Bratislav Misic

@francescopoli.bsky.social

4 Aug 2025

Integrating and interpreting brain maps | doi.org/10.1016/j.ti... Imaging and recording technologies make it possible to map multiple biological features of the brain. How can these features be conceptually integrated into a coherent understanding of brain structure and function? ⤵️

Bratislav Misic reposted

Andrea Luppi, PhD

@loopyluppi.bsky.social

1/ 🚨 Just out in @natneuro.nature.com! 🧠 We profiled >6,000 features of brain dynamics across humans, macaques, marmosets, mice, fish and worms 🧑🐒🐒🐁🐟🪱 to find a shared neural endpoint of anaesthesia: spatiotemporal isolation of local activity 🧵👇 🔗 doi.org/10.1038/s41593-026-02460-4

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Golia Shafiei

@goliashf.bsky.social

So excited that our work is now published in PLOS Biology!! 🎉 Check out the final version here: doi.org/10.1371/jour... And for a bit more context and what we found, here’s our earlier thread: bsky.app/profile/goli...

PLOS Biology@plosbiology.org

How do intrinsic timescales, which reflect the temporal window of neural processing, mature during development? This study by @goliashf.bsky.social @ted-satterthwaite.bsky.social &co identifies a hierarchical trajectory, from sensorimotor to association cortices. 🧪 #NeuroSky plos.io/46RzqRG

Bratislav Misic reposted

Francesco Poli

I can't overstate the importance of this toolbox & this paper! Really amazing stuff

Bratislav Misic@misicbata.bsky.social

netneurotools: a trainee-oriented approach to network neuroscience | doi.org/10.1038/s415... Our lab’s internal toolkit for accomplishing everyday tasks in brain imaging @natprot.nature.com ⤵️

doi.orgnetneurotools: a trainee-oriented approach to network neuroscience - Nature ProtocolsThis is a Perspective covering a Python toolbox for neuroscience research that enables users to fetch datasets, construct networks and null models, estimate graph metrics, fit statistical models and v...

doi.orgSpatial organization of AQP4 water channel expression in the human brainAquaporin-4 (AQP4) water channels support the glymphatic system, a brain-wide pathway that clears cerebral waste products. Here, we use AQP4 gene expression to reconstruct a whole-brain glymphatic-rel...

Spatial organization of AQP4 water channel expression in the human brain | doi.org/10.1126/scia... Aquaporins are a key component of the glymphatic system. How are they distributed + how do they relate to brain function and dysfunction? ⤵️

6️⃣ There are a few other fun things in the supplement, including the mapping of other aquaporins and comparisons with MRI measurements of the glymphatic system (intrathecal CSF tracer gadobutrol).

github.comGitHub - netneurolab/taheri_aquaporin-four: Repository for the project "Spatial organization of AQP4 channels in the human brain: links with perfusion, edema, and disease vulnerability"Repository for the project "Spatial organization of AQP4 channels in the human brain: links with perfusion, edema, and disease vulnerability" - netneurolab/taheri_aquaporin-four

7️⃣ We really like this project because it explores how support systems—in this case whole-brain glymphatic organization—relate to diverse aspects of brain physiology and disease vulnerability. code + maps: github.com/netneurolab/...

4️⃣ Incorporating normative PET markers of neuroinflammation typically strengthens the spatial alignment between AQP4 expression and disease atrophy, suggesting that inflammatory tone and glymphatic-related architecture jointly shape vulnerability.

5️⃣ Finally, we show that peritumoral edema is most frequent in AQP4-enriched regions and is further shaped by regional inflammatory tone.

2️⃣ Linking AQP4 expression to vascular organization, we find that AQP4-enriched regions show lower normative blood perfusion and lower vein density, suggesting that this axis is not simply explained by vascular supply or large-vessel anatomy.

3️⃣ Turning to neurodegeneration, we find that atrophy patterns across multiple neurodegenerative diseases co-localize with AQP4 expression—most strongly for tau and TDP-43 proteinopathies—and high-atrophy regions lie close to AQP4 hotspots.

1️⃣ Aquaporin-4 (AQP4) water channels support the glymphatic system, a brain-wide pathway that clears cerebral waste products. Here we use AQP4 gene expression as a molecular anchor to reconstruct a whole-brain glymphatic-related topography.

netneurotools: a trainee-oriented approach to network neuroscience | doi.org/10.1038/s415... Our lab’s internal toolkit for accomplishing everyday tasks in brain imaging @natprot.nature.com ⤵️

3️⃣ We showcase three walkthroughs of biologically-relevant questions that can be answered using netneurotools, related to structure-function coupling, multimodal connectivity, dynamics and gradients.

github.comGitHub - netneurolab/netneurotools: Useful tools from the Network Neuroscience LabUseful tools from the Network Neuroscience Lab. Contribute to netneurolab/netneurotools development by creating an account on GitHub.

