Stefano Mangiola

Stefano Mangiola

@stemang.bsky.social

Computational cancer-immunology and tumour microenvironment @SAiGENCI and @WEHI_research, VCA fellow @VicGovDH

1.8K followers25 following66 posts

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Only one more week to apply for the #BiocAsia Travel Scholarship, to join us at #BiocAsia2026 and #ABACBS2026. Don't miss the opportunity! Please share with your peers who might be interested. πŸ™ @bioconductor.bsky.social @abacbs.bsky.social

Stefano Mangiola@stemang.bsky.social

Great news! @saigenci.bsky.social, through its Computational System Oncology Program, is a main supporter of #BiocAsia2026! With their support, we will be able to provide travel scholarships; news soon! @bioconductor.bsky.social @abacbs.bsky.social

You still have time to submit your workshop!

Bioconductor@bioconductor.bsky.social

πŸ“£ Call for Workshop Proposals: BioCAsia 2026 BioCAsia 2026 will take place on 19-20 November 2026 in Melbourne, Australia, and the call for workshop proposals is now open. πŸ—“οΈ Submission deadline: 21 August 2026 πŸ”— www.abacbs.org/workshops-20... #BioCAsia #Bioconductor

πŸ“’ πŸ“ƒ Finetuning masking challenges narrow-task evaluation of cell foundation models shorturl.at/dcz3l We tested foundation model architectures across extreme reductions in pretraining scale. We found that standard narrow tasks were insensitive to pretraining scale, up tp 128-fold reduction!

biorxiv.orgFinetuning masking challenges narrow-task evaluation of cell foundation modelsSingle-cell foundation models are large, self-supervised deep learning networks pretrained on millions of cellular transcriptomes. These models promise to deliver cell representations that are transfe...

We call this pattern #finetuning_masking: supervised adaptation on narrow tasks can compensate for weaker pretraining and mask representational quality. This matters because many current benchmarks may not be measuring the properties that cell foundation models are intended to provide.

New #tidyomics blog post! πŸŽ‰ #tidySummarizedExperiment greatly simplifies your omics workflows, giving tidyverse capabilities. We have improved its performance 30x on large datasets with tens of thousands of samples! tidyomics.github.io/tidyomicsBlo... Plz share! @mpibiochem.bsky.social

tidyomics.github.ioSpeeding up tidySummarizedExperiment through query optimisation and the plyxp backend – tidyomicsBlogPerformance optimisation of tidySummarizedExperiment and related benchmark.

A great last #tidyomics meeting of the year, looking forward to more of these in 2026! @bioconductor.bsky.social

Stefano Mangiola@stemang.bsky.social

The last #tidyomics meeting of the year is in 2 days. Everyone welcome! - 16 Dec, 3:30 pm (EST; New York) - 16 Dec, 9:30 pm (CET; Berlin) - 17 Dec, 7:30 am (AEDT; Melbourne) We will chat about plans for next year. Zoom link: shorturl.at/Epbbc @mikelove.bsky.social @bioconductor.bsky.social

The last #tidyomics meeting of the year is in 2 days. Everyone welcome! - 16 Dec, 3:30 pm (EST; New York) - 16 Dec, 9:30 pm (CET; Berlin) - 17 Dec, 7:30 am (AEDT; Melbourne) We will chat about plans for next year. Zoom link: shorturl.at/Epbbc @mikelove.bsky.social @bioconductor.bsky.social

Stefano Mangiola@stemang.bsky.social

Great first #tidyomics meeting, covering 3 continents! 🌍 We discussed data representation with #tidyprint. Stay tuned for the next one to discuss workshop delivery, education and more! Join the slack channel #tidiness_in_bioc community-bioc.slack.com/archives/CEQ... @bioconductor.bsky.social

It's official! The #tidyomics blog is up! πŸš€ Here, the introductory post tidyomics.github.io/tidyomicsBlo... This blog aims to publish not only news about our community but also anything related to tidy interfaces, opinions, events, and more. Plz share! πŸ™ @bioconductor.bsky.social #rstats

tidyomics.github.ioThe Tidyomics Ecosystem – tidyomicsBlogAn introduction to the tidyomics ecosystem, including principles, core packages, publications, and community resources for tidy omic analysis.

