Balance of the Microverse

Balance of the Microverse

@microverse.bsky.social

Understanding principles and dynamics of #microbialbalance #ClusterOfExcellence @uni-jena.de Funded by @dfgpublic.bsky.social

254 followers146 following140 posts

Small wonders, big curiosity! 🔬🐭 65 young researchers explored our new #MicroverseCenterJena with #VR, microscopes and glowing bacteria at #TürenAufMitDerMaus. Thank you for your questions and enthusiasm! Excellent research opens doors – for curious minds of all ages.

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Die #UniJena erhält den Status einer Exzellenzuniversität! Die Exzellenzkommission hat den Antrag „Light. Life. Liberty. – Connecting People and Ideas“ am heutigen 2.Oktober positiv entschieden. 🥳

✨🦠✨ Shine on, you tiny diamond. Meet Flavobacterium IR1, our #MicroverseMicrobeOfTheYear! It creates brilliant, angle-shifting color without pigments, using nanoscale cell structures. Our researchers are exploring what this structural color does in nature. #InternationalMicroorganismDay

microverse-cluster.deShine on, you tiny diamond: Flavobacterium IR1 is the Micro…On the occasion of International Microorganism Day on September 17, the Cluster of Excellence “Balance of the Mi…

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We are hiring! 2-year Postdoc in Metagenomics starting October 2026. We are looking for a highly motivated researcher with strong bioinformatics expertise in metagenomic analyses of soil and/or groundwater microbiomes and a strong publication record. 📧 aquat.geomikrobiologie@uni-jena.de

Three minutes. One idea. The chance to break down walls. 💡 Join #FallingWallsLab Jena on 10 September and discover bold ideas from students, #EarlyCareerResearchers & #innovators. And yes—you get to vote for your favourite! 🗳️ 📍 Imaginata | 5 pm 🎟️ Free @jenainnovation.de

indico.rz.uni-jena.deFALLING WALLS Lab Jena10.09.26 | 17:00 | IMAGINATA, JENA Which are the next walls to fall? Join us for the first FALLING WALLS Lab Jena 2026 and support the next generation of researchers and innovators as they take the st...

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What can we learn from microbes? 🦠 A lot. Deep beneath our feet, microorganisms have survived for billions of years with minimal energy by recycling resources & working together. Our spokesperson Prof. Kirsten Küsel (@kuesellab.bsky.social) explains why their hidden world matters. 🤝 @uni-jena.de

mdr.deLeben am Limit: Bakterien können auch Eisen atmenWas braucht man so zum Leben? Bett, Brot, Smartphone, Klo? Oder schon ein Häuschen mit Kiesauffahrt? Denjenigen, die glauben, sie würden bescheiden leben, sei gesagt: Es gibt Organismen, die brauchen ...

How do microbes survive where there's almost no energy? 🦠⚡ A new #NatureMicrobiology review by Kirsten Küsel (@kuesellab.bsky.social @uni-jena.de) and Mark Dopson (Linnaeus University)University introduces microbial frugality—a concept explaining life at the energy limit in #groundwater.

microverse-cluster.deLife on the energy limit New framework: concept on microbia…How can microorganisms survive when there is hardly any energy or nutrients available? This question is the subjec…

🌡️ Small temperature changes, big consequences: Our researchers found that the microalga Chlamydomonas reinhardtii adjusts the activity of around one-third of its protein-coding genes between 18–33°C—revealing how sensitive microbes are to climate change.

Universität Jena@uni-jena.de

A study from #UniJena and @leibniz-hki.de at @microverse.bsky.social shows that even at moderate temperature changes, a third of protein-coding genes in Chlamydomonas reinhardtii responds – with potential consequences for ecosystems. ➡️ www.uni-jena.de/en/431332/und…

🥖 Meet the good yeast. A close relative of baker's yeast could help fight persistent fungal infections. 🦠 In a new study, @markgresnigt.bsky.social & colleagues (@leibniz-hki.de, the Microverse Cluster & KU Leuven) show it weakens 𝘊𝘢𝘯𝘥𝘪𝘥𝘢 𝘢𝘭𝘣𝘪𝘤𝘢𝘯𝘴 and boosts immune cells. Good yeast vs. bad yeast. ⚔️

microverse-cluster.deGood yeast, bad yeast: Researchers discover New Potential o…Millions of women worldwide suffer from vaginal yeast infections. These infections are most commonly caused by the…

