Eterna

Join the Eterna community tomorrow, Oct. 14 at 12:30 pm PT to hear Antonia Panescu (Yale) discuss her RNA inverse design method and HJ Lee (Stanford) introduce his 3D prediction puzzle for modeling RNA aptamers docking a ligand. Details at: eternagame.org/news/16535855

How do researchers design an RNA in 3D when no accurate 3D prediction model exists? Eterna's collaboration with the @rdaslab.bsky.social at Stanford was able to design novel pseudoknots using a blend of secondary structure prediction and GenAI design methods. 🧪 #RNAsky

OpenKnot Round 9 features secondary structures designed by players to create compact, pseudoknotted RNA using 240 bases. GenAI teams also will be testing whether their methods can perform as well as the expert players at a longer length. Check out the puzzle at: eternagame.org/labs/14343053

Eternacon 12 will be Sunday, July 26, 9am to 2pm PT featuring talks on player pseudoknot design techniques, the Montparnasse algorithm solving the Eterna100, an RNA scaffold for cryo-EM, and results for our pilot Replicase puzzle. #RNAsky Free to register at eternagame.org/eternacon/2026

Eterna's newest puzzle challenges players to design 240-base RNA strands that will fold into compact pseudoknots. The puzzle provides a metric for counting the number of pairs that cross to form large, synthetic pseudoknots. #RNAsky #citsci Check out the puzzle at eternagame.org/labs/14333719

Spotlight on geneticist William Greenleaf and biochemist Rhiju Das: They gathered insights from citizen scientists via a Stanford Medicine-designed video game to help create an affordable RNA sensor for active tuberculosis. stanmed.stanford.edu/molecule-des...

First AI-generated RNA with novel atomically ordered 3D fold! 🧬 The pseudoknotted secondary structure 'Kissing Multiloops' was designed by an Eterna player then solved by 3 GenAI models as confirmed by cryo-EM. ❄️🔬 #RNASky www.biorxiv.org/content/10.6...

The first three CASP 17 RNA targets are molecules designed by Eterna players as part of our OpenKnot puzzle series! Another example of how dedicated citizen scientists #citsci can contribute to cutting-edge research. eternagame.org/challenges/1...

This week, learn about the crowdsource RNA design platform, Eterna, and Anthony Stohr's switch work. In the future, how could Eterna be used to tackle to 3D RNA structure problem? Meeting ID: 934 4593 5624 Passcode: 802843 Mailing list: groups.google.com/g/casp-rna-sig

Town Hall - Saturday, March 14, 9am PT eternagame.org/news/14267278 A University of Delaware researcher will be discussing how he applied #RNA switches Eterna reported in a 2022 PNAS paper to a #CRISPR system for conditional gene activation. #citsci Screenshot of the winning switch design:

I was amazed when I saw @rachael-kretsch.bsky.social present about this in an @rdaslab.bsky.social meeting. ROOL and GOLLD are stunning (dare I say beautiful) structures. She presented about this for @eternagame.org last year too! Recording available at eternagame.org/eternacon/2025 #RNASky 🧪

RNA switches designed by @eternagame.org players not only are highly efficient in vitro, they also work in cells! This is so cool! 🧪 @narjournal.bsky.social @markblenner.bsky.social Metabolite-responsive scaffold RNAs for dynamic CRISPR transcriptional regulation: academic.oup.com/nar/article/...

Introducing gRNAde: our own little "AlphaGo Moment" for RNA design! 🧬🚀 📝: tinyurl.com/gRNAde-paper Unlike proteins, RNA design has long relied on "wisdom of the crowd" (human experts) or the slow crawl of directed evolution — gRNAde changes that! 🧵👇

A new 3-state Replicase challenge has been launched on Eterna and will only be open for two weeks before sequences are collected for experimental testing at the Das Lab. Will Eterna players be able to improve the catalytic activity of the RNA polymerase? eternagame.org/labs/14183416

@eternagame got single RNAs to compute functions like all logic gates, A>B, and A*B/C^2, relevant for tuberculosis detection! Now looking for partners to scale to complex applications. Collab w/ Greenleaf Khatri labs @christianchoe.bsky.social @stanfordmedicine.bsky.social at doi.org/10.1038/s415...

In addition to the RibonanzaNet server hosted by @rdaslab.bsky.social, RNA structure fans can try the new pseudoknotted prediction model in Eterna's RNet Study collection. The 108 puzzles are a mix of experimentally-validated structures and synthetic fabrications. eternagame.org/collections/...

Not exactly citizen science, but such a fun way to connect people with Nature.

Long-standing myths about “silly science” have contributed to the reckless slashing of government-supported research.

Celebrate World RNA Day on August 1 with Eterna In the latest Education Corner, learn about Eterna, an online game which models the base pairing and secondary structure of RNA sequences cdn.rcsb.org/rcsb-pd...

Coming up this weekend, Eternacon will feature presentations about fellow #citsci platform @zooniverse.bsky.social and how participants of both Zooniverse and Eterna have created #machinelearning tools for projects. @noirlabastro.bsky.social Register for free at eternagame.org/eternacon/2025

Eterna players successfully designed antisense oligonucleotides (ASOs) to bind with specific regions of the intron and restore F8 exon 16 splicing. A big thank you to @ucscscience.bsky.social for collaborating with us on this cutting-edge research! #citizenscience @rdaslab.bsky.social

Registration for Eterna's annual online conference July 26-27 is open! Come hear from both researchers and players about new approaches to structure-based RNA design and understanding RNA structure. #citsci Full program and free registration at eternagame.org/eternacon/2025

Summer Newsletter Published Highlights training events, the Ligand Expo shutdown; accessing IHM data at RCSB PDB, and more. In the Education Corner, learn about Interactive RNA Education with the Eterna Game. cdn.rcsb.org/rcsb-pd...

Zooniverse taking the lead in using #machinelearning as a tool for participatory science projects.

Looking forward to attending my first Conference for Advancing the Participatory Sciences this week and delivering a presentation during the Scientific Contributions session on how Eterna players created a large dataset of RNA sequences with pseudoknots for machine learning. 🧪 #CAPS2025

If you weren't able to attend the workshop, be sure to stop by booth 502 to see our RNA folding game in action. #ASBMB25

Tomorrow morning in room 470! #ASBMB25

Hello World The Eterna RNA structure modeling and puzzle platform has landed in the much happier place. We look forward to continuing conversations with the biochemistry, molecular biology, bioinformatics, machine learning, and participatory science communities.