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This one is fun! Check out my new episode of #QuiteCurious featuring Wolf Huetteroth @wolfhuette.bsky.social @northumbriauni.bsky.social talking about play-like behaviour in #drosophila flies. Listen here: linktr.ee/quitecurious
Ariel K. Frame
@arielframe.bsky.social
BSc Biology || PhD Neuroscience || Postdoc with Andrew Lin @andrewclin.bsky.social at University of Sheffield @sheffielduni.bsky.social || Drosophila, aging, learning and memory, neurobiology. Host: linktr.ee/quitecurious bit.ly/ArielFrame_GoogleScholar
1.2K followers418 following108 posts
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This one is fun! Check out my new episode of #QuiteCurious featuring Wolf Huetteroth @wolfhuette.bsky.social @northumbriauni.bsky.social talking about play-like behaviour in #drosophila flies. Listen here: linktr.ee/quitecurious
Ariel K. Frame reposted
🕷️💤 New paper in time for 🎃! Do #spiders really sleep? In our new study on #Portia fimbriata we tested all behavioural criteria of #sleep and found evidence for regulated, two-stage sleep with recurring REM-like stages. Out in @pnas.org! @roesslerdaniela.bsky.social 📄 tinyurl.com/3fky8ze7 🧵1/9
Ariel K. Frame reposted
PhD opportunity in our lab to investigate how the brain makes decisions. 4 year PhD through the BBSRC/MIBTP programme Interested in joining us? Please get in touch! ⏰ Application deadline: 23 November 2026 🔗 www.rezavallab.org #PhDOpportunity #Neuroscience #Drosophila
Ariel K. Frame reposted
Extra memorable episode! In this new episode André Fiala speaks about two #Drosophila papers, @cp-cellreports.bsky.social on higher order learning, and @biologyopen.bsky.social on how certain memories are not maintained through metamorphosis. Listen here: linktr.ee/quitecurious
Extra memorable episode! In this new episode André Fiala speaks about two #Drosophila papers, @cp-cellreports.bsky.social on higher order learning, and @biologyopen.bsky.social on how certain memories are not maintained through metamorphosis. Listen here: linktr.ee/quitecurious
Ariel K. Frame reposted
Looking forward to the Centro de Neurociencias Cajal International Symposium on #Drosophila Neuroscience on October 30 in Madrid with Bassem Hassan, Marta Zlatic, Dr Albert Cardona, Lucia Prieto Godino & Efthimios (Makis) Skoulakis. Register here: form.jotform.com/262652809189...
Seminal #drosopphila study alert! Excellent job turning over the assumption that #mushroombody odour coding is random! Definitely food for thought (pun intended)
Our paper on odour categorization in the Drosophila mushroom body is now out in Cell Reports! 🎉 We found that αβ and α′β′ Kenyon cells—but not γ KCs—distinguish food-related from non-food odours at the population level. Very happy to see this work published! 🪰🧠 doi.org/10.1016/j.ce...
Sometimes it’s nice not only for researchers of #translational #science but also #fundamental science to think about #bioethics and #neuroethics. For both, I highly recommend listening to this great #debate hosted in #canada this month on #geneticengineering humans. overcast.fm/+ABXrnvGn9BU
@asparatics.bsky.social is this the right way to study a disease? @tspiresjones.bsky.social any idea how synaptic changes could explain such immediate effects of this surgery (if real)? @elisabethbik.bsky.social any funny business? Interested in your thoughts folks. High reward with this risk
This controversial surgery for Alzheimer's patients aims to improve drainage of fluid from the brain. What do we know about it? go.nature.com/4zsxmfM
Every day we get closer and closer to plug and play #behaviour analysis. Nice GUI on this one. Would be better with compatibility for multiple animals simultaneously. But, still very glad to see developments like this, which helps facilitate analysis using low power computers. Useful.
SqueakPose Studio, an end-to-end platform for pose estimation and real-time edge-AI deployment
Ariel K. Frame reposted
Social behavior and activity are decoupled in larval and adult fruit flies academic.oup.com/beheco/artic...
Ariel K. Frame reposted
Researchers identify new target in the gut for reducing Alzheimer’s risk news.wisc.edu/researchers-... #Alzheimers #dementia #science #neuroscience #NeuroSkyence
Ariel K. Frame reposted
What do the earliest organisms tell us about where life began on earth? This fantastic paper addresses this issue through analyses that expose early metabolism, & what the environment contributed to kick start it. Even if wrong it is worth reading for the clear introduction to metabolism.
