Stimulating Brains

New publication using Lead-DBS: In this article by Damiani et al., the authors tested whether “hodological matching”—targeting thalamic nuclei anatomically and functionally connected to individual seizure onset zones—enhances... Check out the paper here 👇👇 https://doi.org/10.1038/s41467-025-64922-w

New publication using Lead-DBS: In this article by Köberle et al., they report the first therapeutically successful subthalamic nucleus–targeted deep brain stimulation in a patient with MEGDEL syndrome that produced clinical improvem... Check out the paper here 👇👇 https://doi.org/10.1002/mdc3.70829

📣 Join us on Thurs, Oct 29 at 12 PM ET for our next #StimulatingBrains talk with Samantha Baldi & Joe Taylor! We'll explore brain circuit mapping and targeted stimulation for more precise treatments of neuropsychiatric disorders. Register here for free: stimulatingbrains.org/talk-series/

New publication using Lead-DBS: In this article by Scafa et al., they show that real-time decoding of subthalamic nucleus dynamics can steer activity-dependent adaptive deep brain stimulation to improve locomotor deficits (ga... Check out the paper here 👇👇 https://doi.org/10.1038/s41591-026-04432-4

New publication using Lead-DBS: In this article by Hanafi et al., the authors tested gait-adaptation kinematics, EEG, and FDG‑PET in Parkinson's patients during virtual obstacle avoidance with active versus paused STN‑DBS and... Check out the paper here 👇👇 https://doi.org/10.1016/j.brs.2026.103207

New publication using Lead-DBS: In this article by Kist et al., patients with OCD treated with subthalamic deep brain stimulation performed visual detection and confidence judgments with EEG, showing intact detection but poor... Check out the paper here 👇👇 https://doi.org/10.1038/s41398-026-04423-6

New publication using Lead-DBS: In this article by Singh et al., a three‑center retrospective study of 22 patients with drug‑resistant insular epilepsy treated with responsive neurostimulation or chronic subthreshold stimulation repor... Check out the paper here 👇👇 https://doi.org/10.1002/epi.70479

New publication using Lead-DBS: In this article by Huang et al., the authors mapped pain-related networks using rapid stereo-EEG to enable personalized multinodal stimulation for refractory facial pain. Check out the paper here 👇👇 https://doi.org/10.1016/j.brs.2026.103176

New publication using Lead-DBS: In this article by Meyer et al., the authors tested in 19 Parkinson’s patients whether subthalamic deep brain stimulation modulates automatic response inhibition and showed that stimulation spe... Check out the paper here 👇👇 https://doi.org/10.1093/braincomms/fcag325

New publication using Lead-DBS: In this article by Dary et al., they tested whether circadian modulation of aperiodic and oscillatory intracranial EEG could serve as a biomarker of seizure burden in 19 patients with Lennox–Gastaut syn... Check out the paper here 👇👇 https://doi.org/10.1002/epi.70457

New publication using Lead-DBS: In this article by Liu et al., the authors tested direct substantia nigra DBS in Parkinson's disease at 10, 30, and 130 Hz, observed a frequency-dependent acute motor and stride-length benefit w... Check out the paper here 👇👇 https://doi.org/10.1016/j.brs.2026.103186

New publication using Lead-DBS: In this article by Goede et al., the authors used DBS network mapping across multiple patient cohorts to show that rest tremor and action tremor map to distinct subnetworks within the primary... Check out the paper here 👇👇 https://doi.org/10.1016/j.celrep.2026.117404

🎧 Tune in here 🎶 🎧 👇👇 https://stimulatingbrains.org/81-theodore-schwartz-gray-matters-brain-surgery-from-the-inside-the-history-and-the-future-of-neurosurgery/

Classic publication using Lead-DBS: In this article by Wilkins et al., the authors tested whether swing time variability is a behavioral marker of cortical cholinergic integrity in Parkinson's disease and... Check out the paper here 👇👇 https://linkinghub.elsevier.com/retrieve/pii/S0969996120304095

New publication using Lead-DBS: In this article by Las Vegas Sands Corp. et al., the authors report a lawsuit filed by Las Vegas Sands Corp. against unknown registrants of multiple domain names, including www.wn0000.com, www.wn... Check out the paper here 👇👇 https://doi.org/10.1089/glre.2016.201011

