Organic Syntheses

Large-Scale Rearrangement of Epoxy Esters into Tetrahydrofurans Submitting Authors: Shyam Sathyamoorthi*1 Checking Authors: Alfred K.K. Fung and Pauline Chiu*2

IBX-Mediated Amine Oxidation Submitting Authors: Abigail W. Wilson, Giulianna A. Miseo, Christina A. Rivera, and Neil K. Garg Checking Authors: Jakob Frey, Andreas Benedikt zur Bonsen, and Nuno Maulide

Chromatography-Free Preparation of (4aR,8aR)-2,3-Dimethoxy-2,3-dimethyl-2,3,4a,8a-tetrahydrobenzo[b][1,4]dioxin-6(5H)-one Submitting Authors: Allie W. Guerra, Coleman D. Walker and Joshua G. Pierce Checking Authors: Brandon M. Sarrels and Christopher D. Vanderwal

Synthesis of 2-Aryl Pyrimidines via an Electronically Tuned SNAr Approach Submitting Authors: Ryan J. Sullivan, Ripal Patel, Elnaz Latifi, Dino Alberico, and Jean-Nicolas Desrosiers Checking Authors: Seiya Hosoi, Juri Sakata, and Hidetoshi Tokuyama

Mild Pyrrole C-Acylation Using TCFH-NMI: Synthesis of Methyl 4-(3,5-Dimethyl-1H-pyrrol-2-yl)-4-oxobutanoate Submitting Authors: Grant H. Miller, Gregory L. Beutner, and David A. Vosburg Checking Authors: Alana Rose Meyer and Tehshik P. Yoon

Mild Pyrrole C-Acylation Using TCFH-NMI: Synthesis of Methyl 4-(3,5-Dimethyl-1H-pyrrol-2-yl)-4-oxobutanoate Submitting Authors: Grant H. Miller, Gregory L. Beutner, and David A. Vosburg Checking Authors: Alana Rose Meyer and Tehshik P. Yoon

Professor Ilan Marek of Technion-Israel Institute of Technology, presented the Organic Syntheses Lecture at the University of Hong Kong on June 11, 2026, speaking on "From Strain to Stereochemistry: A Design Principle”. pchiu.chemistry.hku.hk/pc

Preparation of Cinnamyl Carbamate and its Transformation to N-Protected 1-Phenylprop-2-en-1-amine Derivatives Submitting Authors: Mariusz Zalewski and Sebastian Stecko Checking Authors: Dong-Hang Tan, Yu-Ting Chen and Darren J. Dixon

Photochemical Synthesis of Pyrroles from Furans and Amines Submitting Authors: Jaehyun You, Donghyeon Kim, and Yoonsu Park Checking Authors: Eleonore Tacke, Bjarne T. Schulz and Nuno Maulide www.orgsyn.org/demo.aspx?pr...

Congratulations to Larry Yet(University of South Alabama- www.southalabama.edu/colleges/art...), a recipient of an OrgSyn summer research grant for 2026!

Congratulations to Chirs Shugrue (University of Richmond- chemistry.richmond.edu/faculty/cshu...), a recipient of an OrgSyn summer research grant for 2026!

Congratulations to Jared Pienkos (University of Tennessee Chattanooga- www.utc.edu/directory/pv...), a recipient of an OrgSyn summer research grant for 2026!

Congratulations to Jared Pienkos (University of Tennessee Chattanooga- lnkd.in/g6rteKuU), a recipient of an OrgSyn summer research grant for 2026!

Congratulations to Arsalan Mirjafari (State University of New York at Oswego- www.mirjafarilab.com), a recipient of an OrgSyn summer research grant for 2026!

Congratulations to Liangyoung Mei (University of North Florida- meilab.domains.unf.edu), a recipient of an OrgSyn summer research grant for 2026!

Congratulations to Daniel Lee (University of Northern Iowa- sites.google.com/uni.edu/leelab), a recipient of an OrgSyn summer research grant for 2026!

Congratulations to Amy Lane (Rose-Hulman Institute of Technology- www.amylanephd.com), a Noland Awardee and a recipient of an OrgSyn summer research grant for 2026!

Congratulations to John Kiernicki (Drury University- www.kiernickilab.com), a recipient of an OrgSyn summer research grant for 2026!

Congratulations to Ivan Fabe Dempsey Hyatt (Adelphi University- www.hyattresearchgroup.com/hyatt-cv.html), a recipient of an OrgSyn summer research grant for 2026!

Congratulations to Robert J. Hinkle (William and Mary sites.google.com/email.wm.edu...), a recipient of an OrgSyn summer research grant for 2026!

Congratulations to Patrick Hillesheim (Illinois State University- chemistry.illinoisstate.edu/faculty-staf...), a recipient of an OrgSyn summer research grant for 2026!

Congratulations to Timothy Clark (University of San Diego- home.sandiego.edu/~clarkt/), a recipient of an OrgSyn summer research grant for 2026!

Congratulations to Linus Chiang (University of the Fraser Valley- www.ufv.ca/chemistry/co...), a recipient of an OrgSyn summer research grant for 2026!

Congratulations to Ryan Cammarota (California State University Fullerton- www.cammarotagroup.com), a recipient of an OrgSyn summer research grant for 2026!

Congratulations to Daniel Brandes (Skidmore College- brandeslab.domains.skidmore.edu/dan), a recipient of an OrgSyn summer research grant for 2026!

Organic Syntheses is pleased to announce the following 2026 summer research grants for faculty at principally undergraduate institutions!

Organic Syntheses is pleased to announce the following 2026 summer research grants for faculty at principally undergraduate institutions!

Organic Syntheses is pleased to announce the following 2026 summer research grants for faculty at principally undergraduate institutions!