Amazing event! It is good to see the Adelaide community coming together! #ABACBS2025

Feargal Ryan@feargalr.bsky.social

That’s a wrap! Huge thank you to everyone who joined us for #ABACBS2025 & a big shout-out to the Adelaide bioinfo community who worked their butts off. Couldn’t have asked for a better crew or a better venue than Adelaide Oval. @wessidepraxis.bsky.social @linsalrob.bsky.social

The first conference for our Lab! Amazing environment at #ABACBS2025! πŸ™ Congrats, Mengyuan, Chen and Galen, for the great posters, and Haroon for being a finalist with his talk on the democratisation of foundational models. πŸš€

Registrations for the @abacbs.bsky.social and @bioconductor.bsky.social #BiocAsia workshops close TOMORROW at 5PM! Don't miss the opportunity to learn the new trends in computational biology!

Stefano Mangiola@stemang.bsky.social

ABACBS/BioC Asia 2025 Workshops are coming! @ Adelaide 27-28 November. Join us in November for two days of deep-dive sessions on scalable bioinformatics, spatial omics, AI-driven genomics, and more blackochrelabs.au/abacbs2025_w... #Bioinformatics @abacbs.bsky.social @bioconductor.bsky.social

Stefano Mangiola reposted

πŸš€ Curious about #SpatialOmics? Want to master spatial omics data analysis using #Rstats and @bioconductor.bsky.social ? πŸ”₯ Registrations are now OPEN for the 3rd edition of our hands-on course with @stemang.bsky.social ! πŸ“… Save the dates: 18–20 May 2026 www.physalia-courses.org/courses-work...

physalia-courses.orgspatial Omics in R/Bioconductor18-20 May 2026 To foster international participation, this course will be held online

Join us for another tidyomics meeting tomorrow! We will chat about several news - tidyprint - tidybulk V2 - omicslog - and more!

Michael Love@mikelove.bsky.social

Our first Fall #tidyomics meeting will be this Wed 10 September, early in US / noon in Europe / late in Australia. Feel free to join if you're interested in what we are doing to make omics data more amenable to tidy data analysis. Organized with Stefano @stemang.bsky.social

Join us for an interesting discussion on using AI with foundational models in biology!

Australian BioCommons@ausbiocommons.bsky.social

Next in our #AI webinars: Stefano Mangiola @saigenci.bsky.social talks AI models in #SingleCell and if they can uncover biological patterns Anh TN Nguyen @monashuniversity.bsky.social shares how deep learning is accelerating #DrugDiscovery for GPCRs More info www.biocommons.org.au/events/ai-se...

BiocAsia will collaborate with ABACBS for the 2025 conference (Adelaide) to bring you a full day of workshops! Have you thought about teaching a workshop about your or someone else's package or a workflow? This is the time! Submit your proposal by the 1st of August.

Bioconductor@bioconductor.bsky.social

πŸ“£ BioCAsia 2025: Call for Workshops Join the Bioconductor stream at ABACBS 2025 in Adelaide! Submit your hands-on workshop EOI by August 1. Flexible 90-min blocks. ➑️ www.abacbs.org/abacbs-2025-... #Bioconductor #BioCAsia2025 #RStats

What a cover! Looking forward to sharing our work with you!

Seminar this Friday July 4th 1.00pm: β€œModelling and Democratising the Human Cell Atlas” with @stemang.bsky.social, Haroon Shakeel & Chen Zhan (@saigenci.bsky.social) Details & zoom info: doppeldata.au/events/event... #Bioinformatics #SingleCell #HumanCellAtlas #Adelaide #Genomics

Thanks @physaliacourses.bsky.social, it was a blast! And the great active audience made it so enjoyable!

Physalia-courses@ONLINE@physaliacourses.bsky.social

πŸš€ We’re wrapping up our 3-day Spatial Omics in R/ @bioconductor.bsky.social workshop! A huge THANK YOU to @stemang.bsky.social Malvika and all our attendees who made this event a success πŸŽ‰ Until next time β€” www.physalia-courses.org/courses-work... πŸ§¬πŸ—ΊοΈ #SpatialOmics #Bioconductor #RStat

Amazing crew! Tomorrow, we will show the Physalia crew how to use #tidyomics to manipulate and analyse spatial data!

