Inbal Shainer

Inbal Shainer

@ishainer.bsky.social

assistant professor at https://www.technion.ac.il/, studying visual neuroethology in zebrafish 🐟🔬🏳️‍🌈 https://shainer-lab.net.technion.ac.il/

663 followers221 following6 posts

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Excited to share our new paper in Nature! 'Transcriptomic neuron types vary topographically in function and morphology' explores how neurons in the zebrafish optic tectum exhibit diverse functions and shapes despite similar transcriptional profiles. 🔗 rdcu.be/d9GVM

Inbal Shainer reposted

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Inbal Shainer reposted

News: millions of years ago, hybridization gave rise to a tetraploid #fish with two distinct parental subgenomes & this is fascinating: as young barbels develop, they switch from using opsins from one subgenome as larvae to those from the other as adults, fine-tuning their colour #vision! 👁️🌈.

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A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵

Inbal Shainer reposted

Inbal Shainer reposted

I am excited to announce the latest paper from our lab, published in Science ! In this study, we show that thalamocortical-like circuits in the zebrafish brain process sensory information hierarchically across topographically organized forebrain circuits.

science.orgHierarchical sensory processing in zebrafish thalamocortical-like circuitsThalamocortical projections shape the functional regionalization and parallel sensory computations across the mammalian cortex. However, the principles of thalamocortical computations in non-mammalian...

Out now in @science.org by @emreyaksi.bsky.social, Anh-Tuan Trinh and colleagues at the Kavli Institute in Trondheim: Hierarchical sensory processing in zebrafish thalamocortical-like circuits doi.org/10.1126/scie...

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Happy to share our new paper published in @currentbiology.bsky.social! Using in vivo imaging of genetically defined zebrafish retinal ganglion cells (RGCs), we show that while some Satb2+ RGCs maintain stable functional identities during development, others undergo functional changes.

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1/11 Excited to share my postdoc work from @schierlab.bsky.social and Rainer Friedrich! 🐟👃 How does the brain decide whether an odor is good or bad? In larval zebrafish, we find that odor preference is reflected in spatially cohesive neuronal domains of the olfactory bulb. 🧵

Inbal Shainer reposted

Inbal Shainer reposted

🚨 New paper in @nature.com We asked why two hippocampal areas with very different anatomy, CA3 and CA1, often seem to code space so similarly? By recording bats flying up to 200m, we found that the difference was hidden by scale! www.nature.com/articles/s41... 🧵 1/11

nature.comSparse-to-dense coding transformation between hippocampal areas CA3 and CA1 - NatureThe hippocampus exhibits a CA3-to-CA1 coding transformation that combines fast learning with an efficient, compressed neural code.

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In this beautiful paper from the Baier lab, authors show that cichlid fish show innate nest-building behaviors, but they are refined over time as animals learn to improve their nest! Additionally, they find brain activity in a region homologous to the hippocampus. 🐠🧠 www.cell.com/current-biol...

cell.comCognitive ethology of nest building in a shell-dwelling cichlidGrätsch et al. examine nest-building behavior in the shell-dwelling cichlid Lamprologus ocellatus. Nest building follows a stereotyped sequence of innate behavioral motifs that improve with experience...

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New preprint from the group on the evolution of retinal cell types. Check the summary by Dario @dariotommasini.bsky.social !

Dario Tommasini@dariotommasini.bsky.social

Inhibitory neurons are among the most transcriptomically diverse class of neurons in the CNS, with some brain regions having 60+ distinct cell types. Do humans share the same repertoire as rodents? Birds? Fish? 1/13

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New paper out : "Synchronization of behavioral and cardiac dynamics in larval zebrafish" Here, we report a pretty striking relationship between behavioral state and heart rate in larval zebrafish, and then explore the mechanisms that lead to this coupling bit.ly/4ciYt3R

bit.lySynchronization of behavioral and cardiac dynamics in larval zebrafishAnimals reprioritize behavioral goals in response to internal physiological states. Using larval zebrafish, we investigated whether engagement with a …

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Have you ever wondered how the brain should represent the sensory world in order to generate behavior? Read our new preprint: work by Shuhong Huang shuhonghuang.bsky.social with our long-standing collaborator James Fitzgerald at Northwestern.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social

Behavioral alignment as an organizing principle in sensory coding https://www.biorxiv.org/content/10.64898/2026.02.04.703828v1

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New preprint out! www.biorxiv.org/content/10.6... One of the most salient lessons I learned in all my adventures with screening and protein engineering is the importance of context. The context in which you test a gene or protein determines what function it has.

bioRxiv Bioengineering@biorxiv-bioeng.bsky.social

Library transgenesis in zebrafish through delayed site-specific mosaic integration for in vivo pooled screening of transgenes https://www.biorxiv.org/content/10.64898/2026.01.30.702415v1

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Inbal Shainer reposted

Engineering a Mechanoresponsive DNA Origami Capsule for Drug Delivery to Narrowed Arteries pubs.acs.org/doi/10.1021/... Glad we could contribute to this interesting work from Yuval Garini's lab. Kudos to Hadas Omer and the team: Hadeel_Khamis, Zipora Lansky, Netanel Korin, Racheli Boeangiu

pubs.acs.orgEngineering a Mechanoresponsive DNA Origami Capsule for Drug Delivery to Narrowed ArteriesSince their inception, DNA origami nanostructures (DONs) have attracted great interest for their programmable geometry, nanoscale precision, and biocompatibility. Here, we present mechanoresponsive DO...

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Excited to see this preprint out! Siyuan Mei did exceptional work leading this project, and it was a great experience working with the Herz lab. How do zebrafish update their internal compass? They use a multi ring shifter network, similar to flies despite 550M years of divergence. Full thread ⬇️

Portugues Lab@portugueslab.bsky.social

1/n: A new collaborative preprint from the lab to start the year: "A multi-ring shifter network computes head direction in zebrafish" together with Siyuan Mei, Martin Stemmler and Andreas Herz from the LMU, Munich.

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Do you love quantifying animal behavior as much as we do? We have just the tool for you! Presenting #OCTRON - a pipeline that helps you create rich annotation data and enables training of custom segmentation models. Have a look, particularly if you work with non-model / invertebrate organisms!

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🥁We are recruiting PhD students/Postdocs with strong proven background in developmental/molecular/cell biology & related areas, for various projects- check out our lab website👇🏼 We offer: competitive stipends, super equipped lab, fun international team! yanivelkoubylab.com

yanivelkoubylab.comThe Elkouby Lab - Cell and developmental biology of early oogenesisThe Elkouby Lab Illuminating unpredicted cellular machineries in gonad development, germ cell production, and reproduction A Journey to Before the Beginning of Life Exploring the Unknown Developing eg...