David Gerlach

David Gerlach

@dger.bsky.social

Postdoc in bacterial systems biology in the Heilbronner lab, LMU. Previously Peschel lab and Brochado lab.

332 followers421 following35 posts

Please check out our new work demonstrating how S. aureus integration into the nasal microbiome ๐Ÿ‘ƒ can be driven by amino acid availability. This enormous effort was spearheaded by the amazing @laucamus.bsky.social ๐Ÿ‘ฉโ€๐Ÿ”ฌ!

simonheilbronner.bsky.social@simonheilbronner.bsky.social

Happy to see the work of @laucamus.bsky.social published today (rdcu.be/i9p3mJUiX3ta); We show that S. aureus proliferation in nasal communities is impacted by amino acid availability. With amazing support of @linklab.bsky.social, L. Angenent and many more. @lmu.de, @unituebingen.bsky.social

David Gerlach reposted

David Gerlach reposted

โ€œThe end of acute infection is not necessarily the end of the diseaseโ€. I very much appreciate this comment in Nature highlighting the role of infectious disease in the development or exacerbation of chronic disease. Vaccines can prevent chronic diseases, which is often overlooked.

David Gerlach reposted

David Gerlach reposted

David Gerlach reposted

So happy to share that this work is finally out, now in @nature.com! Lots of new goodies since preprint so plz check it out (old thread below). Giant thank you to everybody involved + all @savitski-lab.bsky.social and @typaslab.bsky.social lab members ๐Ÿ™๐Ÿ™๐Ÿ™ @embl.org nature.com/articles/s41...

nature.comPervasive phosphorylation by phage T7 kinase disarms bacterial defences - NatureThe T7 bacteriophage deactivates bacterial defence systems through T7K phosphorylation of nearly all host and phage proteins during infection.
Tara Bartolec@tarabartolec.bsky.social

1/11 - With Karin Mitosch and Clรฉment Potel + colleagues in Savitski lab and @typaslab.bsky.social @embl.org, Iโ€™m very happy to share our discovery of a hyper-promiscuous phage protein kinase (T7K) which broadly deactivates bacterial defenses! ๐Ÿฆ  www.biorxiv.org/content/10.1...

David Gerlach reposted

David Gerlach reposted

๐Ÿšจ Exciting #PhD opportunities across multiple labs, including those of @jorg-vogel-lab.bsky.social, @emmanuel-saliba.bsky.social, @cciollimattioli.bsky.social, @ffaberlab.bsky.social & @westermannlab.bsky.social at #HIRI in Wรผrzburg. ๐ŸŽ“๐Ÿฅผ More about the projects: www.helmholtz-hzi.de/en/career/gr...

helmholtz-hzi.deJoint One Lab Call for Doctoral Researchers 2026The HZI offers 16 fully funded PhD positions - an exceptional opportunity for curious, young scientist to work in a stimulating environment.

๐Ÿšจ We're recruiting! The HZI is offering 16 fully funded PhD positions to tackle pressing challenges in infection research โ€” from basic science to translational innovation. ๐Ÿ“ Braunschweig, Wรผrzburg, Hannover or Saarbrรผcken ๐Ÿ“… Apply by September 11 Learn more: jobs.helmholtz-hzi.de/job/Braunsch...

David Gerlach reposted

Looking for BGCs in large metagenomic datasets? Our new biorxiv preprint introduces metaSMASH, a scalable fork of antiSMASH designed specifically for metagenome-scale BGC detection and analysis : www.biorxiv.org/cgi/content/... Thanks @canerbagci.bsky.social and @kblin.bsky.social โค๏ธ

biorxiv.orgmetaSMASH: Scalable Biosynthetic Gene Cluster Detection for Large Metagenomic AssembliesantiSMASH is widely used for biosynthetic gene cluster (BGC) detection and annotation, but its standard workflow is poorly suited to large metagenomic assemblies, where massive contig counts create severe runtime bottlenecks and complicate downstream result exploration. We present metaSMASH, a re-engineered fork of antiSMASH for metagenome-scale BGC analysis. metaSMASH preserves the original antiSMASH detection and annotation logic while introducing streaming, memory-bounded execution, record-level parallelisation, optional output filtering, and an interactive dashboard for large result sets. Across 25 benchmark metagenome datasets, metaSMASH reproduced identical BGC detection results while dramatically reducing computational cost. Relative to the default antiSMASH configuration, metaSMASH was a geometric-mean 38x faster. It also outperformed an ad hoc chunked antiSMASH workflow: in the default configuration it achieved a geometric-mean 2.9x speed-up and 1.7x lower peak memory, and with extended-analysis modules enabled it was 2.7x faster and used 3.1x less memory while completing all datasets, whereas the ad hoc workflow ran out of memory on the two largest assemblies. By substantially reducing the computational burden of large-scale metagenome analysis without sacrificing result equivalence, metaSMASH makes routine mining of assembled metagenomes more practical and provides a scalable foundation for natural product discovery from complex microbial communities. ### Competing Interest Statement The authors have declared no competing interest. German Center for Infection Research, TTU Novel Antibiotics 09.716 Volkswagen Foundation, 0072511-00

David Gerlach reposted

David Gerlach reposted

Cell Host & Microbe@cp-cellhostmicrobe.bsky.social

A family of lanthipeptides with anti-phage function Discovery of 2,000+ lanthipeptide biosynthetic gene clusters with anti-phage potential. Lanthivirins inhibit phage replication by targeting phage proteins & interfering with phage DNA replication. www.cell.com/cell-host-mi...

