Nature Aging

Nature Aging

@nataging.nature.com

Nature Aging is a thematic journal from the Nature Portfolio that serves the broad aging research community. Follows & posts ≠ endorsements.

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Nature Aging
@nataging.nature.com

🗞️Our October issue is live!✨Read about lipid remodelling and lifespan regulation; how age-related T-cell accumulation drives myelopoiesis; senescent B-cells in rheumatoid arthritis risk; exercise-derived vesicles promote cartilage health & much more! www.nature.com/nataging/vol...

Nature Aging
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Online now! Multimorbidity patterns influenced the efficacy of a multicomponent lifestyle intervention targeting mobility disability in frail older adults. Participants with psychiatric and unspecific disease patterns experienced the most consistent clinical benefits. doi.org/10.1038/s435...

doi.orgMultimorbidity patterns influence mobility disability prevention in frail older adults from the SPRINTT trial - Nature AgingLifestyle interventions can preserve the independence of older adults. Here the authors show that multimorbidity patterns influenced the efficacy of a multicomponent lifestyle intervention targeting m...
Nature Aging
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Online now! @enriquegab.bsky.social @gsotoheredero.bsky.social et al identify an accumulation of cytotoxic CD4+ T cells producing CCL5 in the bone marrow during aging, linked to age-associated myelopoiesis. Blocking this axis improves healthspan in aged mice

nature.comCytotoxic CD4+ T cells induce age-associated myelopoiesis through CCL5–CCR5 signaling - Nature AgingGabandé-Rodríguez, Soto-Heredero and colleagues identify an accumulation of cytotoxic CD4+ T cells producing CCL5 in the bone marrow during aging, linked to age-associated myelopoiesis. CCR5 blockade ...
Nature Aging
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Online now! In a World View, primary care physician Dean Ariel reflects on how conversations about geroscience unfold in his clinic, amidst the evolving landscape of public engagement with aging research

nature.comLongevity medicine cuts ‘desire paths’ in primary care - Nature AgingPatients are arriving in primary care with questions about geroscience that medicine has not prepared clinicians to answer. Here, primary care physician Dean Ariel argues that the profession should pr...
Nature Aging
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Online now!✨Martinez, Morandini et al identify a role for cGAS in chromatin organization: cGAS knockout mice show compromised heterochromatin organization, LINE1 depression, inflammation, and shortened lifespan

nature.comcGAS-deficient mice display premature aging associated with derepression of LINE1 elements and inflammation - Nature AgingDemonstrating a role for cyclic GMP–AMP synthase (cGAS) in chromatin organization, Martinez, Morandini and colleagues report that cGAS-knockout mice exhibit compromised heterochromatin organization, L...
Nature Aging
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Online now! Combining whole-ovary imaging, AI and modelling, the authors mapped over 85,000 mouse oocytes and found that ovaries maintain a stable fraction of newly-activated oocytes throughout aging, suggesting organ-wide control of oocyte activation @Bokelab doi.org/10.1038/s435...

doi.orgThree-dimensional mapping of intact ovaries reveals the aging dynamics of the ovarian reserve - Nature AgingThe spatiotemporal dynamics of the depletion of the ovarian reserve remain incompletely understood. Combining whole-ovary imaging, AI and modeling, the authors mapped over 85,000 mouse oocytes and fou...
Nature Aging
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Online now!✨Cole et al identify fructose as a component of the therapy-induced SASP in senescent ovarian cancer cells and show that it reprograms cancer cells in paracrine, promoting detachment and metastasis @airdlab.bsky.social @wistar.org

nature.comThe chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming - Nature AgingCole and colleagues identify fructose as a component of the secretome in therapy-induced senescent ovarian cancer cells that drives metastasis. Fructose metabolically reprograms neighboring cancer cel...
Nature Aging
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✨SenNet collection✨In a perspective, Schafer, Basisty, Hertzel et al define and operationalize the term ‘senotype’, providing a framework to classify heterogeneous senescent cells

nature.comSenotypes define the diverse landscape of senescent cells - Nature AgingThis Perspective proposes a senotype framework for classifying senescent cells by their origins, molecular features and effects, which will foster comparison of diverse senescent states, including tho...
Nature Aging
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Online now!✨Calubag et al report that reducing dietary valine extends healthspan in male and female mice, and lifespan in male mice @lamminglab.bsky.social www.nature.com/articles/s43...

nature.comLifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice - Nature AgingCalubag et al. report that reduced dietary intake of the branched-chain amino acid valine is sufficient to improve healthspan in both male and female mice, as well as to extend lifespan in male mice.

