Jan Lammerding - Lab

Attending #BMEs2026 and want to learn more about nuclear #mechanobiology? Come and enjoy one of our lab‘s talks or posters, or visit us at the Cornell BME booth. See you in Orlando.

Can protecting the cell nucleus prevent heart failure—even when the genetic defect remains? Our new study in @CircRes suggests it can! We identify nuclear envelope rupture as a key driver of LMNA-related cardiomyopathy. 1/7 doi.org/10.1161/CIRC... #Mechanobiology, #lamins, #LMNA

Our findings suggest that targeting nuclear rupture and its downstream consequences could open new therapeutic avenues for LMNA-related cardiomyopathy! A huge thank you to Noam Zuela-Sopilniak, Julien Morival, who led this study, and our amazing team of collaborators. 6/7

ahajournals.orgAmerican Heart Association Journals

We gratefully acknowledge funding from the The National Institutes of Health (NHLBI, NIAMS, and NIGMS), the Cornell Duffield College of Engineering, and the family of Ray and Kathy Mills. Read the paper: www.ahajournals.org/doi/10.1161/... 7/7

The intriguing part: Disrupting the LINC complex reduces mechanical forces on cardiomyocyte nuclei and nuclear envelope rupture. Remarkably, this reverses MORE THAN HALF of the disease-associated gene expression changes—even without restoring lamin A/C! 4/7

Even more striking: Reducing nuclear envelope rupture dramatically improved cardiac function and extended survival by MORE THAN ONE YEAR in mice with cardiomyocyte-specific lamin A/C depletion! All despite continued lamin A/C depletion. #cardiomyopathy 5/7

Mutations in the LMNA gene, encoding nuclear lamins A/C, cause severe dilated cardiomyopathy. But what drives the disease? Perturbed chromatin organization/gene regulation or mechanical damage to the nucleus? Distinguishing these mechanisms is critical for developing new therapies. 2/7

@hannamariahakkinen.bsky.social

Using bulk, single-nucleus & spatial transcriptomics, we found that nuclear envelope rupture drives widespread gene expression changes in LMNA-related cardiomyopathy. These changes promote inflammatory signaling, fibroblast activation & cardiac fibrosis. 3/7

Jan Lammerding - Lab reposted

Hanna Häkkinen

How do long-lived multipotent stem cells cope with mechanical stress in vivo? We found that neural crest cells are protected from mechanical stress during migration in confined tissue environment. www.nature.com/articles/s41...

nature.comIn vivo DNA damage protection during cell migration across confining embryonic tissue environments - Nature Cell BiologyHäkkinen et al. show that zebrafish neural crest cells encounter increased tissue-scale confinement along the body axis. Despite nuclear deformation, migrating neural crest cells experience neither nu...

Taylor & Francis Research

21 Sept

Looking for a faculty position combining research in fundamental cell and molecular biology with therapeutic discovery? Join our amazing faculty at the @weillinstitute.bsky.social at Cornell University in Ithaca, New York. academicjobsonline.org/ajo/jobs/32657 Apply by Nov. 15! Please share!

Jan Lammerding - Lab reposted

@tandfresearch.bsky.social

16 Sept

Nucleus is delighted to present a new Collection, guest edited by @lammerdinglab.bsky.social (@cornelluniversity.bsky.social) @weillinstitute.bsky.social. Featuring nine articles. This collection offers expert views and top tier analysis of key historical work. spr.ly/63325BGut9D

spr.lyNuclear MechanobiologyExplore the article collection: Nuclear Mechanobiology. Published in Nucleus.

tandfonline.comNuclear mechanobiology: a brief history and five unresolved questionsPublished in Nucleus (Vol. 17, No. 1, 2026)

25 Aug

Interested in nuclear mechanobiology and want to know what some of the big open questions are in the field? Read our recent editorial with input from >15 leading experts in the field, along with a list of review articles on nuclear mechanobiology: www.tandfonline.com/doi/full/10....