Preparation of Vinyltriphenylbismuthonium (Vinyl-Bis) Tetrafluoroborate and Hexafluoroantimonate Salts Submitting Authors: Li Li, Filippo Carpaneto, Adriana Zayia, Jade Feria, and Viresh H. Rawal Checking Authors: James H. Herbort and Kevin M. Maloney www.orgsyn.org/demo.aspx?pr...

Preparation of Enantiopure Bifunctional S(VI) Transfer Reagent (t-BuSF) Submitting Authors: Zachary Shultz, Eve Hall, Prakash Warghude, Yun-Pu Chang, Justin M. Lopchuk Checking Authors: Taylor A. Stephens and Tehshik P. Yoon

Organic Superbase t-Bu-P4 Catalyzed Concerted Nucleophilic Aromatic Substitution Submitting Authors: Ozora Sasamoto, Biswajit Das, and Masanori Shigeno Checking Authors: Hayato Machii, Hirofumi Ueda, and Hidetoshi Tokuyama

Synthesis of 2-Oxo-2H-Pyran-3-yl Trifluoromethanesulfonate from Mucic Acid Submitting Authors: Konstantin Günther, Lorenz Erlbacher, Daniel Kaiser, and Nuno Maulide Checking Authors: Bryce M. Dye and Richard E. Taylor

Preparation of 2-Iodoxybenzoic Acid (IBX) Submitting Authors: Marianna C. Tonoyan, Aimee K. Long, and Neil K. Garg Checking Authors: Milos Vavrik, Nikolaos Skoulikas, and Nuno Maulide

Copper-Mediated Oxidative Bromodifluoromethylation of Phenols: Preparation of Phenyl 4-(bromodifluoromethoxy) benzoate Submitting Authors: Wen-Juan Yuan, Chao-Lai Tong, and Feng-Ling Qing Checking Authors: Uros Vezonik, Sabela Vega-Ces, and Nuno Maulide

Rhodium-Catalyzed Atroposelective Azide-Alkyne Cycloaddition Submitting Authors: Linwei Zeng, Jiaming Li, Sunliang Cui Checking Authors: Moshood O. Ganiu and Nathan D. Ide

Preparation of 3-(Diphenylphosphino)propanol (ProPhos) and its Use in Nickel-Catalyzed Suzuki-Miyaura Coupling Submitting Authors: Jin Yang, Rui Zhang, Tianning Diao Checking Authors: Benjamin S. Y. Chiu and Sophie A. L. Rousseaux

Electrochemical Aromatic C-H DABCOylation: Synthesis of Aryl DABCOnium (Bis)tetrafluoroborate Submitting Authors: Griffin Stewart and Christian Malapit Checking Authors: Negin Nabavi and Sophie A. L. Rousseaux

Intermolecular Hydroamination of Benzotriazole with Tetramethylethylene Submitting Authors: Flora Fan, Emily R. Wearing, Cameron B. Loughney, and Abigail G. Doyle Checking Authors: Robert Gaston, Jr. and Dirk Trauner www.orgsyn.org/demo.aspx?pr...

Synthesis of Aryl Halides via a Safer Sandmeyer Reaction Protocol Submitting Authors: Tim Schulte, Felix Waldbach, Tobias Ritter Checking Authors: Kunj Kapur, Daniya Aynetdinova, and Nuno Maulide www.orgsyn.org/demo.aspx?pr...

Synthesis of N-Pyridinium Aziridines Submitting Authors: Samya Samanta, Hao Tan, Saikat Chatterjee, David C. Powers Checking Authors: Michael M. Gilbert and Nathan D. Ide www.orgsyn.org/demo.aspx?pr...

Simplified Preparation of the (1R,2S)-Berkessel salalen Ligand from cis-1,2-Diaminocyclohexane (cis-DACH) Submitting Authors: Christina Wartmann, Tobias M. Leuther, Hauke Engler, and Albrecht Berkessel Checking Authors: Mengfei Xu and Vy M. Dong www.orgsyn.org/demo.aspx?pr...

Amination of Aryl Boronic Acids Using O-(Diphenylphosphinyl)hydroxylamine (DPPH) Kasie H. Leung and Richard Y. Liu www.orgsyn.org/demo.aspx?pr...

Base-Promoted N-Heteroaryl C-H Oxidative Coupling With Alcohols for N-heteroaryl Ether Synthesis Samuel L. Graf 1 and Jeffrey S. Bandar www.orgsyn.org/demo.aspx?pr...

Iridium-Catalyzed Borylation of Silanes Christina A. Rivera, Benjamin A. Janda, and Neil K. Garg www.orgsyn.org/demo.aspx?pr...

Preparation of (S,S)-B2bg2, a Chiral Diboron Reagent Cliff Yang, Brooklyn Maddox, Anshu Yadav, Robert E. Maleczka Jr. www.orgsyn.org/demo.aspx?pr...

Preparation of Hexafluoroisopropyl Sulfamate (HFIPS) for the Sulfamoylation of Alcohols and Amines Mathew L. Piotrowski, Matthew Sguazzin, Jarrod W. Johnson, and Jakob Magolan www.orgsyn.org/demo.aspx?pr...

Enzymatic Saponification of Esters Containing β-Leaving Groups Benjamin A. Janda, Allison M. Clark, and Neil K. Garg www.orgsyn.org/demo.aspx?pr...

Umpolung Synthesis of α-Bromo Secondary Amides from Unactivated Hydroxamates Rui Wang, Hao Cao, and Wenbo H. Liu www.orgsyn.org/demo.aspx?pr...

Professor David Nagib of Ohio State presented the Organic Syntheses Lecture at the UC Irvine on November 3, 2025 on “Harnessing Radicals and Carbenes to Enable Unconventional Reactivity”.