Nav Bharathan

Check out our paper!! It was such a fun project to work on. Also fantastic mentoring during my master's thesis by Dumont lab members🌟

This artwork (rendered from real FIB-SEM data) was super fun to conceptualize and realize in its final form, and I'm honored to have it featured by @jcb.org! Read our paper if you're interested to learn more about the features we discovered in epithelial desmosomes.

A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵

Volume EM reveals desmosome three-dimensional architecture in epithelial cells and tissue models. New study from Navaneetha Krishnan Bharathan (@genehackrman.bsky.social), Andrew P. Kowalczyk and colleagues: rupress.org/jcb/article/... #Adhesion #StructuralBiology

Excited that this is now out in MBoC @ascbiology.bsky.social Check out our new insights into the subset of cell junction proteins in action in migrating mesenchymal cells. Open access PMC version is in line being processed 🧪 www.molbiolcell.org/doi/10.1091/...

The array of organs in the animal body differ dramatically in their architecture, but cell-cell adhesion mediated by cadherins is a common principle. Our lab usually focuses on epithelia but cadherins are also active in migrating mesenchymal cells like these migrating testis myoblasts 1/n 🧪

What does a desmosome look like in 3D? In my first corresponding author paper (!), we find that desmosomes don't always look identical across epithelia. But the coolest finding by far (and seen in TWO different epithelial models) is a HOLE in the desmosome. PMCID version coming soon!