30 June

Interested in a faculty career in biomedical engineering #BME? Apply for the Rising Stars in Engineering in Health workshop for postdocs and PhD students interested in engineering, medicine & health: be.engineering.upenn.edu/home/rising-... Applications are open until July 31, 2026. Please share!

Two recent new publications from our laboratory, led by the amazing Jacob Odell and Maggie Elpers, respectively, shed new insights into the role of nuclear #lamins and nuclear #mechanobiology in two different contexts.

Another attempt to include some figures from the two papers, which were somehow reduced to black boxes in the original post.

rdcu.bePolarization increases nuclear stiffness in macrophages despite reduction in lamin A/C levelsnpj Biological Physics and Mechanics - Polarization increases nuclear stiffness in macrophages despite reduction in lamin A/C levels

In the second story, led by Maggie and published in npj Biological Physics and Mechanics (rdcu.be/fl0V8), we found that polarization of bone marrow derived macrophages results in increased nuclear stiffness, despite a decrease in lamin A/C levels.

This increase in nuclear stiffness was due to compaction of chromatin associated with polarization into M1-like macrophages and affected the ability of the M1-like macrophages to migrate through confined spaces. Stay tuned for further updates and insights!

tandfonline.comAntagonistic contributions of A-type and B-type lamins to LBR localization and dynamicsLamin B receptor (LBR) is an inner nuclear membrane protein that organizes peripheral heterochromatin and cooperates with lamins to tether chromatin at the nuclear periphery. However, how individua...

In the first story, published in Nucleus (www.tandfonline.com/doi/10.1080/...), we demonstrate that lamin A can result in displacement of LBR from the nuclear envelope to the endoplasmic reticulum (ER).

Given the important function of LBR in chromatin organization, these findings point to a competitive model between A-type lamins, B-type lamins, and LBR at the nuclear envelope that could play key roles during development and disease.

Jan Lammerding - Lab reposted

Nature Cell Biology

@natcellbio.nature.com

9 June

Attending #EESMechanobiology ? If so, be sure to find and chat with @djdavid.bsky.social (Daryl), one of our senior scientific editors. He'll be on site on Tuesday and Wednesday.

Daryl Jason Verzosa David@djdavid.bsky.social

Enroute to #EESMechanobiology! proud to represent both @natcellbio.nature.com as senior editor and npj Biological Physics & Mechanics as advisory editor. Let's discuss your interesting work, science publishing, & more! Find me around &at the #MeetTheEditor lunch On Wed. Note, I'm only here Tues+Wed

@fort-lab-uta.bsky.social

28 May

Great start to the Cornell Mechanobiology Hub Symposium hosted by the @weillinstitute.bsky.social, with keynote speaker Amy Shyer and over 180 participants from more than 15 institutions. #Mechanobiology thrives in Ithaca and the region, including Syracuse, Rochester, Buffalo, and Binghamton.

Jan Lammerding - Lab reposted

fort-lab-uta.bsky.social

23 Apr

First long term confocal imaging #Zeiss from the lab. Adipose-derived stem cells expressing LifeAct.

@leonerossetti.bsky.social

8 Apr

Interested in #Mechanobiology? Join us for the Mechanobiology Symposium, hosted by the new Cornell Mechanobiology Hub @weillinstitute.bsky.social in Ithaca, NY, this summer. More information at mechanobiology.wicmb.cornell.edu/events-progr... Deadline for abstract submission is April 15, 2026

Jan Lammerding - Lab reposted

luskinglab.bsky.social

@luskinglab.bsky.social

25 Mar

Interested in the nuclear envelope? Do you reside in the US northeast (or are willing to pay a visit)? Don't miss this year's NENE (northeast nuclear envelope) - a trainee-led regional meeting that brings together scientists at all levels for a day of exciting talks and discussions. June 5th @ Yale

