PNAS Nexus

PNAS Nexus

@pnasnexus.org

Discover groundbreaking news and research from PNAS Nexus, the sibling journal to @pnas.org - both official research journals of the U.S. National Academy of Sciences. Visit www.pnasnexus.org for more information.

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2026 Issue 9 of PNAS Nexus is now available! Explore research on norms and uses to preserve human-led science; a nuclear archaeology reassesses Heisenberg’s last reactor experiment; the seven virtues of Samurai; and more. https://ow.ly/1TSL50ZUA6n

LLMs were prompted to correct people’s misperceptions about economic policy. The chatbots were 28% less persuasive when study participants were told that they were biased against the participant’s political party. In PNAS Nexus: https://ow.ly/sw335101q07

Researchers developed a drug for Alzheimer's disease and discovered the molecule already exists in human blood, although in lower levels in people with cognitive impairment. They are now exploring the peptide as a biomarker as well as a treatment. In PNAS Nexus: https://ow.ly/tOyl51014xX

🥧 The secret to perfect pie crust? It might be chemistry! Butter, shortening, or bacon fat? LabX's Chemists in the Kitchen puts different fats to the test to explore what makes a deliciously flaky crust. Dig into the experiment: https://ow.ly/Cwq45100mvn

A Perspective calls for a Discovery Compact for science: an agreement that treats scientific discovery as essential infrastructure and goes beyond simply returning to the funding levels and predictability of the postwar era. In PNAS Nexus: https://ow.ly/iBF45100mbx

A Bayesian model forecasts where mass shootings are most likely to occur in the United States. Firearm access, derived from the density of federal firearms licenses, emerged as the dominant predictor of risk in the model. In PNAS Nexus: https://ow.ly/N3A151008Ht

Discover one of the top-performing PNAS Nexus articles on Altmetric for the past three months! “Nanotubes enable intercellular communication in early-branching eukaryotes” by Suma et al. scored 72—driven by strong media attention. Read more: https://ow.ly/GLAQ5100b76

Discover one of the most talked-about PNAS Nexus articles on Altmetric over the past three months! “Why the mortality penalty of smoking is rising over time” by R. Lawton et al. earned an Altmetric score of 101, driven by strong media coverage. Read more: https://ow.ly/p89q50ZZpkk

LLMs were prompted to correct people’s misperceptions about economic policy. The chatbots were 28% less persuasive when study participants were told that they were biased against the participant’s political party. In PNAS Nexus: https://ow.ly/w1sW50ZZorw

Most AI neural networks rely on backpropagation, but biological neurons don’t appear to use the same learning mechanism . The Product Feedback Alignment (PFA) algorithm approximates backpropagation while addressing this weight symmetry problem. In PNAS Nexus: https://ow.ly/YHk550ZZ3jz

Around the world, 15-year-old boys are less likely to agree that “trying hard at school is important” than 15-year-old girls, and this gap—which is largest in the most-developed countries—may help explain why boys underperform girls in education. In PNAS Nexus: https://ow.ly/SEZL50ZZ3fF

🥕 Soup season just got scientific! Roasted or boiled—which carrots make the better soup? Join LabX's Chemists in the Kitchen as they experiment with cooking techniques and explore the science behind a cozy classic. See what's simmering: https://ow.ly/VcPE50ZYvaW

Work-life balance is often blamed for the gender gap at senior levels in academia, but a survey of thousands of current and former tenure-line faculty across the United States finds that feeling devalued at work may be a major contributor. In PNAS Nexus: https://ow.ly/bTnv50ZYum9

When air quality is categorized as “Hazardous” or “Very Unhealthy” in urban China, usage spikes on the Ant Forest program embedded in the Alipay app. Ant Forest offers to plant trees for users in exchange for actions that reduce climate emissions. In PNAS Nexus: https://ow.ly/w1ki50ZXbYP

Researchers surveyed 117 US Catholics four times during the 2025 papal conclave to study how shared emotion and group identity evolve during live-broadcast rituals. Collective enthusiasm peaked at the “Habemus Papam” announcement. In PNAS Nexus: https://ow.ly/r0J850ZWW0W

A study in the UK finds that when researching controversial topics such as climate change, immigration, criminal justice, or COVID-19 policy, AI chatbots may perform on par with a self-directed Google search in terms of accuracy. In PNAS Nexus: https://ow.ly/Rpfp50ZWW0F

More than 41,000 people played a quiz game about famous people. The data show that people are about 10 percentage points more likely to get questions right when asked about a person from their own country rather than from a foreign country. In PNAS Nexus: https://ow.ly/3on850ZWqz9

The National Academy of Engineering’s Fall 2026 issue of The Bridge explores how engineering, medicine, and the life sciences are creating new possibilities for improving human health. Explore the issue: https://ow.ly/2xYW50ZWpzO

A more-diverse-than-average suite of complex molecules has been proposed as a signature of life in the universe. A modeling study of spatially complex environments helps define the boundaries of abiotic complexity. In PNAS Nexus: https://ow.ly/iJnO50ZWmt6

Computational language analysis helps explain why the book Bushido: The Soul of Japan was so popular among Western audiences. The study sheds light on how cultural traditions can reach new societies without losing their core meanings. In PNAS Nexus: https://ow.ly/UynW50ZV50L

Researchers presented 21 LLMs with ethical dilemmas to explore their social norms when interacting with people who do not cooperate. Differences between models could steer people, and society, in more or less cooperative directions. In PNAS Nexus: https://ow.ly/Ujkf50ZU2a1

An analysis of two of the 14 remaining cubes of uranium from the German WWII nuclear project, along with historical records, reveals that the Nazis wouldn’t have been able to create a working bomb with the materials available to them. In PNAS Nexus: https://ow.ly/KVNO50ZU1Sa