Nature Neuroscience

Nature Neuroscience

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News, commentary and research coverage from the international monthly journal publishing the highest quality of work in all areas of neuroscience. https://www.nature.com/neuro/

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Nature Neuroscience
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Check out the @natureportfolio.nature.com Collection for the Nobel Prize in Physiology or Medicine awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for discoveries leading to optogenetics”. Lots of great work from the winners and others in the field! www.nature.com/collections/...

nature.comNobel Prize in Physiology or Medicine 2026The 2026 Nobel Prize in Physiology or Medicine has been awarded jointly to Karl Deisseroth, Peter Hegemann and Georg Nagel “for discoveries leading to ...
Nature Neuroscience
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Congratualations to Karl Deisseroth, Peter Hegemann, and Georg Nagel for winning the Nobel Prize for optogenetics!

Nobel Prize@nobelprize.org

BREAKING NEWS The 2026 Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”

Nature Neuroscience
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🎉We're excited to welcome Qingzhong Ren to our editorial team! Qingzhong is based in our Shanghai office and is handling papers related to neurodegeneration, aging, and cellular and molecular neuroscience.

Nature Neuroscience
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📢 We’re excited for the launch of npj Pain — a new open access @NaturePortfolio journal 📄 Broad scope spanning basic to clinical research, ethics & policy 🌍 Led & edited by a global team of researchers 📬 Submit at: nature.com/npjpain #PainResearch

Nature Neuroscience
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Exciting opportunity to help launch Nature Progress Brain Health! Must be able to work from our Shanghai, Beijing, or Pune offices. springernature.wd3.myworkdayjobs.com/SpringerNatu...

springernature.wd3.myworkdayjobs.comAssociate or Senior Editor Nature Progress Brain Health)Job Title: Associate or Senior Editor Nature Progress Brain Health Location: Shanghai, Beijing or Pune, Hybrid Working Model Application Deadline: Mar 26th, 2026 About Springer Nature Springer Nature ...
Nature Neuroscience
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🚨We're hiring a new editor!🚨 We're especially looking for someone with expertise in neurodegeneration and cellular/molecular neuroscience. Must have a Ph.D. and be able to work from Madrid, Shanghai, or Pune. Deadline to apply is March 9. springernature.wd3.myworkdayjobs.com/SpringerNatu...

springernature.wd3.myworkdayjobs.comAssociate or Senior Editor, Nature NeuroscienceJob Title: Associate or Senior Editor, Nature Neuroscience Locations: Madrid, Shanghai and Pune Application Deadline: March, 9th 2026 candidates will be considered as they apply About Springer Nature ...

Nature Neuroscience reposted

The Transmitter
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Check out “Frameshift,” a Q&A series in which neuroscientists with nontraditional careers discuss their work and how they made the transition away from the lab. In the first entry of the series, @shariwiseman.bsky.social shares how she went from the bench to science publishing. bit.ly/4rZkk5S

bit.lyFrameshift: Shari Wiseman reflects on her pivot from science to publishingAs chief editor of Nature Neuroscience, Wiseman applies critical-thinking skills she learned in the lab to manage the journal’s day-to-day operations.
Nature Neuroscience
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Connectome caricatures remove large-amplitude coactivation patterns in resting-state fMRI to emphasize individual differences www.nature.com/articles/s41...

nature.comConnectome caricatures remove large-amplitude coactivation patterns in resting-state fMRI to emphasize individual differences - Nature NeuroscienceDominant coactivation patterns are primarily studied in resting-state fMRI. Here, the authors study the rest of the signal, which reveals ‘caricatured’ connectomes with improved behavioral prediction.
Nature Neuroscience
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Parietal cortex output neurons form a specialized population code that enhances the propagation of information to a downstream target and potentially improves the accuracy of decision-making www.nature.com/articles/s41...

nature.comSpecialized structure of neural population codes in parietal cortex outputs - Nature NeuroscienceCortical neurons comprising an output pathway form a specialized population code that enhances the propagation of information to a downstream target, potentially improving the accuracy of decision-mak...
Nature Neuroscience
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TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD www.nature.com/articles/s41...

nature.comTDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD - Nature NeuroscienceTDP-43 dysfunction in ALS/FTD causes faulty splicing of the KCNQ2 ion channel, leading to toxic protein buildup, neuron hyperactivity and a potential new biomarker and treatment target using RNA-based...
Nature Neuroscience
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Attentional failures during wakefulness after sleep deprivation are tightly orchestrated in a series of brain–body changes, including neuronal shifts, pupil constriction and cerebrospinal fluid (CSF) flow pulsations @lauradata.bsky.social @ziy027.bsky.social www.nature.com/articles/s41...

nature.comAttentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics - Nature NeuroscienceYang et al. show that moments of failed attention we experience after sleep deprivation reflect brief ‘sleep-like’ episodes in the brain, corresponding to a brain- and body-wide event with altered bra...
Nature Neuroscience
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The brain’s wake-to-sleep transition follows bifurcation dynamics with a distinct tipping point preceded by a critical slowing down www.nature.com/articles/s41...