Jan Lammerding - Lab reposted

Journal of Cell Biology

@jcb.org

19 Mar

Deb Roy, Inoue et al. @jhu.edu introduce an #optogenetics tool to rapidly induce #microtubule acetylation in living cells and show that this triggers release of the RhoGEF GEF-H1 from #microtubules, thereby driving persistent directional cell migration. rupress.org/jcb/article/... #Cytoskeleton

Jan Lammerding - Lab reposted

Leone Rossetti

26 Feb

Interested in a PhD in collective cell migration & mechanobiology? I'm looking to support a candidate applying for a fully funded UK/Home PhD. The project studies the biophysics of migrating cells, using force measurements & optogenetics, with collaborators in Japan. #mechanobiology #PhD eb4bm.org

eb4bm.orgHome - Engineering Biology For BiomedicineEngineering Biology for Biomedicine A UKRI:BBSRC Centre for doctoral training Why EB4BM “ Our graduates bridge fundamental biological design principles with biomedical bottlenecks, delivering engineer...

22 Feb

Considering a graduate degree in biomedical engineering and wondering if a Master of Engineering degree is worth it? Join this virtual information session hosted by the Meinig School of Biomedical Engineering at Cornell University: www.duffield.cornell.edu/bme/meng/ MEng applications are still open!

17 Feb

Great summer research opportunity for undergraduate students interested in cardiovascular research at Cornell BME. Projects range from tissue engineering and cardiac device to disease models and spatial & single cell transcriptomics. Apply at: www.cnf.cornell.edu/education/re.... Please share.

cnf.cornell.eduCornell Cardiac Undergraduate Research Experience (CURE) Program | CNF

1 Feb

New undergraduate summer research opportunities in cardiac research and biomedical engineering at the Cornell Meinig School of Biomedical Engineering, sponsored by the American Heart Association. Apply by Feb. 28 at www.cnf.cornell.edu/education/re.... Please share.

Lamins A and C is required to anchor emerin at the nuclear envelope, and mutations in these proteins cause devastating diseases such as Emery-Dreifuss muscular dystrophy (EDMD). In work now available in #JBiolChem at www.jbc.org/article/S002..., we identify a novel lamin A/C-emerin binding site.

Preventing lamin A/C polymerization, or using lamin A/C truncations that bind to the nuclear membrane but are unable to form filaments, is sufficient to ensure nuclear emerin localization, but insufficient to keep it firmly in place.

Inserting the novel lamin A/C emerin-binding domain into lamin B, which normally does not bind emerin, is sufficient to anchor emerin to the nuclear envelope. The novel emerin-binding domains acts in addition to the well established emerin-binding domain in the lamin A/C tail.

This work, led by fantastic Cornell BMCB PhD graduate Jacob Odell, and with support of Kristen Nedza, we show that lamin A/C has not one, but two independent emerin-binding domains, and that lamin filaments are required to ensure emerin localization to the nuclear envelope and anchor it in place.

Very exciting work from @maggieutgaard.bsky.social in the Beach & Oakes labs pointing to a novel mechanoresponsive roles of septins in protecting the nucleus from mechanical stress. Enjoy the science, and the beautiful movies!

Maggie Utgaard@maggieutgaard.bsky.social

So excited to share the preprint with the bulk of my PhD work in the Beach @myosincity.bsky.social and Oakes @pwoakes.bsky.social Labs at Loyola University Chicago! We investigate the structure, recruitment, and function of septin networks around the nucleus. A thread: doi.org/10.64898/202...

doi.orgdoi.org

22 Jan

Negin Majedi delivering a fantastic kick-off presentation on the #mechanobiology of cancer immune engineering as part of the new #MechanobiologyHub seminar series hosted by the @weillinstitute.bsky.social at Cornell University.

7 Dec 2025

Attending the ASCB/EMBO Cell Bio #cellbio2025 in Philadelphia? Check out the posters from our lab on nuclear mechanobiology, lamins, and mechanotransduction today and on Tuesday. I will be there too and look forward to catching up!