Congratulations to @ameliabarberphd.bsky.social on her next career step! From July 1, she joins @fzborstel.bsky.social & @uni-kiel.de as Group Leader and Professor. We'll miss her interdisciplinary spirit and fungal expertise. Best of luck in Kiel and Borstel, Amelia! 🦠💻

microverse-cluster.deNew Chapter for Amelia Barber: From Jena to KielAfter a highly successful time in the Cluster of Excellence “Balance of the Microverse,” Amelia Barber is taki…

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Which wall will your research break? 🧱💡 The #FallingWallsLab is coming to Jena for the first time ever! We are looking for students, researchers, and recent graduates with breakthrough ideas that address today's societal challenges.

🇩🇪🤔 Ever been told to put the butter next to the fish or that the barrel is about to overflow? Our new Microverse Kitchen Postcards turn quirky German idioms into hilarious illustrations—and connect international researchers with support resources via QR code. 🧈🐟🛢️

🦠 A virus can dominate an ecosystem without evolving—but give it access to a new community, and evolution shifts into fast-forward. Our latest study reveals how migration drives viral adaptation and host switching. 🤝 @jeroenmeijer.bsky.social 🔬 Published in Science Advances Microbiology #Virology:

microverse-cluster.deEvolution in Fast-Forward: How Migration Accelerates Viral …Viruses do not always evolve rapidly, even during massive outbreaks. Yet when they encounter a new community with …

🦠 Why do antibiotics stop working? Antibiotic resistance evolves faster than many people realize. In the latest MDR podcast microbiologist Kai Papenfort explains how bacteria develop resistance—and why resistance genes often exist from the very beginning. 🤝 @uni-jena.de

ardsounds.dePodcast: Warum Antibiotika plötzlich nicht mehr helfen?Host Karsten Möbius hat vor Kurzem über längere Zeit mehrere Antibiotika schlucken müssen. Ihn überkommt dann jedes Mal ein komisches Gefühl, ob er sich damit nicht resistente Keime "anzüchtet", "antr...

🦠 How do bacteria control the viruses hidden in their own genomes? Researchers from @uni-jena.de uncovered a new defense mechanism: the small RNA CisR acts as a molecular brake, limiting replication of the cholera toxin–encoding CTX phage in Vibrio cholerae. Published in @pnas.org.

microverse-cluster.deResearch from Jena deciphers a new form of bacterial virus …us. The findings were published in the journal Proceedings of the National Academy of Sciences (PNAS). Microbial p…

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📺 Jena & its university on TV: The latest episode of 3sat Ländermagazin highlights Jena as a city driven by science, innovation & academic excellence — The documentary includes insights from our speaker Kirsten Küsel and follows students Emily & Samira through everyday life in research and study.

ardmediathek.deLändermagazin: Jena und seine Uni – Exzellenz aus Tradition - hier anschauenSeit Jahrhunderten verändert und prägt die Friedrich-Schiller-Universität die Stadt Jena in Thüringen – mit ihren Studenten, Forschenden, innovativen Projekten und Gebäudekomplexen.

Congrats to @hellmichgroup.bsky.social on her #MaxPlanckFellowship! As a PI at our #ClusterOfExcellence she advances research on signaling in microbial systems. Excited for the new group on Signaling Dynamics and future collaborations!

Congratulations to @hellmichgroup.bsky.social! The Max Planck Society awarded her a Max Planck Fellowship. We are happy to have her as a Max Planck Fellow and look forward to intensifying our collaboration with her. www.ice.mpg.de/556225/ute-h...

Bye, bye HKI 👋 On Monday, the Microverse admin office moves to the new Microverse Center Jena. Today: a sunny farewell with colleagues after years at @leibniz-hki.de (since 2016). Thanks for everything! We stay close—just 300 m away. A tiny “microbe friend” comes with us as a reminder 💛

It was a pleasure!

Leibniz-HKI@leibniz-hki.de

🔬✨ Yeast, bright colors, and a dash of curiosity Together with @microverse.bsky.social, we welcomed 34 students for this year’s “Forsche Schüler” Day. Hands on experiments from yeast to data driven research offered insights into real lab work. 👉 Read more: www.leibniz-hki.de/en/news/yeas...

