MICROB-PREDICT

📣 “If the project were a child, it would be in school by now!” 🥳 Jonel Trebicka opened #MICROB-PREDICT's Final GA Meeting today, looking back on 7 years of research, 100+ publications & major achievements. Now it’s time for the final push! 🔬👏 #ACLF #cirrhosis #microbiome @medblab.bsky.social

🎤 Science Slam, 🔮 Delphi Oracle, 💍 Conference Planning, 💎 Nanotech & 🔬 a lab tour: A fitting #Masterclass finale of 7.5 years #MICROB-PREDICT💙 Thanks to everyone who made this journey so special. Safe travels back home & see you in the next research project – it’s a small world 😉 @icn2.bsky.social

Day 2 of MICROB-PREDICT's Final #GeneralAssembly: 🩺 ALB-TRIAL wrap-up, #biomarkers, #POC biosensors & key decisions on data, #IP + exploitation 👩‍🔬 🫶 A heartfelt thank you to SEAB member Prof. Tilman Sauerbruch for his unwavering support throughout the years! #cirrhosis #ACLF @medblab.bsky.social

✨ Creativity meets impact at #MICROB-PREDICT's final GA Meeting! Marko Korenjak took us on a lively 7-year-long journey, while Minneke Coenraad & Robert Schierwagen highlighted the Delphi consensus, patient communication & the project's legacy. 🚀 #Hepatology #Horizon2020 @europeliver.bsky.social

28 Aug

🧬 MICROB-PREDICT's Final GA Meeting is coming up soon in Bellaterra, Spain, from 28–30 September! 🥳 Partners will reflect on results, the ALB-TRIAL, biomarkers, publications, the project's legacy and exploitation. 🎤 Wednesday's Masterclass will start with a Science Slam! #Microbiome #LiverHealth

20 July

📣 Just out: onlinelibrary.wiley.com/doi/10.1002/... We show that oral–gut microbial translocation in advanced cirrhosis drives metabolic convergence and increased ammonia & acetate production, linking the microbiome to systemic metabolic stress. 🧠🔬 #Cirrhosis #Microbiome #Hepatology #LiverDisease

Bork Group at EMBL Heidelberg

13 July

👏 Looking back: What a fantastic #EASLCongress 2026! 💪 50+ talks, posters, sessions & symposia, with outstanding work from early-career scientists. ✨ Main highlights: The MICROB-PREDICT Consensus Conference & Networking Session 🎉Congratulations to the whole team! #ACLF #microbiome #cirrhosis

MICROB-PREDICT reposted

@borklab.bsky.social

1 June

New in @natgenet.nature.com: a moving obituary for Peer. Francesca Ciccarelli, Jan Korbel & Christian von Mering reflect on his scientific vision, from protein domains and genome evolution to metagenomics, and on his generosity as a mentor and friend to so many. www.nature.com/articles/s41...

nature.comPeer Bork (1963–2026) - Nature GeneticsNature Genetics - Peer Bork (1963–2026)

MICROB-PREDICT reposted

Marisa Isabell Keller

@maelschermarisa.bsky.social

1 June

Our work exploring host-microbial co-metabolism of bile acids in patients with alcohol-related liver disease (ALD) has been published in the JHEP Reports: www.sciencedirect.com/science/arti... 🪐 A big thank you to everyone involved, to the GALAXY and MicrobLiver consortia who made this possible! 🙌

sciencedirect.comAlcohol-related liver disease disrupts bile acid homeostasis and gut microbial bile acid metabolismAlcohol overuse disrupts liver function and alters gut microbial communities, with alcohol-related liver disease (ALD) causing half of all liver-relat…

MICROB-PREDICT reposted

ELPA

@europeliver.bsky.social

20 May

Why ELPA is going on a unique European Liver Screening Tour ELPA is going on a unique European Liver Screening Tour because Europe can no longer afford to wait for liver disease to become visible only when it is already advanced. For too long, liver disease has remained silent.