4️⃣ All built and maintained by our trainees, led by @zhenqi.bsky.social @vincebaz.bsky.social Code: github.com/netneurolab/... Documentation: netneurolab.github.io/netneurotools/

netneurotools: a trainee-oriented approach to network neuroscience | doi.org/10.1038/s415... Our lab’s internal toolkit for accomplishing everyday tasks in brain imaging @natprot.nature.com ⤵️

1️⃣ Neuroimaging is complex: multiple data types, formats, and specialized packages. netneurotools is our lab’s Swiss army knife: functions that we often use but that are not part of any established pipeline. Code: github.com/netneurolab/... Documentation: netneurolab.github.io/netneurotools/

nature.comnetneurotools: a trainee-oriented approach to network neuroscience - Nature ProtocolsThis is a Perspective covering a Python toolbox for neuroscience research that enables users to fetch datasets, construct networks and null models, estimate graph metrics, fit statistical models and v...

2️⃣ By design, netneurotools is trainee-centric and focuses on accessibility and usability. The functions are grouped into intuitive modules, covering the full lifecycle of a project. Like "desire paths" in urban design — we only pave the routes people are already walking.

Bratislav Misic reposted

Rosy Favicchio

@rosyf.bsky.social

15 Sept

netneurotools is a Python toolkit that has been continuously developed by lab trainees as a set of tools to navigate the complex informatics ecosystem of brain imaging. @natprot.nature.com @misicbata.bsky.social 🧪 🧠 #imaging

Bratislav Misic reposted

PLOS Biology

@plosbiology.org

16 June

#Aging drives changes in the #brain and #metabolism, but how independent are these effects? This study by @asafarahani.bsky.social, @misicbata.bsky.social &co identifies two axes of brain-body associations, each primarily related to age or metabolic health. 🧪#AcademicSky plos.io/4eoIu3L

Bratislav Misic reposted

PLOS Biology

@plosbiology.org

16 June

Bratislav Misic reposted

Alex Fornito

@alexfornito.bsky.social

7 June

Our latest, led by @ivaili.bsky.social out now in Nature Mental Health using normative modelling to understand the heterogeneity of atypical FC in autism. Peep the thread...

Iva Ilioska@ivaili.bsky.social

Our paper “Multiscale heterogeneity of atypical functional connectivity in autism” is now out in Nature Mental Health www.nature.com/articles/s44... With @alexfornito.bsky.social, Jan Buitelaar, Marianne Oldehinkel

nature.comMultiscale heterogeneity of atypical functional connectivity in autism - Nature Mental HealthUsing normative modeling to measure the interindividual variability of atypical brain functional connectivity in autism, the authors identify heterogeneity at the level of specific connections alongsi...

Bratislav Misic reposted

Armin Raznahan

@bogglerapture.bsky.social

28 May

Do humans show sex differences in brain activation? If so, are these task-specific or general — and do they relate to sex differences in brain anatomy and behavior? We dove deep into these questions in a new paper just out in Nature Communications | tinyurl.com/3rdrb524

Bratislav Misic reposted

Andrea Luppi, PhD

@loopyluppi.bsky.social

20 May

Delighted that our paper about benchmarking gene expression 🧬 in macaque brain 🐒🧠(www.science.org/doi/10.1126/...) was selected for this year's Brain Star Award of the Canadian Neuroscience Association 🇨🇦 - what an honour to be named among such talented scientists!

science.orgscience.org

Canadian Association for Neuroscience@canacn.bsky.social

CAN and CIHR-INMHA are very proud to announce the winners of the 2025 Brain Star awards. See all their profiles here: can-acn.org/congratulati...

Bratislav Misic reposted

Leon Lotter

@leondlotter.de

7 May

My most recent and biggest work so far is finally out as a preprint! 🧠🧵 *Linking human brain functional connectivity to underlying neurotransmission* doi.org/10.64898/202... 1/n TL;DR below ↓ #neuroskyence #neuroimaging #MedSky #PsySciSky

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bioRxiv Neuroscience

@biorxiv-neursci.bsky.social

30 Apr

Benchmarking spatial interpolation methods for brain maps https://www.biorxiv.org/content/10.64898/2026.04.27.721143v1

Bratislav Misic reposted

Alain Dagher

@alaindagher.bsky.social

17 Apr

Comparative anatomy of brain metabolism in human and macaque (and other species). The dichotomy between glucose as fuel and glucose for tissue building is conserved across species. @moohebatpe.bsky.social and @misicbata.bsky.social www.biorxiv.org/content/10.6...

biorxiv.orgbiorxiv.org

Bratislav Misic reposted

Thomas Yeo

@bttyeo.bsky.social

9 Apr

We develop a new TMS targeting algorithm and test it in an open label trial in a treatment-resistant depression population with high comorbidities. Preprints by @rubykong92.bsky.social Phern-Chern Tor 1. doi.org/10.1101/2025... 2. doi.org/10.64898/202... Our new approach ...

