thecleverslab.bsky.social

thecleverslab.bsky.social

@thecleverslab.bsky.social

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thecleverslab.bsky.social
@thecleverslab.bsky.social

‼️New review by @amandaanderssonr.bsky.social and @hansclevers.bsky.social discussing the latest applications for organoids is now out in Nature Reviews Molecular Cell Biology: “New developments and applications of human organoids.” 🧫 🔗Read here: www.nature.com/articles/s41...

nature.comNew developments and applications of human organoids - Nature Reviews Molecular Cell BiologyOrganoids are powerful tools for studying human development and disease mechanisms in vitro. This Review discusses their limitations and recent advances that increase their complexity to better mimic ...
thecleverslab.bsky.social
@thecleverslab.bsky.social

1/4 New in Science: Gut renewal is not passive “crowd control.” Instead of being pushed out by crowding or dying from apoptosis, cells compete in a mechanical tug-of-war. Weaker cells are eliminated—reframing intestinal homeostasis as a force-regulated process. www.science.org/doi/10.1126/...

science.orgEpithelial tension controls intestinal cell extrusionCell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...
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thecleverslab.bsky.social
@thecleverslab.bsky.social

3/4 This reveals a safeguard mechanism: epithelial cells constantly test each other’s mechanical strength. Too little (or too much) force destabilizes the barrier, linking extrusion to diseases like tufting enteropathy. Gut renewal is an active, force-regulated process.

thecleverslab.bsky.social
@thecleverslab.bsky.social

1/4 New in Science: Gut renewal is not passive “crowd control.” Instead of being pushed out by crowding or dying from apoptosis, cells compete in a mechanical tug-of-war. Weaker cells are eliminated—reframing intestinal homeostasis as a force-regulated process. www.science.org/doi/10.1126/...

science.orgEpithelial tension controls intestinal cell extrusionCell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...
thecleverslab.bsky.social
@thecleverslab.bsky.social

Check out this new article highlighting our postdoc @amandaanderssonr.bsky.social ’s work on a novel pancreatic organoid model that includes all three key cell types, offering new insights into pancreatic development: www.the-scientist.com/a-novel-thre...

the-scientist.comA Novel Three-in-One Pancreatic OrganoidAn innovative organoid model mirrors the pancreas' complexity, generating all three key cell types to explore development and possible regeneration.

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