Adlung Lab

🚨 New paper out today in Nature Microbiology! During my postdoc we explored how the gut microbiome of people living with HIV impacts immune function and susceptibility to opportunistic infections. 🧵 1/10

Mechanistic study in @cp-cell.bsky.social showing how sex hormones lead to gut bacteria producing bile acid-derivate implied in chronic liver disease: www.cell.com/cell/fu... 🧪

Very smart approach, I'll definitely try it out (and encouraged my group and others to do so, too!) Congrats, Florian!

Wonderful perspective in Cell Metabolism discussing the immune-regulatory functions of adipocytes. For me, current literature draws a more and more coherent and stunning picture with respect to anti-microbial defence: www.cell.com/cell-me... 🧪

I was very humbled to meet Ada several times during my life in Israel and also afterwards at #LINO23. She was a true idol in terms of dedication and thoroughness for me as a non-academic lower working-class man. May her memory be a blessing. www.nature.com/artic... 🧪

We are trying to understand what's going (wr)on(g) in the liver through non-invasive monitoring of peripheral blood. A new paper in Cell Systems shows that the liver explains more plasma protein variation than any other organ: www.cell.com/cell-sy... 🧪

I really wonder why people use these AI tools journals offer to summarise the main findings of a research paper instead of just reading the abstract?

Cool Science Advances paper on the effects of regular exercise on immune cells in the human peripheral blood: antigen-presentation is enhanced. While (auto)inflammation is tamed down, there's increased epigenetic preparedness of cytotoxic T and NK cells: www.science.org/doi/... 🧪

Such a neat implementation of a straightforward idea to learn functional features of perturbed mitochondria from time-resolved light-sheet microscopy data in @cp-cell.bsky.social www.cell.com/cell/fu... 🧪

This (abstract and editor's summary) reads like a super cool paper combining ideas of quorum sensing in macrophages with metabolic control. Can't access it in full on the train but looking forward to reading it: www.science.org/doi/10.1126/... 🧪 Congrats @nicolasavilalab.bsky.social

Really cool example from my good friends @weizmann.ac.il of how extracellular matrix and intestinal stem cells are implied in wound healing processes relevant to inflammatory bowel disease: www.cell.com/immunit... out now in Immunity 🧪

Weizmann Institute researchers discover that transient intestinal inflammation can leave irreversible changes in the gut lining, leading to Crohn’s disease and ulcerative colitis. The findings point to new directions for treatment and early detection >> bit.ly/gut-remember...

I don't like that they're opening up the competition to industry while restricting "openness" of the code and the science... Still a great challenge. We also host a team at @uni-hamburg.de

Interesting mechanistic study in Nature Metabolism showing that macrophages in brown adipose tissue release itaconate to suppress succinate uptake and in turn thermogenesis in brown adipocytes: www.nature.com/artic... 🧪

Learn spatial transcriptomes (of >4k genes) from HE slides only! www.nature.com/artic... @natcomputsci.nature.com 🧪 I'll have to try this for some of our Visium data.

Great review by Fawaz Alzaid ... Florent Ginhoux in Immunity on metabolic inflammation, obesity and cancer. Confirmed that macrophages are metabolically remodelled in the obese tumour microenvironment impacting carcinogenesis: www.cell.com/immunit... 🧪

That's a very smart idea to experimentally address one of the most concerning bottlenecks in the field! Thanks for sharing, @labwaggoner.bsky.social. I'd have missed it otherwise.

Great Nature Career piece on the "lottery" aspect of grant decisions, its pros and cons. Still liked the VolkswagenStiftung approach! www.nature.com/artic... 🧪

What would David Hilbert say about challenging problems with AI in cell biology? Read it in @cp-cell.bsky.social: www.cell.com/cell/fulltex... 🧪

Very cool name (scRICH), very cool approach to infer cell-cell communication and related pathway activities from scRNA-seq data: www.cell.com/cell-systems... 🧪 from Federico Bocci @rimls.bsky.social in @cp-cellsystems.bsky.social

Nice work from our good friends from @uni-kiel.de in @cp-immunity.bsky.social: Th17 restricted to just a few proteins in fungal extracellular vesicles from C. albicans. These Th17s are shared between oral and intestinal mucosa, adapting in Crohn's. www.cell.com/immunity/ful... 🧪

Really cool paper @embojournal.org showing the trade-off between oxidative phosphorylation and anti-microbial peptide (AMP) production in murine intestinal Paneth cells: link.springer.com/article/10.1... 🧪

I'm trying to catch up with my reading, this is definitely a good one: "Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning" from the great @priscaliberali.bsky.social www.cell.com/cell/fulltex... 🧪

As an alumnus, I just opted in to serve as a reviewer to @gso-forresearchers.bsky.social for the #KTBoostFund. Looking forward to reading (yes, I read, and I enjoy it...) your applications!

