Stephan Hacker

Finding new covalent antibiotics usually hits two major walls: the time-consuming synthesis of tailored libraries and the challenge of target identification after phenotypic screening. Storm van der Voort addressed both bottlenecks in one comprehensive workflow. (1/8) doi.org/10.26434/che...

A massive thank you to all co-authors and collaborators, who made this work possible: Sophie van 't Ooster, @berendgagestein.bsky.social, Bobby Florea and Richard van den Berg. (7/8)

Finding new covalent antibiotics usually hits two major walls: the time-consuming synthesis of tailored libraries and the challenge of target identification after phenotypic screening. Storm van der Voort addressed both bottlenecks in one comprehensive workflow. (1/8) doi.org/10.26434/che...

🔹 Structural Validation: In collaboration with Tessa Gote and @armstrongchembio.bsky.social within our @led3hub.bsky.social, we resolved a crystal structure of the protein in complex with our top hit. This revealed covalent engagement at C111 and key interactions for future optimization. (5/8)

Finding new covalent antibiotics usually hits two major walls: the time-consuming synthesis of tailored libraries and the challenge of target identification after phenotypic screening. Storm van der Voort addressed both bottlenecks in one comprehensive workflow. (1/8) doi.org/10.26434/che...

🔹Direct-to-Biology (D2B) Screening: Storm established a combinatorial, in-plate synthesis approach to screen crude compounds directly against MRSA. Crucially, hit potency and rank order closely matched between crude mixtures and re-synthesized, pure compounds. (3/8)

Finding new covalent antibiotics usually hits two major walls: the time-consuming synthesis of tailored libraries and the challenge of target identification after phenotypic screening. Storm van der Voort addressed both bottlenecks in one comprehensive workflow. (1/8) doi.org/10.26434/che...

Great talk by Sara Buhrlage at the 4th Drug Discovery and Development Summit. She talked about exciting new insights into targeting deubiquitinases (DUBs) with covalent inhibitors. Interesting insights into preferences for different reactive groups. www.nature.com/articles/s41...

I had a great time visiting the University of Michigan yesterday and giving a talk with a very good discussion afterwards. It was amazing to re-connect with Alexey Nesvizhskii and Fengchao Yu and discuss all the cool new applications that are possible in MS-based proteomics using FragPipe.

Sometimes spontaneous interactions work out great. Last week, when I posted here about my US trip, Dina Schuster (Dina Schuster) reached out, if I would consider adding a trip to Stanford University. I was extremely happy about the invite and we made it possible on super short notice. (1/3)

I definitely did not regret it, as I had an amazing visit to Stanford meeting with Dina Schuster (Dina Schuster), Haopeng Xiao and Tinghu Zhang as well as with an amazing group of PhD candidates and postdocs. (2/3)

I had a great time visiting UCSF last week. Thank you very much to Balyn Zaro for inviting me and to everyone, who attended my talk, met with me for a great discussion or joined us for dinner. Thank you so much for having me! (1/2) #ChemBio #Chemistry #Science

Great talk by Douglas Mitchell at #ICBS2026. He gave exciting insights into ribosomally synthesized and post-translationally modified peptides (RiPPs) that fold into lasso peptides and their potential to treat cancer. www.cell.com/trends/genet...

Interesting talk by Ziyang Zhang at #ICBS2026. He presented his group's exciting work on small molecules that enhance GTP hydrolysis by KRAS with important implications in switching off signaling by KRAS Q61 mutants in cancer cell lines. www.nature.com/articles/s41...

Thank you to the International Chemical Biology Society for inviting me to present some of our latest research today in San Francisco. #ICBS2026 is truly an amazing conference. Thank you to Michelle Arkin and her team for the great organization. Photo credit: @billy-ng.bsky.social

O-GlcNAcylation is a posttranslational modification with important implications in health and disease. In his talk at #ICBS2026, @billy-ng.bsky.social gave an overview, how they use proximity-inducing OGTACs to introduce this modification on target proteins. www.cell.com/cell-chemica...

Can the properties of psychedelics be optimized into safe, non-cardiotoxic and non-hallucinogenic antipsychotic drugs? Great talk by David Olson (@deolsonlab.bsky.social) at #ICBS2026 on their work in this field in the context of lysergic acid diethylamide analogs. www.pnas.org/doi/10.1073/...

Interesting talk by Jie Liu from thr group of Kevan Shokat at #ICBS2026. He talked about the development of BisRoc, a bivalent rocaglamide, that functions as a molecular glue to form higher-order eIF4A-RNA complexes for cancer cell-specific translation suppression pubs.acs.org/acscii/artic...

How can the targeted degradation of #RNA be exploited to treat diseases? Peng Wu gave an insightfull talk at #ICBS2026 on his group's work on RNA-degrading RIBOTACs e.g. on the example of an NRAS mRNA degrader with implications in #cancer. pubs.acs.org/jaaucr/artic...

How can we specifically address RNA with small molecules? Amanda Garner gave an exciting talk at #ICBS2026, in which she discussed her group's work on developing tools for studying small molecule-RNA interactions in cells and disrupting RNA-protein interactions. pubs.acs.org/acbcct/artic...