Department of Pharmacology | University of Cambridge

Department of Pharmacology | University of Cambridge

@phar.cam.ac.uk

Focused on research and education, as part of the School of Biological Sciences at the University of Cambridge.

301 followers150 following128 posts

Pharmacology Seminar Series: PDRA Talk, Dr Maria Zacharopoulou and Dr Belkis Merve Akis Yildirim - Friday 30 November, 12:15 Our next seminar is this Friday! This is our termly Postdoctoral Researcher talk. Dr Maria Zacharopoulou and Dr Belkis Merve Akis Yıldırım will present.

Department of Pharmacology | University of Cambridge reposted

Recruiting: Research Assistant/Associate, closes 4th October Applications are invited for a Postdoctoral Research Associate position in DNA nanotechnology for the targeted delivery of fibrinolytics to activated platelets, in the Mela and Harper Groups.

On Friday, 25th September, we hosted a Macmillan Coffee Morning Bake-Off event!Congratulations to Ellis Wilde, whose Passionfruit Cake won! We raised £153.75. This will help Macmillan continue to provide invaluable support to people living with cancer and their families 🎂

Department of Pharmacology | University of Cambridge reposted

Department of Pharmacology | University of Cambridge reposted

Department of Pharmacology | University of Cambridge reposted

Video up now on the @painresforum.bsky.social You Tube channel in case you weren't able to attend live: www.youtube.com/watch?v=lalu...

youtube.comPRF Webinar: Osteoarthritis Pain Research on July 10, 2026YouTube video by Pain Research Forum
Ewan St. John Smith@psalmotoxin.bsky.social

Excited to be moderating this @painresforum.bsky.social webinar on all things osteoarthritis & pain on July 10th, registration 👉 painresearchforum.org/register-for... #PainResearch #neuroskyence #immunosky

Department of Pharmacology | University of Cambridge reposted

Department of Pharmacology | University of Cambridge reposted

Department of Pharmacology | University of Cambridge reposted

Department of Pharmacology | University of Cambridge reposted

Excited to have this #PainResearch paper out from our @phar.cam.ac.uk lab: "Monoclonal antibody inhibition of PAR2 reduces phenotype severity and pain in murine inflammatory bowel disease" journals.lww.com/painrpts/ful...

journals.lww.comMonoclonal antibody inhibition of PAR2 reduces phenotype... : PAIN Reportsmising therapeutic target for visceral pain management in IBD. Objectives: We set out to determine signaling mechanisms deployed by PAR2 in the lumbar splanchnic nerve and whether inhibiting PAR2 with the mouse monoclonal antibody (mAb), PAR650097 (mPAR650097) provided therapeutic benefit in dextran sulfate sodium (DSS)-induced colitis. Methods: We first used ex vivo electrophysiological recordings of mouse lumbar splanchnic nerve to determine how stimulation of PAR2 alters afferent activity and the intracellular signaling mechanisms involved. Second, we used the DSS model of colitis in mice and determined how mPAR650097 altered disease activity, behavior, colon histology, and the activity of nociceptive circuitry. Results: Protease-activated receptor 2 stimulation in the colon activated visceral afferent fibers and sensitized them to mechanical and chemical stimuli. We found that endosomal internalization and protein kinase A/C signaling mediate both activating and sensitizing effects of PAR2 in visceral pain. We further show that inhibiting PAR2 with the mAb mPAR650097 reduces DSS-induced colitis severity and pain. mPAR650097 also reduced several colitis-induced pain correlates at key points along the pain-signaling axis, including peripheral nociceptive neuron signaling and sensitivity, expression of proinflammatory mediators, spinal cord signaling, and, fundamentally, behavior. Conclusion: These findings illustrate that mAb inhibition of PAR2 represents a promising approach to provide relief from abdominal pain in those living with IBD....