Nature Aging reposted

Akis (Argyris) Papantonis
@akispapantonis.bsky.social

Our latest is now out in @nataging.nature.com giving reason to celebrate! Led by talented Spiros Palikyras, it improves our preprint (posted 2 years ago!) dissecting the mechanism and functional consequences of CTCF clustering upon senescence commitment of human cells. www.nature.com/articles/s43...

nature.comSenescent cells cluster CTCF on nuclear speckles to instruct an alternative splicing program - Nature AgingPalikyras and colleagues investigate chromatin reorganization upon senescence induction, reporting that components of nuclear speckles coordinate chromatin rewiring and a senescence-associated splicin...
Nature Aging
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Online now! A new study shows that IL-11, which is elevated in aging ovaries of mice, rats and humans, activates fibroblasts to secrete extracellular matrix, increasing ovarian stiffness. IL-11 is implicated as a potential therapeutic target for ovarian aging. doi.org/10.1038/s435...

doi.orgModulating IL-11-dependent matrix stiffness to delay ovarian aging - Nature AgingThe ovarian stroma becomes increasingly stiff with age, impairing ovarian function. The mechanisms that underlie this process are only partly understood. Here, the authors show that IL-11, which is el...
Nature Aging
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Online now!✨Oppezzo et al therapeutically block telomeric DNA damage signalling to restore hematopoietic function in telomerase-deficient and aged mice, while reducing senescence and inflammation @fdadf.bsky.social @ifomresearch.bsky.social www.nature.com/articles/s43...

nature.comTherapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging - Nature AgingOppezzo and colleagues report that therapeutically blocking telomeric DNA damage signaling reduces senescence and inflammation and restores hematopoietic function in telomerase-deficient and physiolog...
Nature Aging
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Online now! Spatial atlas of aging mouse ovary shows that reproductive decline reflects progressive loss of spatiotemporal coordination #OvarianAging #WomensHealth @hattaca.bsky.social @davidsebfischer.bsky.social @akochersberger.bsky.social @jennifergarrison.bsky.social doi.org/10.1038/s435...

doi.orgAging disrupts spatiotemporal coordination in the cycling murine ovary - Nature AgingOvarian cycles of follicle development, ovulation and tissue regeneration require cooperative functions of constituent cells. Here the authors provide a spatial atlas of the aging mouse ovary, reveali...
Nature Aging
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🗞️Our April issue is live! ✨The cover art depicts work on macrophage senescence as postage stamps 🎨The issue includes studies on improving vaccine efficacy in aging, endogenous regulation of cGAS, repurposing drugs for vascular dementia & much more nature.com/nataging/vol...

Nature Aging
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Online now! To dissect lncRNA functions in aging, here the authors perform a CRISPRi-based single-nucleus multi-omics screen perturbing 32 aging- and senescence-associated lncRNAs, and measuring matched changes in gene expression and chromatin accessibility. (rdcu.be/fblsB) doi.org/10.1038/s435...

rdcu.beMultiomic single-cell perturbation screens reveal critical lncRNA regulators of senescenceNature Aging - To dissect lncRNA functions in aging, here the authors perform a CRISPRi-based single-nucleus multiomics screen systematically perturbing 32 aging- and senescence-associated lncRNAs...
Nature Aging
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Online now! Here the authors show that the killifish exhibit age-related transformation in the immune system which rapidly develops inflammation, genome instability, and functional decline. doi.org/10.1038/s435...

doi.orgSpontaneous aging-associated inflammation and genome instability in the immune system of turquoise killifish - Nature AgingTurquoise killifish are naturally short-lived vertebrates that serve as a model system for aging. The authors show that killifish exhibit age-related transformation in the immune system, which rapidly...
Nature Aging
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🗞️Our March issue is live, with killifish artwork by Dario Valenzano on the cover!🎨Read work on senescence in mammary gland remodelling, structural protein changes as readouts of Alzheimer’s disease, the 201 Parkinson’s disease trial & more ✨https://nature.com/nataging/volumes/6/issues/3

