Nezha Benabdallah

SS18::SSX activates Polycomb target genes without BAF ❌ Instead, transcription relies on EP300 via the SS18 QPGY domain www.biorxiv.org/content/10.6... ➡️ Coactivator targeting emerges as a new therapeutic strategy in synovial sarcoma 🎯 Team work from @banitolab.bsky.social and @uoe-igc.bsky.social

🎉 Our paper is out today in @science.org! How does the intestine maintain the right balance of cell types? We find that signalling rhythms matter! So proud of our three shared first authors, Sonja Weterings, @hiromuneeto.bsky.social & @jddeleede.bsky.social! 🔗 www.science.org/doi/10.1126/...

📚🦠 J'ai une petite passion pour les bactéries, mais surtout j’adore faire de la recherche fondamentale ! Pour partager cette joie avec le grand public francophone, j’ai écrit un court ouvrage qui sort aujourd’hui : Mille milliards de vies invisibles, édité par @premierparallele.bsky.social !

Microscopy images are scientific evidence, and that image processing must be transparent and faithful to the underlying biology. Reinforce those standards, especially now-insist Nikon uphold them. #NikonSWiM2026 Read the letter: tinyurl.com/OpenLetterSW... Add your name: forms.gle/TyGRELnCxq5z...

As of noon today, we are just shy of 200 signatures from 22 countries and country... let's keep up the pressure! #ScienceIntegrity #MicroscopyMatters #ShareTheRawData #CiliaGate

Effet matilda, invisibilisation ou mentrification, je connaissais Je découvre aujourd'hui le mot cryptogynie #womeninstem #womeninscience olivia.science/cryptogyny/ fr.wikipedia.org/wiki/Effacem...

A study led by @andrewwood.bsky.social's lab has found the way cancer-causing proteins accumulate in tumours may influence how effectively a promising new generation of medicines can remove them. Read more here 👉 edin.ac/4cWw7Mh @cp-cellchembiol.bsky.social @cmvm-edinburghuni.bsky.social

And here's a beautifully complementary work from @trayon.bsky.social and @jamesbriscoe.bsky.social group, showing broad differences in protein stability in human and mouse neural progenitors - again, protein degradation is slower in human cells! authors.elsevier.com/sd/article/S... 5/

New paper from the lab! authors.elsevier.com/sd/article/S... We find that protein degradation is broadly slower in human segmentation clock cells than in mouse cells, regardless of the degradation pathway or protein category! 1/

Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch www.science.org/doi/10.1126/...

Our new study led by Dr. David Kirsch @uhn.ca @uhnresearch.ca describes an innovative dual recombinase preclinical model of CIC::DUX4 sarcoma, an aggressive cancer affecting young adults, and identifies a promising treatment approach in lab models. doi.org/10.1172/jci2...

"Somewhere in a university shared drive, there is probably an Athena Swan action plan that took months to produce, drew on years of data, involved hours of unpaid or under-recognised labour, and identified inequalities that everyone agreed mattered." This really hit home.

The @US_FDA granted traditional approval to the targeted therapy selpercatinib for patients 2 and older with advanced solid tumors that have a RET gene fusion whose disease progressed on or following systemic treatment or who have no alternative options: buff.ly/Od4Phzl

The FDA has granted full approval for an engineered cell therapy called afamitresgene autoleuecel (Tecelra®, also known as afami-cel) for treating advanced synovial sarcoma. More about the clinical trials resulting in the drug’s approval, led by MSK's Dr. Sandra D’Angelo: https://bit.ly/4eVcTZ4

1/ Very excited to share the first publication from my lab! In this work, we developed an efficient strategy to precisely mutate mammalian histone genes in their native genomic context using CRISPR prime editing: www.nature.com/articles/s41...

Very honoured that the lab has been selected as the first UK Center for Excellence by the CdLS foundation www.cdlsusa.org/centers-for-.... We aim to advance knowledge about this genetic condition and to explore similarities to other rare genetic disorders that affect gene regulation.