Bratislav Misic reposted

Marc L Seal

@parkvillegeek.bsky.social

8 Apr

👀 Structure-function coupling in the human brainstem | bioRxiv www.biorxiv.org/content/10.6...

Bratislav Misic reposted

bioRxiv Neuroscience

@biorxiv-neursci.bsky.social

7 Apr

Structure-function coupling in the human brainstem https://www.biorxiv.org/content/10.64898/2026.04.05.716603v1

Bratislav Misic reposted

Thomas Yeo

@bttyeo.bsky.social

27 Mar

Do you censor high motion frames in fMRI? In two preprints by @twktan.bsky.social @mandymejia.bsky.social, we find that we may be censoring too much! doi.org/10.64898/202... arxiv.org/html/2603.07... Strict censoring leads to worse personalized TMS targets than no censoring, even with high motion!

Bratislav Misic reposted

Laura Lewis

@lauradata.bsky.social

20 Mar

Our lab has an opening for a full-time research assistant, to work on human neuroimaging techniques and the neuroscience of sleep! To apply: massgeneralbrigham.wd1.myworkdayjobs.com/en-US/MGBExt...

massgeneralbrigham.wd1.myworkdayjobs.comClinical Research CoordinatorSite: The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to adva...

Bratislav Misic reposted

Eric Ceballos

@cebric.bsky.social

18 Mar

Curious about how brain and body communicate, or how circuit states are regulated over seconds to hours? Read our paper about neuropeptide systems and how they contribute to neural architecture and function #neuroskyence #compneuro #neuroscience

Bratislav Misic@misicbata.bsky.social

Organization of neuropeptide systems in the human brain | doi.org/10.1038/s415... Neuropeptides are functionally diverse signaling molecules in the brain and body. @cebric.bsky.social curates an atlas of neuropeptide receptors and relates it to brain function @natneuro.nature.com 🧩 🧠 ⤵️

Bratislav Misic reposted

Alessandro Gozzi

@gozziale.bsky.social

18 Mar

📢 New preprint from the lab🧠 ▶️doi.org/10.64898/2026.03.12.710517 What does fMRI connectivity actually reflect at the neural level? The natural intuition is: more neural activity = more connectivity! Using cortical perturbations we show this is not necessarily the case: sometimes less is more! 👇🧵

Bratislav Misic reposted

Alessandro Gozzi

@gozziale.bsky.social

bcw2026.orgProgram — BCW 2026: June 10-12

Our work on gene therapy for creatine transporter deficiency is now online in #Brain ➡️https://doi.org/10.1093/brain/awaf275 In this study we (i) characterize network-level and behavioral alterations in a common form of monogenic #autism and (ii) test whether gene therapy can rescue these deficits 🧵

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Randy McIntosh

@ar0mcintosh.bsky.social

16 Mar

The program is coming together well for the Brain Connectivity Workshop www.bcw2026.org/program. This will be our 25th year! Consider coming just before the #OHBM annual meeting. #Neuroscience

8⃣ Finally, we replicate all findings using alternative processing and analytical choices. We also conduct multiple sanity check/domain knowledge experiments, including detailed analysis of peptides related to feeding, sexual dimorphism and vasomodulation.

github.comGitHub - netneurolab/ceballos_neuropeptide-organization: Repository for the project "Mapping neuropeptide signaling in the human brain"Repository for the project "Mapping neuropeptide signaling in the human brain" - netneurolab/ceballos_neuropeptide-organization

9⃣ Collectively, these results show that the neuropeptide receptors are highly organized across the human brain and closely intertwined with multiple features of brain structure and function. paper: rdcu.be/e8zTZ data + code: github.com/netneurolab/...

6⃣ To investigate the behavioural consequences of distributed neuropeptide systems, we apply meta-analytic decoding to neuropeptide maps and show a gradient of functions that mirrors neuropeptide expression, from sensory-cognitive to reward and bodily functions.

7⃣ Evolutionary analysis indicates extended positive selection for neuropeptides in early mammals, suggesting that refinement of neuropeptides coincides with the emergence of neocortex and higher cognitive function.

4️⃣ How does neuropeptide organization align with the anatomy of the hypothalamus, the nexus of neuropeptide communication? Across eight hypothalamic nuclei, we find a tuberal to mammillary gradient (tracking embryogenesis), and a mediolateral gradient (tracking cytoarchitecture).

5️⃣ Looking to related chemical signalling systems, we find that neuropeptides preferentially co-localize with metabotropic neurotransmitters, suggesting a brain-wide correspondence between slow-acting molecular signaling mechanisms.

2⃣ Using gene transcription as a proxy, we reconstruct a topographic cortical and subcortical atlas of neuropeptide receptors for 38 neuropeptide receptors, across 14 different neuropeptide families.

3⃣ Most neuropeptide receptors are highly expressed either in cortex or subcortex, delineating an anatomical cortical-subcortical gradient. We find lots of 'textbook' hits (e.g. oxytocin in amygdala, leptin in hypothalamus, opioid in accumbens).