Robert Blelloch

cell.comEngineered human iPSC-derived dendritic cells dressed with tumor MHC complexes as a cancer vaccineBlelloch and colleagues create genetically engineered universal human iPSCs, differentiate them into CCR7+ migratory dendritic cells, and dress them with tumor-derived MHC class I-antigen complexes to...

@ucsfstemcell.bsky.social Why we believe this paper is so important: www.cell.com/cell-stem-ce...

5. Given that we are dressing a universal cell product with full repertoire of MHC-peptides from the patient’s tumor, the resulting cells are both recognized as self while presenting the full complexity of potentially immune activating tumor epitopes.

@ucsfstemcell.bsky.social Why we believe this paper is so important: www.cell.com/cell-stem-ce...

4. The approach produces a near homogeneous migratory DC population, the specific population of dendritic cells that travel to the lymph nodes to induce naïve T cells into effector cells that can then attack the tumor.

@ucsfstemcell.bsky.social Why we believe this paper is so important: www.cell.com/cell-stem-ce...

3. Given the starting population is always the same, the quantity and quality of cells produced is reproducible, unlike autologous approaches which vary greatly based on quality and quantity of the cells collected from the patient.

@ucsfstemcell.bsky.social Why we believe this paper is so important: www.cell.com/cell-stem-ce...

2. Given that we are starting with the iPSCs, there are essentially no constraints on the types and number of genetic optimizations that can be made.

@ucsfstemcell.bsky.social Why we believe this paper is so important: www.cell.com/cell-stem-ce...

UCSF Broad Stem Cell Center

1. Reproducible production of an unlimited number of off-the-shelf genetically optimized CCR7+ migratory dendritic cells which are then personalized to each patient’s tumor.

Robert Blelloch reposted

@ucsfstemcell.bsky.social

25 Aug

@robertblelloch.bsky.social + team engineered iPSC-derived dendritic cells coated w/ patient tumor membranes to present multiple cancer antigens to T cells. The approach induced tumor-specific T cell responses in patient samples and slowed tumor growth in humanized mice. www.cell.com/cell-stem-ce...

Robert Blelloch reposted

Deniz Gökbuget

@denizgoekbuget.bsky.social

25 Aug

Excited to share this new paper: Universal iPSC-derived dendritic cells "dressed" with tumor MHC complexes as an off-the-shelf cancer vaccine. Glad I could help on the computational side. Congrats to @huaigengxu.bsky.social, Chisato, @robertblelloch.bsky.social for getting this over the finish line!