Minczuk Lab

Delighted to share the launch of the Cambridge-led, £50m MRC Centre of Research Excellence in Mitochondrial Genome Therapeutics (CoRE-MitoGT). Over 14 years, we will unite international expertise to understand mtDNA disease & develop therapies targeting its root causes. www.ukri.org/news/mrc-fun...

How can #mtDNA change rapidly over just a few generations, and remain compatible with the independently inherited, evolving nuclear genome? Find out in @mitogene.bsky.social fascinating @natureportfolio.nature.com review: lnkd.in/p/gPHJdCRs #mitoscientists #mitochondria #mitochondrialevolution

New project in the lab - engineering phages to edit mitochondria! We team up with Ian Collinson @ianofbristol.bsky.social + Nicholas Taylor @nmitaylorlab.bsky.social in the ProMit consortium led by Michal Minczuk @mitogene.bsky.social. PostDoc Ruta Prakapaite @rootspr.bsky.social is ready to go! 🪄🧬

The ProMiT consortium led by Michal Minczuk @mitogene.bsky.social is funded by ARIA @aria-research.bsky.social - read all the details here on their website: aria.org.uk/opportunity-...

Congrats to Pedro Guiomar on our new paper published today! 🧬 We show that PUSL1 pseudouridylates U39 in mitochondrial tRNAs and link disruption of this pathway to human neurological phenotypes. A great team effort — congratulations to everyone involved! academic.oup.com/nar/article/...

Please check out our bioRxiv preprint 🧬 We present MitoBEAP, the R package for analysing mito. base-editing experiments, enabling assessment of editing efficiency and off-targets from NGS data. A huge congratulations to @lindseyvanhaute.bsky.social and the team 🎉 www.biorxiv.org/content/10.6...

We're hiring a Postdoctoral Research Associate at the MRC Mitochondrial Biology Unit @mrc-mbu.bsky.social Cambridge Join our ARIA Precision Mitochondria project with Bitrobius Genetics to develop novel technologies for mitochondrial DNA delivery and genome engineering www.cam.ac.uk/jobs/researc...

We are pleased to share a new review published in Cell Reports Medicine @cellpress.bsky.social: “Emerging therapeutic strategies for mitochondrial DNA-related diseases” Full article: doi.org/10.1016/j.xc... #Mitochondria #mtDNA #GeneTherapy #GenomeEditing #RareDiseases #TranslationalMedicine

Great to bring together 70+ researchers & partners at the LifeArc Centre for Rare Mitochondrial Diseases Annual Meeting in Cambridge last week! From scientific updates and flash talks to patient voice discussions it was a day full of insight and collaboration!

Looking forward to seeing you soon at Queen Square Advances in Mitochondrial Medicine 2026! We hope you'll join us for the day, plus the networking reception after (drinks and snacks provided). UCL/UCLH staff & students - contact us via email for your free registration code: bit.ly/QSmitomed2026

Clinicians and researchers with an interest in #mitochondrial disease: Queen Square Advances in Mitochondrial Medicine (5 May 2026) is a CPD-approved course covering pre-clinical & translational research, and the latest updates in NHS diagnostic testing. Registration: www.ucl.ac.uk/brain-scienc...

Faulty mitochondria cause deadly diseases: fixing them is about to get a lot easier. CRISPR-based tools can’t easily access the DNA in these organelles, but researchers are finding other ways in www.nature.com/articles/d41...

@mitogene.bsky.social we are looking forward to your presentation at #MitoCellFate in Malta! Please share this with your followers to let them know the Earlybird & Talk submission deadline is fast approaching - Monday 10 November. Register & Submit here: bit.ly/46TS4Ii

It’s here – World Mitochondrial Disease Week! 💚 We’re proud to collaborate with other mito charities across the UK to put mito on the map – let's spread the word together! 👉 See how you can get involved: 🔗 thelilyfoundation.org.uk/charity/get-involved/world-mitochondrial-disease-week

Don't forget to register and submit your abstract for our #MitoCellFate conference in Malta next year ☀️ 📢Check out our wonderful speaker line-up so far! 📅Early-bird & talk deadline: 10 Nov 2025 bit.ly/46xBYVt #FusionStemCells #FusionAgingResearch

Massive congratulations to @lucialugut.bsky.social on receiving the prestigious 2025 CSAR Award! 🎉 Lucia's groundbreaking work in modeling and correcting mtDNA mutations paves the way for innovative future therapies for mitochondrial diseases. @mrc-mbu.bsky.social www.csar.org.uk/student-awar...

