Albert Pol Lab

Our group investigates the role of #lipid droplets (green) in killing intracellular pathogens (blue, E coli in human macrophages) when they are searching for nutrients. In our family we have nicknamed them defensive lipid droplets and FATal attraction. Credit @robparton.bsky.social @UQpress

Cripes. The ERC StG success rate is expected at around 5% this year: 373 grants for 7710 applications. Research strategies across the EU are shaped around securing ERC grants. But with such low odds, aligning national or institutional priorities with ERC objectives becomes a deeply flawed strategy.

Curious how lipid droplets support innate immunity in our cells? Check out our lipidomics by Bosch et al @cp-cellreports.bsky.social! Critical role of LD phospholipids and lipases in supplying defensive w6 arachidonic acid for inflammation and bacterial phagocytosis. www.cell.com/cell-reports...

Curious how lipid droplets support innate immunity in our cells? Check out our lipidomics by Bosch et al @cp-cellreports.bsky.social! Critical role of LD phospholipids and lipases in supplying defensive w6 arachidonic acid for inflammation and bacterial phagocytosis. www.cell.com/cell-reports...

Dysfunction of #caveolae in muscle disease: a cell biological perspective. From Harriet P. Lo, Robert G. Parton and colleagues (The University of Queensland) rupress.org/jcb/article/... #Organelles #Development #Membrane #lipid #Disease #SkeletalMuscle

this year, I have received nearly 40 articles to review (for free). While I find the idea of ​​publishers creating dozens of new journals to line their own pockets questionable, the fact that they take advantage of the scientist’s good faith strikes me as downright exploitative. Any fair solution?

New pre-print from the lab! Host lipid droplets coordinate the synthesis of defensive PUFAs and become PUFA reservoirs and suppliers that mediate inflammation, bacterial phagocytosis, and elimination of microbes. Have a look www.biorxiv.org/content/10.6...

www.biorxiv.org/content/10.6...

New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social‬ 🙌 @IBECBarcelona www.biorxiv.org/content/10.1...

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...

Tenure track position alert! Assistant Professor of Molecular Therapeutics in MCB @UCBerkeley. Apply and come be our colleague! 🎉 aprecruit.berkeley.edu/JPF05098

💥 A gut microbe metabolite that drives #atherosclerosis? Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol. 🧪 We show the pathway—and how to block it. nature.com/articles/s41... #OpenAccess at @Nature @CNIC_CARDIO #CVD #immunosky #cardiosky #microbiomesky

Journal of Cell Science is published by a not-for-profit charitable organisation (@biologists.bsky.social) that exists to benefit science, not shareholders. We provide Travelling Fellowships, Training Grants, support for ECRs and more. For details, visit: journals.biologists.com/jcs/pages/re...

Congratulations to newly elected @embo.org members Special shout out to friends & colleagues: Andy Oates, Jody Rosemblatt & Pete Currie Outstanding life scientists elected to the EMBO Membership – Press releases – EMBO share.google/9z7IS2lZBmll...

Well what do you know!? This might be the most interesting unorthodox orthodox metabolism paper this year.

The #MembraneTrafficking online seminars are back this Thursday (June 26th, 5pm CEST). We'll hear from @jnuechel.bsky.social about how to find the right partner for a TANGO, and from Maohan Su about the organizational principles of the Golgi. @ishier.bsky.social @franbottanelli.bsky.social

Happy summer!! A new issue of #cebooc is here! Read the latest paper on oocyte cell biology here: biomed.news/bims-cebooc/... Thanks @biomednews.bsky.social for preselecting!

Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia. Brief Skytorial! 1/9

What an inspiring morning at the CatCat Symposium! Thank you so much for inviting me @gallegolab.bsky.social and @felixmendu.bsky.social, it's been a pleasure visiting you in Barcelona 😊

Pleased to see Kevin's paper on the Retromer complex interaction with yeast Vps5 and Vps17 proteins now online!

We are looking for a PhD candidate starting on the 01-10-2025. The project aims to understand how the host cells use copper and oxidative species to fight Salmonella infection and how this pathogen evades this antimicrobial response. SHORT DEADLINE ! 20-04-2025 jobs.inrae.fr/en/ot-25517

Our paper on the regulation of the tight junction leak pathway by Arhgap12/N-Wasp is out ! www.cell.com/cell-reports...

Did you know… It’s free to publish in Journal of Cell Science – there are no submission charges, page charges or colour fees. We also plant a tree for every peer-reviewed article we publish🌳 For details, visit our website: journals.biologists.com/jcs/pages/re...

Together with @gallegolab.bsky.social we are organizing the next CATCAT morning on "Dynamics in biology, from molecules to tissues", with an amazing lineup of local and international speakers. If in Barcelona on May 26th, don't miss it, it's free! www.catcat-celltissuebiology.cat/event/9th-ca...

A Postdoctoral Research position is available in the group of Lipid Trafficking and Disease (@idibaps.bsky.social Barcelona) to participate in the ERC granted project ‘Lipid droplets as innate immunity hubs’. @albertpol.bsky.social @albertherms.bsky.social focalplane.biologists.com/cell-biology...

