @lamminglab.bsky.social year in review! Some of our accomplishments and successes are described in the thread below.

onlinelibrary.wiley.comTissue‐Specific Effects of Dietary Protein on Cellular Senescence Are Mediated by Branched‐Chain Amino AcidsRestriction of dietary BCAAs protects male mice from the metabolic consequences of both normal- and high-protein diets. BCAA restriction also protects from hepatic cellular senescence in vivo and in ...

We published 5 research papers, beginning with “Tissue-Specific Effects of Dietary Protein on Cellular Senescence Are Mediated by Branched-Chain Amino Acids” by graduate student Mariah Calubag and other lab members and collaborators: onlinelibrary.wiley.com/doi/10.1111/...

nature.comFasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer’s disease - Nature CommunicationsCaloric restriction improves Alzheimer’s Disease outcomes in mice, but this diet not only reduces calories, but imposes a prolonged fast between meals. Here, the authors show this fast is essential to...

Next came our paper focused on Alzheimer's disease, “Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease” by graduate student www.nature.com/articles/s41...

Pleased to annouce the publication of our new collaboration with Spencer Haws and @johndenu.bsky.social "Depletion of individual dietary amino acids induce distinct metabolic and chromatin states"

These effects are not only cell-intrinsic, but are distinct from the effects of rapamycin, suggesting that the effects of AA-depletion on the epigenome are largely mTOR-independent

This was the result of a great partnership with @johndenu.bsky.social led by his postdoc Spencer Haws, with Yang Liu, @drcaragreen.bsky.social and Reji Babygirija from the Lamming Lab contributing!

Pleased to annouce the publication of our new collaboration with Spencer Haws and @johndenu.bsky.social "Depletion of individual dietary amino acids induce distinct metabolic and chromatin states"

This long-awaited article demonstrates that depletion of individual essential amino acids induces profound changes in the liver epigenome, with AA-specific molecular changes at the level of histone PTMs, the transcriptome, and metabolome www.jbc.org/article/S002...

Isoleucine, the focus of much of our labs research recently, had the strongest effect, w/ "expression of select chromatin modifying and metabolic enzymes that led to a prominent epigenetic state of histone H2A/H4 hypoacetylation and maintained hepatic acetyl-CoA levels"

Pleased to announce the publication of talented postdoc Dr. Yeh's new paper "Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction"!

It's been almost a century and we still don't know exactly why CR improves health and extends lifespan - but we are making progress!

Thanks to all our lab members who contributed to this paper!

Pleased to announce the publication of talented postdoc Dr. Yeh's new paper "Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction"!

CR as typically delivered leads to long periods of fasting between meals - and fasting normally induces ketogenesis. So here, Dr. Yeh tested the hypothesis that ketogenesis contributes to the metabolic benefits of CR.

Surprisingly, this is not the case - ketogenesis is dispensable for the metabolic effects of CR. Indeed, Dr. Yeh discovered that CR mice adapt to the repeated fasting by CR, and over time stop inducing ketogenesis during their inter-meal fast.

Pleased to announce the publication of talented postdoc Dr. Yeh's new paper "Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction"!