๐งต My former office mate and esteemed colleague Anna Huhn has co-authored a groundbreaking study in @naturecomms.bsky.social. ๐ฆ We're talking viruses and antibodies! 1/5
Post
๐งฎ Supervised by Omer Dushek (with the fantastic handle @tcell.bsky.social), they've tackled a longstanding immunology question: โฐ Why does viral neutralization by antibodies sometimes fail to correlate with their antigen-binding affinity? 2/5
๐ Using a mathematical model & experiments, they showed that antibodies with greater molecular reach are significantly more effective in neutralizing SARS-CoV-2, even when binding affinity is identical. ๐ This discovery underscores the importance of spatial dynamics in antibody function. 4/5
0 reposts5 likes
๐ Dive into this fascinating work here: doi.org/10.1038/s414... . ๐ Kudos to Anna Huhn et al. for this remarkable contribution to basic immunology! ๐งช 5/5
doi.orgThe molecular reach of antibodies crucially underpins their viral neutralisation capacityNature Communications - Researchers developed an accurate model to analyse bivalent antibody binding. By analysing many SARS-CoV-2-specific antibodies, they found that their molecular reach can...