🎧 Tune in here 🎶 🎧 👇👇 https://stimulatingbrains.org/78-keith-mullett-medtronic-pain-and-the-prehistory-of-modern-dbs/

Classic publication using Lead-DBS: In this article by Mosley et al., the authors tested whether individual variability in initiation, inhibition and strategy use in Parkinson's patients receiving subthala... Check out the paper here 👇👇 https://linkinghub.elsevier.com/retrieve/pii/S1053811920308387

Classic publication using Lead-DBS: In this article by Suresh et al., the authors tested nocturnal centromedian thalamic nucleus DBS in a patient with drug‑resistant idiopathic generalized epilepsy u... Check out the paper here 👇👇 https://www.frontiersin.org/articles/10.3389/fnhum.2024.1392100/full

Classic publication using Lead-DBS: In this article by Davidson et al., the authors tested deep brain stimulation of the nucleus accumbens as a treatment for severe alcohol use disorder in a phase I pilot trial. Check out the paper here 👇👇 https://www.nature.com/articles/s41380-022-01677-6

🎧 Tune in here 🎶 🎧 👇👇 https://stimulatingbrains.org/79-karl-friston-the-origins-of-spm-and-the-making-of-modern-human-brain-mapping/

Classic publication using Lead-DBS: In this article by Coblentz et al., the authors reported outcomes of GPi deep brain stimulation in 11 pediatric patients with refractory dystonia and used MR... Check out the paper here 👇👇 https://thejns.org/view/journals/j-neurosurg-pediatr/27/3/article-p346.xml

Classic publication using Lead-DBS: In this article by Wong et al., the authors report a case of GPi deep brain stimulation–induced ‘‘dystypia’’ (impaired typing), document improvement with the device... Check out the paper here 👇👇 https://www.frontiersin.org/articles/10.3389/fnhum.2020.583441/full

🎧 Tune in here 🎶 🎧 👇👇 https://stimulatingbrains.org/71-harold-sackeim-the-founding-editor-of-brain-stimulation-and-a-founding-figure-in-modern-electroconvulsive-therapy/

Classic publication using Lead-DBS: In this article by Bouwens Van Der Vlis et al., the authors report clinical outcomes in eight refractory OCD patients treated with ventral capsule/ventral striatum DBS a... Check out the paper here 👇👇 https://linkinghub.elsevier.com/retrieve/pii/S1094715921000891

New publication using Lead-DBS: In this article by Bryant et al., the authors introduce subcortex_visualization, an open-source Python and R toolbox providing standardized, vector-based 2D visualizations of region-level subco... Check out the paper here 👇👇 https://doi.org/10.64898/2026.01.23.699785

🎧 Tune in here 🎶 🎧 👇👇 https://stimulatingbrains.org/69-terrence-sanger-pushing-boundaries-in-pediatric-dbs-from-multi-electrode-stimulation-to-closed-loop-strategies/

New publication using Lead-DBS: In this article by Chen et al., they tested whether long‑latency reflex II (LLR II) is modulated by STN‑DBS parameters and dopaminergic medication in Parkinson's disease, finding higher LLR II with clin... Check out the paper here 👇👇 https://doi.org/10.1002/mds.70508

Classic publication using Lead-DBS: In this article by Filip et al., the authors tested whether subthalamic nucleus deep brain stimulation normalizes resting-state functional MRI metrics in Parkinson’s dis... Check out the paper here 👇👇 https://linkinghub.elsevier.com/retrieve/pii/S240584402406729X

Classic publication using Lead-DBS: In this article by Hell et al., the authors recorded subthalamic nucleus LFPs in Parkinson’s patients during walking and rest with and without stimulation and showed gai... Check out the paper here 👇👇 https://linkinghub.elsevier.com/retrieve/pii/S2213158218301475

Classic publication using Lead-DBS: In this article by Dembek et al., the authors tested five published DBS sweetspot-mapping methods in silico across eight scenarios and found highly variable identified s... Check out the paper here 👇👇 https://linkinghub.elsevier.com/retrieve/pii/S1094715921064205

Classic publication using Lead-DBS: In this article by Ge et al., the authors prospectively tested deep brain stimulation of the nucleus accumbens with or without the anterior limb of the internal capsule in 20 treatm... Check out the paper here 👇👇 https://www.nature.com/articles/s41398-025-03635-6