MICROB-PREDICT reposted

Nina Donner

@ninadonner.bsky.social

1 June

Back home from an inspiring & energising #EASLCongress in sunny + hot Barcelona 🌅. These were my personal highlights (sound on 🔊) - what were your‘s? 😎 #Barcelona #EASL2026 #LiverDisease #LiverHealth #ACLF @europeliver.bsky.social @medblab.bsky.social @horizoneu.bsky.social @easlnews.bsky.social

31 May

🩺 #POSTER SAT-532 by Markus Maagaard et al. evaluated if direct #prothrombin concentration🩸can improve prognostic performance of the #MELD (Model for End-Stage Liver Disease) score in patients with decompensated #cirrhosis (compared to INR, the international normalised ratio). @easlnews.bsky.social

😁 Those two had fun at their #Poster: Congratulations to Philipp Althaus & Sabine Klein together with other colleagues from the MedB Lab (Münster, Germany), on this excellent poster presentation at #EASLCongress 2026 this Saturday! @medblab.bsky.social @easlnews.bsky.social @europeliver.bsky.social

🧬 Their work highlights miR-92a inhibition as a promising therapeutic strategy against #MASLD progression & #PortalHpertension, demonstrating reduced fibrosis, inflammation, hepatocellular injury, and portal pressure in preclinical models. #EASL2026 #LiverDisease #TranslationalResearch

👏 Two posters by David Tornai today at #EASLCongress! #POSTER SAT-414-YI explored the prognostic value of serum secretory #IgA in patients with #PSC. #POSTER SAT-415 evaluated circulating #macrophage activation markers as prognostic tools in #PSC. @easlnews.bsky.social @europeliver.bsky.social

🧬 Rocking the presentation of two posters at #EASLCongress 2026 - wow 🤩! 👏 Sania Arif did a great job at these posters today. #ACLF #Cirrhosis #Metabolomics #BacterialInfection #Hepatology #SystemicInflammation #Microbiome @medblab.bsky.social @easlnews.bsky.social @europeliver.bsky.social

🩺 Mortality prediction using non-invasive fibrosis scores independent of chronic liver disease in patients with COVID-19: #POSTER SAT-515 by Maximilian Joseph Brol et al. 📍Presented at #EASLCongress #EASL2026 #COVID19 #LiverDisease #Fibrosis #Hepatology #ClinicalResearch @medblab.bsky.social

The study found that FIB-4, APRI and NFS were strong independent predictors of mortality, suggesting that these scores may reflect systemic disease severity beyond liver-specific pathology.

💪 Strong finish of #EASL2026 with ✨ Highlights from the MICROB-PREDICT Consensus Conference ✨ at our #Networking session - Thanks for coming 🤗! #Microbiome-based #mechanisms #biomarkers #PatientStratification #cirrhosis #ACLF @medblab.bsky.social @easlnews.bsky.social @europeliver.bsky.social

💊 Non-selective #betablocker use was associated with improved survival across all stages of chronic #LiverDisease, including pre-ACLF & #ACLF: 👏 #POSTER SAT-458-YI by Josune Cabello Calleja et al. #EASL2026 #Cirrhosis #Hepatology @medblab.bsky.social @easlnews.bsky.social @europeliver.bsky.social

Today at #EASLCongress 2026 🎤: Thesession "EASL / EF-CLIF: The Road Ahead – Horizon Scanning in #Cirrhosis & #PortalHypertension" spotlighted the next wave of evidence that could reshape the management of advanced #LiverDisease! @europeliver.bsky.social @easlnews.bsky.social @medblab.bsky.social

👉 Javier Fenández (Hospital Clinic Barcelona & EF CLIF Governing Board Member) highlighted the COMBAT-TRIAL of the DECISION-Project (EU-funded Horizon2020 project coordinated by Pierre-Emmanuel Rautou) and MICROB-PREDICT's almost finished ALB-TRIAL. @decision4liver.bsky.social @easlnews.bsky.social

☺️ What a refreshingly honest #workshop on Friday eve: 💪 How can we turn setbacks into strengths? Former EASL Secretary General Aleksander Krag spoke with a group of #YoungInvestigators about his own career path that also included failures & setbacks. @easlnews.bsky.social #EASL2026 #EASLCongress