David Gerlach reposted

David Gerlach reposted

๐Ÿšจ We're hiring! My new lab at EMBL Hamburg is looking for a Research Technician. I'm looking for someone excited by phages, metabolism, enzymes, structural biology and bacterial immunityโ€”if you know the right person, please share this post!๐Ÿงตโฌ‡๏ธ Apply here: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

embl.wd103.myworkdayjobs.comResearch Technician (Osterman Group โ€“ Metabolism-driven immunity)EMBL Hamburg / CSSB The European Molecular Biology Laboratory (EMBL) is Europeโ€™s flagship life sciences organization, with more than 110 independent research groups across Heidelberg, Hamburg, Grenobl...

David Gerlach reposted

David Gerlach reposted

The #Rstats development team receives some well-deserved recognition! "As part of the prize, the R team - who have thus-far been unpaid [for R work] - will get to split $1m (ยฃ755,000) between them." "The Oxford professor making sense of the world's data" www.bbc.com/news/article...

bbc.comProf Brian Ripley on developing R to manage the world's dataProf Brian Ripley has spent the past three decades working on a computer software that analyses data.

David Gerlach reposted

What if bacteria were using wax esters to shape skin microbiomes? Staphylococcal lipases convert skin antimicrobial fatty acids into harmless wax esters. This publication is the very first first-author paper for my first PhD student, my first time acting as last author, and our first ISME paper.

track.smtpsendmail.comExtracellular wax ester biosynthesis by staphylococcal lipases detoxifies skin fatty acids and shapes interspecies competitionAbstract. To maintain its barrier function, human skin requires lipids, including cholesterol, ceramides, free fatty acids, and wax esters. In contrast to

David Gerlach reposted

Mart Krupovic@mkrupovic.bsky.social

With Eugene Koonin, we wrote a rather comprehensive review on the origin, evolution and organization of the #virosphere. We describe all 10 viral realms and the logic behind them, and so much more. Check it out! comptes-rendus.academie-sciences.fr/biologies/ar...

David Gerlach reposted

David Gerlach reposted

Come and join us @ceplas.bsky.social cluster of excellence @hhu.de 12 postdocs & 7 PhD positions in Dรผsseldorf www.ceplas.eu/en/training-...

ceplas.euCEPLAS: Join our team!

๐ŸšจJob Alert โ€“ Please RT! Weโ€™re looking for bright minds to join our community! We are looking for 12 postdocs and 7 PhD students! Details on all projects and application: www.ceplas.eu/en/training-... @leibnizipk.bsky.social @mpipz.bsky.social @hhu.de @fz-juelich.de @unicologne.bsky.social

David Gerlach reposted

Do you have experience in bioinformatics and are looking for a new challenge? To immerse yourself in a group and institute doing highly diverse research? Then come and join our group !

Microbiome Research Lab, ETH Zรผrich@microbiomeresearch.bsky.social

๐ŸšจWe are hiring a Bioinformatician who will be embedded in our lab and work with members of the NCCR Microbiomes at ETH Zurich, as well as the Institute of Microbiology.๐Ÿšจ nccr-microbiomes.ch jobs.ethz.ch/job/view/JOP...

David Gerlach reposted

๐Ÿ”ฌ๐Ÿฆ ๐—๐—ผ๐—ถ๐—ป ๐˜‚๐˜€ ๐—ฎ๐˜ ๐˜๐—ต๐—ฒ ๐——๐—ญ๐—œ๐—™/๐—ฃ๐—˜๐—š ๐—๐—ผ๐—ถ๐—ป๐˜ ๐— ๐—ฒ๐—ฒ๐˜๐—ถ๐—ป๐—ด! We are excited to invite you to the joint Annual Meeting of DZIF & PEG: Explore how infection research is evolving in the age of antibiotic resistance, gender medicine, and precision medicine ๐Ÿ“… February 23โ€“24, 2026 ๐Ÿ“ Bonn ๐Ÿ”— Register now: t1p.de/dzif-peg-2026

David Gerlach reposted

Just a reminder ๐Ÿ”” that early bird registration for the VAAM Annual Conference 2026 in Berlin ends ๐Ÿ“†January 11 Register soon to save your spot and some money. Hope to see you there!

David Gerlach reposted

๐Ÿš€ We're hiring! We are offering several exciting #PhD & #postdoc positions spanning a range of topics, from jumbo phage biology & phage therapy to programmable RNA therapeutics & Fusobacterium nucleatum research. The application deadline is Jan 11. Learn more: www.helmholtz-hiri.de/en/jobs-tale...

helmholtz-hiri.deWorking at HIRIAt the HIRI, we do not just value excellent research. Short distances, an open door policy, and a good working atmosphereโ€”this is what distinguishes us from others. Have a look at our current jobโ€ฆ

Our popular science article (in German) with @simonheilbronner.bsky.social on the commensal and pathogenic struggles of Staphylococcus aureus

BIOspektrum@claudialudy.bsky.social

Spannendes zum Kampf von Staphylococcus aureus im Kampf mit dem nasalen Mikrobiom im Artikel von Simon Heilbronner und David Gerlach: www.biospektrum.de/system/files... @dger.bsky.social