Physalia-courses@ONLINE@physaliacourses.bsky.social

πŸš€ Just kicked off our Spatial Omics in R/Bioconductor course with @stemang.bsky.social In this 3-day course, we're gonna explore spatial technologies & hands-on data analysis in R and Bioconductor using tidy principlesπŸ§¬πŸ§ πŸ“Š www.physalia-courses.org/courses-work... #SpatialOmics #RStats #Bioconductor

In few hours we have the second #tidyomics meeting! where we will talk about workshops, communication and education and more. Thursday March 27 with a Europe friendly meeting time (12:00 CET) Join the @bioconductor.bsky.social slack channel to know more #tidiness_in_bioc channel Join us

Stefano Mangiola@stemang.bsky.social

Great first #tidyomics meeting, covering 3 continents! 🌍 We discussed data representation with #tidyprint. Stay tuned for the next one to discuss workshop delivery, education and more! Join the slack channel #tidiness_in_bioc community-bioc.slack.com/archives/CEQ... @bioconductor.bsky.social

Great first #tidyomics meeting, covering 3 continents! 🌍 We discussed data representation with #tidyprint. Stay tuned for the next one to discuss workshop delivery, education and more! Join the slack channel #tidiness_in_bioc community-bioc.slack.com/archives/CEQ... @bioconductor.bsky.social

Stefano Mangiola@stemang.bsky.social

Tomorrow, we will have our first #tidyomics meeting for 2025! We will discuss how to centralise tidy display for biological data -> github.com/tidyomics/ti... Wednesday 12th of March - 4PM NY - 9PM London - 8AM (Thursday) Melbourne details -> community-bioc.slack.com/archives/CEQ... Pls share!

We encourage diverse participation regardless of background, gender, or beliefs. The meetings are friendly and open! You don't need to participate actively; you can join simply to stay updated on #tidyomics development. We welcome you!

Stefano Mangiola reposted

πŸš€ Interested Spatial Omics with R/Bioconductor? 🧨Do you want to learn how to analyse these data in R with the #tidyverse? Join us in May for this course with @stemang.bsky.social & @lgmartelotto.bsky.social πŸ”— www.physalia-courses.org/courses-work... #SpatialOmics #Bioinformatics #RStats

physalia-courses.orgspatial Omics in R/Bioconductor19-21 May 2025 To foster international participation, this course will be held online

Stefano Mangiola reposted

πŸ“… Tidyomics next meeting is Wed, Mar 12 at 4PM NY / 9PM London / 8AM (Thurs) Melbourne. They'll discuss enhancing SummarizedExperiment display & seek feedback on tidyprint package. See Bioconductor Slack #tidiness-in-bioc channel or events calendar for more info: buff.ly/rdhL3jL #Tidyomics #RStats

buff.lyBioconductor - EventsThe Bioconductor project aims to develop and share open source software for precise and repeatable analysis of biological data. We foster an inclusive and collaborative community of developers and…

Would you open your paper to a modular open-collaboration model? It was game-changing for #tidyomics If you love #crowdResearch and #CommunityBuilding have your say on the #crowdToPaper model guidelines Comment on the shared doc: docs.google.com/document/d/1... Please share πŸ™

docs.google.comCTP-1.0CTP guidelines 1.0 Definition and Operational Details of the Crowd-to-Paper Model This document, called β€œCTP-1.0”, is a template that includes the guiding principles of projects based on the crowd-to-...

The hope is that this collaborative model can be applied more broadly, creating a virtuous circle to boost research and support research diversity. Contributions are welcome from diverse computational fields, e.g. #Physics #ecology #maths #biology, ...

πŸ“’πŸ™ Dear Research Community! A call πŸ‘‡ to contribute to defining the #guidelines of the #CrowdToPaper research model, as tested for tidyomics doi.org/10.1038/s415... We welcome feedback from all research fields through comments on docs.google.com/document/d/1... πŸ™ Plz Share! ❀️Thank you!

docs.google.comCTP-1.0CTP guidelines 1.0 Definition and Operational Details of the Crowd-to-Paper Model This document, called β€œCTP-1.0”, is a template that includes the guiding principles of projects based on the crowd-to-...

πŸ“’πŸ’»πŸ§ͺ 2 #PhD #Scholarships available @SAiGENCI: 1) Hybrid wet-dry: #multiomics to predict neoadjuvant response in #cancer 2) #Bioinformatics, comp-bio: large-scale #singlecell modelling and infrastructure πŸ”—https://researchers.adelaide.edu.au/profile/stefano.mangiola#my-research Please share! πŸ™