"Journal-based metrics should not be used as surrogate measures of the quality of individual research articles, or to assess scientists in hiring, promotion or funding." Everyone says so, but who acts after it? via @paulbrainey.bsky.social academicrenewal.substack.com/p/when-acade... 🧪

"This work identifies EP2 signaling in tissue-resident macrophages as a central regulator of organ-wide aging through its control of senescent neutrophil clearance, reframing aging as a failure of active cellular clearance rather than passive degeneration." www.science.org/doi/10.1126/... 🧪

Great review on the discovery of antimicrobial peptides and other novel antibiotics. Thanks for sharing. #WeeklyRead 🧪

Very happy to see this out - made a humble contribution analyzing some sequencing data to see our hypothesis confirmed in vitro and in a human cohort. 🧪

Uncertainty-quantification in neural ODEs: www.nature.com/artic... 🧪

Crazy mechanism: Spiga et al. show how the toxin BFT reprograms colonocytes to fermentation, raising lactate and oxygen so anaerobic Bacteroides fragilis can grow oxidatively in the inflamed gut. Broad Institute @cp-cell.bsky.social doi.org/10.1016/j.ce... 🧪

We worked on ChREBP, we work on aging. Now Hager et al. (@umich.edu) report opposite ChREBP regulation in liver and brown adipose tissue of five mouse models with extended longevity, indicating tissue specific lipogenesis contributes to aging. American Aging Association doi.org/10.1007/s113... 🧪

🚀 What an amazing #SBMC2026! From inspiring welcome addresses, to the MTZ Award ceremony, scientific sessions, panel discussion, poster sessions, and Poster Awards — thank you to everyone who made these three days so special. Wonderful science, great discussions, and even better networking! 📸✨

It's been a while, but now I want to start over: Li et al. find oxytocin signaling in maternal adipocytes is required for milk fat production! Oxtr deletion impairs milk triglycerides and offspring growth. @bidmcreseach.bsky.social Cell Metabolism doi.org/10.1016/j.cm... 🧪

I was really delighted to attend the talk from @mathonco.bsky.social at the 10th conference on systems biology of mammalian cells (SBMC) by @lisymcancer.bsky.social in Mannheim yesterday. Paul, you’re a true role model, and I definitely had the good-coding vibe after your presentation. Thank you!

Was really cool to give a "triplet talk" with my clinical partners last week at the Danish Diabetes and Endocrine Academy

😦 I gave this to DeepL: Our core international scientific collaborations span Israel, Poland, Sweden, the UK, Switzerland, Austria, France and the US. What came out: Our core international scientific collaborations span Israel, Poland, Sweden, the UK, Switzerland, Austria and France.

I just read a first article from the new Cell Press Blue journal: Zhang et al. (University of Georgia) identify conjugated PUFAs as lipid senolytics that exploit ferroptosis to selectively eliminate senescent cells and extend healthspan in aged mice doi.org/10.1016/j.cp... 🧪

Was very stimulating to attend the "Mathematical statistics" colloquium @uni-hamburg.de today with Ivo Sbalzarini from @mosaicgroup.bsky.social on Data-Driven Inference of Self-Organization and Shape in Living Systems. I learned that the developing embryo behaves like an active liquid crystal! 🧪

Tens of thousands of publications from 2025 might include invalid references generated by AI, a Nature analysis suggests. #ResearchPublishing #Academicsky 🧪

Start Good Friday right: With intestinal tuft cells that refresh immune memory to prepare for parasite re-infection by Jakob von Moltke in Immunity www.cell.com/immunit... 🧪

Today I was very excited to be invited to give a talk at this year's SBMC in Mannheim, Germany. The conference has a strong focus on biomedical AI and eHealth, so please come join us, and spread the word: www.lisym-cancer.org/sbmc2026 🧪

Scanpy and Seurat produce (slightly) different results when analysing the same scRNA-seq data. Lior Pachter thoroughly quantified differences in Cell Systems and rightfully concluded that we need max. transparency for max. reproducibility: www.cell.com/cell-sy... 🧪

Today I was very excited to be invited to give a talk at this year's SBMC in Mannheim, Germany. The conference has a strong focus on biomedical AI and eHealth, so please come join us, and spread the word: www.lisym-cancer.org/sbmc2026 🧪

Impressive Science Immunology paper from Hélène Moreau Inserm showing that macrophages regulate extracellular matrix remodelling in the tumor microenvironment and Tcf4 and Col3a1 are indicative of T cell and neutrophil infiltration: www.science.org/doi/... 🧪

In a meeting yesterday, someone said: "Quick-and-dirty approaches are usually just dirty" – and I thought this was great sentiment.

Online now: Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or function in obese mice and humans