James Pirruccello πŸŽƒπŸ¦‡πŸ§Ή

James Pirruccello πŸŽƒπŸ¦‡πŸ§Ή

@jamespirruccello.com

AI slop enjoyer

3.4K followers2.7K following3.6K posts

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🫑 President Don't Know

Political Poll Bot@pollresults.org

National Presidential Primary Oct 12 - 19, 2026 Don't know 45.35% (+33.2%) Kamala Harris (D) 12.13% Gavin Newsom (D) 8.97% Pete Buttigieg (D) 6.54% Alexandria Ocasio-Cortez (D) 5.5% Jon Ossoff (D) 4.07% Mark Kelly (D) 2.51% +15 more The New York Times/Siena University 1170 RV View Poll

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Update your software

Russ Cox@swtch.com

The details are now public, as of two hours ago. bugzilla.mozilla.org/show_bug.cgi... The secret P-384 keys for these intermediate CAs are all zeros except the last 8 bits. All not-updated software can be MITM'ed now. IOT boxes that can't or don't update are now trivially MITM'able forever.

James Pirruccello πŸŽƒπŸ¦‡πŸ§Ή reposted

The details are now public, as of two hours ago. bugzilla.mozilla.org/show_bug.cgi... The secret P-384 keys for these intermediate CAs are all zeros except the last 8 bits. All not-updated software can be MITM'ed now. IOT boxes that can't or don't update are now trivially MITM'able forever.

bugzilla.mozilla.org2083449 - Private key compromise of eMudhra Intermediate CertificatesNEW (nobody) in CA Program - CA Certificate Compliance. Last updated 2026-10-20.
Russ Cox@swtch.com

If you make HTTPS requests or have other TLS clients and care about MITM attacks, you need to update today. If you run Go: go get go@1.27.3 If you run Homebrew: brew update brew install ca-certificates If you run Linux, maybe stay off the internet for now.

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James Pirruccello πŸŽƒπŸ¦‡πŸ§Ή reposted

Delighted to share this new article where we propose our view for the next generation of human genetics. We argue a need for "Trait Causal Models" linking genetics to effects at all levels of biological structures, and talk about how to get there using gwas, perturbations and observational omics

Jeff Spence@jeffspence.github.io

It's been 30 years (!!!) since the conceptualization of GWAS. GWAS has driven tons of discoveries, but with recent experimental developments (CRISPR, single-cell omics), we thought it was time to think about how to drive the next 30 years of human genetics. doi.org/10.5281/zeno...

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