Each year, we highlight companies that received sizeable early-stage funding in the previous year. Trogenix's platform for generating ‘synthetic super-enhancers’ could drive highly cell-specific gene therapy-based treatment of solid tumors such as glioblastoma www.nature.com/articles/s41...

How do cells combine cell-intrinsic & tissue-level cues create stable patterns during intestinal regeneration? 🤔 Our paper w/ @cschwayer.bsky.social @silviabarbiero.bsky.social @ehannezo.bsky.social @priscaliberali.bsky.social is out! 🥳 A thread on the theory part 🧵⬇️ www.cell.com/cell/fulltex...

“It’s just a microscopic water droplet surrounded by a fatty membrane and stuffed with chemicals and snippets of DNA encoding a mere 36 genes. But it’s also arguably the closest researchers have come to building a living cell from scratch.”🧪 My story in @science.org on a fascinating preprint:

I have been thinking since yesterday about why I find the 1% thing so, so disturbing. It's a visceral reaction of 'just no', which goes beyond the general yuck towards the enshittification of/via AI. I have finally put my finger on it: it is the feeling you get when

Congratulations to Professor Andrew Jackson who has been awarded a 2.5 million euros @erc.europa.eu Advanced Grant to study the 'Mechanisms of Epigenetic Ageing and Sizing' #ERCAdG Read more 👉 edin.ac/4uMJULv @cmvm-edinburghuni.bsky.social

I know it seems like a heretical idea, but one way to figure out if a preprint is really interesting (to you) is... to read the preprint. Then, in the spirit of sharing, send a note to authors: a simple kudos or a more detailed question. I do this a dozen times a year. It's awesome. Try it.

When reality surpasses fiction! Top: fictional forecast for August 2050, broadcast by French TV in 2014 to warn about the consequences of global warming. Bottom: Real French forecast for yesterday, June 22, 2026.

Programming and reprogramming living systems take center stage at the #mdcBerlin Bioengineering Symposium 2026. Our speakers will share insights from synthetic biology, immunology, and systems biology. 🗓️ July 6 | Berlin-Buch More info and registration: 👉 www.mdc-berlin.de/BioE-2026 👈

Let's step inside a neuron together, and ask, "how did all this get here?" 🤔 In this review, I trace the history and transformations of a neuron's molecules, pay homage to major discoveries in brain development ... and make a call to action for neuroscience. www.annualreviews.org/content/jour...

Scotland has colonised the U.S.

Online today @natcellbio.nature.com! The Cai Lab discovered a type of large condensate in the nucleus of renal cell carcinoma cells with high levels of the TEAD1 transcription factor that are different than previously characterized transcriptional condensates (1/3)

Really good well balanced piece about the place of interviewing in grants (well, my remarks are not particularly well balanced, but the piece is!). Featuring @kirstygrainger.bsky.social too 🙂 www.researchprofessionalnews.com/rr-news-worl...

📢 We are looking for a Junior Group Leader to join us at @institutcurie.bsky.social! Having joined the department just over a year ago, I can honestly say that it is an exceptionally stimulating and supportive scientific environment, filled with outstanding colleagues — all in the heart of Paris.

Excited to share the first pre-print from our lab!! Check it out here! www.biorxiv.org/content/10.6... We found that many RNA-binding proteins canonically understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.

Excited to share our new paper at Cell Reports @cp-cellreports.bsky.social led by fantastic Gabe Dolsten! We characterized multi-megabase and interchromosomal chromatin interactions in primary T cells, revealing a previously underappreciated layer of genome organization: doi.org/10.1016/j.ce...

⚡New preprint from the lab⚡: A key early checkpoint in gene expression is promoter proximal pausing of RNA polymerase II. For over 20 years, we as field have not been able to recreate pausing under realistic cellular conditions. @robertovn.bsky.social shows that ELOF1 is the missing piece.

Help please! We need to do some large(ish) cell culture inhibiting E-cadherin with a monoclonal antibody. Does anyone have the DECMA-1 hybridoma cell line so we could purify our own antibody? or a similar monoclonal that would do the job. Any help greatly appreciated, just DM me. Please repost!