Excellence in microbiome research: Today the Microverse Early Career Scientist Awards honored Beatrix Heinze & @hsuma.bsky.social for outstanding interdisciplinary work on microbial ecosystems. 👏 Congrats to both awardees! 🤝@pstallforth.bsky.social, @kuesellab.bsky.social & @uni-jena.de

microverse-cluster.deExcellence in Microbiome Research: Microverse Presents 2025…The Cluster of Excellence “Balance of the Microverse” at the University of Jena has awarded the Microverse Ear…

And another success from the microverse: Congratulations to our spokesperson Kirsten Küsel! @kuesellab.bsky.social

Universität Jena@uni-jena.de

On Friday, 10 April, 4 researchers from #UniJena were elected to @saw-leipzig-1846.bsky.social: art historian Prof. Dr Johannes Grave, Indo-Europeanist Prof. Dr Martin Joachim Kümmel, geomicrobiologist Prof. Dr Kirsten Küsel and chemist Prof. Dr Birgit Weber. 💐 ➡️ www.uni-jena.de/en/400158/vie…

Congratulations to our long-standing colleague Prof. Wilhelm Boland! – You’ve more than earned it.

Leibniz-HKI@leibniz-hki.de

We congratulate Prof. Wilhelm Boland on receiving the Xience Award 2026! 👏 In recognition of his outstanding scientific achievements and long-standing support, the Leibniz-HKI has presented the second Xience award to the chemist from @mpi-ce.bsky.social. 👉 More: www.leibniz-hki.de/en/press-rel...

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New paper out with our friends the Nina Morgner Lab on how to quantify homodimer affinities by native MS 💕 pubs.acs.org/doi/10.1021/... Never thought it possible, but this concludes our JACS triple - 3 papers in 3 months 😋🥳🧪 @crc1507.bsky.social @microverse.bsky.social @lifeprofile.bsky.social

pubs.acs.orgQuantifying Protein Homodimer Affinities and the Effect of Molecular Glues and Interface Residues Using Native Mass SpectrometryBiological processes rely on finely tuned homo- and heteromeric interactions between (biomacro)molecules. The strength of an interaction, typically given by the dissociation constant (KD), plays a crucial role in basic research and must be monitored throughout the development of drugs and agrochemicals. An ideal method for KD determination is applicable to various analytes with a large range of affinities, tolerates complex matrix compositions, does not require labeling, and simultaneously provides information on the structural integrity of the binding partners. Native mass spectrometry meets these criteria but typically struggles with homooligomeric complexes due to overlapping mass signals. To overcome this, we resolve monomer/dimer contributions to overlapping MS-peaks by separately analyzing the charge state distribution of each oligomeric species via sample dilution and covalent cross-linking. Following this approach, we show that quantitative laser-induced liquid bead ion desorption mass spectrometry (qLILBID-MS) accurately captures the affinities of Bovine Serum Albumin (BSA) and chemically induced dimers of Tryparedoxin (Tpx), an oxidoreductase from human pathogenic Trypanosoma brucei parasites, with various molecular glues and homodimer affinities. Conveniently, qLILBID-MS requires a fraction of sample used by other methods such as isothermal titration calorimetry (ITC) and yields previously inaccessible protein homodimer KDs in the high micromolar range, which allowed us to monitor the gradual decrease in homodimer affinity via mutation of crucial dimer interface contacts. Overall, qLILBID-MS is a sensitive, robust, fast, scalable, and cost-effective alternative to quantify protein/protein interactions, that can accelerate contemporary drug discovery workflows, e.g. the efficient screening for proximity inducing molecules like proteolysis targeting chimera (PROTACs) and molecular glues.

𝗕𝗶𝗴 𝗻𝗲𝘄𝘀 𝗳𝗿𝗼𝗺 𝘁𝗵𝗲 𝗠𝗶𝗰𝗿𝗼𝘃𝗲𝗿𝘀𝗲 🔬 Kai Papenfort, PI in our #ClusterOfExcellence at @uni-jena.de, has been elected Fellow of the European Academy of Microbiology. His work on small RNAs reveals how tiny molecules shape microbial life. Congrats! 👏 Read more: www.microverse-cluster.de/en/news/kai-...

microverse-cluster.deKai Papenfort elected Fellow of the European Academy of Mic…Kai Papenfort, Principal Investigator in the Cluster of Excellence “Balance of the Microverse“ at the Universi…