🧪 Minneke Coenraad (LUMC) chaired the last #PosterTour today on "Experimental and Pathophysiology" at the Cirrhosis & Complications Track Hub! 💫 Marie Bobowski-Gerard (GENFIT) did a fantastic job presenting this poster, a collaboration with @medblab.bsky.social: 👉 #Poster FRI-383 #EASLCongress

Congrats to V. Legry et al. on this #ACLF translational advance presented by Cristina López-Vicario at #EASLCongress, #POSTER FRI-412. ASK1 inhibitor SRT-015 reduced IL-6, IL-1β, TNFα & CXCL10 while preserving/enhancing antibacterial #ImmuneFunction, including phagocytosis & macrophage polarisation.

💬Prof. @aleksanderkrag.bsky.social co-chairs a symposium on #MetALD Key takeaways: • Structured diagnosis & prognosis • Managing AUD in liver patients • Integrating cardiometabolic risk control Focus: Practical application for #clinicalcare #Hepatology #EASL2026

👏 Minneke Coenraad's group (LUMC) has a strong presence during today's #PosterSession at #EASLCongress! See below what they investigated by watching our short movie clip 🎬... #Hepatology #LiverTransplantation #MELD #Cirrhosis @easlnews.bsky.social @europeliver.bsky.social @unileiden.bsky.social

✨ Poster Tour Highlight ✨ 🩺 Reductions in phosphatidylethanol #PEth are associated with improvements in #BloodPressure & lipid profile in steatotic liver disease #SLD. Shown by Nikolaj Torp et al. in #POSTER THU-204. #EASL2026 #SLD #MASLD #Hepatology @easlnews.bsky.social @europeliver.bsky.social

🦠 Incidence, risk factors & outcomes of #cytomegalovirus infection after liver transplantation: #POSTER FRI-474 by Maximilian Joseph Brol et al. investigates the incidence & clinical impact of CMV infection following #LiverTransplantation. 📍Presented at #EASLCongress #EASL2026 @medblab.bsky.social

We're back in the #EASLStudio. This time, @debbieshawcross.bsky.social, EASL Secretary General, chairs the session 'From evidence to action: Will the EASL-LANCET commission 2.0 move the needle on liver disease?' @thelancet.com @easlnews.bsky.social #EASL2026 #EASLCongress #liverdisease

🧬 Impaired endothelial FoxO1 signalling may contribute to endothelial dysfunction in ACLF. 👉 #POSTER FRI-428-YI by Fabian Schachteli et al. #EASL2026 #EASLCongress #ACLF #Cirrhosis #Hepatology @medblab.bsky.social @easlnews.bsky.social @europeliver.bsky.social

The study suggests that impaired FoxO1 signalling contributes to endothelial dysfunction in ACLF by reducing angiogenesis and endothelial proliferation, highlighting a potential mechanistic pathway in disease progression.

🧬 Maladaptive emergency #myelopoiesis may drive progression from acutely decompensated cirrhosis to ACLF. 👉 #POSTER FRI-388-YI by Zhujun Cao et al. #EASLCongress #EASL2026 #ACLF #Cirrhosis #Immunology #DecompensatedCirrhosis @medblab.bsky.social @europeliver.bsky.social @easlnews.bsky.social

📊 A nationwide German study highlights changing trends in hepatocellular carcinoma severity, treatment strategies & complications 2005-2019: #POSTER FRI-220 by Josune Cabello Calleja et al. #EASL2026 #HCC #LiverCancer #Hepatology @medblab.bsky.social @easlnews.bsky.social @europeliver.bsky.social

Prof. @aleksanderkrag.bsky.social (FLASH OUH) co-chairs today's #EASLStudio on the EASL-Lancet Commission on sustainable liver health in 🇪🇺 The session is dedicated to Michael Manns (1951-2025) @thelancet.com @easlnews.bsky.social #EASL2026

Manns (1951-2025) dedicated his life to #liverresearch. Led Hannover's gastroenterology clinic for 30 years, pioneered Hep C/D treatments, 1k+ publications, co-chaired the EASL-Lancet Commission. Passed at 73 from cancer.