Nature Aging
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Online now! Costa, Chen et al. performed RNA-seq on 13 tissues, six ages in male and female African turquoise killifish. The Killifish Aging Atlas provides a comprehensive resource for aging studies. @emkcosta.bsky.social @jingxunchen.bsky.social @brunetlab.bsky.social doi.org/10.1038/s435...

doi.orgMulti-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish - Nature AgingCharacterizing molecular aging features is crucial for understanding systemic and local factors contributing to the aging process. Here Costa, Chen et al. performed RNA sequencing on 13 tissues across...
Nature Aging
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Online now! A new study shows transplanting gut microbiota from estropausal female mice to young adult female mice improves ovarian hormone profiles, follicle metrics, and fertility-related outcomes. @bbparis1984.bsky.social doi.org/10.1038/s435...

doi.orgEstropausal gut microbiota transplant improves measures of ovarian function in adult mice - Nature AgingTo investigate the link between the gut microbiome and ovarian health, here the authors transplant gut microbiota from estropausal female mice to young adult female mice. Microbial transplantation imp...
Nature Aging
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🗞️Our February issue is live! Read work on precision responses to therapy-induced senescence, senolytic resistance mechanisms, AD biomarkers in Latin America, the exposure of older adults to health misinformation, links from DNA damage in macrophages to autoimmunity & more ✨

Nature Aging
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Online now! ✨Chiche, Djoual, Charifou et al identify a dual role for senescence in postpartum tissue remodelling: senescent cells drive mammary gland involution, yet predispose to postpartum tumor initiation @hanli-pasteur.bsky.social @pasteur.fr

nature.comInduction of senescence during postpartum mammary gland involution supports tissue remodeling and promotes postpartum tumorigenesis - Nature AgingChiche, Djoual, Charifou and colleagues identify a dual role for cell senescence in postpartum tissue remodeling: senescent cells drive mammary gland involution, yet create a permissive niche for tumo...
Nature Aging
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Online now! Study shows LINE-1 is increasingly expressed in mouse hearts with age, its de-repression is accompanied by cGAS-STING activation and cardiac dysfunction, while pharmacological inhibition of LINE-1 or STING improves cardiac function in aged mice. (rdcu.be/e0JU0) doi.org/10.1038/s435...

doi.orgTargeting age-related LINE-1 activation alleviates cardiac aging - Nature AgingLINE-1 retrotransposons are implicated in aging, but their role in cardiac aging specifically is not well understood. Here the authors show that LINE-1 expression rises in mouse hearts with age. Genet...
Nature Aging
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Online now! Kalia et al. investigate metabolic changes in Alzheimer’s disease (AD) using blood metabolomics, and show that lysophosphatidylcholines are associated with early amyloidosis in AD as measured by P-tau181 and P-tau217. doi.org/10.1038/s435...

doi.orgLysophosphatidylcholines are associated with amyloidosis in early stages of Alzheimer’s disease - Nature AgingKalia et al. investigate metabolic changes in Alzheimer’s disease (AD) using blood metabolomics, and show that lysophosphatidylcholines are associated with early amyloidosis in AD as measured by P-tau...
Nature Aging
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Online now! Sun et al. identify GRHL2 downregulation as a driver of prostate aging. They show GRHL2 transactivates CDK19 to inhibit p53-p21 signaling, and demonstrate that GRHL2 gene therapy alleviates age-related urinary dysfunction in mice. (rdcu.be/e0fbZ) doi.org/10.1038/s435...

doi.orgReprogramming the GRHL2−CDK19 axis by gene therapy alleviates prostate aging - Nature AgingThe prostate is an important part of the male reproductive system whose aging process is incompletely understood. Sun et al. identify GRHL2 downregulation as a driver of prostate aging. They show that...
Nature Aging
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Online now! Ma et al. present scMORE, a polygenic method integrating single-cell multiomics and GWAS to prioritize cell-type-specific, trait-relevant eRegulons. doi.org/10.1038/s435...

doi.orgIntegrating polygenic signals and single-cell multiomics identifies cell-type-specific regulomes critical for immune- and aging-related diseases - Nature AgingIn this technical report Ma et al. present scMORE, a polygenic method integrating single-cell multiomics and GWAS to prioritize cell-type-specific, trait-relevant eRegulons. scMORE revealed regulators...