Amelie Stein

10/10 no notes

Academia in a nutshell

Big congratulations to Aleksandra Panfilova who defended her PhD last week! Aleks has been teasing apart models of protein interactions and consequences of mutations on these, preprint coming soon! She’s now looking for new opportunities in Estonia, so reach out to hear if you’re hiring 😊

Annika raises many good points about the challenges with (not) “just putting the slides online”

So looking forward to this meeting!

Junior professor position at the University of Kaiserslautern! Our Department of Biology is seeking a colleague working with microalgae. This is a wonderful place to do wonderful science with great people! Please, repost :) Further details: jobs.rptu.de/jobposting/1...

T’is the season When I scrape ice Off my saddle

🧵 Thread👇 Heute Nachmittag im Fokus: Wissenschaftliche Karrierewege An der Uni wird oft nur das Karriereziel Professur diskutiert, aber der Weg dahin ist schwer, wenig planbar und die anderen Berufsoptionen sehr vielfältig (und zumeist sogar besser).

I lament all the research and writing I never got to do because I was too busy fighting sex pests and institutionalized misogyny

Adding citations of people who might review the paper

One of my science heroes, Joan Brugge, talks about how science funding cuts are slowing their work on breast cancer prevention--share this widely www.facebook.com/60minutes/vi...

Fall is beautiful, even on gray days 🍂 🍁

My 11yo is more active in her Teams chats than I am in mine.

Danish design cup

Looks like OpenFold3 has been formally released in a public "preview". Not quite on parity with AlphaFold3 on a few benchmarks shown, in particular for antibody interactions. All info on the github link. I am sure we will hear more about this from the developers github.com/aqlaboratory...

The UNC Department of Biology is seeking a Director of Biology Teaching Labs, a key leadership role overseeing our undergraduate laboratory program. 1/n Learn more and apply here: unc.peopleadmin.com/postings/308...

I have a very bad feeling about this...

Alternatively, lads, might be worth thinking about supporting the German car industry to remain viable in the future rather than locking them into a dying business model. But sure, you go off...

Kiel

As I tell my students, if you arrived at a simple answer in biology you have done one of two things: arrived at the wrong answer or asked the wrong question

Kindergarten teacher asks what I teach (biological sequence analyses), I try to explain. She turns to the 3yo and asks „What do you want to be when you grow up?“ Prompt and confident answer: „A butterfly 🦋!“

The proteasome-substrate-shuttle protein UBQLN2 contains—like other quality control system proteins—a long region devoid of lysine (a lysine desert) Martin Grønbæk-Thygesen (from @rhp-lab.bsky.social) et al show that introducing K here causes ubiquitylation and degradation doi.org/10.1101/2025...

For every Nobel that goes to a criminally under-recognized woman scientist (Brunkow, Karikó), or fails to go (Candy Lee), a week of mourning and reform for an academic system wherein you can do Nobel-prize-worthy-work and still end up without a conceivable path to being a professor.

Fun & action the local science museum #experimentarium

This October I’m drawing one molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 2/31 Prompt WEAVE N-terminal domain of a Fibrion - a building block of silk fiber produced by silkworms. Pdb: 3UA0 Next prompt is CROWN and I would love your suggestions!

Some interesting thoughts on the Perspective Harper Raiken and I wrote over the summer

I don’t know who wrote this, but it’s absolutely perfect

Why are transcription factors disordered? Come join us in Oxford as a postdoc and we'll find out together! Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays! biophysics transcription protein:DNA interactions my.corehr.com/pls/uoxrecru...

Recruiting the next generation of bioinformatics students

We’re recruiting a PhD Fellow in Computational Systems Immunology. Work on large-scale immune receptor datasets and develop computational models in close collaboration with experimental labs. Apply here: www.jobbnorge.no/en/available...

Job opportunities at an absolutely amazing place for molecular biology 🧫

Almost done, just need to add a bit of background.

Different supervision task today 🍿

Deadline extended - last chance, second edition!

Cool project with the Pless lab on disease-associated variants in a membrane protein, NALCN, that needs to be in complex to function. Most of our computational work was done by PhD student Aleks Panfilova.

Interested in structural biology, membrane proteins, biophysics and working to understand hormone transport in plants?☘️🔬👩‍🔬🧪 We have an open PhD position: - 3 years fully funded. - Details and application link: www.linkedin.com/posts/plant-... Please repost 💚

The journal version of "Biophysics-based protein language models for protein engineering" with @philromero.bsky.social is live! Mutational Effect Transfer Learning (METL) is a protein language model trained on biophysical simulations that we use for protein engineering. 1/ doi.org/10.1038/s415...

🎯

🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬 Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...

One of those days when Copenhagen is trying to play San Francisco 🌫️ Fortunately we got to keep the trains.

"We can and should reject that AI output is ‘good enough,’ not only because it is not good, but also because there is inherent value in thinking for ourselves."

BIG NEWS!! We will be hiring a new professor with 25 years of endowed funding at the @biozentrum.unibas.ch @unibas.ch, focused on using biophysics and structural biology to explore climate-related fundamental science topics. Come start an innovative research cluster with us! 🧪🔬🧶🧬🌾🌍

Successfully taught my first bioinformatics class in Danish 🇩🇰 Based on feedback, the most helpful bit was rather language-Independent, when I said that affine gap scores are kinda like Affinity in Magic The Gathering 🧙‍♀️ 📜