Ariel K. Frame reposted
Neurons and Glia Exhibit Distinct Age-Associated MitoTimer-Based Mitochondrial Dynamics in the Drosophila Mushroom Body Calyx #micropublication #biology #data #caltechlibrary #Drosophila #Undergraduat https://micropublication.org/journals/biology/micropub-biology-002249
Ariel K. Frame reposted
We looking for a postdoc with NHP electrophysiology experience to do simultaneous Neuropixel recordings across the corticothalamic motor circuit to better understand the neural control of reaching and grasping. We start looking at applications on August 31st. docs.google.com/document/d/1...
Newest episode of Quite Curious featuring Mikko Juusola! We talk about #electrophysiology in eyes of #flies Musca domestica showing #synapse jumping at such high frequency that it brings into question what the minimum delay is between sensing and reality. Take a listen! linktr.ee/quitecurious
Ariel K. Frame reposted
What does it really take to land a faculty position? @jazlynmooney.bsky.social shares insights on preparing competitive applications, navigating interviews, building a research vision, and more. 🔗: buff.ly/nLWXT9m
Ariel K. Frame reposted
Phenomena such as blindsight remind us that intelligent, even emotionally attuned behavior does not imply conscious experience or genuine agency, write Vanessa Hadid, @karimjerbi.bsky.social and John W. Krakauer. #neuroskyence www.thetransmitter.org/artificial-i...
#Drosophila #neuroscience researchers you still have time to make it for early bird registration and abstraction submission deadline for #neurofly 2026 - it’s June 7th. neurofly.org See all you #fly folks there!
This is really bad for #science. It’s vital for #researchintegrity that scientists commit to ensuring all citations are real & correctly cited. If AI finds papers, it’s crucial to double check them. www.thelancet.com/journals/lan...
Surge in fake citations uncovered by audit of 2.5 million biomedical science papers. An analysis of 97 million citations has found that rates of fabricated citations have climbed steeply since 2023. www.nature.com/articles/d41...
Ariel K. Frame reposted
Mitochondria-lysosome coupling contributes to lysosome acidification and aging: Molecular Cell www.cell.com/molecular-ce...
Ariel K. Frame reposted
Fuck no. medicalnewsbulletin.com/mosquitoes-c... 🧪 #evosky 🩸🧪 medsky, 🩺,⚕️ #Neuroscience, #Neuroskyence SciNews
Sounds like a very useful new method to me! I’m always intrigued by new and improved balancers too. I think I might even go ahead and order your new 4th balancer from @bdsc.bsky.social now! BDSC #90851 + #90852
Chasing donor backbone insertions in #CRISPR knock-in experiments is a great way to waste an afternoon (or more), unless you use a dominant marker. We like this one from the Carthew lab, in which animals containing the backbone have degenerated eyes: www.tandfonline.com/doi/full/10.... #Drosophila
Correction: Seems to be a mistake in either the paper or how BDSC ended up cataloguing these lines. BDSC #90851 is not listed as GATeya/CrkdsRed by BDSC, it says it is CrkdsRed/ci. BDSC#90850 is listed by BDSC as GATeya/CrkdsRed. @crisprflydesign.bsky.social
Calling #Drosophila #neuroscience researchers! Listen to @andrewclin.bsky.social @sheffielduni.bsky.social speak on 2 @jphysiol.bsky.social fly papers: #brain #mushroombody #homeostaticplasticity, #genetic #neuron tools, NaChBac advice, & #mathematicalmodelling tiny.cc/qcu2 #sciencecommunication
Ariel K. Frame reposted
This is another one of those studies I really want to hear the story behind. You don't just go "I wonder, what would happen if we keep some fruit flies at 7Gs for a while?" 🧪 (They don't like it first, but seem to adapt) Link: https://doi.org/10.1242/jeb.251327
Ariel K. Frame reposted
Selecting an effect size for power analysis is hard. Many researchers fall back on Cohen's thresholds, but they have no empirical basis and vary wildly by field. Our new paper offers a better option: field-specific effect size distributions built from meta-analytic data doi.org/10.3758/s134...
Ariel K. Frame reposted
PhD Opportunity! 4-year funded PhD @uniexecec.bsky.social: “From cognition to conservation: using cognitive and behavioural research to enhance animal reintroductions”. Closes: 5 June 2026. Funding: @royalsociety.org (UK/Home students only). More info & to apply: www.exeter.ac.uk/study/fundin... 1/
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Beyond delighted to share our amazing collaboration with Thierry Alquier's lab @alquierthierry.bsky.social on a conserved role for neuronal lipid droplets in regulating energy homeostasis in vivo led by Celena Cherian, Romane Manceau, Danie Majeur, and Colin Miller www.nature.com/articles/s42... /1
Ariel K. Frame reposted
What do The Bee Gees and bumblebees have in common? Both bees have rhythm!🕺🪩🐝 check out this new paper where authors show that bumblebees can discriminate rhythms across sensory modalities! www.science.org/doi/10.1126/...
