Research at UHN

Research at UHN

@uhnresearch.ca

Research news from Canada's largest research hospital. 🔗 uhnresearch.ca

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Research at UHN
@uhnresearch.ca

An early-phase trial shows encouraging preliminary results for invikafusp alfa, an investigational immunotherapy designed to activate specific cancer-fighting T cells. Researchers observed signs of anti-tumour activity in patients with advanced cancers. 🔗: www.nature.com/articles/s41...

Princess Margaret Cancer Centre@pmresearch-uhn.bsky.social

New therapies are urgently needed for patients with advanced solid tumours that no longer respond to existing treatments. Our researchers co-led a clinical trial that showed encouraging early results of a new immunotherapy in these patients. @natureportfolio.nature.com www.nature.com/articles/s41...

Research at UHN
@uhnresearch.ca

(2/3) Researchers found that the treatment with semaglutide protected the kidneys by improving blood flow, preventing scarring, and supporting the health of the cells that line kidney blood vessels.

Research at UHN
@uhnresearch.ca

(3/3) UHN was a clinical trial site for this study. Dr. David Cherney is a Senior Scientist at UHN’s Organ Systems & Integrated Health Sciences Research Institute. The trial was funded by Novo Nordisk. Corresponding authors: Drs. Katherine R. Tuttle, Petter Bjornstad, and Matthias Kretzler.

Research at UHN reposted

Krembil Brain Institute 🧠
@kbi-uhn.bsky.social

🔬 With over 300 registrants and 100 posters, the #NEURONTO research symposium was a vibrant display of the neuroscience and mental health community in Toronto. 🤝 Together, we continue to strengthen the networks that drive discovery in neuroscience through this event.

Research at UHN
@uhnresearch.ca

Congratulations on your achievement, Drs. Xie and Dong! 👏 #TeamUHN #StemCellResearch

Stem Cell Network@stemcellnetwork.ca

(1/2) Congrats to Dr. @stephxie.bsky.social, recipient of the 2026 Till & McCulloch Award! 👏 Dr. Xie is being recognized for her Nature publication revealing how inflammatory experiences can leave a lasting “memory” in human blood-forming #StemCells, with implications for aging and disease risk.

Research at UHN
@uhnresearch.ca

(2/2) Dr. Bhat is using #AI to improve transplant decision-making and patient outcomes, while Dr. Howe is developing new ways to target the blood vessel damage that leads to heart attacks and #stroke. Each will receive $500,000 over five years to advance their research.

Research at UHN reposted

Donald K. Johnson Eye Institute
@dkjei-uhn.bsky.social

📢 New publication alert! A recent study led by Dr. Jarryll Uy, a Postdoctoral Researcher, has uncovered an unexpected role for SCN2A, one of the risk genes associated with autism, revealing that it begins shaping brain development much earlier than previously understood >> bit.ly/4hz6Xor (1/2)

Research at UHN
@uhnresearch.ca

🚨Out today in @natimmunol.nature.com, a study from @pmresearch-uhn.bsky.social’s Dr. Anastasia Tikhonova identifies distinctive early changes in the bone marrow environment in people with age-related blood #StemCell mutations, before blood cancer develops. ⬇️

Princess Margaret Cancer Centre@pmresearch-uhn.bsky.social

In people with age-related blood stem cell mutations, our study found early pre-fibrosis and inflammatory regions in the bone marrow, that may set the stage for blood cancer development. The @natimmunol.nature.com study was led by Dr. Anastasia Tikhonova: www.nature.com/articles/s41...

Research at UHN
@uhnresearch.ca

Out today in @natbiotech.nature.com, a study from Dr. Bowen Li (@pmresearch-uhn.bsky.social) shows a new strategy for improving the non-viral delivery of large mRNA cargo for gene editing—an approach with the potential to expand the reach of gene editing therapies. 🔗: www.nature.com/articles/s41...

nature.comLipid nanoparticles optimized for large RNA cargo and tissue targeting enhance in vivo genome editing - Nature BiotechnologyLipid nanoparticles are improved by including RNA cargo size in the design process.
Princess Margaret Cancer Centre@pmresearch-uhn.bsky.social

A new lipid nanoparticle, LC-1, overcame gene editing barriers and efficiently delivered large RNA tools to the preclinical models of liver, lungs, and brain. The Nature Biotechnology study was led by Dr. Bowen Li @uhn.ca Princess Margaret Cancer Centre: www.nature.com/articles/s41...