🛜 Conferences like #EASLCongress are the perfect chance to network, exchange ideas & collaborate ☺️: As part of the "German Cirrhosis Study Group", the MedB Lab is excited to be represented so strongly at #EASL2026 in Barcelona! #Hepatology #LiverResearch @medblab.bsky.social @easlnews.bsky.social

🌎 Regional variation in #Rifaximin use & #GutMicrobiota composition in European patients with decompensated #cirrhosis: ✨ The outstanding international collaboration & poster SAT-467-YI by Susan Fischer et al. was featured during today's afternoon #PosterTour at Track Hub 6! #EASL2026 #Hepatology

🧬Constitutive #MAS1 activation may reduce #LiverFibrosis and #PortalHypertension in chronic liver disease! 🚨See POSTER FRI-329 by Philipp Althaus et al. (last author + #PosterTour presenter today: Sabine Klein, @medblab.bsky.social at UKM) #EASLCongress #Hepatology #EASL2026 @easlnews.bsky.social

🚨 Michael Praktiknjo et al. validated a custom-built 22G #EUS-PPG system with great correlation to the commercial 25G platform. 👉 Lower cost💲+ better availability may expand access to #PortalHypertension assessment worldwide 🌎! @medblab.bsky.social @europeliver.bsky.social @easlnews.bsky.social

📊 More inclusive definitions of non-acute decompensation #NAD to improve #RiskStratification in chronic #LiverDisease. ✨ POSTER WED-485 by Martin S. McCoy et al. was featured in today's #PosterTour! #EASLCongress #Cirrhosis @medblab.bsky.social @easlnews.bsky.social @europeliver.bsky.social

🔬 Can a simple urine #dipstick predict acute decompensation in #cirrhosis? #POSTER THU-436 by Susan Fischer (LUMC) investigated this question: Low #UrinaryChloride (≤38 mmol/L) was independently associated with a significantly higher risk of #AcuteDecompensation within 90 days. @easlnews.bsky.social

🧬 Reduced #apoptosis in HBV/HDV-expressing #hepatocytes: Poster THU-595 by @Pia Lembeck et al. investigated how HDV modulates apoptotic + #StressResponse pathways in HBV/HDV-expressing hepatocytes. 📍Presented at #EASLCongress 2026 @medblab.bsky.social @easlnews.bsky.social @europeliver.bsky.social

👉 The study suggests that HDV promotes hepatocyte survival through suppression of NF-kappaB/AP-1 activity and downregulation of EphA signalling, mechanisms that may contribute to viral persistence and HCC development.

💡Co-chaired by Maria Papp (Debrecen, Hungary), this was a key session at #EASLCongress today on acute #encephalopathy in #cirrhosis and the challenges of recognising hepatic encephalopathy (HE) versus other causes of altered mental status in the ICU. @easlnews.bsky.social @europeliver.bsky.social

🚨Takeaways included systematic diagnostic workup, early management of triggers, and the complexity of handling #AlcoholWithdrawal in acutely decompensated patients. A strong reminder of the value of multidisciplinary care in improving outcomes for #LiverPatients.

👏 Special honours go to Josune Cabello Calleja for being featured in this afternoon’s #PosterTour on #Cirrhosis & its complications - #ACLF & Critical illness. 👉 SAT-458-YI Beneficial impact of consequent non-selective #BetaBlocker intake on patient outcomes in all stages of chronic #LiverDisease

MICROB-PREDICT member @debbieshawcross.bsky.social, EASL Secretary General co-chaired the Global Liver Forum on Alcohol. #EASL2026 #EASLCongress @easlnews.bsky.social

🩺 TIPS placement was associated with a lower risk of AKI than contrast-enhanced CT imaging in patients with decompensated cirrhosis. #POSTER2 THU-461 by Markus Kimmann et al. 💪 #EASL2026 #AKI #TIPS #Cirrhosis