@renkawitzteam.bsky.social

25 Nov 2025

Motivational video for #MigrationMovieMonday. A persistent 4T1 breast cancer cell squeezing itself through a tight constriction despite undergoing repetitive nuclear envelope rupture. Credit: Kristen Nedza @weillinstitute.bsky.social

Jan Lammerding - Lab reposted

Renkawitz Lab

13 Nov 2025

Thanks to @katemiro.bsky.social , Megan King, Verena Ruprecht & @lammerdinglab.bsky.social for organising the very first meeting on the “Mechanobiology of the Nucleus” #MBNSRC @faseborg.bsky.social and for the invitation to present our discoveries. The conference was fantastic!

This post is unavailable.

6 Nov 2025

It’s been a pleasure working with @apdaria.bsky.social, Julie Heffler, and the Prosser Lab on this study, supported by the Leducq Foundation and the National Institutes of Health (NIH). This research is one step to get us closer to an effective treatment for cardiac #laminopathies and #LMNA-DCM.

Daria Amiad Pavlov@apdaria.bsky.social

It is finally out! Updated with exciting in-vivo microtubule disruption results to protect Lmna deficient nuclei from damage. My final postdoc project with Prosser Lab and a great collaboration with @lammerdinglab.bsky.social, Shenoy Lab, and Jain lab.

29 Aug 2025

Final call to register and submit abstracts for the @faseborg.bsky.social conference on the Mechanobiology of the Cell Nucleus (#MBNSRC) to be considered for platform presentations. The conference takes place in Melbourne, FL, Oct. 26-30, 2025. See more info at: events.faseb.org/event/Mechan...

29 Aug 2025

Speakers include: @luskinglab.bsky.social @renkawitzteam.bsky.social @pcusachs.bsky.social @gabrielneurohr.bsky.social @simonereber.bsky.social @zierlab.bsky.social @katemiro.bsky.social @sarawickstrom.bsky.social @rashmi-priya.bsky.social @stroudlab.bsky.social @becklab.bsky.social & many more!

24 Sept 2025

Registration is still open, and abstracts for posters are still accepted (email me for info or questions)!

How do LMNA mutations cause dilated cardiomyopathy (DCM) and other #laminopathies? In our latest preprint (doi.org/10.1101/2024...), led by the amazing Noam Zuela-Sopilniak and Julien Morival, we show that cardiomyocyte-specific lamin A/C depletion causes severe DCM, consistent with other studies.

A big Thank You to the general support from the NIH-NHLBI, the Leducq Foundation, the American Heart Association @ahascience.bsky.social, a Fleming Research Fellowship, and the Mills family.

A big thank you for the GENEROUS support, although general support is good too! :)

Detailed transcriptomic analyses indicate that a subset of cardiomyocytes drives disease progression by expression of genes associated with sterile inflammation, likely downstream of nuclear envelope rupture and activation of cytosolic DNA sensors, independent of cGAS/STING.

@martinhumphries.bsky.social

Expression of a dominant negative nesprin domain, DN KASH, which disrupts the LINC complex, reduces forces on the nucleus, reduces nuclear envelope rupture, and restores expression of many dysregulated genes. DN KASH expression also rescues cardiac function and extends survival by >1 year.

Jan Lammerding - Lab reposted

Martin Humphries

3 Sept 2025

Odell, J et al. (@lammerdinglab.bsky.social lab) A-type lamins anchor emerin at the inner nuclear membrane via two independent binding sites. bioRxiv posted 2 September 2025 doi:10.1101/2025.09.01.673543. www.biorxiv.org/content/10.1...

biorxiv.orgA-type lamins anchor emerin at the inner nuclear membrane via two independent binding sitesLamins form a dense meshwork at the inner surface of the inner nuclear membrane (INM), where they interact with other nuclear envelope proteins such as emerin. Emerin is an integral membrane protein t...

29 Aug 2025