Research at UHN
@uhnresearch.ca

(2/2) #ICYMI: Another recent study from Dr. Li’s lab on a new class of non-viral therapies for genetic diseases that restores protein function without altering the genome. 🔗 www.uhnresearch.ca/news/8-27-20...

uhnresearch.caA New Class of RNA Therapies | UHN ResearchUniversity Health Network (UHN) is a research hospital affiliated with the University of Toronto and a member of the Toronto Academic Health Science Network. The scope of research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care.
Research at UHN
@uhnresearch.ca

Congratulations to Dr. Tak Mak, Senior Scientist at @pmresearch-uhn.bsky.social, on receiving the German Society of Immunology's German Immunology Prize. 🎉 As the Society's highest scientific honour, the award recognizes outstanding contributions to immunology. 🔗: idw-online.de/en/news877636

Deutsche Gesellschaft für Immunologie e.V. (DGfI)@dgfi-org.bsky.social

Die Deutsche Gesellschaft für Immunologie e.V. (DGfI) vergibt ihre höchste wissenschaftliche Auszeichnung dieses Jahr an Prof. Mark Davis und Prof. Tak Mak. Die beiden Forscher haben die moderne Immunologie grundlegend geprägt. Siehe dgfi.org/mark-davis-u...

Research at UHN
@uhnresearch.ca

Postdoctoral researchers play an important role in advancing discovery and innovation at @uhn.ca. During #PostdocAppreciationWeek, we're highlighting members of UHN's postdoctoral community and the work they're leading across a range of research areas. 🧵⬇️

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Research at UHN
@uhnresearch.ca

Postdoctoral researchers play an important role in advancing discovery and innovation at @uhn.ca. During #PostdocAppreciationWeek, we're highlighting members of UHN's postdoctoral community and the work they're leading across a range of research areas. 🧵⬇️

Research at UHN
@uhnresearch.ca

2/ First author: Ximing Li Senior author: Dr. Anastasia Tikhonova Featured on the cover of @bloodjournals.hematology.org: ashpublications.org/blood/articl... -- @uhn.ca @oicr.on.ca @stemcellnetwork.ca

ashpublications.orgIFN-γ drives long-term bone marrow niche dysfunction following doxorubicin-based chemotherapyKey PointsDOX remodels the BM niche, inducing arteriolar damage, MSC dysfunction, and sustained expansion of phenotypic HSCs.IFN-γ signaling from CD8+ T ce

Research at UHN reposted

Princess Margaret Cancer Centre
@pmresearch-uhn.bsky.social

Congratulations to Dr. Long Nguyen on being named Canada's Top 40 Under 40 by @financialpost.com for leading a research program uncovering how cancer cells evolve, adapt, and develop resistance to treatment, to improve patient outcomes. @uhnresearch.ca @uhn.ca

Financial Post@financialpost.com

Meet Canada's Top 40 Under 40 for 2026 financialpost.com/news/meet-ca...

financialpost.comMeet Canada's Top 40 Under 40 for 2026Canada’s Top 40 Under 40 is back after a four year hiatus. Here is the 2026 list of honourees. Find out more.
Research at UHN
@uhnresearch.ca

#NewPublication🚨 Researchers at @pmresearch-uhn.bsky.social have developed a new #AI tool that can identify rare immune cells with the ability to recognize and respond to #cancer. 🔗 Read more: www.uhnresearch.ca/news/9-16-20...

Princess Margaret Cancer Centre@pmresearch-uhn.bsky.social

Finding immune cells that naturally recognize cancer has been a barrier to developing T cell-based therapies. Our study used AI to decode what makes γδ T cells respond to tumour cells, unlocking new therapeutic potentials. @nature.com : www.nature.com/articles/s41... @uhnresearch.ca @uhn.ca