Excited to share our first story led by @martinacapriati.bsky.social! How do cells control the expression of viability genes? We find that single transcription factors can drive both chromatin opening and gene activation from densely co-bound CpG island promoters, including at essential genes

If it walks like a duck and develops like a duck ... the enhancers might still align to humans 🥚🦆 (chicken, actually, but you get the picture) Fun collaboration led by Stella Kyomen and @marketa-kau.bsky.social at @mpi-evolbio.bsky.social

If you want to know what 3′UTRs with long conserved sequence stretches do, check out our BioRxiv preprint doi.org/10.64898/202.... They form functional intermolecular 3′UTR-3′UTR interactions that enable co-folding of proteins to rapidly induce transcriptional programs.

#RIP Pierre Chambon (1931-2026) 1963 PARP 1970 RNA Pol II 1975 Nucleosome 1977 Split genes 1980 Promoter 1983 enhancer 1986 Nuclear receptor

This a very important, and extremely well-executed study from Ralph Grand’s group @uniheidelberg.bsky.social. Congrats to all the authors! www.biorxiv.org/content/10.6...

I'm in @theobserveruk.bsky.social today looking at why so many unis are in financial trouble and what the government needs to do to save HE. observer.co.uk/news/columni...

Our researchers are exploring whether radiotherapy for soft tissue sarcoma can be delivered in a shorter, less burdensome way without compromising outcomes. The SCOPES studies mark an exciting step forward in rethinking long‑standing treatment standards. Read more ➡️ www.nki.nl/news-events/...

Calling all alumni of the MRC Human Genetics Unit Join us on Wednesday 23rd Sept to mark the last ever intake of PhD students to the HGU, and to celebrate the achievements of our alumni, and current PhD cohort. To secure a place, please registerat: www.eventbrite.co.uk/e/mrc-hgu-ph...

I am giving a "Crash Course in Embryo Development" for the general public (no science background needed! pitched around GCSE-level) in London on 21st May www.crick.ac.uk/whats-on/cri... We'll dip into development, with a splash of embryo models, and a pinch of ethics. And it's free! Book online 👍

What does it take to truly understand #cancer in all of its complexity? Delighted to share our Review in Cell "Cancer ecosystems: A dynamic interplay across scales" with Daniela Quail, where we propose a multi-scale framework connecting tumor ecology with physiology 🧪⚕️ www.cell.com/cell/fulltex...

there goes the central dogma, i guess. is nothing sacred anymore?

🧬📖 En page de couverture de Development : publication de Louise Maillard @lmaillard.bsky.social (équipe Mounia Lagha @laghalab.bsky.social) et ses collaborateurs ! 🔬✨ Un très beau travail d’équipe 👏 @dev-journal.bsky.social @biologists.bsky.social journals.biologists.com/dev/article/...

How diverse is bacterial immunity ? We report in @science.org how language models allowed us to predict 2.4M antiphage proteins spanning >23K novel potential systems. 👏 @emordret.bsky.social, @alexhv.bsky.social & al doi.org/10.1126/scie... Explore them here defensefinder.mdmlab.fr/wiki/refseq_...

We are recruiting! We are searching for an exceptional postdoctoral fellow to lead the single-cell phenoscaping efforts of the REWIRE-CAN Cancer Grand Challenge @cancergrand.bsky.social For more information and to apply please visit: www.ucl.ac.uk/work-at-ucl/...

We are looking for a new group leader to join the IGH (Montpellier, France). I can’t wait to meet my future colleague! Apply :-) More infos here: igh.cnrs.fr/join-igh-as-...

🚨🚨🚨 My institute, the @i2bcparissaclay.bsky.social in beautiful Gif-sur-Yvette and part of @univparissaclay.bsky.social, is recruiting group leaders! Announcement here: www.i2bc.paris-saclay.fr/join-i2bc/te... Open to early career scientist from anywhere or mid-career already in France. Please RB!

We are offering 5 Postdoc Positions within the Max Planck Postdoc Program! Take advantage and apply by April 13, 2026 to the positions in the labs of @ralfhadams.bsky.social, @ruibenedito.bsky.social and @katemiro.bsky.social. Link to our website: www.mpi-muenster.mpg.de/max-planck-p...