Classic publication using Lead-DBS: In this article by Zhang et al., the authors showed that electrode reconstruction can assist postoperative contact selection in deep brain stimulation. Check out the paper here 👇👇 https://linkinghub.elsevier.com/retrieve/pii/S1878875019301998

New publication using Lead-DBS: In this article by Unknown et al., they announce a ScienceDirect article in press in Assessing Writing. Check out the paper here 👇👇 https://doi.org/10.1016/s1075-2935(04)00016-9

🎧 Tune in here 🎶 🎧 👇👇 https://stimulatingbrains.org/67-jonathan-downar-tms-for-depression-towards-a-one-day-protocol/

New publication using Lead-DBS: In this article by Luo et al., the authors identified brain circuits associated with gait impairment after stroke and with gait changes following subthalamic DBS for Parkinson's disease, and found lesio... Check out the paper here 👇👇 https://doi.org/10.1002/ana.78320

Classic publication using Lead-DBS: In this article by Segura-Amil et al., the authors used patient-specific probabilistic tractography in 20 Parkinson's disease patients with bilateral STN DBS to build models link... Check out the paper here 👇👇 https://onlinelibrary.wiley.com/doi/10.1002/hbm.26390

🎧 Tune in here 🎶 🎧 👇👇 https://stimulatingbrains.org/72-john-rolston-closed-loop-stimulation-seizure-epilepsy/

Classic publication using Lead-DBS: In this article by Ehlen et al., the authors tested effects of thalamic (VIM) deep brain stimulation in essential tremor patients on verbal fluency, finding DBS ON prolo... Check out the paper here 👇👇 https://linkinghub.elsevier.com/retrieve/pii/S0278262616302883

New on Stimulating Brains: @doriswang.bsky.social on adaptive DBS synchronized with the moment-by-moment rhythm of walking—and what it could mean for gait and falls in Parkinson’s disease. 🎧 stimulatingbrains.org/82-doris-wan... #DeepBrainStimulation #AdaptiveDBS #ParkinsonsDisease #Neurosurgery

Classic publication using Lead-DBS: In this article by Provenza et al., the authors used continuous ventral-striatum recordings from 12 people with treatment‑resistant OCD receiving DBS to show that pre‑stimulation th... Check out the paper here 👇👇 https://www.nature.com/articles/s41591-024-03125-0

🎧 Tune in here 🎶 🎧 👇👇 https://stimulatingbrains.org/58-ali-rezai-long-lasting-effects-of-focused-ultrasound-for-addiction/

🎧 Tune in here 🎶 🎧 👇👇 https://stimulatingbrains.org/54-phil-starr-using-cortical-signals-to-guide-dbs-how-lesions-may-produce-brain-signals-and-open-collaborations-in-the-field/

Classic publication using Lead-DBS: In this article by Zvarova et al., the authors developed and validated a multimodal neuroimaging‑informed model—combining active contact coordinates, electric fields, tract activations, and structur... Check out the paper here 👇👇 https://doi.org/10.1002/ana.78206

🎧 Tune in here 🎶 🎧 👇👇 https://stimulatingbrains.org/68-todd-herrington/

New publication using Lead-DBS: In this review by Hagelschuer et al., the authors summarize current knowledge on deep brain stimulation in pediatric acquired dystonia, covering short- and long-term motor and non-motor effects... Check out the paper here 👇👇 https://doi.org/10.3389/fneur.2026.1735832

🎧 Tune in here 🎶 🎧 👇👇 https://stimulatingbrains.org/64-balint-varkuti-making-use-of-side-effects-redefining-brain-computer-interfaces-with-ceregate/

Classic publication using Lead-DBS: In this article by Sarica et al., the authors tested MRI‑guided transcranial ultrasound stimulation (TUS) of M1, GPi, or occipital control in Parkinson’s patients with STN electrodes and... Check out the paper here 👇👇 https://doi.org/10.1126/scitranslmed.ady1883

🎧 Tune in here 🎶 🎧 👇👇 https://stimulatingbrains.org/63-mark-mcauley-susan-boehnke-patient-led-research-patient-centered-care-and-neuroscience-education/

Classic publication using Lead-DBS: In this article by Balachandar et al., the authors recorded GPi-DBS local field potentials in 10 children longitudinally and showed that status dystonicus is a distinct state charac... Check out the paper here 👇👇 https://www.nature.com/articles/s41467-025-64416-9