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Adlung Lab
@adlunglab.com

šŸ§® Supervised by Omer Dushek (with the fantastic handle @tcell.bsky.social), they've tackled a longstanding immunology question: ā° Why does viral neutralization by antibodies sometimes fail to correlate with their antigen-binding affinity? 2/5

Adlung Lab
@adlunglab.com

šŸ–„ļøšŸ§¬ Their research introduces a novel metric, molecular reach, i.e., the maximum antigen separation that still allows bivalent antibody binding. 3/5

Adlung Lab
@adlunglab.com

šŸ”„ Using a mathematical model & experiments, they showed that antibodies with greater molecular reach are significantly more effective in neutralizing SARS-CoV-2, even when binding affinity is identical. šŸ“ This discovery underscores the importance of spatial dynamics in antibody function. 4/5

Adlung Lab
@adlunglab.com

šŸ”— Dive into this fascinating work here: doi.org/10.1038/s414... . šŸ Kudos to Anna Huhn et al. for this remarkable contribution to basic immunology! šŸ§Ŗ 5/5

doi.orgThe molecular reach of antibodies crucially underpins their viral neutralisation capacityNature Communications - Researchers developed an accurate model to analyse bivalent antibody binding. By analysing many SARS-CoV-2-specific antibodies, they found that their molecular reach can...