We are looking for a Postdoc to join our lab at @oxfordbiochemistry.bsky.social. This is a dry-lab focused post on the computational analysis of long read single-cell sequencing data to understand the role of transposable elements (TEs) in early development. my.corehr.com/pls/uoxrecru...#TEsky
New preprint from the lab! We dig into the regulatory roles of TEs in the mouse placenta, with some surprising findings. Led by the awesome @smamante.bsky.social. Particular kudos to him for navigating the many twists and turns of the project.
📣We are looking for a Project Assistant to join my group at the Wallenberg Center for Molecular Medicine at Umeå University. Join us if you are interested in transposable elements, epigenetics and human brain aging. 🧠🧬 Dont hesitate to reach out with any questions! 📣
umu.varbi.com/en/what:job/...
Had an absolute blast presenting my “Last Minute Breakthrough talk” at #EMBOmobilegenome today! 🔥 What an incredible crowd, the energy in the room was unreal. Huge thanks to the organizers for selecting me and to everyone who came, asked questions, and made it such a fun session! 🙌
How do pluripotent stem cells resist harmful interferon responses to safeguard development? Through total epigenetic lockdown of ligands, sensors and effectors of IFN-I. In our preprint, James Holt shares his PhD discoveries on the ground state of immune evasion 😊: www.biorxiv.org/cgi/content/...
🌟Im happy to share that this winter I'll be starting my lab at the Wallenberg Center for Molecular Medicine at Umeå University! Excited to join the Department of Medical and Translational Biology as a Wallenberg Fellow and looking forward to new collaborations and cool transposon research 🤩 🧬
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
⚡⚡Excited to announce I'll be starting my lab at the Max Planck Institute of Molecular Genetics (@molgen.mpg.de) in Berlin in December! Leaving sunny California to join a fantastic environment with colleagues who do super cool work.
🔬🦠I'm hiring at all levels! 🔬🦠Check: www.molgen.mpg.de/fueyo-lab
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
Very happy to share our protocols paper for CELLO-seq. This will make single cell long read RNA-seq more accessible and provides analysis guidelines. We hope this helps the #transposon#TEsky community and folks working on #singleCell isoform and allelic #gene expression. doi.org/10.1038/s415...
We are looking for new colleagues to come join us in Galway as group leaders (Junior and Senior). The Centre for Chromosome Biology is a great place and it is a good time to join. Please reach out if you want to chat about the opportunity!
www.nature.com/naturecareer...
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Very proud of this work where we define how the MORC2 ATPase directs CpG methylation of active human L1 transposons in early development.
Thanks to co-authors, funders & wonderful environment @lundstem.bsky.socialwww.biorxiv.org/content/10.1...
Brief thread below (do people still do that?) 1/X
Second, the factor directing human L1 methylation in early development was unknown - a deletion in the ancestral promoter is thought to evade silencing by the KRAB-ZNF/TRIM28 system. We show MORC2 is critical here, at least for those most dangerous elements transcribed in the pluripotent state. 8/X
The work was led by my inspiring PhD student Fereshteh Dorazehi and ably supported by a team of wonderful scientists over many years! Fereshteh and I have presented/will present the story at some recent and upcoming meetings and are happy to hear feedback. For now it's time for summer holidays! 9/9
Very proud of this work where we define how the MORC2 ATPase directs CpG methylation of active human L1 transposons in early development.
Thanks to co-authors, funders & wonderful environment @lundstem.bsky.socialwww.biorxiv.org/content/10.1...
Brief thread below (do people still do that?) 1/X
Apart from relating human genetic L1 activation to a clear cellular phenotype in development cell models, we are excited about these results for two main reasons...
6/X
First, MORC2 ATPase mutations cause severe developmental disorders: we explain how ATPase activity is coupled to chromatin binding and CpG methylation patterning of different targets. That many of the hyperrepressed genes encode KRAB-ZNFs, themselves TE silencers, is conceptually fascinating! 7/X
Very proud of this work where we define how the MORC2 ATPase directs CpG methylation of active human L1 transposons in early development.
Thanks to co-authors, funders & wonderful environment @lundstem.bsky.socialwww.biorxiv.org/content/10.1...
Brief thread below (do people still do that?) 1/X
Explaining the persistence of these transcriptional phenotypes we found striking loss of CpG methylation over the youngest human- and hominoid specific L1s (including polymorphic alleles), and hypermethylation of gene promoters. 4/X
Very proud of this work where we define how the MORC2 ATPase directs CpG methylation of active human L1 transposons in early development.
Thanks to co-authors, funders & wonderful environment @lundstem.bsky.socialwww.biorxiv.org/content/10.1...
Brief thread below (do people still do that?) 1/X
We engineered mutations to figure out requirements of MORC2 binding to its distinct chromatin targets. Accumulation of MORC2 at L1s and other broad targets requires reversible ATP-dependent dimerization, whereas engagement of gene promoters does not. Mutation misdirects MORC2 onto promoters. 2/X
Modelling these effects in pluripotent stem cells, we observed loss of function (transcriptional activation) at L1s and gain of function (transcriptional repression) at promoters, an effect which persisted upon differentiation to neural progenitors. 3/X
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...
A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...
Lund University is offering 2-year visiting professorships (20% time) for full professors, with a deadline of August 17. Women are encouraged to apply. More info: https://lu.varbi.com/en/what:job/jobID:835541/#job
The call just opened!
ki.se/en/about-ki/...
You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics
ki.varbi.com/what:job/job...
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDNgithub.com/tobiaszehnde...
I am looking for postdocs to join my group at NIH. Are you interested in Development, Evolution, Genetics, Genomics, and Human health? Please apply! www.training.nih.gov/jobs/pdf-mb-...
Back at work full-time after six month parental leave with kid 2.
Spring blossoms out in Lund 🌸🌸🌸
Now on this new site and wondering if anyone is using it.
Hi! 👋
#transposons#epigenetics