The first-ever conference dedicated entirely to mitochondrial DNA just wrapped up in Nashville! From mutation mechanisms to repair strategies and cutting-edge editing techniques, it was a landmark event. See the full recap 👇 mitoworld.org/mechanisms-o...

🎙️ Focus Speakers – Michal Minczuk @mitogene.bsky.social 👀 Curious to know who will be speaking at #euromit2026 ? ✨ Today, we’re introducing Michal Minczuk who will be taking the stage at the congress. #euromit2026 #mitochondria #angers @univangers.bsky.social @ua-recherche.bsky.social

Coverage of this important work led by @daniellahock.bsky.social and @dstroudlab.bsky.social who support our @lifearc.bsky.social research to replicate this @medicalsciencesncl.bsky.social @neygenomics.bsky.social @mitocamb.bsky.social @londonmito.bsky.social @lilyfoundation.bsky.social

Last chance to join us for the Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee @faseborg.bsky.social

🚨 Join us for the @faseborg.bsky.social Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!

Hello fellow mitochondriacs! Are you passionate about mtDNA? We now offer a 2-year postdoc opportunity for studies of mtDNA instability and its signaling. Apply by May 18th to join our international team in exotic Umeå. Please share! www.umu.se/en/work-with...

Yesterday we were proud to join the launch of the LifeArc Centre for Rare Mitochondrial Diseases - a major step forward in mito research We led a workshop on making complex science clear – because involving patients is key to success #mitochondrialdisease #mitoresearch #patientvoice #raredisease

Very full schedule at our #IMGCglasgow workshop last week, delivered by MitoCluster team @robpitceathly.bsky.social, Carlo Viscomi, @mitogene.bsky.social, and @jim-ca.bsky.social. A pleasure to attend, thanks for the invite @mrcmousenetwork.bsky.social & IMGS! 🧬 #mitochondria #MouseModels #ECR

🚨 Join us for the @faseborg.bsky.social Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!

Clinically translatable mitochondrial #GeneTherapy in muscle using tandem mtZFN architecture. By P. Nash, @mitogene.bsky.social & colleagues @mrc-mbu.bsky.social 🗞️ doi.org/10.1038/s443... Read also related N&V by A. Ghifari & M. Ott 👉 doi.org/10.1038/s443...

Great opportunity!

Exciting news from Pretzel Therapeutics! We’ve launched a Phase 1 trial for our POLG activator—PX578—targeting rare mitochondrial syndromes with potential for Parkinson’s & Alzheimer’s diseases. Congratulations to the entire team—proud to be part of this journey! www.pretzeltx.com/pretzel-ther...

We are hiring #bioinformaticians. One post to work on the new @lifearc.bsky.social centre for rare #mitochondrial diseases, and one is a joint project @mrc-mbu.bsky.social with Prof Patrick Chinnery & @mitogene.bsky.social Apply here: www.jobs.cam.ac.uk/job/50861/ www.jobs.cam.ac.uk/job/50860/

Really interesting read from #Beacon for RD about their involvement in the @lifearc.bsky.social centres for #raredisease Read it here: www.rarebeacon.org/blog/beacons... @lilyfoundation.bsky.social @robpitceathly.bsky.social @taylorlabncl.bsky.social @ritahorvath.bsky.social @mrc-mbu.bsky.social

Exciting News: Learn about the Speakers of Euromit 2026! We are happy to announce the amazing speakers for Euromit 2026, the leading congress on mitochondrial pathology.🌍✨ 📢 See the full list ! 👇 #euromit2026 #mitochondria #science #innovation #angers

Looking forward to #IMGC2025 Glasgow next month! MitoCluster will be delivering an #ECR Workshop on Mouse Models of #Mitochondrial DNA Disease, featuring cluster lead @robpitceathly.bsky.social and investigators Carlo Viscomi, @jim-ca.bsky.social, and @mitogene.bsky.social🐁

🌍Euromit 2026 is coming to Angers!🌍 ✨The international congress dedicated to mitochondrial research, will take place in France, at the Centre des Congrès of Angers. from May 31 to June 4, 2026! ✨ 📢 Stay informed by following this page and get ready for an exceptional scientific experience! 🚀🔬

REGISTRATION OPEN for @faseborg.bsky.social Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair | June 1 - 5, 2025 | Nashville, Tennessee. Apply before it is too late: events.faseb.org/event/mitoch... Please re-post!

If you are interested in mitochondria, Nashville is the place to be June 1-5. Check out this FASEB meeting. Please RT. events.faseb.org/event/mitoch...