Ariel K. Frame reposted
I nearly died when @tspiresjones.bsky.social and @janetulloch.bsky.social surprised us with this complete *YEAR LONG* study at our lab meeting. academic.oup.com/braincomms/a...
Ariel K. Frame reposted
In this new study, @dogagingproject.bsky.social identified overlapping metabolites linked to a subset of dogs and human mortality, supporting dogs as a compelling model for studying human aging. doi.org/10.1093/gero... @academic.oup.com
Ariel K. Frame reposted
Very cool! Useful tool for #Drosophila folks. Would be great adopted by whole labs / institutions. Considering it's newness, add features? Tinkering & I don't yet see: 1) Retrospective dating / bulk stock flipping 2) Stock acquisition date 3) Column sort by chromosome 4) Reference usage citation
We just launched flyRoom — modern web-based stock management for Drosophila labs. No more spreadsheets, no more messy labels, no more lost stocks. Free to start, built by researchers for researchers. www.flyroom.net
Ariel K. Frame reposted
Ariel K. Frame reposted
Ariel K. Frame reposted
Conflicting adaptations in an inhibitory feedback circuit #Drosophila
I love these micropublications. Great way to disseminate small but impactful findings. This #drosophila study shows glutamate neurons w/ reduced ATP production related #mitochondria protein causes more day #sleep at young and after #aging. Could this explain lifespan extension (Keppley et al. 2018)?
Reduced expression of the electron transport chain component ATPsynβL in glutamate neurons changes Drosophila melanogaster sleep patterns through adulthood. #micropublication #biology #data #caltechli https://micropublication.org/journals/biology/micropub-biology-002033
Thank you so much for generating these lines! Exciting new tools for #drosophila optogenetic activation of the Gal4 UAS system! Drosophilists rejoice: here’s the list of lines->
#Drosophila calling. Delighted to share our new collection of ShineGAL4 drivers for CNS, FB, muscles, enterocytes, oenocytes and MTs made by @vgirard.bsky.social, @sebsorge.bsky.social and colleagues @crick.ac.uk. All at Bloomington @bdsc.bsky.social @dev-journal.bsky.social tinyurl.com/4jpw9jd6
For all #Drosophila #neuroskyence researchers that have explained to someone, yes #insects have #brains: Here is @scottishwaddell.bsky.social & Annie Park's excellent argument for four 'cognitive primitives' underlying fundamental brain function conserved from humans to flies. tiny.cc/4cog
I’ve really been enjoying this podcast since it started a few months ago: The Rest is Science. tiny.cc/restsci Professor Hannah Fry and VSauce's Michael Stevens are amazing at #sciencecommunication Highly recommend! Even better: partners with a good cause @cancerresearchuk.org
Ariel K. Frame reposted
This is a superb explanation of why we age from an evolutionary perspective, packed full of fun animal examples! It makes clear that evolution *did* optimise for lifespan (why wouldn’t it?), and that implies intervening in aging might not be that hard…
Ariel K. Frame reposted
MRC Laboratory of Molecular Biology Cambridge seeks a Postdoctoral Researcher to develop amyloid filament methods using cryo EM to study tau neurodegeneration. Closing date: 4th January www.dementiaresearcher.nihr.ac.uk/job/postdoct...
Ariel K. Frame reposted
@nature.com asked me to write an op-ed on the perspective of the AI reviewing process, prompted by the recent partnership between @biorxivpreprint.bsky.social and @qedscience.bsky.social Hope my perspective adds value to the conversation. www.nature.com/articles/d41...
Ariel K. Frame reposted
Encased in a blanket of blubber that is nearly half a metre thick, the 80,000-kilogram bowhead whale does not, at first glance, seem a natural poster child for health and longevity go.nature.com/4qTyrcz
Ariel K. Frame reposted
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government go.nature.com/47hn0n5
Ariel K. Frame reposted
PhD studentshipship available through @swbiodtp.bsky.social! This project will take advantage of an incredible RNAseq dataset we are generating using 40 species and multiple infection types to learn how immune systems evolve. For more info, see: bit.ly/43zNa20 #Drosophila #Immunity
Ariel K. Frame reposted
Two weeks left to apply for a PhD position in my laboratory at #Glasgow. The project focuses on #Ageing, #Mitochondria, and #Drosophila, with emphasis on Complex I (CI) function. Fees are fully covered for applicants eligible for UK Home Student status. www.findaphd.com/phds/project...