Sarah Nicolas

Sarah Nicolas

@sarah-nicolas.bsky.social

Marie Skłodowska-Curie Postdoctoral Fellow at CRCA-CBI #Microglia #Exercise #microbiota #GutBrainAxis #Alzheimer

743 followers752 following22 posts

Sarah Nicolas reposted

NSF-Simons NITMB
@nitmb.bsky.social

🎵 Discovering the rhythm of nature Guy Amichay, NITMB Trainee and Research Associate in the Danny Abrams lab at Northwestern University, spoke with @sciam.bsky.social about recent NITMB-supported research investigating a widespread communication tempo found across species 🔗 in the reply 👇️

Sarah Nicolas reposted

Joao Barbosa
@jbarbosa.org

Looking for a (neuroscience) PI position in France? You still have time to do it this year, but you need to act fast. If you have no idea how to do it, start by reading this! l1nk.dev/hk1mx6e 1/

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Sarah Nicolas
@sarah-nicolas.bsky.social

Finally, IL-1β increased CD8⁺ T cell infiltration into the dorsal hippocampus, independently of exercise. These cytotoxic T cells negatively correlated with neurogenesis, suggesting they may directly suppress new neuron survival.

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Sarah Nicolas
@sarah-nicolas.bsky.social

IL-1β caused microglial lipid-droplet accumulation (LDAM) — a hallmark of dysfunctional, pro-inflammatory microglia seen in ageing. And… Exercise paradoxically exacerbated this lipid accumulation in IL-1β animals.

Sarah Nicolas
@sarah-nicolas.bsky.social

We then performed some transcriptomics analysis of hippocampal microglia (CD11b⁺ sorted) which revealed that: - In healthy rats exercise had clean anti-inflammatory gene-level effects (↓Cxcr3, ↑Fgf10) - In IL-1β rats exercise enriched immune activation & leukocyte trafficking pathways (TREM)

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Sarah Nicolas
@sarah-nicolas.bsky.social

In fact, IL-1β blunted exercise-induced neurogenesis, particularly in the dorsal hippocampus. Exercise increased new immature neuron numbers in healthy controls, but this effect was significantly reduced in IL-1β animals.

Sarah Nicolas
@sarah-nicolas.bsky.social

Exercise is one of the most powerful tools that supports brain plasticity. It boosts the birth of new neurons in the hippocampus (adult hippocampal neurogenesis, AHN) and supports memory. But does it work under all conditions?

Sarah Nicolas
@sarah-nicolas.bsky.social

We used a rat model of chronic low-grade hippocampal neuroinflammation by overexpressing IL-1β locally in the hippocampus mimicking the kind of inflammation seen in ageing and neurodegeneration also called «inflammageing ». Rats then had voluntary access to running wheels for several weeks. 🐀🏃

Sarah Nicolas reposted

Fabien Naneix
@fabnaneix.bsky.social

New review on Dopamine ensembles regulating appetite, feeding, and energy homeostasis now available in Trends in Endocrinology & Metabolism. Thank you @peppeganga.bsky.social for the invite, and to Oriane Onimus and @katepeters3.bsky.social for their fantastic work www.cell.com/trends/endoc...

cell.comDopamine ensembles regulating appetite, feeding, and energy homeostasisBeyond its classical role in gating reward processes, dopamine (DA) also contributes to the orchestration of feeding and energy balance. This review synthesizes and discusses recent advances in unders...

Sarah Nicolas reposted

Roli Roberts
@roliroberts.bsky.social

This is such a cool study, arising from a chance observation in the field. The authors were filming the flashing of fireflies in Thailand, but noticed that the chirping of nearby crickets seemed to be synced to the flashes...

PLOS Biology@plosbiology.org

Do animals have a favored tempo for communicating with each other? This study reveals a hotspot of 0.5-4 Hz for #communication across distinct species & modalities, hypothesizing that this may driven by biophysical commonalities of the receivers' #neurons @plosbiology.org 🧪 plos.io/4ccWuhh

Sarah Nicolas reposted

PLOS Biology
@plosbiology.org

Do animals have a favored tempo for communicating with each other? This study reveals a hotspot of 0.5-4 Hz for #communication across distinct species & modalities, hypothesizing that this may driven by biophysical commonalities of the receivers' #neurons @plosbiology.org 🧪 plos.io/4ccWuhh

Sarah Nicolas
@sarah-nicolas.bsky.social

Happy to see this work, led by our amazing Dr Caruso now out in Neuropharmacology !

APC Microbiome Ireland@apcmicrobiomeirel.bsky.social

#Exercise type can shape brain-related outcomes differently. A new paper in 𝑵𝒆𝒖𝒓𝒐𝒑𝒉𝒂𝒓𝒎𝒂𝒄𝒐𝒍𝒐𝒈𝒚 found that after 8 weeks, treadmill exercise improved spatial memory, while wheel running increased adult hippocampal #neurogenesis in rats. 📰 buff.ly/YS5tNUI #brainhealth @oliviafoleary.bsky.social

Sarah Nicolas reposted

Nature Portfolio
@natureportfolio.nature.com

Ancient DNA from grape seeds spanning 4,000 years reveals the domestication, cultivation, and trade of grapes in France over this period, according to research in Nature Communications. The authors find that one Medieval sample is genetically identical to modern Pinot Noir grapes. 🧬 🏺 🧪

go.nature.comAncient DNA reveals 4000 years of grapevine diversity, viticulture and clonal propagation in France - Nature CommunicationsHere, the authors present aDNA from 49 grape pips spanning the Bronze Age to Medieval period in France and surrounding areas. They find evidence of long-distance exchange of domestic varieties through vegetative clones and one Medieval sample that is nearly identical to modern Pinot Noir.

Sarah Nicolas reposted

Andrew Octavian Sasmita
@aosasmita.bsky.social

Where does Aβ come from in Alzheimer’s disease? 🔍 In this review, we explore Aβ production and functions of APP processing in non-neuronal cells as well as how targeting non-neuronal Aβ could lead to a more holistic disease prevention/targeting. link.springer.com/article/10.1...

link.springer.comA Question of Origins: Non-neuronal Sources of Amyloid-β - Neuroscience BulletinAmyloid-β (Aβ) plaques and neurofibrillary tau tangles are hallmarks of Alzheimer’s disease (AD). While the intracellular localization of tau tangles within neurons nominates them as the primary produ...
Sarah Nicolas
@sarah-nicolas.bsky.social

Happy to see published the last piece of a fruitful (and fun!) collaboration on Adiporon… from depression to osteoporosis. www.sciencedirect.com/science/arti...

sciencedirect.comThe adiponectin agonist AdipoRon accelerates osteoporosis development in two different models and modulates adipocyte differentiationOsteoporosis is an increasing concern in the aging population worldwide, culminating in increased economic concerns and diminished quality of life. Si…

Sarah Nicolas reposted

AFP News Agency
@en.afp.com

A major power outage hit the area around the French Rivera resort of #Cannes on Saturday, the final day of the city's film festival, though organisers said the closing ceremony would not be affected ➡️ u.afp.com/SpTb

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