Looking for a PostDoc? Exciting science and great city! Join us @albertpol.bsky.social @albertherms.bsky.social in @idibaps.bsky.social Barcelona to work in an @ercresearch.bsky.social funded project to study how lipid droplets attract and kill bacteria. www.clinicbarcelona.org/uploads/medi...

What are 26 different Rab GTPases doing on Lipid Droplets? Are lipids transferred by membrane contact sites? Moving the FAT: Emerging roles of Rab GTPases in the regulation of lipid droplet contact sites M Alonso @albertpol.bsky.social and Harriet P Lo www.sciencedirect.com/science/arti...

What are 26 different Rab GTPases doing on Lipid Droplets? Are lipids transferred by membrane contact sites? Moving the FAT: Emerging roles of Rab GTPases in the regulation of lipid droplet contact sites M Alonso @albertpol.bsky.social and Harriet P Lo www.sciencedirect.com/science/arti...

this is how it feels to reach 30 MILLION users!!!

JCS Editor-in-Chief @drmichaelway.bsky.social introduces our new Associate Editors. We are delighted to welcome Sophie Acton @actonlab.bsky.social, Pedro Carvalho, @guijacquemet.bsky.social, @ckirchhelle.bsky.social and Aryeh Warmflash to the JCS team. journals.biologists.com/jcs/article/...

This is just a reminder that the #cancermetabolism and #mitochondrialbiology community is ever-growing, and the third starter pack is becoming very juicy. Starter pack 1: go.bsky.app/VavECSX Starter pack 2: go.bsky.app/CH1MctZ Starter pack 3: go.bsky.app/7Uwa6fb

Zebrafish Ph.D scholarships available in Brisbane, Australia #zebrafish 2 PhD positions are available under the supervision of Dr Thomas Hall and Dr Harriet Lo at the IMB, University of Queensland, Brisbane, Australia with negotiable start time during 2025 Further details in the thread below

Check out this preprint from collaborator Lance Johnson @johnsonlab.bsky.social and team characterizing the APOE3 vs E4 #LipidDroplet -ome! Some interesting Easter eggs in there 🐇🥚😉

#PaperAlert we bring wonderful news about @WAutophagy ... our Mericka McCabe and our founders just published a @NatureCellBio article explaining the wonders of our Network...don't miss a bit!! With very valuables testimonials of our volunteers... rdcu.be/d10N6

Good Sunday. This weekly summary of papers in #cancermetabolism and #mitochondrialbiology is full of exciting discoveries. Check it here: biomed.news/bims-camemi/... @biomednews.bsky.social "The greatest obstacle to living is expectancy, which hangs upon tomorrow and loses today."-Seneca

Interested in #organelle biogenesis, subcellular #membrane #protein targeting or #LipidMetabolism? We are hiring! #PhD student or #postdoc. We combine #Biochemistry & #CellBiology with Computational Modeling & Experimental Physics / Physical Chemistry approaches. #research #academicsky #AcademicJob

I am honored to be named a 2024 Distinguished Investigator in #Organelle Communication! I'm especially excited to work with Assaf Zaritsky and Shalin Mehta to image and model organelle interactions throughout differentiation alleninstitute.org/division/fro...

🆕A 3D culture system makes it possible to simulate the behavior of epithelial tissue This technique is an key step forward in understanding how mutations expand in tissues as we age @albertherms.bsky.social @albertpol.bsky.social @hospitalclinic.bsky.social www.clinicbarcelona.org/en/news/a-ne...

Proud of @albertherms.bsky.social and this amazing paper in nature genetics! Super useful 3D organoids! Have a look 👇 @idibaps.bsky.social www.clinicbarcelona.org/en/news/a-ne...

christoph: Q did andela mention this 👇 or is she already miles ahead of it? (she's not on 🔵bsky ?) I was so fascinated by this paper! pubmed.ncbi.nlm.nih.gov/34983838/

Reflecting on the power of friendship and collaboration in science—it's been three months since publishing this work with Christophe @christlet.bsky.social and still absolutely thrilled about it! 🔬

Are you a scientist working or interested in RNA Translation? Join our starter pack and share ideas, methodologies and tips to advance our knowledge in how life came to be! #RNA #ribosome go.bsky.app/VN78eTo

Our latest paper with @brettcollins.bsky.social is on bioRxiv. Fantastic work driven by Carlos Anton-Plagaro with unbelievable help from Kai-en Chen in Brett’s lab. A data-rich study with lots of new insight into Retromer, Retriever and potential AD/PD connections. www.biorxiv.org/content/10.1...

For my first post on Bluesky, here is our BioID map of RAB GTPases! It was a collective effort from many in the lab initiated by Benoît, Raphaëlle, and Dominique and followed up extensively by Véronique! I'll happily share the associated data if anyone is interested. www.biorxiv.org/content/10.1...

Obesity-dependent selection of driver mutations in cancer - Nature Genetics 🧪 www.nature.com/articles/s41... Congrats to Ed Reznik & colleagues

Woohoo! The JCS Special Issue on Imaging Cell Architecture and Dynamics is complete, featuring our poster on ‘Imaging interorganelle contacts at a glance”!