nature.comFalling asleep follows a predictable bifurcation dynamic - Nature NeuroscienceLi et al. propose a conceptual framework to study the phenomenon of falling asleep based on electroencephalogram data. They show that a tipping point marks the brain’s nonlinear wake-to-sleep transiti...
Nature Neuroscience
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Connectome datasets alone are generally not sufficient to predict neural activity. However, pairing connectivity information with neural recordings can produce accurate predictions of activity in unrecorded neurons www.nature.com/articles/s41...

nature.comPrediction of neural activity in connectome-constrained recurrent networks - Nature NeuroscienceThe authors show that connectome datasets alone are generally not sufficient to predict neural activity. However, pairing connectivity information with neural recordings can produce accurate predictio...
Nature Neuroscience
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Longitudinal measures of monkey brain structure and activity through adolescence predict cognitive maturation @cconstan.bsky.social www.nature.com/articles/s41...

nature.comLongitudinal measures of monkey brain structure and activity through adolescence predict cognitive maturation - Nature NeuroscienceWorking memory improves during adolescent brain development. Zhu et al. tracked monkeys through adolescence, revealing that maturation of white matter tracts and refinement of neural firing patterns s...
Nature Neuroscience
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Large-scale chromatin accessibility profiling (ATAC-seq) of neurons and non-neurons from 2 human neocortical regions from 469 unique donors, comprising controls and individuals diagnosed with schizophrenia and bipolar disorder www.nature.com/articles/s41...

nature.comThe neuronal chromatin landscape in brains from individuals with schizophrenia is linked to early fetal development - Nature NeuroscienceThis study maps chromatin accessibility in neurons and glia in schizophrenia, revealing fetal-like regulatory patterns in adult neurons enriched for genetic risk variants, linking early brain developm...
Nature Neuroscience
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Cortical and subcortical mapping of the human allostatic–interoceptive system using 7 Tesla fMRI www.nature.com/articles/s41...

nature.comCortical and subcortical mapping of the human allostatic–interoceptive system using 7 Tesla fMRI - Nature NeuroscienceThe brain is constantly monitoring the systems in the body. Here the authors use 7 Tesla functional magnetic resonance imaging to map a large-scale brain system for body regulation in humans, includin...
Nature Neuroscience
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Characterization of the circadian translatomes of astrocytes and microglia in mouse cortex in the setting of amyloid pathology or aging, revealing cell and disease-specific circadian reprogramming of neurodegeneration-related pathways www.nature.com/articles/s41...

nature.comA glial circadian gene expression atlas reveals cell-type and disease-specific reprogramming in response to amyloid pathology or aging - Nature NeuroscienceSheehan et al. have characterized the circadian translatomes of astrocytes and microglia in the mouse cortex in the context of amyloid pathology or aging, revealing cell- and disease-specific reprogra...
Nature Neuroscience
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Leptin-sensitive neuronal subpopulations in the lateral hypothalamus enable adaptive fulfillment of vital needs despite anxiogenic conditions www.nature.com/articles/s41...

nature.comA lateral hypothalamic neuronal population expressing leptin receptors counteracts anxiety to enable adaptive behavioral responses - Nature NeuroscienceFigge-Schlensok et al. show that leptin-sensitive neurons in the lateral hypothalamus encode anxiogenic stimuli and facilitate adaptive strategies to enable an animal to overcome anxiety in threatenin...
Nature Neuroscience
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Oxytocin modulates respiratory heart rate variability through a hypothalamus–brainstem–heart neuronal pathway @julie.buron.bsky.social @inmed.bsky.social @insermpacacorse.bsky.social D54@incia-neurocampus.bsky.social www.nature.com/articles/s41...

nature.comOxytocin modulates respiratory heart rate variability through a hypothalamus–brainstem–heart neuronal pathway - Nature NeuroscienceBuron et al. show that oxytocin enhances heart rate variability linked to breathing during recovery from stress. This calming and cardio-protective effect is produced through a hypothalamus–brainstem ...
Nature Neuroscience
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High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN), a common target for Parkinson’s disease, activates afferent axons while inhibiting STN neurons www.nature.com/articles/s41...

nature.comDifferential synaptic depression mediates the therapeutic effect of deep brain stimulation - Nature NeuroscienceThe authors show that deep brain stimulation (DBS) inhibits local neural activity via differential suppression of glutamate and GABA release, and they developed a chemogenetic therapy as a less invasi...
Nature Neuroscience
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A noninvasive, CSF-specific MRI technique that enables detailed in vivo measurement of CSF mobility in humans, down to the level of perivascular spaces located around penetrating vessels www.nature.com/articles/s41...

nature.comRegion-specific drivers of CSF mobility measured with MRI in humans - Nature NeuroscienceBrain clearance mechanisms are challenging to visualize in humans. Using magnetic resonance imaging, the authors noninvasively mapped cerebrospinal fluid motion across the brain, showing region-specif...
Nature Neuroscience
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C9orf72 mutations impair immune activation in ALS, highlighting key differences in the cellular and molecular pathways underlying sporadic and genetics forms of the disease @mancusorenzo.bsky.social @c9laura72.bsky.social @baukje-bij.bsky.social @cmn-vib.bsky.social www.nature.com/articles/s41...

nature.comC9orf72 hexanucleotide repeat expansions impair microglial response in ALS - Nature NeuroscienceThis study shows that C9orf72 mutations impair immune activation in ALS, affecting how brain cells communicate, and highlights key differences in the cellular and molecular pathways underlying sporadi...